메뉴 건너뛰기




Volumn 300, Issue 6, 2011, Pages

Gas6 deficiency prevents liver inflammation, steatohepatitis, and fibrosis in mice

Author keywords

Axl; CDE diet; Chronic liver diseases; Liver progenitor cells; Macrophages

Indexed keywords

CARBON TETRACHLORIDE; CHOLINE; COLLAGEN TYPE 1; ETHIONINE; GROWTH ARREST SPECIFIC PROTEIN 6; INTERLEUKIN 1BETA; LYMPHOTOXIN BETA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

EID: 79957955754     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00311.2010     Document Type: Article
Times cited : (58)

References (45)
  • 1
    • 0034868440 scopus 로고    scopus 로고
    • A modified choline-deficient, ethionine-supplemented diet protocol effectively induces oval cells in mouse liver
    • Akhurst B, Croager EJ, Farley-Roche CA, Ong JK, Dumble ML, Knight B, Yeoh GC. A modified choline-deficient, ethionine-supplemented diet protocol effectively induces oval cells in mouse liver. Hepatology 34: 519-522, 2001.
    • (2001) Hepatology , vol.34 , pp. 519-522
    • Akhurst, B.1    Croager, E.J.2    Farley-Roche, C.A.3    Ong, J.K.4    Dumble, M.L.5    Knight, B.6    Yeoh, G.C.7
  • 2
    • 12844273466 scopus 로고    scopus 로고
    • Differential lymphotoxin-beta and interferon gamma signaling during mouse liver regeneration induced by chronic and acute injury
    • Akhurst B, Matthews V, Husk K, Smyth MJ, Abraham LJ, Yeoh GC. Differential lymphotoxin-beta and interferon gamma signaling during mouse liver regeneration induced by chronic and acute injury. Hepatology 41: 327-335, 2005.
    • (2005) Hepatology , vol.41 , pp. 327-335
    • Akhurst, B.1    Matthews, V.2    Husk, K.3    Smyth, M.J.4    Abraham, L.J.5    Yeoh, G.C.6
  • 4
    • 16244416190 scopus 로고    scopus 로고
    • Fibrosis correlates with a ductular reaction in hepatitis C: Roles of impaired replication, progenitor cells and steatosis
    • Clouston AD, Powell EE, Walsh MJ, Richardson MM, Demetris AJ, Jonsson JR. Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis. Hepatology 41: 809-818, 2005.
    • (2005) Hepatology , vol.41 , pp. 809-818
    • Clouston, A.D.1    Powell, E.E.2    Walsh, M.J.3    Richardson, M.M.4    Demetris, A.J.5    Jonsson, J.R.6
  • 5
    • 27744571055 scopus 로고    scopus 로고
    • Expression and role of growth arrest-specific gene 6 protein and of its receptor axl in hepatic regeneration from oval cells
    • Couchie D, Lafdil F, Martin N, Laperche Y, Zafrani ES, Mavier P. Expression and role of growth arrest-specific gene 6 protein and of its receptor axl in hepatic regeneration from oval cells. Gastroenterology 129: 1633-1642, 2005.
    • (2005) Gastroenterology , vol.129 , pp. 1633-1642
    • Couchie, D.1    Lafdil, F.2    Martin, N.3    Laperche, Y.4    Zafrani, E.S.5    Mavier, P.6
  • 6
    • 30044431801 scopus 로고    scopus 로고
    • From fat to inflammation
    • Day CP. From fat to inflammation. Gastroenterology 130: 207-210, 2006.
    • (2006) Gastroenterology , vol.130 , pp. 207-210
    • Day, C.P.1
  • 8
    • 0034710974 scopus 로고    scopus 로고
    • Hematopoietic progenitor cells grow on 3T3 fibroblast monolayers that overexpress growth arrest-specific gene-6 (GAS6)
    • Dormady SP, Zhang XM, Basch RS. Hematopoietic progenitor cells grow on 3T3 fibroblast monolayers that overexpress growth arrest-specific gene-6 (GAS6). Proc Natl Acad Sci USA 97: 12260-12265, 2000.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12260-12265
