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Volumn 205, Issue 1, 2008, Pages 219-232

MerTK is required for apoptotic cell-induced T cell tolerance

Author keywords

[No Author keywords available]

Indexed keywords

CD11 ANTIGEN; CD8ALPHA ANTIGEN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE MER; UNCLASSIFIED DRUG; CD8 ANTIGEN; CD8ALPHAALPHA ANTIGEN; GLYCOPROTEIN P 15095; INTERLEUKIN 12; MERTK PROTEIN, MOUSE; ONCOPROTEIN;

EID: 38749108510     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20062293     Document Type: Article
Times cited : (122)

References (53)
  • 1
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr, J.F., A.H. Wyllie, and A.R. Currie. 1972. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer. 26:239-257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 2
    • 0026508561 scopus 로고
    • Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
    • Fadok, V.A., D.R. Voelker, P.A. Campbell, J.J. Cohen, D.L. Bratton, and P.M. Henson. 1992. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J. Immunol. 148:2207-2216.
    • (1992) J. Immunol , vol.148 , pp. 2207-2216
    • Fadok, V.A.1    Voelker, D.R.2    Campbell, P.A.3    Cohen, J.J.4    Bratton, D.L.5    Henson, P.M.6
  • 3
    • 27744482874 scopus 로고    scopus 로고
    • Immunoregulation of dendritic cells
    • Wallet, M.A., P. Sen, and R. Tisch. 2005. Immunoregulation of dendritic cells. Clin. Med. Res. 3:166-175.
    • (2005) Clin. Med. Res , vol.3 , pp. 166-175
    • Wallet, M.A.1    Sen, P.2    Tisch, R.3
  • 4
    • 3543053363 scopus 로고    scopus 로고
    • Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes
    • Albert, M.L., S.F. Pearce, L.M. Francisco, B. Sauter, P. Roy, R.L. Silverstein, and N. Bhardwaj. 1998. Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J. Exp. Med. 188:1359-1368.
    • (1998) J. Exp. Med , vol.188 , pp. 1359-1368
    • Albert, M.L.1    Pearce, S.F.2    Francisco, L.M.3    Sauter, B.4    Roy, P.5    Silverstein, R.L.6    Bhardwaj, N.7
  • 6
    • 43949172708 scopus 로고
    • Phagocyte recognition of cells undergoing apoptosis
    • Savill, J., V. Fadok, P. Henson, and C. Haslett. 1993. Phagocyte recognition of cells undergoing apoptosis. Immunol. Today. 14:131-136.
    • (1993) Immunol. Today , vol.14 , pp. 131-136
    • Savill, J.1    Fadok, V.2    Henson, P.3    Haslett, C.4
  • 8
    • 0141791335 scopus 로고    scopus 로고
    • Surfactant protein A enhances apoptotic cell uptake and TGF-beta1 release by inflammatory alveolar macrophages
    • Reidy, M.F., and J.R. Wright. 2003. Surfactant protein A enhances apoptotic cell uptake and TGF-beta1 release by inflammatory alveolar macrophages. Am. J. Physiol. Lung Cell. Mol. Physiol. 285:L854-L861.
    • (2003) Am. J. Physiol. Lung Cell. Mol. Physiol , vol.285
    • Reidy, M.F.1    Wright, J.R.2
  • 9
    • 0036143018 scopus 로고    scopus 로고
    • Phosphatidylserine- dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation
    • Huynh, M.L., V.A. Fadok, and P.M. Henson. 2002. Phosphatidylserine- dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J. Clin. Invest. 109:41-50.
    • (2002) J. Clin. Invest , vol.109 , pp. 41-50
    • Huynh, M.L.1    Fadok, V.A.2    Henson, P.M.3
  • 10
    • 0034614886 scopus 로고    scopus 로고
    • The induction of tolerance by dendritic cells that have captured apoptotic cells
    • Steinman, R.M., S. Turley, I. Mellman, and K. Inaba. 2000. The induction of tolerance by dendritic cells that have captured apoptotic cells. J. Exp. Med. 191:411-416.
