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Volumn 131, Issue 2, 2011, Pages 509-517

Axl promotes cutaneous squamous cell carcinoma survival through negative regulation of pro-apoptotic Bcl-2 family members

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CYTOCHROME C; PROTEIN BAD; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE AXL; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

EID: 78651392223     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.326     Document Type: Article
Times cited : (30)

References (38)
  • 1
    • 16844368716 scopus 로고    scopus 로고
    • The E7 protein of cutaneous human papillomavirus type 8 causes invasion of human keratinocytes into the dermis in organotypic cultures of skin
    • Akgul B, Garcia-Escudero R, Ghali L et al. (2005) The E7 protein of cutaneous human papillomavirus type 8 causes invasion of human keratinocytes into the dermis in organotypic cultures of skin. Cancer Res 65:2216-23
    • (2005) Cancer Res , vol.65 , pp. 2216-2223
    • Akgul, B.1    Garcia-Escudero, R.2    Ghali, L.3
  • 2
    • 47849087710 scopus 로고    scopus 로고
    • Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: A prospective study
    • Brantsch KD, Meisner C, Schonfisch B et al. (2008) Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study. Lancet Oncol 9:713-20
    • (2008) Lancet Oncol , vol.9 , pp. 713-720
    • Brantsch, K.D.1    Meisner, C.2    Schonfisch, B.3
  • 3
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X et al. (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-41
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3
  • 4
    • 3042691035 scopus 로고    scopus 로고
    • AKT status controls susceptibility of malignant keratinocytes to the early-activated and UVB-induced apoptotic pathway
    • Decraene D, Van Laethem A, Agostinis P et al. (2004) AKT status controls susceptibility of malignant keratinocytes to the early-activated and UVB-induced apoptotic pathway. J Invest Dermatol 123:207-12
    • (2004) J Invest Dermatol , vol.123 , pp. 207-212
    • Decraene, D.1    Van Laethem, A.2    Agostinis, P.3
  • 5
    • 0036241593 scopus 로고    scopus 로고
    • The epidemiology of skin cancer
    • Diepgen TL, Mahler V (2002) The epidemiology of skin cancer. Br J Dermatol 146(Suppl 61):1-6
    • (2002) Br J Dermatol , vol.146 , Issue.SUPPL. 61 , pp. 1-6
    • Diepgen, T.L.1    Mahler, V.2
  • 6
    • 24344451296 scopus 로고    scopus 로고
    • Role of apoptosis in basal cell and squamous cell carcinoma formation
    • Erb P, Ji J, Wernli M et al. (2005) Role of apoptosis in basal cell and squamous cell carcinoma formation. Immunol Lett 100:68-72
    • (2005) Immunol Lett , vol.100 , pp. 68-72
    • Erb, P.1    Ji, J.2    Wernli, M.3
  • 7
    • 0033595099 scopus 로고    scopus 로고
    • Gas6-mediated survival in NIH3T3 cells activates stress signalling cascade and is independent of Ras
    • Goruppi S, Ruaro E, Varnum B et al. (1999) Gas6-mediated survival in NIH3T3 cells activates stress signalling cascade and is independent of Ras. Oncogene 18:4224-36
    • (1999) Oncogene , vol.18 , pp. 4224-4236
    • Goruppi, S.1    Ruaro, E.2    Varnum, B.3
  • 8
    • 33646851254 scopus 로고    scopus 로고
    • Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours
    • Green J, Ikram M, Vyas J et al. (2006) Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours. Br J Cancer 94:1446-51
    • (2006) Br J Cancer , vol.94 , pp. 1446-1451
    • Green, J.1    Ikram, M.2    Vyas, J.3
  • 9
    • 0036931169 scopus 로고    scopus 로고
    • Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin
    • Hafizi S, Alindri F, Karlsson R et al. (2002) Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. Biochem Biophys Res Commun 299:793-800
    • (2002) Biochem Biophys Res Commun , vol.299 , pp. 793-800
    • Hafizi, S.1    Alindri, F.2    Karlsson, R.3
  • 10
    • 76749123429 scopus 로고    scopus 로고
    • R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer
    • Holland SJ, Pan A, Franci C et al. (2010) R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res 70:1544-54
    • (2010) Cancer Res , vol.70 , pp. 1544-1554
    • Holland, S.J.1    Pan, A.2    Franci, C.3
  • 11
    • 0037194353 scopus 로고    scopus 로고
    • Reduced apoptotic levels in squamous but not basal cell carcinomas correlates with detection of cutaneous human papillomavirus
    • Jackson S, Ghali L, Harwood C et al. (2002) Reduced apoptotic levels in squamous but not basal cell carcinomas correlates with detection of cutaneous human papillomavirus. Br J Cancer 87:319-23
    • (2002) Br J Cancer , vol.87 , pp. 319-323
    • Jackson, S.1    Ghali, L.2    Harwood, C.3
  • 12
    • 0027255417 scopus 로고
    • Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis
    • Kaufmann SH, Desnoyers S, Ottaviano Y et al. (1993) Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res 53:3976-85
    • (1993) Cancer Res , vol.53 , pp. 3976-3985
    • Kaufmann, S.H.1    Desnoyers, S.2    Ottaviano, Y.3
  • 13
    • 34147141585 scopus 로고    scopus 로고
    • The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest
    • Kaufmann T, Tai L, Ekert PG et al. (2007) The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest. Cell 129:423-33
    • (2007) Cell , vol.129 , pp. 423-433
    • Kaufmann, T.1    Tai, L.2    Ekert, P.G.3
  • 14
    • 33751513394 scopus 로고    scopus 로고
    • Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
    • Kim H, Rafiuddin-Shah M, Tu HC et al. (2006) Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nat Cell Biol 8:1348-58
    • (2006) Nat Cell Biol , vol.8 , pp. 1348-1358
    • Kim, H.1    Rafiuddin-Shah, M.2    Tu, H.C.3
  • 15
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
    • Kluck RM, Bossy-Wetzel E, Green DR et al. (1997) The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275:1132-6
    • (1997) Science , vol.275 , pp. 1132-1136
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3
  • 16
    • 0345276414 scopus 로고    scopus 로고
    • Bcl-2-family proteins and the role of mitochondria in apoptosis
    • Kuwana T, Newmeyer DD (2003) Bcl-2-family proteins and the role of mitochondria in apoptosis. Curr Opin Cell Biol 15:691-9
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 691-699
    • Kuwana, T.1    Newmeyer, D.D.2
  • 17
    • 34248562252 scopus 로고    scopus 로고
    • Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL
    • Lay JD, Hong CC, Huang JS et al. (2007) Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL. Cancer Res 67:3878-87
    • (2007) Cancer Res , vol.67 , pp. 3878-3887
    • Lay, J.D.1    Hong, C.C.2    Huang, J.S.3
  • 18
    • 33749385170 scopus 로고    scopus 로고
    • Caspase-dependent and -independent pathways for cadmium-induced apoptosis in cultured kidney proximal tubule cells
    • Lee WK, Abouhamed M, Thevenod F (2006) Caspase-dependent and -independent pathways for cadmium-induced apoptosis in cultured kidney proximal tubule cells. Am J Physiol Renal Physiol 291:F823-32
    • (2006) Am J Physiol Renal Physiol , vol.291
    • Lee, W.K.1    Abouhamed, M.2    Thevenod, F.3
  • 19
    • 85047698138 scopus 로고    scopus 로고
    • Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis
    • Lee WP, Wen Y, Varnum B et al. (2002) Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis. Oncogene 21:329-36
    • (2002) Oncogene , vol.21 , pp. 329-336
    • Lee, W.P.1    Wen, Y.2    Varnum, B.3
  • 20
    • 0036728834 scopus 로고    scopus 로고
    • Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
    • Letai A, Bassik MC, Walensky LD et al. (2002) Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2:183-92
    • (2002) Cancer Cell , vol.2 , pp. 183-192
    • Letai, A.1    Bassik, M.C.2    Walensky, L.D.3
  • 21
    • 0032555716 scopus 로고    scopus 로고
    • Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
    • Luo X, Budihardjo I, Zou H et al. (1998) Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94:481-90
    • (1998) Cell , vol.94 , pp. 481-490
    • Luo, X.1    Budihardjo, I.2    Zou, H.3
  • 22
    • 69449084464 scopus 로고    scopus 로고
    • Increased invasive behaviour in cutaneous squamous cell carcinoma with loss of basement-membrane type VII collagen
    • Martins VL, Vyas JJ, Chen M et al. (2009) Increased invasive behaviour in cutaneous squamous cell carcinoma with loss of basement-membrane type VII collagen. J Cell Sci 122:1788-99
    • (2009) J Cell Sci , vol.122 , pp. 1788-1799
    • Martins, V.L.1    Vyas, J.J.2    Chen, M.3
  • 23
    • 0036184567 scopus 로고    scopus 로고
    • Expression profile of tyrosine kinases in breast cancer
    • Meric F, Lee WP, Sahin A et al. (2002) Expression profile of tyrosine kinases in breast cancer. Clin Cancer Res 8:361-7
    • (2002) Clin Cancer Res , vol.8 , pp. 361-367
    • Meric, F.1    Lee, W.P.2    Sahin, A.3
  • 24
    • 0038046166 scopus 로고    scopus 로고
    • Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation
    • Nijhawan D, Fang M, Traer E et al. (2003) Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev 17:1475-86
    • (2003) Genes Dev , vol.17 , pp. 1475-1486
    • Nijhawan, D.1    Fang, M.2    Traer, E.3
  • 25
    • 0034030578 scopus 로고    scopus 로고
    • Spontaneous keratinocyte cell lines representing early and advanced stages of malignant transformation of the epidermis
    • Proby CM, Purdie KJ, Sexton CJ et al. (2000) Spontaneous keratinocyte cell lines representing early and advanced stages of malignant transformation of the epidermis. Exp Dermatol 9:104-17