    • Dormady, S.P.1    Zhang, X.M.2    Basch, R.S.3
  • 9
    • 4644297019 scopus 로고    scopus 로고
    • Natural history of nonalcoholic steatohepatitis: A longitudinal study of repeat liver biopsies
    • Fassio E, Alvarez E, Dominguez N, Landeira G, Longo C. Natural history of nonalcoholic steatohepatitis: a longitudinal study of repeat liver biopsies. Hepatology 40: 820-826, 2004.
    • (2004) Hepatology , vol.40 , pp. 820-826
    • Fassio, E.1    Alvarez, E.2    Dominguez, N.3    Landeira, G.4    Longo, C.5
  • 10
    • 14944350367 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor receptor 2-mediated endothelial cell activation by Axl tyrosine kinase receptor
    • Gallicchio M, Mitola S, Valdembri D, Fantozzi R, Varnum B, Avanzi GC, Bussolino F. Inhibition of vascular endothelial growth factor receptor 2-mediated endothelial cell activation by Axl tyrosine kinase receptor. Blood 105: 1970-1976, 2005.
    • (2005) Blood , vol.105 , pp. 1970-1976
    • Gallicchio, M.1    Mitola, S.2    Valdembri, D.3    Fantozzi, R.4    Varnum, B.5    Avanzi, G.C.6    Bussolino, F.7
  • 11
    • 33751079330 scopus 로고    scopus 로고
    • Gas6 and protein S. vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily
    • Hafizi S, Dahlback B. Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily. FEBS J 273: 5231-5244, 2006.
    • (2006) FEBS J , vol.273 , pp. 5231-5244
    • Hafizi, S.1    Dahlback, B.2
  • 12
  • 13
    • 77449117735 scopus 로고    scopus 로고
    • Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance
    • Huang W, Metlakunta A, Dedousis N, Zhang P, Sipula I, Dube JJ, Scott DK, O'Doherty RM. Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance. Diabetes 59: 347-357, 2010.
    • (2010) Diabetes , vol.59 , pp. 347-357
    • Huang, W.1    Metlakunta, A.2    Dedousis, N.3    Zhang, P.4    Sipula, I.5    Dube, J.J.6    Scott, D.K.7    O'Doherty, R.M.8
  • 15
    • 34548786662 scopus 로고    scopus 로고
    • Attenuated liver progenitor (oval) cell and fibrogenic responses to the choline deficient, ethionine supplemented diet in the BALB/c inbred strain of mice
    • Knight B, Akhurst B, Matthews VB, Ruddell RG, Ramm GA, Abraham LJ, Olynyk JK, Yeoh GC. Attenuated liver progenitor (oval) cell and fibrogenic responses to the choline deficient, ethionine supplemented diet in the BALB/c inbred strain of mice. J Hepatol 46: 134-141, 2007.
    • (2007) J Hepatol , vol.46 , pp. 134-141
    • Knight, B.1    Akhurst, B.2    Matthews, V.B.3    Ruddell, R.G.4    Ramm, G.A.5    Abraham, L.J.6    Olynyk, J.K.7    Yeoh, G.C.8
  • 16
    • 35949001284 scopus 로고    scopus 로고
    • Interferon-gamma exacerbates liver damage, the hepatic progenitor cell response and fibrosis in a mouse model of chronic liver injury
    • Knight B, Lim R, Yeoh GC, Olynyk JK. Interferon-gamma exacerbates liver damage, the hepatic progenitor cell response and fibrosis in a mouse model of chronic liver injury. J Hepatol 47: 826-833, 2007.
    • (2007) J Hepatol , vol.47 , pp. 826-833
    • Knight, B.1    Lim, R.2    Yeoh, G.C.3    Olynyk, J.K.4
  • 17
    • 22944437771 scopus 로고    scopus 로고
    • Liver inflammation and cytokine production, but not acute phase protein synthesis, accompany the adult liver progenitor (oval) cell response to chronic liver injury
    • Knight B, Matthews VB, Akhurst B, Croager EJ, Klinken E, Abraham LJ, Olynyk JK, Yeoh G. Liver inflammation and cytokine production, but not acute phase protein synthesis, accompany the adult liver progenitor (oval) cell response to chronic liver injury. Immunol Cell Biol 83: 364-374, 2005.
