메뉴 건너뛰기




Volumn 401, Issue , 2015, Pages 213-220

The Keap1-Nrf2-antioxidant response element pathway: A review of its regulation by melatonin and the proteasome

Author keywords

Bax; Bcl 2; Keap1; Melatonin; NF B; Proteasome

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MELATONIN; PROTEASOME; PROTEASOME INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT; KEAP1 PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN; SIGNAL PEPTIDE;

EID: 84922335135     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2014.12.013     Document Type: Review
Times cited : (209)

References (133)
  • 2
    • 84872225149 scopus 로고    scopus 로고
    • PGC1α and mitochondrial metabolism - emerging concepts and relevance in ageing and neurodegenerative disorders
    • Austin S., St-Pierre J. PGC1α and mitochondrial metabolism - emerging concepts and relevance in ageing and neurodegenerative disorders. J. Cell Sci 2012, 125:4963-4971.
    • (2012) J. Cell Sci , vol.125 , pp. 4963-4971
    • Austin, S.1    St-Pierre, J.2
  • 4
    • 0035111047 scopus 로고    scopus 로고
    • Effect of melatonin on oxidative status of rat brain, liver and kidney tissues under constant light exposure
    • Baydas G., Ercel E., Canatan H., Donder E., Akyol A. Effect of melatonin on oxidative status of rat brain, liver and kidney tissues under constant light exposure. Cell Biochem. Funct 2001, 19:37-41.
    • (2001) Cell Biochem. Funct , vol.19 , pp. 37-41
    • Baydas, G.1    Ercel, E.2    Canatan, H.3    Donder, E.4    Akyol, A.5
  • 6
    • 84922328489 scopus 로고    scopus 로고
    • Exogenous melatonin supplementation prevents oxidative stress-evoked DNA damage in human spermatozoa
    • Bejarano I., Monllor F., Marchena A.M., Ortiz A., Lozano G., Jimenez M.I., et al. Exogenous melatonin supplementation prevents oxidative stress-evoked DNA damage in human spermatozoa. J. Pineal Res 2014, 57:333-339.
    • (2014) J. Pineal Res , vol.57 , pp. 333-339
    • Bejarano, I.1    Monllor, F.2    Marchena, A.M.3    Ortiz, A.4    Lozano, G.5    Jimenez, M.I.6
  • 7
    • 84868025913 scopus 로고    scopus 로고
    • Melatonin protection against burn-induced hepatic injury by down-regulation of nuclear factor kappa B activation
    • Bekyarova G., Apostolova M., Kotzev I. Melatonin protection against burn-induced hepatic injury by down-regulation of nuclear factor kappa B activation. Int. J. Immunopathol. Pharmacol 2012, 25:591-596.
    • (2012) Int. J. Immunopathol. Pharmacol , vol.25 , pp. 591-596
    • Bekyarova, G.1    Apostolova, M.2    Kotzev, I.3
  • 8
    • 84922327350 scopus 로고    scopus 로고
    • Melatonin modulates the expression of Bcl-2 family proteins in liver after thermal injury in rats
    • Bekyarova G., Tzaneva M., Hristova M. Melatonin modulates the expression of Bcl-2 family proteins in liver after thermal injury in rats. Adv. Biosci. Biotechnol 2013, 4:41-47.
    • (2013) Adv. Biosci. Biotechnol , vol.4 , pp. 41-47
    • Bekyarova, G.1    Tzaneva, M.2    Hristova, M.3
  • 9
    • 84887972761 scopus 로고    scopus 로고
    • Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review
    • Bizzarri M., Proietti S., Cucina A., Reiter R.J. Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review. Expert Opin. Ther. Targets 2013, 17:1483-1496.
