Evaluation of Tyro3 expression, Gas6-mediated akt phosphorylation, and the impact of anti-Tyro3 antibodies in melanoma cell lines

Biochemistry

Volumn 52, Issue 18, 2013, Pages 3102-3118

  Demarest, Stephen J ^a,d   Gardner, Jennifer ^a   Vendel, Michelle C ^a,b   Ailor, Eric ^a,c   Szak, Suzanne ^a   Huang, Flora ^a   Doern, Adam ^a   Tan, Xiangyang ^a   Yang, Weixing ^a   Grueneberg, Dorre A ^a   Richards, Edward J ^a   Endege, Wilson O ^a   Harlow, Ed ^a   Koopman, Louise A ^a,e  

^a BIOGEN   (United States)

^b PFIZER INC   (United States)

^c SORRENTO THERAPEUTICS   (United States)

^d ELI LILLY AND COMPANY   (United States)

^e Celgene Avilomics Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY MEASUREMENT; AKT PHOSPHORYLATION; APOPTOTIC MECHANISMS; CELLULAR ASSAYS; EXTRACELLULAR DOMAINS; MELANOMA CELLS; MONOCLONAL ANTIBODIES (MABS); RECEPTOR TYROSINE KINASE;

AMINO ACIDS; CELL CULTURE; CELL DEATH; DERMATOLOGY; LIGANDS; MONOCLONAL ANTIBODIES; PHOSPHORYLATION; RNA;

ONCOLOGY;

B RAF KINASE; CALCIUM; CASPASE 3; GROWTH ARREST SPECIFIC PROTEIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY TYRO3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN AXL; PROTEIN KINASE B; PROTEIN MER; PROTEIN TYRO3; PROTEIN TYROSINE KINASE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BASAL CELL CARCINOMA; BINDING AFFINITY; CANCER CELL CULTURE; CELL DEATH; CELL SURVIVAL; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GENE MUTATION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRACELLULAR SIGNALING; MELANOMA CELL; MOUSE; NONHUMAN; ONCOGENE N RAS; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PHOSPHORYLATION; SQUAMOUS CELL CARCINOMA;

ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; CALORIMETRY, DIFFERENTIAL SCANNING; CELL DIVISION; CELL LINE, TUMOR; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOPRECIPITATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MELANOMA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR PROTEIN-TYROSINE KINASES; RNA, MESSENGER;

EID: 84877331690     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301588c     Document Type: Article

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