Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 4, 2013, Pages 1046-1050

  Powell, Noel A ^a,b   Hoffman, Jennifer K ^a   Ciske, Fred L ^a   Kaufman, Michael D ^a   Kohrt, Jeffrey T ^a   Quin III, John ^a   Sheehan, Derek J ^a   Delaney, Amy ^a   Baxi, Sangita M ^a   Catana, Cornel ^a   McConnell, Patrick ^a   Ohren, Jeff ^a   Perrin, Lisa A ^a   Edmunds, Jeremy J ^a  

^a PFIZER INC   (United States)

^b EISAI INC   (United States)

Author keywords

Anti platelet therapy; Hit to lead; Kinase Inhibitor

Indexed keywords

2,4 DIAMINOPYRIMIDINE 5 CARBOXAMIDE DERIVATIVE; ANTITHROMBOCYTIC AGENT; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; LIVER MICROSOME; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

AMIDES; ANIMALS; HUMANS; MICE; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RECEPTOR PROTEIN-TYROSINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84872915717     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.12.013     Document Type: Article

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