    • (2013) Expert Opin. Ther. Targets , vol.17 , pp. 1483-1496
    • Bizzarri, M.1    Proietti, S.2    Cucina, A.3    Reiter, R.J.4
  • 10
    • 84905472527 scopus 로고    scopus 로고
    • Light exposure at night disrupts host/cancer circadian regulatory dynamics: impact on the Warburg effect, lipid signaling and tumor growth prevention
    • Blask D.E., Dauchy R.T., Dauchy E.M., Mao L., Hill S.M., Greene M.W., et al. Light exposure at night disrupts host/cancer circadian regulatory dynamics: impact on the Warburg effect, lipid signaling and tumor growth prevention. PLoS ONE 2014, 9:e85311.
    • (2014) PLoS ONE , vol.9 , pp. e85311
    • Blask, D.E.1    Dauchy, R.T.2    Dauchy, E.M.3    Mao, L.4    Hill, S.M.5    Greene, M.W.6
  • 11
    • 78149411295 scopus 로고    scopus 로고
    • Melatonin: action as antioxidant and potential applications in human disease and aging
    • Bonnefont-Rousselot D., Collin F. Melatonin: action as antioxidant and potential applications in human disease and aging. Toxicology 2010, 278:55-67.
    • (2010) Toxicology , vol.278 , pp. 55-67
    • Bonnefont-Rousselot, D.1    Collin, F.2
  • 12
    • 0346059342 scopus 로고    scopus 로고
    • Melatonin inhibits nuclear factor kappa B activation and oxidative stress and protects against thioacetamide induced liver damage in rats
    • Bruck R., Aeed H., Avni Y., Shirin H., Matas Z., Shahmurov M., et al. Melatonin inhibits nuclear factor kappa B activation and oxidative stress and protects against thioacetamide induced liver damage in rats. J. Hepatol 2004, 40:86-93.
    • (2004) J. Hepatol , vol.40 , pp. 86-93
    • Bruck, R.1    Aeed, H.2    Avni, Y.3    Shirin, H.4    Matas, Z.5    Shahmurov, M.6
  • 15
    • 84874669462 scopus 로고    scopus 로고
    • Pharmacological does of melatonin induce alterations in mitochondrial mass and potential, bcl-2 levels and K+ currents in UVB-exposed U937 cells
    • Canonico B., Luchetti F., Ambrogini P., Arcangeletti M., Betti M., Cesarini E., et al. Pharmacological does of melatonin induce alterations in mitochondrial mass and potential, bcl-2 levels and K+ currents in UVB-exposed U937 cells. Cell Biol. Int 2013, 37:213-226.
    • (2013) Cell Biol. Int , vol.37 , pp. 213-226
    • Canonico, B.1    Luchetti, F.2    Ambrogini, P.3    Arcangeletti, M.4    Betti, M.5    Cesarini, E.6
  • 16
    • 84861464050 scopus 로고    scopus 로고
    • Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging
    • Chapple S.J., Siow R.C., Mann G.E. Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging. Int. J. Biochem. Cell Biol 2012, 44:1315-1320.
    • (2012) Int. J. Biochem. Cell Biol , vol.44 , pp. 1315-1320
    • Chapple, S.J.1    Siow, R.C.2    Mann, G.E.3
  • 17
    • 84905437927 scopus 로고    scopus 로고
    • Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin
    • (in press)
    • Charan R.A., Johnson B.N., Zaganelli S., Nardozzi J.D., LaVoie M.J. Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin. Cell Death Dis 2014, (in press).
    • (2014) Cell Death Dis
    • Charan, R.A.1    Johnson, B.N.2    Zaganelli, S.3    Nardozzi, J.D.4    LaVoie, M.J.5
  • 18
    • 23144449789 scopus 로고    scopus 로고
    • Ubiquitin signaling in the NF-kappaB pathway
    • Chen Z.J. Ubiquitin signaling in the NF-kappaB pathway. Nat. Cell Biol 2005, 7:758-765.
    • (2005) Nat. Cell Biol , vol.7 , pp. 758-765
    • Chen, Z.J.1
  • 19
    • 84891696200 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis
    • Cherry A.D., Suliman H.B., Bartz R.R., Piatadosi C.A. Peroxisome proliferator-activated receptor γ co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis. J. Biol. Chem 2014, 289:41-52.
