메뉴 건너뛰기




Volumn 20, Issue 12, 2012, Pages 2291-2303

Targeting Axl with an high-affinity inhibitory aptamer

Author keywords

[No Author keywords available]

Indexed keywords

APTAMER; AXL PROTEIN; GL21 T APTAMER; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

EID: 84870615894     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2012.163     Document Type: Article
Times cited : (132)

References (50)
  • 1
    • 0028981356 scopus 로고
    • Stimulation of sky receptor tyrosine kinase by the product of growth arrest-specific gene 6
    • Ohashi, K, Nagata, K, Toshima, J, Nakano, T, Arita, H, Tsuda, H et al. (1995). Stimulation of sky receptor tyrosine kinase by the product of growth arrest-specific gene 6. J Biol Chem 270: 22681-22684.
    • (1995) J Biol Chem , vol.270 , pp. 22681-22684
    • Ohashi, K.1    Nagata, K.2    Toshima, J.3    Nakano, T.4    Arita, H.5    Tsuda, H.6
  • 2
    • 0028913076 scopus 로고
    • The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
    • Stitt, TN, Conn, G, Gore, M, Lai, C, Bruno, J, Radziejewski, C et al. (1995). The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell 80: 661-670.
    • (1995) Cell , vol.80 , pp. 661-670
    • Stitt, T.N.1    Conn, G.2    Gore, M.3    Lai, C.4    Bruno, J.5    Radziejewski, C.6
  • 3
    • 0028985212 scopus 로고
    • Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6
    • Varnum, BC, Young, C, Elliott, G, Garcia, A, Bartley, TD, Fridell, YW et al. (1995). Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6. Nature 373: 623-626.
    • (1995) Nature , vol.373 , pp. 623-626
    • Varnum, B.C.1    Young, C.2    Elliott, G.3    Garcia, A.4    Bartley, T.D.5    Fridell, Y.W.6
  • 4
    • 0029968267 scopus 로고    scopus 로고
    • Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl
    • Mark, MR, Chen, J, Hammonds, RG, Sadick, M and Godowsk, PJ (1996). Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl. J Biol Chem 271: 9785-9789.
    • (1996) J Biol Chem , vol.271 , pp. 9785-9789
    • Mark, M.R.1    Chen, J.2    Hammonds, R.G.3    Sadick, M.4    Godowsk, P.J.5
  • 5
    • 27444442173 scopus 로고    scopus 로고
    • Both protein S and Gas6 stimulate outer segment phagocytosis by cultured rat retinal pigment epithelial cells
    • Hall, MO, Obin, MS, Heeb, MJ, Burgess, BL and Abrams, TA (2005). Both protein S and Gas6 stimulate outer segment phagocytosis by cultured rat retinal pigment epithelial cells. Exp Eye Res 81: 581-591.
    • (2005) Exp Eye Res , vol.81 , pp. 581-591
    • Hall, M.O.1    Obin, M.S.2    Heeb, M.J.3    Burgess, B.L.4    Abrams, T.A.5
  • 6
    • 42149149898 scopus 로고    scopus 로고
    • Auto-oxidation and oligomerization of protein S on the apoptotic cell surface is required for Mer tyrosine kinase-mediated phagocytosis of apoptotic cells
    • Uehara, H and Shacter, E (2008). Auto-oxidation and oligomerization of protein S on the apoptotic cell surface is required for Mer tyrosine kinase-mediated phagocytosis of apoptotic cells. J Immunol 180: 2522-2530.
    • (2008) J Immunol , vol.180 , pp. 2522-2530
    • Uehara, H.1    Shacter, E.2
  • 8
    • 33644876133 scopus 로고    scopus 로고
    • Expression of axl in lung adenocarcinoma and correlation with tumor progression
    • Shieh, YS, Lai, CY, Kao, YR, Shiah, SG, Chu, YW, Lee, HS et al. (2005). Expression of axl in lung adenocarcinoma and correlation with tumor progression. Neoplasia 7: 1058-1064.
