메뉴 건너뛰기




Volumn 3, Issue 1, 2013, Pages

Inhibition of MerTK increases chemosensitivity and decreases oncogenic potential in T-cell acute lymphoblastic leukemia

Author keywords

MerTK; receptor tyrosine kinase; T cell leukemia; xenograft mouse model

Indexed keywords

CYTARABINE; ETOPOSIDE; MER RECEPTOR TYROSINE KINASE; MERCAPTOPURINE; METHYLCELLULOSE; PROTEIN TYROSINE KINASE; STAT PROTEIN; UNCLASSIFIED DRUG;

EID: 84873638978     PISSN: None     EISSN: 20445385     Source Type: Journal    
DOI: 10.1038/bcj.2012.46     Document Type: Article
Times cited : (48)

References (36)
  • 2
    • 77953022239 scopus 로고    scopus 로고
    • Epidemiology of childhood cancer
    • Kaatsch P. Epidemiology of childhood cancer. Cancer Treat Rev 2010; 36: 277-285.
    • (2010) Cancer Treat Rev , vol.36 , pp. 277-285
    • Kaatsch, P.1
  • 3
    • 56749161747 scopus 로고    scopus 로고
    • Cancer survivorship: A pediatric perspective
    • Landier W, Bhatia S. Cancer survivorship: a pediatric perspective. Oncologist 2008; 13: 1181-1192.
    • (2008) Oncologist , vol.13 , pp. 1181-1192
    • Landier, W.1    Bhatia, S.2
  • 5
    • 0142008436 scopus 로고    scopus 로고
    • Childhood T-cell acute lymphoblastic leukemia: The Dana-Farber Cancer Institute acute lymphoblastic leukemia consortium experience
    • Goldberg JM, Silverman LB, Levy DE, Dalton VK, Gelber RD, Lehmann L et al. Childhood T-cell acute lymphoblastic leukemia: the Dana-Farber Cancer Institute acute lymphoblastic leukemia consortium experience. J Clin Oncol 2003; 21: 3613-3622.
    • (2003) J Clin Oncol , vol.21 , pp. 3613-3622
    • Goldberg, J.M.1    Silverman, L.B.2    Levy, D.E.3    Dalton, V.K.4    Gelber, R.D.5    Lehmann, L.6
  • 6
    • 0026072791 scopus 로고
    • Six-year experience with a comprehensive approach to the treatment of recurrent childhood acute lymphoblastic leukemia (ALL-REZ BFM 85)
    • Henze G, Fengler R, Hartmann R, Kornhuber B, Janka-Schaub G, Niethammer D et al. Six-year experience with a comprehensive approach to the treatment of recurrent childhood acute lymphoblastic leukemia (ALL-REZ BFM 85). A relapse study of the BFM group. Blood 1991; 78: 1166-1172.
    • (1991) A Relapse Study of the BFM Group. Blood , vol.78 , pp. 1166-1172
    • Henze, G.1    Fengler, R.2    Hartmann, R.3    Kornhuber, B.4    Janka-Schaub, G.5    Niethammer, D.6
  • 9
    • 42649140235 scopus 로고    scopus 로고
    • Immunobiology of the TAM receptors
    • Lemke G, Rothlin CV. Immunobiology of the TAM receptors. Nat Rev Immunol 2008; 8: 327-336.
    • (2008) Nat Rev Immunol , vol.8 , pp. 327-336
    • Lemke, G.1    Rothlin, C.V.2
  • 10
    • 33846872571 scopus 로고    scopus 로고
    • A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation
    • Sather S, Kenyon KD, Lefkowitz JB, Liang X, Varnum BC, Henson PM et al. A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation. Blood 2007; 109: 1026-1033.
    • (2007) Blood , vol.109 , pp. 1026-1033
    • Sather, S.1    Kenyon, K.D.2    Lefkowitz, J.B.3    Liang, X.4    Varnum, B.C.5    Henson, P.M.6
  • 11
    • 0029910706 scopus 로고    scopus 로고
    • Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases
    • Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H et al. Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. J Biol Chem 1996; 271: 30022-30027.
    • (1996) J Biol Chem , vol.271 , pp. 30022-30027
    • Nagata, K.1    Ohashi, K.2    Nakano, T.3    Arita, H.4    Zong, C.5    Hanafusa, H.6
  • 12
    • 0028913076 scopus 로고
    • The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
    • Stitt TN, Conn G, Gore M, Lai C, Bruno J, Radziejewski C et al. The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell 1995; 80: 661-670.
    • (1995) Cell , vol.80 , pp. 661-670
    • Stitt, T.N.1    Conn, G.2    Gore, M.3    Lai, C.4    Bruno, J.5    Radziejewski, C.6
  • 14
    • 0027182792 scopus 로고
    • The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade
    • Manfioletti G, Brancolini C, Avanzi G, Schneider C. The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. Mol Cell Biol 1993; 13: 4976-4985.
