Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia

Cancer Letters

Volumn 268, Issue 2, 2008, Pages 314-324

  Hong, Chih Chen ^a,b   Lay, Jong Ding ^b,c   Huang, Jhy Shrian ^b   Cheng, Ann Lii ^b,d   Tang, Jih Luh ^d   Lin, Ming Tseh ^d   Lai, Gi Ming ^b   Chuang, Shuang En ^b  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c National Taichung Nursing College   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Acute myeloid leukemia; AXL; CCWGG methylation; Drug resistance; Gas6

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; DOXORUBICIN; ETOPOSIDE; GROWTH ARREST SPECIFIC PROTEIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BCL 2; PROTEIN TYROSINE KINASE; RECEPTOR TYROSINE KINASE AXL; TRANSCRIPTION FACTOR TWIST;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CANCER RESISTANCE; CELL STRAIN U937; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN METHYLATION; PROTEIN PHOSPHORYLATION; UPREGULATION;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; DRUG RESISTANCE, NEOPLASM; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKEMIA, MYELOID, ACUTE; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEINS; PROMOTER REGIONS (GENETICS); RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; U937 CELLS;

EID: 48549094691     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2008.04.017     Document Type: Article

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