    • (2005) Immunol Cell Biol , vol.83 , pp. 364-374
    • Knight, B.1    Matthews, V.B.2    Akhurst, B.3    Croager, E.J.4    Klinken, E.5    Abraham, L.J.6    Olynyk, J.K.7    Yeoh, G.8
  • 19
    • 33745907270 scopus 로고    scopus 로고
    • Induction of Gas6 protein in CCl4-induced rat liver injury and anti-apoptotic effect on hepatic stellate cells
    • Lafdil F, Chobert MN, Couchie D, Brouillet A, Zafrani ES, Mavier P, Laperche Y. Induction of Gas6 protein in CCl4-induced rat liver injury and anti-apoptotic effect on hepatic stellate cells. Hepatology 44: 228-239, 2006.
    • (2006) Hepatology , vol.44 , pp. 228-239
    • Lafdil, F.1    Chobert, M.N.2    Couchie, D.3    Brouillet, A.4    Zafrani, E.S.5    Mavier, P.6    Laperche, Y.7
  • 21
    • 56549117448 scopus 로고    scopus 로고
    • Animal models of NASH: Getting both pathology and metabolic context right
    • Larter CZ, Yeh MM. Animal models of NASH: getting both pathology and metabolic context right. J Gastroenterol Hepatol 23: 1635-1648, 2008.
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 1635-1648
    • Larter, C.Z.1    Yeh, M.M.2
  • 22
    • 0037290890 scopus 로고    scopus 로고
    • Macrophage regulation by Tyro 3 family receptors
    • Lemke G, Lu Q. Macrophage regulation by Tyro 3 family receptors. Curr Opin Immunol 15: 31-36, 2003.
    • (2003) Curr Opin Immunol , vol.15 , pp. 31-36
    • Lemke, G.1    Lu, Q.2
  • 23
    • 0032964899 scopus 로고    scopus 로고
    • Oval cell numbers in human chronic liver diseases are directly related to disease severity
    • Lowes KN, Brennan BA, Yeoh GC, Olynyk JK. Oval cell numbers in human chronic liver diseases are directly related to disease severity. Am J Pathol 154: 537-541, 1999.
    • (1999) Am J Pathol , vol.154 , pp. 537-541
    • Lowes, K.N.1    Brennan, B.A.2    Yeoh, G.C.3    Olynyk, J.K.4
  • 24
    • 0035854442 scopus 로고    scopus 로고
    • Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family
    • Lu Q, Lemke G. Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science 293: 306-311, 2001.
    • (2001) Science , vol.293 , pp. 306-311
    • Lu, Q.1    Lemke, G.2
  • 25
    • 18244367899 scopus 로고    scopus 로고
    • Role of Gas-6 in adipogenesis and nutritionally induced adipose tissue development in mice
    • Maquoi E, Voros G, Carmeliet P, Collen D, Lijnen HR. Role of Gas-6 in adipogenesis and nutritionally induced adipose tissue development in mice. Arterioscler Thromb Vasc Biol 25: 1002-1007, 2005.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1002-1007
    • Maquoi, E.1    Voros, G.2    Carmeliet, P.3    Collen, D.4    Lijnen, H.R.5
  • 27
    • 0032487404 scopus 로고    scopus 로고
    • Increased expression of Axl tyrosine kinase after vascular injury and regulation by G protein-coupled receptor agonists in rats
    • Melaragno MG, Wuthrich DA, Poppa V, Gill D, Lindner V, Berk BC, Corson MA. Increased expression of Axl tyrosine kinase after vascular injury and regulation by G protein-coupled receptor agonists in rats. Circ Res 83: 697-704, 1998.
    • (1998) Circ Res , vol.83 , pp. 697-704
    • Melaragno, M.G.1    Wuthrich, D.A.2    Poppa, V.3    Gill, D.4    Lindner, V.5    Berk, B.C.6    Corson, M.A.7
  • 29
    • 1542504567 scopus 로고    scopus 로고
    • Portal tract fibrogenesis in the liver
