Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 4, 2013, Pages 1051-1055

  Powell, Noel A ^a   Hoffman, Jennifer K ^a   Ciske, Fred L ^a   Kohrt, Jeffrey T ^a   Baxi, Sangita M ^a   Peng, Yun Wen ^a   Zhong, Min ^a   Catana, Cornel ^a   Ohren, Jeff ^a   Perrin, Lisa A ^a   Edmunds, Jeremy J ^a  

^a PFIZER INC   (United States)

Author keywords

Anti platelet therapy; Hit to lead; Tyrosine receptor kinase

Indexed keywords

2,4 DIAMINOPYRIMIDINE 5 CARBOXAMIDE; 2,4 DIAMINOPYRIMIDINE DERIVATIVE; AMIDE; PROTEIN TYROSINE KINASE INHIBITOR; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG METABOLISM; ENZYME INHIBITION; IC 50; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; REACTION OPTIMIZATION; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION;

AMIDES; ANIMALS; HUMANS; MICE; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RECEPTOR PROTEIN-TYROSINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84872892894     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.12.028     Document Type: Article

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