    • (2000) Exp Dermatol , vol.9 , pp. 104-117
    • Proby, C.M.1    Purdie, K.J.2    Sexton, C.J.3
  • 26
    • 33750312678 scopus 로고    scopus 로고
    • Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA
    • Qin JZ, Xin H, Sitailo LA et al. (2006) Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA. Cancer Res 66:9636-45
    • (2006) Cancer Res , vol.66 , pp. 9636-9645
    • Qin, J.Z.1    Xin, H.2    Sitailo, L.A.3
  • 27
    • 0018902467 scopus 로고
    • Serial cultivation of normal human epidermal keratinocytes
    • Rheinwald JG (1980) Serial cultivation of normal human epidermal keratinocytes. Methods Cell Biol 21A:229-54
    • (1980) Methods Cell Biol , vol.21 A , pp. 229-254
    • Rheinwald, J.G.1
  • 28
    • 20144384673 scopus 로고    scopus 로고
    • Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor
    • Sainaghi PP, Castello L, Bergamasco L et al. (2005) Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor. J Cell Physiol 204:36-44
    • (2005) J Cell Physiol , vol.204 , pp. 36-44
    • Sainaghi, P.P.1    Castello, L.2    Bergamasco, L.3
  • 29
    • 33847008999 scopus 로고    scopus 로고
    • Growth arrest-specific gene 6 and Axl signaling enhances gastric cancer cell survival via Akt pathway
    • Sawabu T, Seno H, Kawashima T et al. (2007) Growth arrest-specific gene 6 and Axl signaling enhances gastric cancer cell survival via Akt pathway. Mol Carcinog 46:155-64
    • (2007) Mol Carcinog , vol.46 , pp. 155-164
    • Sawabu, T.1    Seno, H.2    Kawashima, T.3
  • 30
    • 0034123026 scopus 로고    scopus 로고
    • Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: A potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release
    • Slee EA, Keogh SA, Martin SJ (2000) Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release. Cell Death Differ 7:556-65
    • (2000) Cell Death Differ , vol.7 , pp. 556-565
    • Slee, E.A.1    Keogh, S.A.2    Martin, S.J.3
  • 31
    • 0032475861 scopus 로고    scopus 로고
    • Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
    • Stambolic V, Suzuki A, De la Pompa JL et al. (1998) Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95:29-39
    • (1998) Cell , vol.95 , pp. 29-39
    • Stambolic, V.1    Suzuki, A.2    De La Pompa, J.L.3
  • 32
    • 0034607702 scopus 로고    scopus 로고
    • Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
    • Tournier C, Hess P, Yang DD et al. (2000) Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288:870-4
    • (2000) Science , vol.288 , pp. 870-874
    • Tournier, C.1    Hess, P.2    Yang, D.D.3
  • 33
    • 33645821049 scopus 로고    scopus 로고
    • Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival
    • Vajkoczy P, Knyazev P, Kunkel A et al. (2006) Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival. Proc Natl Acad Sci USA 103:5799-804
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 5799-5804
    • Vajkoczy, P.1    Knyazev, P.2    Kunkel, A.3
  • 34
    • 0035966127 scopus 로고    scopus 로고
    • Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex
    • Vazquez F, Grossman SR, Takahashi Y et al. (2001) Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J Biol Chem 276:48627-30
    • (2001) J Biol Chem , vol.276 , pp. 48627-48630
    • Vazquez, F.1    Grossman, S.R.2    Takahashi, Y.3
  • 35
    • 0033946740 scopus 로고    scopus 로고
    • Phosphorylation of the PTEN tail regulates protein stability and function
    • Vazquez F, Ramaswamy S, Nakamura N et al. (2000) Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol 20:5010-8
    • (2000) Mol Cell Biol , vol.20 , pp. 5010-5018
    • Vazquez, F.1    Ramaswamy, S.2    Nakamura, N.3
  • 36
    • 0035957653 scopus 로고    scopus 로고
    • Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
    • Wei MC, Zong WX, Cheng EH et al. (2001) Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292:727-30
    • (2001) Science , vol.292 , pp. 727-730
    • Wei, M.C.1    Zong, W.X.2    Cheng, E.H.3
  • 37
    • 0030584088 scopus 로고    scopus 로고
    • Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
    • Zha J, Harada H, Yang E et al. (1996) Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 87:619-28
    • (1996) Cell , vol.87 , pp. 619-628
    • Zha, J.1    Harada, H.2    Yang, E.3
  • 38
    • 40949156351 scopus 로고    scopus 로고
    • AXL is a potential target for therapeutic intervention in breast cancer progression
    • Zhang YX, Knyazev PG, Cheburkin YV et al. (2008) AXL is a potential target for therapeutic intervention in breast cancer progression. Cancer Res 68:1905-15
    • (2008) Cancer Res , vol.68 , pp. 1905-1915
    • Zhang, Y.X.1    Knyazev, P.G.2    Cheburkin, Y.V.3


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