Preventing cleavage of Mer promotes efferocytosis and suppresses acute lung injury in bleomycin treated mice

Toxicology and Applied Pharmacology

Volumn 263, Issue 1, 2012, Pages 61-72

  Lee, Ye Ji ^a   Lee, Seung Hae ^a   Youn, Young So ^a   Choi, Ji Yeon ^a   Song, Keung Sub ^a   Cho, Min Sun ^a   Kang, Jihee Lee ^a  

^a Ewha Womans University School of Medicine   (South Korea)

Author keywords

Apoptotic cell clearance; Bleomycin; Lung injury; Mer receptor tyrosine kinase; TAPI 0

Indexed keywords

BLEOMYCIN; CASPASE 3; CASPASE 9; CYTOKINE; DISINTEGRIN; LACTATE DEHYDROGENASE; MER RECEPTOR TYROSINE KINASE; METALLOPROTEINASE; METALLOPROTEINASE 17; N [2 [ DEXTRO,LEVO (HYDROXYAMINOCARBONYL)METHYL] 4 METHYLPENTANOYL] LEVO 3 (2 NAPHTYL) ALANYLALANINE 2 AMINOETHYL AMIDE; PROTEIN TYROSINE KINASE; PROTEINASE INHIBITOR; SCATTER FACTOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; PROTEIN EXPRESSION;

ACUTE LUNG INJURY; ADAM PROTEINS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BLEOMYCIN; BLOTTING, WESTERN; CASPASE 3; CASPASE 9; DIPEPTIDES; DNA DAMAGE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HYDROXAMIC ACIDS; MALE; MICE; MICE, INBRED C57BL; PHAGOCYTOSIS; RECEPTOR PROTEIN-TYROSINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

MUS;

EID: 84864135401     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.05.024     Document Type: Article

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