    • (2005) Neoplasia , vol.7 , pp. 1058-1064
    • Shieh, Y.S.1    Lai, C.Y.2    Kao, Y.R.3    Shiah, S.G.4    Chu, Y.W.5    Lee, H.S.6
  • 10
    • 40949156351 scopus 로고    scopus 로고
    • AXL is a potential target for therapeutic intervention in breast cancer progression
    • Zhang, YX, Knyazev, PG, Cheburkin, YV, Sharma, K, Knyazev, YP, Orfi, L et al. (2008). AXL is a potential target for therapeutic intervention in breast cancer progression. Cancer Res 68: 1905-1915.
    • (2008) Cancer Res , vol.68 , pp. 1905-1915
    • Zhang, Y.X.1    Knyazev, P.G.2    Cheburkin, Y.V.3    Sharma, K.4    Knyazev, Y.P.5    Orfi, L.6
  • 11
    • 0036321937 scopus 로고    scopus 로고
    • Clinical significance of AXL kinase family in gastric cancer
    • Wu, CW, Li, AF, Chi, CW, Lai, CH, Huang, CL, Lo, SS et al. (2002). Clinical significance of AXL kinase family in gastric cancer. Anticancer Res 22(2B): 1071-1078.
    • (2002) Anticancer Res , vol.22 , Issue.2 B , pp. 1071-1078
    • Wu, C.W.1    Li, A.F.2    Chi, C.W.3    Lai, C.H.4    Huang, C.L.5    Lo, S.S.6
  • 12
    • 85046914648 scopus 로고    scopus 로고
    • The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target
    • Koorstra, JB, Karikari, CA, Feldmann, G, Bisht, S, Rojas, PL, Offerhaus, GJ et al. (2009). The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target. Cancer Biol Ther 8: 618-626.
    • (2009) Cancer Biol Ther , vol.8 , pp. 618-626
    • Koorstra, J.B.1    Karikari, C.A.2    Feldmann, G.3    Bisht, S.4    Rojas, P.L.5    Offerhaus, G.J.6
  • 14
    • 40749123639 scopus 로고    scopus 로고
    • Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme
    • Hutterer, M, Knyazev, P, Abate, A, Reschke, M, Maier, H, Stefanova, N et al. (2008). Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme. Clin Cancer Res 14: 130-138.
    • (2008) Clin Cancer Res , vol.14 , pp. 130-138
    • Hutterer, M.1    Knyazev, P.2    Abate, A.3    Reschke, M.4    Maier, H.5    Stefanova, N.6
  • 15
    • 36849065315 scopus 로고    scopus 로고
    • Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
    • Rikova, K, Guo, A, Zeng, Q, Possemato, A, Yu, J, Haack, H et al. (2007). Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131: 1190-1203.
    • (2007) Cell , vol.131 , pp. 1190-1203
    • Rikova, K.1    Guo, A.2    Zeng, Q.3    Possemato, A.4    Yu, J.5    Haack, H.6
  • 17
    • 80855138159 scopus 로고    scopus 로고
    • Human cutaneous melanomas lacking MITF and melanocyte differentiation antigens express a functional Axl receptor kinase
    • Sensi, M, Catani, M, Castellano, G, Nicolini, G, Alciato, F, Tragni, G et al. (2011). Human cutaneous melanomas lacking MITF and melanocyte differentiation antigens express a functional Axl receptor kinase. J Invest Dermatol 131: 2448-2457.
    • (2011) J Invest Dermatol , vol.131 , pp. 2448-2457
    • Sensi, M.1    Catani, M.2    Castellano, G.3    Nicolini, G.4    Alciato, F.5    Tragni, G.6
  • 18
    • 79951470770 scopus 로고    scopus 로고
    • The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: Implications for therapy
    • Ghosh, AK, Secreto, C, Boysen, J, Sassoon, T, Shanafelt, TD, Mukhopadhyay, D et al. (2011). The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy. Blood 117: 1928-1937.