    • (2014) J. Biol. Chem , vol.289 , pp. 41-52
    • Cherry, A.D.1    Suliman, H.B.2    Bartz, R.R.3    Piatadosi, C.A.4
  • 20
    • 79951645465 scopus 로고    scopus 로고
    • Melatonin inhibits Prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-6 in murine macrophages by suppressing NF-κB and STAT1 activity
    • Choi E.Y., Jin J.Y., Lee J.Y., Choi J.I., Choi I.S., Kim S.J. Melatonin inhibits Prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-6 in murine macrophages by suppressing NF-κB and STAT1 activity. J. Pineal Res 2011, 50:197-206.
    • (2011) J. Pineal Res , vol.50 , pp. 197-206
    • Choi, E.Y.1    Jin, J.Y.2    Lee, J.Y.3    Choi, J.I.4    Choi, I.S.5    Kim, S.J.6
  • 21
    • 84881476323 scopus 로고    scopus 로고
    • Nrf2 is controlled by two distinct β-TrCP recognition sites in its Neh6 domain, one of which can be modulated by GSK-3 activity
    • Chowdhry S., Zhang Y., McMahon M., Sutherland C., Cuadrado A., Hayes J.D. Nrf2 is controlled by two distinct β-TrCP recognition sites in its Neh6 domain, one of which can be modulated by GSK-3 activity. Oncogene 2013, 32:3765-3781.
    • (2013) Oncogene , vol.32 , pp. 3765-3781
    • Chowdhry, S.1    Zhang, Y.2    McMahon, M.3    Sutherland, C.4    Cuadrado, A.5    Hayes, J.D.6
  • 22
    • 0030272628 scopus 로고    scopus 로고
    • Effects of melatonin on NF-κB DNA-binding activity in rat spleen
    • Chuang J.I., Natarajan M., Meltz M.L., Reiter R.J. Effects of melatonin on NF-κB DNA-binding activity in rat spleen. Cell Biol. Int 1996, 20:687-692.
    • (1996) Cell Biol. Int , vol.20 , pp. 687-692
    • Chuang, J.I.1    Natarajan, M.2    Meltz, M.L.3    Reiter, R.J.4
  • 23
    • 84893835698 scopus 로고    scopus 로고
    • Proteasome inhibitors in progressive renal diseases
    • Coppo R. Proteasome inhibitors in progressive renal diseases. Nephrol. Dial. Transplant 2014, (Suppl. 1):i25-i30.
    • (2014) Nephrol. Dial. Transplant , pp. i25-i30
    • Coppo, R.1
  • 24
    • 0032702845 scopus 로고    scopus 로고
    • The protective role of endogenous melatonin in carrageenan-induced pleurisy in the rat
    • Cuzzocrea S., Tan D.X., Costantino G., Mazzon E., Caputi A.P., Reiter R.J. The protective role of endogenous melatonin in carrageenan-induced pleurisy in the rat. FASEB J. 1999, 13:1930-1938.
    • (1999) FASEB J. , vol.13 , pp. 1930-1938
    • Cuzzocrea, S.1    Tan, D.X.2    Costantino, G.3    Mazzon, E.4    Caputi, A.P.5    Reiter, R.J.6
  • 25
    • 27244462417 scopus 로고    scopus 로고
    • Glutathiolation of the proteasome is enhanced by proteolytic inhibitors
    • Demasi M., Silva G.M., Netto L.E. Glutathiolation of the proteasome is enhanced by proteolytic inhibitors. Arch. Biochem. Biophys 2001, 389:254-263.
    • (2001) Arch. Biochem. Biophys , vol.389 , pp. 254-263
    • Demasi, M.1    Silva, G.M.2    Netto, L.E.3
  • 27
    • 84921938403 scopus 로고    scopus 로고
    • Melatonin antagonizes Mn-induced oxidative injury through the activation of Keap1-Nrf2-ARE signaling pathway in the striatum of mice
    • (in press)
    • Deng Y., Zhu J., Mi C., Xu B., Jiao C., Li Y., et al. Melatonin antagonizes Mn-induced oxidative injury through the activation of Keap1-Nrf2-ARE signaling pathway in the striatum of mice. Neurotox. Res 2014, (in press).