    • (1993) Mol Cell Biol , vol.13 , pp. 4976-4985
    • Manfioletti, G.1    Brancolini, C.2    Avanzi, G.3    Schneider, C.4
  • 15
    • 77957092501 scopus 로고    scopus 로고
    • Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors
    • Linger RM, Keating AK, Earp HS, Graham DK. Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors. Expert Opin Ther Targets 2010; 14: 1073-1090.
    • (2010) Expert Opin Ther Targets , vol.14 , pp. 1073-1090
    • Linger, R.M.1    Keating, A.K.2    Earp, H.S.3    Graham, D.K.4
  • 17
    • 78649714537 scopus 로고    scopus 로고
    • Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis
    • Caberoy NB, Zhou Y, Li W. Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis. EMBO J 2010; 29: 3898-3910.
    • (2010) EMBO J , vol.29 , pp. 3898-3910
    • Caberoy, N.B.1    Zhou, Y.2    Li, W.3
  • 18
    • 82655173829 scopus 로고    scopus 로고
    • Galectin-3a jack-of-all-trades in cancer
    • Newlaczyl AU, Yu LG. Galectin-3a jack-of-all-trades in cancer. Cancer Lett 2011; 313: 123-128.
    • (2011) Cancer Lett , vol.313 , pp. 123-128
    • Newlaczyl, A.U.1    Yu, L.G.2
  • 19
    • 0032926887 scopus 로고    scopus 로고
    • Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB
    • Georgescu MM, Kirsch KH, Shishido T, Zong C, Hanafusa H. Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB. Mol Cell Biol 1999; 19: 1171-1181.
    • (1999) Mol Cell Biol , vol.19 , pp. 1171-1181
    • Georgescu, M.M.1    Kirsch, K.H.2    Shishido, T.3    Zong, C.4    Hanafusa, H.5
  • 20
    • 0028875948 scopus 로고
    • Mitogenic signals and transforming potential of Nyk, a newly identified neural cell adhesion molecule-related receptor tyrosine kinase
    • Ling L, Kung HJ. Mitogenic signals and transforming potential of Nyk, a newly identified neural cell adhesion molecule-related receptor tyrosine kinase. Mol Cell Biol 1995; 15: 6582-6592.
    • (1995) Mol Cell Biol , vol.15 , pp. 6582-6592
    • Ling, L.1    Kung, H.J.2
  • 22
    • 19044399684 scopus 로고    scopus 로고
    • Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling
    • Yeoh EJ, Ross ME, Shurtleff SA, Williams WK, Patel D, Mahfouz R et al. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 2002; 1: 133-143.
    • (2002) Cancer Cell , vol.1 , pp. 133-143
    • Yeoh, E.J.1    Ross, M.E.2    Shurtleff, S.A.3    Williams, W.K.4    Patel, D.5    Mahfouz, R.6
  • 23
    • 33749836690 scopus 로고    scopus 로고
    • Lymphoblastic leukemia/lymphoma in mice overexpressing the Mer (MerTK) receptor tyrosine kinase
    • Keating AK, Salzberg DB, Sather S, Liang X, Nickoloff S, Anwar A et al. Lymphoblastic leukemia/lymphoma in mice overexpressing the Mer (MerTK) receptor tyrosine kinase. Oncogene 2006; 25: 6092-6100.
    • (2006) Oncogene , vol.25 , pp. 6092-6100
    • Keating, A.K.1    Salzberg, D.B.2    Sather, S.3    Liang, X.4    Nickoloff, S.5    Anwar, A.6
  • 24
    • 77952205519 scopus 로고    scopus 로고
    • Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity
    • Keating AK, Kim GK, Jones AE, Donson AM, Ware K, Mulcahy JM et al. Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity. Mol Cancer Ther 2010; 9: 1298-1307.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1298-1307
    • Keating, A.K.1    Kim, G.K.2    Jones, A.E.3    Donson, A.M.4    Ware, K.5    Mulcahy, J.M.6
  • 25
    • 84880922644 scopus 로고    scopus 로고
    • Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer
    • e-pub ahead of print 13 August, doi: 10.1038/ onc.2012.355
    • Linger RM, Cohen RA, Cummings CT, Sather S, Migdall-Wilson J, Middleton DH et al. Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer. Oncogene 2012 (e-pub ahead of print 13 August 2012; doi:10.1038/ onc.2012.355).
    • (2012) Oncogene 2012
    • Linger, R.M.1    Cohen, R.A.2    Cummings, C.T.3    Sather, S.4    Migdall-Wilson, J.5    Middleton, D.H.6
  • 26
    • 84857423087 scopus 로고    scopus 로고
    • Prolonged exposure to a Mer ligand in leukemia: Gas6 favors expression of a partial Mer glycoform and reveals a novel role for Mer in the nucleus