    • (2011) Blood , vol.117 , pp. 1928-1937
    • Ghosh, A.K.1    Secreto, C.2    Boysen, J.3    Sassoon, T.4    Shanafelt, T.D.5    Mukhopadhyay, D.6
  • 19
    • 48549094691 scopus 로고    scopus 로고
    • Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia
    • Hong, CC, Lay, JD, Huang, JS, Cheng, AL, Tang, JL, Lin, MT et al. (2008). Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia. Cancer Lett 268: 314-324.
    • (2008) Cancer Lett , vol.268 , pp. 314-324
    • Hong, C.C.1    Lay, J.D.2    Huang, J.S.3    Cheng, A.L.4    Tang, J.L.5    Lin, M.T.6
  • 20
    • 70149109569 scopus 로고    scopus 로고
    • Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: Activation of AXL
    • Liu, L, Greger, J, Shi, H, Liu, Y, Greshock, J, Annan, R et al. (2009). Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL. Cancer Res 69: 6871-6878.
    • (2009) Cancer Res , vol.69 , pp. 6871-6878
    • Liu, L.1    Greger, J.2    Shi, H.3    Liu, Y.4    Greshock, J.5    Annan, R.6
  • 21
    • 84858794811 scopus 로고    scopus 로고
    • Fra-1 controls motility of bladder cancer cells via transcriptional upregulation of the receptor tyrosine kinase AXL
    • Sayan, AE, Stanford, R, Vickery, R, Grigorenko, E, Diesch, J, Kulbicki, K et al. (2012). Fra-1 controls motility of bladder cancer cells via transcriptional upregulation of the receptor tyrosine kinase AXL. Oncogene 31: 1493-1503.
    • (2012) Oncogene , vol.31 , pp. 1493-1503
    • Sayan, A.E.1    Stanford, R.2    Vickery, R.3    Grigorenko, E.4    Diesch, J.5    Kulbicki, K.6
  • 22
    • 79952532529 scopus 로고    scopus 로고
    • AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma
    • Xu, MZ, Chan, SW, Liu, AM, Wong, KF, Fan, ST, Chen, J et al. (2011). AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma. Oncogene 30: 1229-1240.
    • (2011) Oncogene , vol.30 , pp. 1229-1240
    • Xu, M.Z.1    Chan, S.W.2    Liu, A.M.3    Wong, K.F.4    Fan, S.T.5    Chen, J.6
  • 23
    • 46449103344 scopus 로고    scopus 로고
    • TAM receptor tyrosine kinases: Biologic functions, signaling, and potential therapeutic targeting in human cancer
    • Linger, RM, Keating, AK, Earp, HS and Graham, DK (2008). TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer. Adv Cancer Res 100: 35-83.
    • (2008) Adv Cancer Res , vol.100 , pp. 35-83
    • Linger, R.M.1    Keating, A.K.2    Earp, H.S.3    Graham, D.K.4
  • 25
    • 76749123429 scopus 로고    scopus 로고
    • R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer
    • Holland, SJ, Pan, A, Franci, C, Hu, Y, Chang, B, Li, W et al. (2010). R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res 70: 1544-1554.
    • (2010) Cancer Res , vol.70 , pp. 1544-1554
    • Holland, S.J.1    Pan, A.2    Franci, C.3    Hu, Y.4    Chang, B.5    Li, W.6
  • 26
    • 77957109253 scopus 로고    scopus 로고
    • An anti- Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies
    • Ye, X, Li, Y, Stawicki, S, Couto, S, Eastham-Anderson, J, Kallop, D et al. (2010). An anti- Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies. Oncogene 29: 5254-5264.
    • (2010) Oncogene , vol.29 , pp. 5254-5264
    • Ye, X.1    Li, Y.2    Stawicki, S.3    Couto, S.4    Eastham-Anderson, J.5    Kallop, D.6
  • 27
    • 80052225958 scopus 로고    scopus 로고
    • Nucleic acid aptamers against protein kinases
    • Cerchia, L and de Franciscis, V (2011). Nucleic acid aptamers against protein kinases. Curr Med Chem 18: 4152-4158.