    • (2014) Neurotox. Res
    • Deng, Y.1    Zhu, J.2    Mi, C.3    Xu, B.4    Jiao, C.5    Li, Y.6
  • 28
    • 84891645843 scopus 로고    scopus 로고
    • The role of oxidative stress in Parkinson's disease
    • Dias V., Junn E., Mouradian M.M. The role of oxidative stress in Parkinson's disease. J. Parkinsons Dis 2013, 3:461-491.
    • (2013) J. Parkinsons Dis , vol.3 , pp. 461-491
    • Dias, V.1    Junn, E.2    Mouradian, M.M.3
  • 29
    • 84901328016 scopus 로고    scopus 로고
    • Melatonin stimulated antioxidant enzymes and reduced oxidative stress in experimental traumatic brain injury: the Nrf2-ARE signaling pathway as a potential mechanism
    • Ding K., Wang H., Xu J., Li T., Zhang L., Ding Y., et al. Melatonin stimulated antioxidant enzymes and reduced oxidative stress in experimental traumatic brain injury: the Nrf2-ARE signaling pathway as a potential mechanism. Free Radic. Biol. Med 2014, 73:1-11.
    • (2014) Free Radic. Biol. Med , vol.73 , pp. 1-11
    • Ding, K.1    Wang, H.2    Xu, J.3    Li, T.4    Zhang, L.5    Ding, Y.6
  • 30
    • 79955647069 scopus 로고    scopus 로고
    • Proteasome inhibition induces a p38 MAPK pathway-dependent antiapoptotic program via Nrf2 in thyroid cancer cells
    • Du Z.X., Yan Y., Zhang H.Y., Liu B.Q., Gao Y.Y., Niu X.F., et al. Proteasome inhibition induces a p38 MAPK pathway-dependent antiapoptotic program via Nrf2 in thyroid cancer cells. J. Clin. Endocrinol. Metab 2011, 96:E763-E771.
    • (2011) J. Clin. Endocrinol. Metab , vol.96 , pp. E763-E771
    • Du, Z.X.1    Yan, Y.2    Zhang, H.Y.3    Liu, B.Q.4    Gao, Y.Y.5    Niu, X.F.6
  • 31
    • 84861136640 scopus 로고    scopus 로고
    • Impaired ubiquitin-proteasome-mediated PGC-1a protein turnover and induced mitochondrial biogenesis secondary to complex-I deficiency
    • Farhoud M.H., Nijtmans L.G., Wanders R.J.A., Wessels H.J.C.T., Lasonder E., Janssen A.J., et al. Impaired ubiquitin-proteasome-mediated PGC-1a protein turnover and induced mitochondrial biogenesis secondary to complex-I deficiency. Proteomics 2012, 12:1349-1362.
    • (2012) Proteomics , vol.12 , pp. 1349-1362
    • Farhoud, M.H.1    Nijtmans, L.G.2    Wanders, R.J.A.3    Wessels, H.J.C.T.4    Lasonder, E.5    Janssen, A.J.6
  • 32
    • 84874825677 scopus 로고    scopus 로고
    • Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy- 2'-deoxyguanosine) in ex vivo human skin
    • Fischer T.W., Kleszczynski K., Hardkop L.H., Kruse N., Zillikins D. Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy- 2'-deoxyguanosine) in ex vivo human skin. J. Pineal Res 2013, 53:303-312.
    • (2013) J. Pineal Res , vol.53 , pp. 303-312
    • Fischer, T.W.1    Kleszczynski, K.2    Hardkop, L.H.3    Kruse, N.4    Zillikins, D.5
  • 33
    • 84876730349 scopus 로고    scopus 로고
    • Targeting of NF-kappaB signaling pathway, other signaling pathways and epigenetics in therapy of multiple myeloma
    • Fuchs O. Targeting of NF-kappaB signaling pathway, other signaling pathways and epigenetics in therapy of multiple myeloma. Cardiovasc. Hematol. Disord. Drug Targets 2013, 13:16-34.
