Novel mechanism for gonadotropin-releasing hormone neuronal migration involving Gas6/ark signaling to p38 mitogen-activated protein kinase

Molecular and Cellular Biology

Volumn 22, Issue 2, 2002, Pages 599-613

  Allen, M P ^a   Linseman, D A ^a   Udo, H ^a   Xu, M ^a   Schaack, J B ^a   Varnum, B ^a   Kandel, E R ^a   Heidenreich, K A ^a   Wierman, M E ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACTIN; GENE PRODUCT; GONADORELIN; GROWTH ARREST SPECIFIC PROTEIN 6; GUANOSINE TRIPHOSPHATASE; HEAT SHOCK PROTEIN 25; MEMBRANE RECEPTOR ADHESION RELATED KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE ACTIVATED PROTEIN KINASE 2; PHOSPHOTRANSFERASE; PROTEIN KINASE; RAC PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CELL IMMORTALIZATION; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; HYPOTHALAMUS; LAMELLIPODIUM; MOUSE; NERVE CELL; NERVE CELL MEMBRANE; NONHUMAN; OLFACTORY CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SEXUAL MATURATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CELL MOVEMENT; CYTOSKELETON; GONADOTROPIN-RELEASING HORMONE; HEAT-SHOCK PROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM PROTEINS; NEURONS; ONCOGENE PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEINS; RAC GTP-BINDING PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION;

ADENOVIRIDAE; ANIMALIA;

EID: 0036135698     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.2.599-613.2002     Document Type: Article

References (73)

1. Myocyte enhancer factors-2B and -2C are required for adhesion related kinase repression of neuronal gonadotropin releasing hormone gene expression
2. Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt
3. The guanine nucleotide exchange factor trio mediates axonal development in the Drosophila embryo
4. The receptor tyrosine kinase ARK mediates cell aggregation by homophilic binding
5. Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation
6. Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases
7. Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1
8. New insights into the control of cell growth; the role of the AxI family
9. Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth
10. Identification of novel factors that regulate GnRH gene expression and neuronal migration
11. A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules
12. Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the AxI receptor tyrosine kinase
13. GAS6 induces Axl-mediated chemotaxis of vascular smooth muscle cells
14. Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism
15. Gas6, the ligand of Axl tyrosine kinase receptor, has mitogenic and survival activities for serum starved NIH3T3 fibroblasts
16. Gas6-mediated survival in NIH3T3 cells activates stress signalling cascade and is independent of Ras
17. Rho GTPases and the actin cytoskeleton
18. Cyclic AMP-induced neuronal differentiation via activation of p38 mitogen-activated protein kinase
19. A simplified system for generating recombinant adenoviruses
20. A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration
21. C-reactive protein inhibits chemotactic peptide-induced p38 mitogen-activated protein kinase activity and human neutrophil movement
22. Specific activation of the p38 mitogen-activated protein kinase signaling pathway and induction of neurite outgrowth in PC12 cells by bone morphogenetic protein-2
23. A novel putative tyrosine kinase receptor with oncogenic potential
24. The genetic aspects of primary eunuchoidism
25. Asef, a link between the tumor suppressor APC and G-protein signaling
26. Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3
27. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase
28. An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system
29. Modulation of actin dynamics during stress and physiological stimulation by a signaling pathway involving p38 MAP kinase and heat-shock protein 27
30. Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II
31. The guanine nucleotide exchange factor Tiam1 affects neuronal morphology: Opposing roles for the small GTPases Rac and Rho
32. The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules
33. Identification of Gas6 as a growth factor for human Schwann cells
34. Dosagesensitive, reciprocal genetic interactions between the Ab1 tyrosine kinase and the putative GEF Trio reveal Trio's role in axon pathfinding
35. Tyro-3 family receptors are essential regulators of mammalian spermatogenesis
36. Immortalized luteinizing hormone-releasing hormone neurons show a different migratory activity in vitro
37. Platelet-derived growth factor activates p38 mitogen-activated protein kinase through a Ras-dependent pathway that is important for actin reorganization and cell migration
38. GAS6 mediates adhesion of cells expressing the receptor tyrosine kinase Axl
39. Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis
40. Inhibitors of p38 MAP kinase increase the survival of transplanted dopamine neurons
41. Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cells
42. Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases
43. Trio combines with Dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila
44. Role of p38 mitogenactivated protein kinase in a murine model of pulmonary inflammation
45. Axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase
46. The 27-kDa heat shock protein facilitates basic fibroblast growth factor release from endothelial cells
47. Expression of the receptor protein-tyrosine kinases Tyro-3, Axl, and mer in the developing rat central nervous system
48. Gas6, a ligand for the receptor protein-tyrosine kinase Tyro-3, is widely expressed in the central nervous system
49. Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice
50. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
51. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
52. A putative receptor tyrosine kinase with unique structural topology
53. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
54. Ontogeny of gonadotropin-releasing hormone-containing neurons in early fetal development of rhesus macaques
55. p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells
56. Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility
57. Efficient selection of recombinant adenoviruses by vectors that express beta-galactosidase
58. Luteinizing hormonereleasing hormone (LHRH)-expressing cells do not migrate normally in an inherited hypogonadal (Kallmann) syndrome
59. Origin of luteinizing hormone-releasing hormone neurons
60. Gonadotropinreleasing hormone deficiency in the human (idiopathic hypogonadotropic hypogonadism and Kallmann's syndrome): Pathophysiological and genetic considerations
61. Intrahypothalamic injection of a cell line secreting gonadotropin-releasing hormone results in cellular differentiation and reversal of hypogonadism in mutant mice
62. Initial characterization of anosmin-1, a putative extracellular matrix protein synthesized by definite neuronal-cell populations in the central nervous system
63. Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells
64. Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growtharrest-specific gene 6
65. Intrinsic pulsatile secretory activity of immortalized luteinizing hormone-releasing hormonesecreting neurons
66. Evidence that cells expressing luteinizing hormone-releasing hormone mRNA in the mouse are derived from progenitor cells in the olfactory placode
67. A subset of peripherin positive olfactory axons delineates the luteinizing hormone releasing hormone neuronal migratory pathway in developing mouse
68. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
69. Phosphatidylinositol 3-kinases regulate ERK and p38 MAP kinases in canine colonic smooth muscle
70. The migration of luteinizing hormone-releasing hormone neurons in the developing rat is associated with a transient, caudal projection of the vomeronasal nerve
71. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1
72. An alternative gonadotropin-releasing hormone (GnRH) RNA splicing product found in cultured GnRH neurons and mouse hypothalamus
73. Role of a new Rho family member in cell migration and axon guidance in C. elegans