    • (2011) Curr Med Chem , vol.18 , pp. 4152-4158
    • Cerchia, L.1    De Franciscis, V.2
  • 28
    • 80054825739 scopus 로고    scopus 로고
    • New insight into clinical development of nucleic acid aptamers
    • Esposito, CL, Catuogno, S, de Franciscis, V and Cerchia, L (2011). New insight into clinical development of nucleic acid aptamers. Discov Med 11: 487-496.
    • (2011) Discov Med , vol.11 , pp. 487-496
    • Esposito, C.L.1    Catuogno, S.2    De Franciscis, V.3    Cerchia, L.4
  • 29
    • 34548724257 scopus 로고    scopus 로고
    • Nucleic acid-based aptamers as promising therapeutics in neoplastic diseases
    • Cerchia, L and de Franciscis, V (2007). Nucleic acid-based aptamers as promising therapeutics in neoplastic diseases. Methods Mol Biol 361: 187-200.
    • (2007) Methods Mol Biol , vol.361 , pp. 187-200
    • Cerchia, L.1    De Franciscis, V.2
  • 30
    • 77956876990 scopus 로고    scopus 로고
    • Targeting cancer cells with nucleic acid aptamers
    • Cerchia, L and de Franciscis, V (2010). Targeting cancer cells with nucleic acid aptamers. Trends Biotechnol 28: 517-525.
    • (2010) Trends Biotechnol , vol.28 , pp. 517-525
    • Cerchia, L.1    De Franciscis, V.2
  • 32
    • 80054730117 scopus 로고    scopus 로고
    • Rational truncation of an RNA aptamer to prostate-specific membrane antigen using computational structural modeling
    • Rockey, WM, Hernandez, FJ, Huang, SY, Cao, S, Howell, CA, Thomas, GS et al. (2011). Rational truncation of an RNA aptamer to prostate-specific membrane antigen using computational structural modeling. Nucleic Acid Ther 21: 299-314.
    • (2011) Nucleic Acid Ther , vol.21 , pp. 299-314
    • Rockey, W.M.1    Hernandez, F.J.2    Huang, S.Y.3    Cao, S.4    Howell, C.A.5    Thomas, G.S.6
  • 33
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D and Weinberg, RA (2011). Hallmarks of cancer: the next generation. Cell 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 34
    • 0030740540 scopus 로고    scopus 로고
    • Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site
    • Braunger, J, Schleithoff, L, Schulz, AS, Kessler, H, Lammers, R, Ullrich, A et al. (1997). Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site. Oncogene 14: 2619-2631.
    • (1997) Oncogene , vol.14 , pp. 2619-2631
    • Braunger, J.1    Schleithoff, L.2    Schulz, A.S.3    Kessler, H.4    Lammers, R.5    Ullrich, A.6
  • 36
    • 0032549528 scopus 로고    scopus 로고
    • GAS6 induces Axl-mediated chemotaxis of vascular smooth muscle cells
    • Fridell, YW, Villa, J Jr, Attar, EC and Liu, ET (1998). GAS6 induces Axl-mediated chemotaxis of vascular smooth muscle cells. J Biol Chem 273: 7123-7126.
    • (1998) J Biol Chem , vol.273 , pp. 7123-7126
    • Fridell, Y.W.1    Villa Jr., J.2    Attar, E.C.3    Liu, E.T.4
  • 37
    • 33645821049 scopus 로고    scopus 로고
    • Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival
    • Vajkoczy, P, Knyazev, P, Kunkel, A, Capelle, HH, Behrndt, S, von Tengg-Kobligk, H et al. (2006). Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival. Proc Natl Acad Sci USA 103: 5799-5804.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 5799-5804
    • Vajkoczy, P.1    Knyazev, P.2    Kunkel, A.3    Capelle, H.H.4    Behrndt, S.5    Von Tengg-Kobligk, H.6
  • 39
    • 0038048211 scopus 로고    scopus 로고
    • Role of MAP kinase in tumor progression and invasion
    • Reddy, KB, Nabha, SM and Atanaskova, N (2003). Role of MAP kinase in tumor progression and invasion. Cancer Metastasis Rev 22: 395-403.
