Tyro-3 family receptors are essential regulators of mammalian spermatogenesis

Nature

Volumn 398, Issue 6729, 1999, Pages 723-728

  Lu, Qingxian ^a   Gore, Martin ^a,h   Zhang, Qing ^b   Camenisch, Todd ^c   Boast, Sharon ^b   Casagranda, Franca ^e   Lai, Cary ^f   Skinner, Michael K ^g   Klein, Rüdiger ^e   Matsushima, Glenn K ^c   Earp, H Shelton ^d   Goff, Stephen P ^b   Lemke, Greg ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b Columbia Univ Coll Phys Surgs ^*  (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

^e EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^f SCRIPPS RESEARCH INSTITUTE   (United States)

^g WASHINGTON STATE UNIVERSITY   (United States)

^h ARENA PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE; TYROSINE KINASE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; GENE ACTIVATION; GENE EXPRESSION; GENE MUTATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; SPERMATOGENESIS; TISSUE DISTRIBUTION;

ANIMALS; GENE EXPRESSION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LEYDIG CELLS; LIGANDS; MALE; MICE; MICE, MUTANT STRAINS; NEURAL CELL ADHESION MOLECULES; ONCOGENE PROTEINS; PHENOTYPE; PROTEIN S; PROTEINS; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; SERTOLI CELLS; SPERMATOGENESIS;

EID: 0033594411     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/19554     Document Type: Article

References (30)

1. Crosier, K. E. & Crosier, P. S. New insights into the control of cell growth; the role of the Axl family. Pathology 29, 131-135 (1997).
2. Lai, C., Gore, M. & Lemke, G. Structure, expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase. Oncogene 9, 2567-2578 (1994).
3. O'Bryan, J. P. et al. Axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol. Cell. Biol. 11, 5016-5031 (1991).
4. Graham, D. K., Dawson, T. L., Mullaney, D. L., Snodgrass, H. R. & Earp, H. S. Cloning and mRNA expression analysis of a novel human protooncogene, c-mer. Cell Growth Differ. 5, 647-657 (1994).
5. Skinner, M. K. Cell-cell interactions in the testis. Endocrine Rev. 12, 45-77 (1991).
6. Skinner, M. K. in The Sertoli Cell (eds Russell, L. D. & Griswold, M. D.) 237-247 (Cache River, Clearwater, Florida, 1993).
7. Griswold, M. D. Interactions between germ cells and Sertoli cells in the testis. Biol. Refrod. 52, 211-216 (1995).
8. Lai, C. & Lemke, G. An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. Neuron 6, 691-704 (1991).
9. Mark, M. R. et al. RSE, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain. J. Biol. Chem. 269, 10720-10728 (1994).
10. Taylor, I. C., Roy, S., Yaswen, P., Stampfer, M. R. & Varmus, H. E. Mouse mammary tumors express elevated levels of RNA encoding the murine homology of SKY, a putative receptor tyrosine kinase. J. Biol. Chem. 270, 6372-6880 (1995).
11. Rescigno, J., Mansukhani, A. & Basilico, C. A putative receptor tyrosine kinase with unique structural topology. Oncogene 6, 1909-1913 (1991).
12. Janssen, J. W. et al. A novel putative tyrosine kinase receptor with oncogenic potential. Oncogene 6, 2113-2120 (1991).
13. Jia, R. & Hanafusa, H. The proto-oncogene of v-eyk (v-ryk) is a novel receptor-type protein tyrosine kianse with extracellular Ig/GN-III domains. J. Biol. chem. 269, 1839-1844 (1994).
14. Stitt, T. N. et al. The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/ Axl family of receptor tyrosine kinases. Cell 80, 661-670 (1995).
15. Godowski, P. J. et al. Reevaluation of the roles of protein S and Gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3. Cell 82, 355-358 (1995).
16. Chen, J., Carey, K. & Godowski, P. J. Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation. Oncogene 14, 2033-2039 (1997).
17. Nagata, K. et al. Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. J. Biol. Chem. 271, 30022-30027 (1996).
18. Joseph, D. R. Sequence and functional relationships between androgen-binding protein/sex hormone-binding globulin and its homologs protein S, Gas6, laminin, and agrin. Steroids 62, 578-588 (1997).
19. Capecchi, M. R. Altering the genome by homologous recombination. Science 244, 1288-1292 (1989).
20. Camenisch, T. D., Koller, B. H., Earp, H. S. & Matsushima, G. K. A novel receptor tyrosine kinase, Mer, inhibits TNF-α production and lipopolysaccaride-induced endotoxic shock. J. Immunol. 162, 3498-3503 (1999).
21. Smiley, S. T., Stitt, T. N. & Grusby, M. J. Cross-linking of protein S bound to lymphocytes promotes aggregation and inhibits proliferation. Cell. Immunol. 181, 120-126 (1997).
22. Leblond, C. P. & Clemont, Y. Definition of the stages of the cycle of the seminiferous epithelium in the rat. Ann. N. Y. Acad. Sci. 55, 548-573 (1952).
23. Henriksén, K., Hakovirta, H. & Parvinen, M. Testosterone inhibits and induces apoptosis in rat seminiferous tubules in a stage-specific manner. Endocrinology 136, 3285-3291 (1995).
24. Sun, Y.-T, Wreford, N. G., Robertson, D. M. & De Kretser, D. M. Quantitative cytological studies of spermatogenesis in intact and hypophysectomized rats: Identification of androgen-dependent stages. Endocrinology 127, 1215-1223 (1991).
25. Wong, V. & Russell, L. D. Three-dimensional reconstruction of a rat stage V Sertoli cell: I. Methods, basic configuration, and dimensions. Am. J. Anat. 167, 143-161 (1983).
26. Yomogida, K. et al. Developmental stage-and spermatogenic cycle-specific expression of transcription factor GATA-1 in mouse Sertoli cells. Development 120, 1759-1766 (1994).
27. Lewis, P. A., Crosier, K. E., Wood, C. R. & Crosier, P. S. Analysis of the murine Dtk gene identifies conservation of genomic structure within a new receptor tyrosine kinase subfamily. Genomics 31, 13-19 (1996).
28. Biesecker, L. G., Giannola, D. M. & Emerson, S. G. Identification of alternative exons, including a novel exon, in the tyrosine kinase receptor gene Etk2/tyro3 that explains differences in 5′ cDNA sequences. Oncogene 10, 2239-2242 (1995).
29. Schulz, A. S., Schleithoff, L., Faust, M., Bartram, C. R. & Janssen, J. W. G. The genomic structure of the human UFO receptor. Oncogene 8, 509-513 (1993).
30. Bellosta, P., Zhang, Q., Goff, S. P. & Basilico, C. Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation. Oncogene 15, 2387-2397 (1997).