    • (2013) Cardiovasc. Hematol. Disord. Drug Targets , vol.13 , pp. 16-34
    • Fuchs, O.1
  • 34
    • 11144264663 scopus 로고    scopus 로고
    • BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase
    • Furukawa M., Xiong Y. BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Mol. Cell. Biol 2005, 162-171.
    • (2005) Mol. Cell. Biol , pp. 162-171
    • Furukawa, M.1    Xiong, Y.2
  • 35
    • 84922328629 scopus 로고    scopus 로고
    • On the direct scavenging ability of melatonin towards hydroxyl and a series of peroxyl radicals
    • Galano A. On the direct scavenging ability of melatonin towards hydroxyl and a series of peroxyl radicals. Phys. Chem. Chem. Phys 2011, 115:4538-4546.
    • (2011) Phys. Chem. Chem. Phys , vol.115 , pp. 4538-4546
    • Galano, A.1
  • 36
    • 79960380554 scopus 로고    scopus 로고
    • Melatonin as a natural ally against oxidative stress: a physicochemical examination
    • Galano A., Tan D.X., Reiter R.J. Melatonin as a natural ally against oxidative stress: a physicochemical examination. J. Pineal Res 2011, 51:1-16.
    • (2011) J. Pineal Res , vol.51 , pp. 1-16
    • Galano, A.1    Tan, D.X.2    Reiter, R.J.3
  • 37
    • 84896116486 scopus 로고    scopus 로고
    • Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review
    • Garcia J.J., Lopez-Pingarron L., Almedia-Souza P., Tres A., Escudero P., Garcia-Gil F.A., et al. Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review. J. Pineal Res 2014, 56:225-237.
    • (2014) J. Pineal Res , vol.56 , pp. 225-237
    • Garcia, J.J.1    Lopez-Pingarron, L.2    Almedia-Souza, P.3    Tres, A.4    Escudero, P.5    Garcia-Gil, F.A.6
  • 38
    • 77949439403 scopus 로고    scopus 로고
    • Proteasome inhibitors: recent advances and new perspectives in medicinal chemistry
    • Genin E., Rebod-Ravaux N., Vidal J. Proteasome inhibitors: recent advances and new perspectives in medicinal chemistry. Curr. Top. Med. Chem 2010, 10:232-256.
    • (2010) Curr. Top. Med. Chem , vol.10 , pp. 232-256
    • Genin, E.1    Rebod-Ravaux, N.2    Vidal, J.3
  • 39
    • 0031862076 scopus 로고    scopus 로고
    • Melatonin inhibits expression of the inducible isoform of nitric oxide synthase in murine macrophages: role of inhibition of NF-kappaB activation
    • Gilad E., Wong H.R., Zingarelli B., Virag L., O'Connor M., Salzman A.L., et al. Melatonin inhibits expression of the inducible isoform of nitric oxide synthase in murine macrophages: role of inhibition of NF-kappaB activation. FASEB J. 1998, 12:685-693.
    • (1998) FASEB J. , vol.12 , pp. 685-693
    • Gilad, E.1    Wong, H.R.2    Zingarelli, B.3    Virag, L.4    O'Connor, M.5    Salzman, A.L.6
  • 40
    • 33750523632 scopus 로고    scopus 로고
    • NF-kappaB activation by reactive oxygen species: fifteen years later
    • Gloire G., Legrand-Poels S., Piette J. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem. Pharmacol 2006, 72:1493-1505.
    • (2006) Biochem. Pharmacol , vol.72 , pp. 1493-1505
    • Gloire, G.1    Legrand-Poels, S.2    Piette, J.3
  • 41
    • 59249091837 scopus 로고    scopus 로고
    • Rotovirus NSP1 inhibits NFkappaB activation by inducing proteasome-dependent degradation of Beta-TrCP: a novel mechanism of IFN antagonism
    • Graff J.W., Ettayebi K., Hardy M.E. Rotovirus NSP1 inhibits NFkappaB activation by inducing proteasome-dependent degradation of Beta-TrCP: a novel mechanism of IFN antagonism. PLoS Pathog 2009, 5:e1000280.