    • (2003) Cancer Metastasis Rev , vol.22 , pp. 395-403
    • Reddy, K.B.1    Nabha, S.M.2    Atanaskova, N.3
  • 40
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: Bidirectional, allosteric signaling machines
    • Hynes, RO (2002). Integrins: bidirectional, allosteric signaling machines. Cell 110: 673-687.
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 41
    • 75749115996 scopus 로고    scopus 로고
    • Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival
    • Gjerdrum, C, Tiron, C, Høiby, T, Stefansson, I, Haugen, H, Sandal, T et al. (2010). Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. Proc Natl Acad Sci USA 107: 1124-1129.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 1124-1129
    • Gjerdrum, C.1    Tiron, C.2    Høiby, T.3    Stefansson, I.4    Haugen, H.5    Sandal, T.6
  • 42
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery, JP (2002). Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 45
    • 79955122447 scopus 로고    scopus 로고
    • Transcriptional activation of the Axl and PDGFR-A by c-Met through a ras- and Src-independent mechanism in human bladder cancer
    • Yeh, CY, Shin, SM, Yeh, HH, Wu, TJ, Shin, JW, Chang, TY et al. (2011). Transcriptional activation of the Axl and PDGFR-a by c-Met through a ras- and Src-independent mechanism in human bladder cancer. BMC Cancer 11: 139.
    • (2011) BMC Cancer , vol.11 , pp. 139
    • Yeh, C.Y.1    Shin, S.M.2    Yeh, H.H.3    Wu, T.J.4    Shin, J.W.5    Chang, T.Y.6
  • 46
    • 84862308455 scopus 로고    scopus 로고
    • Macrophage-tumor crosstalk: Role of TAMR tyrosine kinase receptors and of their ligands
    • Schmidt, T, Ben-Batalla, I, Schultze, A and Loges, S (2012). Macrophage-tumor crosstalk: role of TAMR tyrosine kinase receptors and of their ligands. Cell Mol Life Sci 69: 1391-1414.
    • (2012) Cell Mol Life Sci , vol.69 , pp. 1391-1414
    • Schmidt, T.1    Ben-Batalla, I.2    Schultze, A.3    Loges, S.4
  • 48
    • 70249110439 scopus 로고    scopus 로고
    • Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
    • Dassie, JP, Liu, XY, Thomas, GS, Whitaker, RM, Thiel, KW, Stockdale, KR et al. (2009). Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. Nat Biotechnol 27: 839-849.
    • (2009) Nat Biotechnol , vol.27 , pp. 839-849
    • Dassie, J.P.1    Liu, X.Y.2    Thomas, G.S.3    Whitaker, R.M.4    Thiel, K.W.5    Stockdale, K.R.6
  • 49
    • 79954481313 scopus 로고    scopus 로고
    • Intracellular delivery of RNA-based therapeutics using aptamers
    • Thiel, KW and Giangrande, PH (2010). Intracellular delivery of RNA-based therapeutics using aptamers. Ther Deliv 1: 849-861.
    • (2010) Ther Deliv , vol.1 , pp. 849-861
    • Thiel, K.W.1    Giangrande, P.H.2
  • 50
    • 77954362096 scopus 로고    scopus 로고
    • Aptamer-targeted cell-specific RNA interference
    • Zhou, J and Rossi, JJ (2010). Aptamer-targeted cell-specific RNA interference. Silence 1: 4.
    • (2010) Silence , vol.1 , pp. 4
    • Zhou, J.1    Rossi, J.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.