    • (2000) J. Exp. Med , vol.191 , pp. 411-416
    • Steinman, R.M.1    Turley, S.2    Mellman, I.3    Inaba, K.4
  • 12
  • 14
    • 0035854442 scopus 로고    scopus 로고
    • Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family
    • Lu, Q., and G. Lemke. 2001. Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science. 293:306-311.
    • (2001) Science , vol.293 , pp. 306-311
    • Lu, Q.1    Lemke, G.2
  • 16
    • 0033559140 scopus 로고    scopus 로고
    • A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock
    • Camenisch, T.D., B.H. Koller, H.S. Earp, and G.K. Matsushima. 1999. A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock. J. Immunol. 162:3498-3503.
    • (1999) J. Immunol , vol.162 , pp. 3498-3503
    • Camenisch, T.D.1    Koller, B.H.2    Earp, H.S.3    Matsushima, G.K.4
  • 18
    • 0033757463 scopus 로고    scopus 로고
    • Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa
    • Gal, A., Y. Li, D.A. Thompson, J. Weir, U. Orth, S.G. Jacobson, E. Apfelstedt-Sylla, and D. Vollrath. 2000. Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. Nat. Genet. 26:270-271.
    • (2000) Nat. Genet , vol.26 , pp. 270-271
    • Gal, A.1    Li, Y.2    Thompson, D.A.3    Weir, J.4    Orth, U.5    Jacobson, S.G.6    Apfelstedt-Sylla, E.7    Vollrath, D.8
  • 21
    • 0034073163 scopus 로고    scopus 로고
    • Promotion of the uptake of PS liposomes and apoptotic cells by a product of growth arrest-specific gene, gas6
    • Ishimoto, Y., K. Ohashi, K. Mizuno, and T. Nakano. 2000. Promotion of the uptake of PS liposomes and apoptotic cells by a product of growth arrest-specific gene, gas6. J. Biochem. (Tokyo). 127:411-417.
    • (2000) J. Biochem. (Tokyo) , vol.127 , pp. 411-417
    • Ishimoto, Y.1    Ohashi, K.2    Mizuno, K.3    Nakano, T.4
  • 23
    • 0027378612 scopus 로고
    • Following a diabetogenic T cell from genesis through pathogenesis
    • Katz, J.D., B. Wang, K. Haskins, C. Benoist, and D. Mathis. 1993. Following a diabetogenic T cell from genesis through pathogenesis. Cell. 74:1089-1100.
    • (1993) Cell , vol.74 , pp. 1089-1100
    • Katz, J.D.1    Wang, B.2    Haskins, K.3    Benoist, C.4    Mathis, D.5
  • 26
    • 0030981120 scopus 로고    scopus 로고
    • Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation
    • Chen, J., K. Carey, and P.J. Godowski. 1997. Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation. Oncogene. 14:2033-2039.
    • (1997) Oncogene , vol.14 , pp. 2033-2039
    • Chen, J.1    Carey, K.2    Godowski, P.J.3
  • 27
    • 0029087510 scopus 로고
    • Reevaluation of the roles of protein S and Gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3
    • Godowski, P.J., M.R. Mark, J. Chen, M.D. Sadick, H. Raab, and R.G. Hammonds. 1995. Reevaluation of the roles of protein S and Gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3. Cell. 82:355-358.
    • (1995) Cell , vol.82 , pp. 355-358
    • Godowski, P.J.1    Mark, M.R.2    Chen, J.3    Sadick, M.D.4    Raab, H.5    Hammonds, R.G.6
  • 29
    • 27444442173 scopus 로고    scopus 로고
    • Both protein S and Gas6 stimulate outer segment phagocytosis by cultured rat retinal pigment epithelial cells
    • Hall, M.O., M.S. Obin, M.J. Heeb, B.L. Burgess, and T.A. Abrams. 2005. Both protein S and Gas6 stimulate outer segment phagocytosis by cultured rat retinal pigment epithelial cells. Exp. Eye Res. 81:581-591.
    • (2005) Exp. Eye Res , vol.81 , pp. 581-591
    • Hall, M.O.1    Obin, M.S.2    Heeb, M.J.3    Burgess, B.L.4    Abrams, T.A.5