    • Migdall-Wilson J, Bates C, Schlegel J, Brandao L, Linger RM, DeRyckere D et al. Prolonged exposure to a Mer ligand in leukemia: Gas6 favors expression of a partial Mer glycoform and reveals a novel role for Mer in the nucleus. PLoS One 2012; 7: e31635.
    • (2012) PLoS One , vol.7
    • Migdall-Wilson, J.1    Bates, C.2    Schlegel, J.3    Brandao, L.4    Linger, R.M.5    Deryckere, D.6
  • 27
    • 84866535796 scopus 로고    scopus 로고
    • Mer receptor tyrosine kinase inhibition impedes glioblastoma multiforme migration and alters cellular morphology
    • Rogers AE, Le JP, Sather S, Pernu BM, Graham DK, Pierce AM et al. Mer receptor tyrosine kinase inhibition impedes glioblastoma multiforme migration and alters cellular morphology. Oncogene 2012; 31: 4171-4181.
    • (2012) Oncogene , vol.31 , pp. 4171-4181
    • Rogers, A.E.1    Le, J.P.2    Sather, S.3    Pernu, B.M.4    Graham, D.K.5    Pierce, A.M.6
  • 28
    • 83255191885 scopus 로고    scopus 로고
    • TAM receptors in leukemia: Expression, signaling, and therapeutic implications
    • Brandao L, Migdall-Wilson J, Eisenman K, Graham DK. TAM receptors in leukemia: expression, signaling, and therapeutic implications. Crit Rev Oncog 2011; 16: 47-63.
    • (2011) Crit Rev Oncog , vol.16 , pp. 47-63
    • Brandao, L.1    Migdall-Wilson, J.2    Eisenman, K.3    Graham, D.K.4
  • 29
    • 46449103344 scopus 로고    scopus 로고
    • TAM receptor tyrosine kinases: Biologic functions, signaling, and potential therapeutic targeting in human cancer
    • Linger RM, Keating AK, Earp HS, Graham DK. TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer. Adv Cancer Res 2008; 100: 35-83.
    • (2008) Adv Cancer Res , vol.100 , pp. 35-83
    • Linger, R.M.1    Keating, A.K.2    Earp, H.S.3    Graham, D.K.4
  • 31
    • 0035734121 scopus 로고    scopus 로고
    • Continuing therapy for childhood acute lymphoblastic leukaemia: Clinical and cellular pharmacology of methotrexate, 6-mercaptopurine and 6-thioguanine
    • Estlin EJ. Continuing therapy for childhood acute lymphoblastic leukaemia: clinical and cellular pharmacology of methotrexate, 6-mercaptopurine and 6-thioguanine. Cancer Treat Rev 2001; 27: 351-363.
    • (2001) Cancer Treat Rev , vol.27 , pp. 351-363
    • Estlin, E.J.1
  • 32
    • 15444339209 scopus 로고    scopus 로고
    • A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
    • Lacronique V, Boureux A, Valle VD, Poirel H, Quang CT, Mauchauffe M et al. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 1997; 278: 1309-1312.
    • (1997) Science , vol.278 , pp. 1309-1312
    • Lacronique, V.1    Boureux, A.2    Valle, V.D.3    Poirel, H.4    Quang, C.T.5    Mauchauffe, M.6
  • 33
    • 36849033963 scopus 로고    scopus 로고
    • TAM receptors are pleiotropic inhibitors of the innate immune response
    • Rothlin CV, Ghosh S, Zuniga EI, Oldstone MB, Lemke G. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 2007; 131: 1124-1136.
    • (2007) Cell , vol.131 , pp. 1124-1136
    • Rothlin, C.V.1    Ghosh, S.2    Zuniga, E.I.3    Oldstone, M.B.4    Lemke, G.5
  • 34
    • 0029791664 scopus 로고    scopus 로고
    • Unique signal transduction of Eyk: Constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase
    • Zong C, Yan R, August A, Darnell Jr JE, Hanafusa H. Unique signal transduction of Eyk: constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase. EMBO J 1996; 15: 4515-4525.
    • (1996) EMBO J , vol.15 , pp. 4515-4525
    • Zong, C.1    Yan, R.2    August, A.3    Darnell Jr., J.E.4    Hanafusa, H.5
  • 35
  • 36
    • 0033811659 scopus 로고    scopus 로고
    • Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation
    • Shan X, Czar MJ, Bunnell SC, Liu P, Liu Y, Schwartzberg PL et al. Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation. Mol Cell Biol 2000; 20: 6945-6957.
    • (2000) Mol Cell Biol , vol.20 , pp. 6945-6957
    • Shan, X.1    Czar, M.J.2    Bunnell, S.C.3    Liu, P.4    Liu, Y.5    Schwartzberg, P.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.