    • Ramadori G, Saile B. Portal tract fibrogenesis in the liver. Lab Invest 84: 153-159, 2004.
    • (2004) Lab Invest , vol.84 , pp. 153-159
    • Ramadori, G.1    Saile, B.2
  • 30
    • 33645828659 scopus 로고    scopus 로고
    • Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation
    • Reddy JK, Rao MS. Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. Am J Physiol Gastrointest Liver Physiol 290: G852-G858, 2006.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Reddy, J.K.1    Rao, M.S.2
  • 32
    • 50049097587 scopus 로고    scopus 로고
    • Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet
    • Rinella ME, Elias MS, Smolak RR, Fu T, Borensztajn J, Green RM. Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet. J Lipid Res 49: 1068-1076, 2008.
    • (2008) J Lipid Res , vol.49 , pp. 1068-1076
    • Rinella, M.E.1    Elias, M.S.2    Smolak, R.R.3    Fu, T.4    Borensztajn, J.5    Green, R.M.6
  • 33
    • 34548272744 scopus 로고    scopus 로고
    • Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis
    • Rivera CA, Adegboyega P, van Rooijen N, Tagalicud A, Allman M, Wallace M. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J Hepatol 47: 571-579, 2007.
    • (2007) J Hepatol , vol.47 , pp. 571-579
    • Rivera, C.A.1    Adegboyega, P.2    van Rooijen, N.3    Tagalicud, A.4    Allman, M.5    Wallace, M.6
  • 35
    • 36849033963 scopus 로고    scopus 로고
    • TAM receptors are pleiotropic inhibitors of the innate immune response
    • Rothlin CV, Ghosh S, Zuniga EI, Oldstone MB, Lemke G. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131: 1124-1136, 2007.
    • (2007) Cell , vol.131 , pp. 1124-1136
    • Rothlin, C.V.1    Ghosh, S.2    Zuniga, E.I.3    Oldstone, M.B.4    Lemke, G.5
  • 39
    • 2942566011 scopus 로고    scopus 로고
    • Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts
    • Stenhoff J, Dahlback B, Hafizi S. Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts. Biochem Biophys Res Commun 319: 871-878, 2004.
    • (2004) Biochem Biophys Res Commun , vol.319 , pp. 871-878
    • Stenhoff, J.1    Dahlback, B.2    Hafizi, S.3
  • 40
    • 75449101395 scopus 로고    scopus 로고
    • Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferatoractivated receptor alpha activity
    • Stienstra R, Saudale F, Duval C, Keshtkar S, Groener JE, van Rooijen N, Staels B, Kersten S, Muller M. Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferatoractivated receptor alpha activity. Hepatology 51: 511-522, 2010.
    • (2010) Hepatology , vol.51 , pp. 511-522
    • Stienstra, R.1    Saudale, F.2    Duval, C.3    Keshtkar, S.4    Groener, J.E.5    van Rooijen, N.6    Staels, B.7    Kersten, S.8    Muller, M.9
  • 43
    • 66149109566 scopus 로고    scopus 로고
    • Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury
    • Van Hul NK, Abarca-Quinones J, Sempoux C, Horsmans Y, Leclercq IA. Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury. Hepatology 49: 1625-1635, 2009.
    • (2009) Hepatology , vol.49 , pp. 1625-1635
    • van Hul, N.K.1    Abarca-Quinones, J.2    Sempoux, C.3    Horsmans, Y.4    Leclercq, I.A.5
  • 45
    • 0023833533 scopus 로고
    • The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes
    • Yao ZM, Vance DE. The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes. J Biol Chem 263: 2998-3004, 1988.
    • (1988) J Biol Chem , vol.263 , pp. 2998-3004
    • Yao, Z.M.1    Vance, D.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.