  • 30
    • 34247580796 scopus 로고    scopus 로고
    • Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells
    • Seitz, H.M., T.D. Camenisch, G. Lemke, H.S. Earp, and G. Matsushima. 2007. Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells. J. Immunol. 178:5635-5642.
    • (2007) J. Immunol , vol.178 , pp. 5635-5642
    • Seitz, H.M.1    Camenisch, T.D.2    Lemke, G.3    Earp, H.S.4    Matsushima, G.5
  • 31
    • 33645845142 scopus 로고    scopus 로고
    • Phosphatidylserine recognition by phagocytes: A view to a kill
    • Wu, Y., N. Tibrewal, and R.B. Birge. 2006. Phosphatidylserine recognition by phagocytes: a view to a kill. Trends Cell Biol. 16:189-197.
    • (2006) Trends Cell Biol , vol.16 , pp. 189-197
    • Wu, Y.1    Tibrewal, N.2    Birge, R.B.3
  • 32
  • 33
    • 0037122009 scopus 로고    scopus 로고
    • Opsonization of apoptotic cells by autologous iC3b facilitates clearance by immature dendritic cells, down-regulates DR and CD86, and up-regulates CC chemokine receptor 7
    • Verbovetski, I., H. Bychkov, U. Trahtemberg, I. Shapira, M. Hareuveni, O. Ben-Tal, I. Kutikov, O. Gill, and D. Mevorach. 2002. Opsonization of apoptotic cells by autologous iC3b facilitates clearance by immature dendritic cells, down-regulates DR and CD86, and up-regulates CC chemokine receptor 7. J. Exp. Med. 196:1553-1561.
    • (2002) J. Exp. Med , vol.196 , pp. 1553-1561
    • Verbovetski, I.1    Bychkov, H.2    Trahtemberg, U.3    Shapira, I.4    Hareuveni, M.5    Ben-Tal, O.6    Kutikov, I.7    Gill, O.8    Mevorach, D.9
  • 34
    • 14644411712 scopus 로고    scopus 로고
    • A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells
    • Wu, Y., S. Singh, M.M. Georgescu, and R.B. Birge. 2005. A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells. J. Cell Sci. 118:539-553.
    • (2005) J. Cell Sci , vol.118 , pp. 539-553
    • Wu, Y.1    Singh, S.2    Georgescu, M.M.3    Birge, R.B.4
  • 37
    • 0037008769 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic β cells to tumor necrosis factor
    • Chong, M.M., H.E. Thomas, and T.W. Kay. 2002. Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic β cells to tumor necrosis factor. J. Biol. Chem. 277:27945-27952.
    • (2002) J. Biol. Chem , vol.277 , pp. 27945-27952
    • Chong, M.M.1    Thomas, H.E.2    Kay, T.W.3
  • 41
    • 0033591630 scopus 로고    scopus 로고
    • Interleukin 12-dependent interferon gamma production by CD8alpha+ lymphoid dendritic cells
    • Ohteki, T., T. Fukao, K. Suzue, C. Maki, M. Ito, M. Nakamura, and S. Koyasu. 1999. Interleukin 12-dependent interferon gamma production by CD8alpha+ lymphoid dendritic cells. J. Exp. Med. 189:1981-1986.
    • (1999) J. Exp. Med , vol.189 , pp. 1981-1986
    • Ohteki, T.1    Fukao, T.2    Suzue, K.3    Maki, C.4    Ito, M.5    Nakamura, M.6    Koyasu, S.7
  • 42
    • 0035339882 scopus 로고    scopus 로고
    • Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets
    • Hochrein, H., K. Shortman, D. Vremec, B. Scott, P. Hertzog, and M. O'Keeffe. 2001. Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets. J. Immunol. 166:5448-5455.
    • (2001) J. Immunol , vol.166 , pp. 5448-5455
    • Hochrein, H.1    Shortman, K.2    Vremec, D.3    Scott, B.4    Hertzog, P.5    O'Keeffe, M.6
  • 44
    • 0032519925 scopus 로고    scopus 로고
    • Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF
    • Fadok, V.A., D.L. Bratton, A. Konowal, P.W. Freed, J.Y. Westcott, and P.M. Henson. 1998. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J. Clin. Invest. 101:890-898.
    • (1998) J. Clin. Invest , vol.101 , pp. 890-898
    • Fadok, V.A.1    Bratton, D.L.2    Konowal, A.3    Freed, P.W.4    Westcott, J.Y.5    Henson, P.M.6
  • 45
    • 0019225636 scopus 로고
    • Cell death: The significance of apoptosis
    • Wyllie, A.H., J.F. Kerr, and A.R. Currie. 1980. Cell death: the significance of apoptosis. Int. Rev. Cytol. 68:251-306.
    • (1980) Int. Rev. Cytol , vol.68 , pp. 251-306
    • Wyllie, A.H.1    Kerr, J.F.2    Currie, A.R.3
  • 46
    • 0041474715 scopus 로고    scopus 로고
    • The mer receptor tyrosine kinase: Expression and function suggest a role in innate immunity
    • Behrens, E.M., P. Gadue, S.Y. Gong, S. Garrett, P.L. Stein, and P.L. Cohen. 2003. The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity. Eur. J. Immunol. 33:2160-2167.
    • (2003) Eur. J. Immunol , vol.33 , pp. 2160-2167
    • Behrens, E.M.1    Gadue, P.2    Gong, S.Y.3    Garrett, S.4    Stein, P.L.5    Cohen, P.L.6
  • 47
    • 33846680141 scopus 로고    scopus 로고
    • MERTK polymorphisms associated with risk of haematological disorders among Korean SLE patients
    • Cheong, H.S., S.O. Lee, C.B. Choi, Y.K. Sung, H.D. Shin, and S.C. Bae. 2006. MERTK polymorphisms associated with risk of haematological disorders among Korean SLE patients. Rheumatology (Oxford). 46:209-214.
    • (2006) Rheumatology (Oxford) , vol.46 , pp. 209-214
    • Cheong, H.S.1    Lee, S.O.2    Choi, C.B.3    Sung, Y.K.4    Shin, H.D.5    Bae, S.C.6
  • 48
    • 0031914643 scopus 로고    scopus 로고
    • Subcongenic analysis of the Idd13 locus in NOD/Lt mice: Evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin
    • Serreze, D.V., M. Bridgett, H.D. Chapman, E. Chen, S.D. Richard, and E.H. Leiter. 1998. Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin. J. Immunol. 160:1472-1478.
    • (1998) J. Immunol , vol.160 , pp. 1472-1478
    • Serreze, D.V.1    Bridgett, M.2    Chapman, H.D.3    Chen, E.4    Richard, S.D.5    Leiter, E.H.6
  • 49
    • 21244473273 scopus 로고    scopus 로고
    • Fine mapping of a QTL region with large effects on growth and fatness on mouse chromosome 2
    • Jerez-Timaure, N.C., E.J. Eisen, and D. Pomp. 2005. Fine mapping of a QTL region with large effects on growth and fatness on mouse chromosome 2. Physiol. Genomics. 21:411-422.
    • (2005) Physiol. Genomics , vol.21 , pp. 411-422
    • Jerez-Timaure, N.C.1    Eisen, E.J.2    Pomp, D.3
  • 52
    • 3843104695 scopus 로고    scopus 로고
    • Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IκB kinase activity
    • Bhattacharyya, S., P. Sen, M. Wallet, B. Long, A.S. Baldwin Jr., and R. Tisch. 2004. Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IκB kinase activity. Blood. 104:1100-1109.
    • (2004) Blood , vol.104 , pp. 1100-1109
    • Bhattacharyya, S.1    Sen, P.2    Wallet, M.3    Long, B.4    Baldwin Jr., A.S.5    Tisch, R.6
  • 53
    • 31144440201 scopus 로고    scopus 로고
    • Early autoimmune destruction of islet grafts is associated with a restricted repertoire of IGRP-specific CD8+ T cells in diabetic nonobese diabetic mice
    • Wong, C.P., L. Li, J.A. Frelinger, and R. Tisch. 2006. Early autoimmune destruction of islet grafts is associated with a restricted repertoire of IGRP-specific CD8+ T cells in diabetic nonobese diabetic mice. J. Immunol. 176:1637-1644.
    • (2006) J. Immunol , vol.176 , pp. 1637-1644
    • Wong, C.P.1    Li, L.2    Frelinger, J.A.3    Tisch, R.4


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