    • (2009) PLoS Pathog , vol.5 , pp. e1000280
    • Graff, J.W.1    Ettayebi, K.2    Hardy, M.E.3
  • 42
    • 77956202732 scopus 로고    scopus 로고
    • Neuroprotection through stimulation of mitochondrial antioxidant protein expression
    • Greco T., Fiskum G. Neuroprotection through stimulation of mitochondrial antioxidant protein expression. J. Alzheimers Dis 2010, (Suppl. 2):S427-S437.
    • (2010) J. Alzheimers Dis , pp. S427-S437
    • Greco, T.1    Fiskum, G.2
  • 44
    • 84922283635 scopus 로고    scopus 로고
    • Melatonin improves mitochondrial function by promoting MT1/SIRT1/PGC-2 alpha-dependent mitochondrial biogenesis in cadmium-induced hepatotoxicity in vitro
    • Guo P., Pi H., Xu S., Zhang L., Li Y., Li M., et al. Melatonin improves mitochondrial function by promoting MT1/SIRT1/PGC-2 alpha-dependent mitochondrial biogenesis in cadmium-induced hepatotoxicity in vitro. Toxicol. Sci 2014, 142:182-195.
    • (2014) Toxicol. Sci , vol.142 , pp. 182-195
    • Guo, P.1    Pi, H.2    Xu, S.3    Zhang, L.4    Li, Y.5    Li, M.6
  • 45
    • 53849094099 scopus 로고    scopus 로고
    • Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model
    • Gutierrez-Cuesta J., Tajes M., Jimenez A., Coto-Montes A., Camins A., Pallas M. Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model. J. Pineal Res 2008, 45:497-505.
    • (2008) J. Pineal Res , vol.45 , pp. 497-505
    • Gutierrez-Cuesta, J.1    Tajes, M.2    Jimenez, A.3    Coto-Montes, A.4    Camins, A.5    Pallas, M.6
  • 47
    • 84882736324 scopus 로고    scopus 로고
    • Age-related decline in melatonin and its MT1 receptor are associated with decreased sensitivity to melatonin and enhanced mammary tumor growth
    • Hill S.M., Cheng C., Yuan L., Mao L., Jockers R., Dauchy B., et al. Age-related decline in melatonin and its MT1 receptor are associated with decreased sensitivity to melatonin and enhanced mammary tumor growth. Curr. Aging Sci 2013, 6:125-133.
    • (2013) Curr. Aging Sci , vol.6 , pp. 125-133
    • Hill, S.M.1    Cheng, C.2    Yuan, L.3    Mao, L.4    Jockers, R.5    Dauchy, B.6
  • 48
    • 84896131726 scopus 로고    scopus 로고
    • Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells
    • Hong Y., Won J., Lee Y., Lee S., Park K., Chang K.T., et al. Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells. J. Pineal Res 2014, 56:264-274.
    • (2014) J. Pineal Res , vol.56 , pp. 264-274
    • Hong, Y.1    Won, J.2    Lee, Y.3    Lee, S.4    Park, K.5    Chang, K.T.6
  • 49
    • 84862846436 scopus 로고    scopus 로고
    • Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1
    • Hong Y.S., Hong S.W., Kim S.M., Jin D.H., Shin J.S., Yoon D.H., et al. Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1. Int. J. Oncol 2012, 41:76-82.
    • (2012) Int. J. Oncol , vol.41 , pp. 76-82
    • Hong, Y.S.1    Hong, S.W.2    Kim, S.M.3    Jin, D.H.4    Shin, J.S.5    Yoon, D.H.6
  • 50
    • 84857659914 scopus 로고    scopus 로고
    • Aceyl-L-carnitine-mediated neuroprotection during hypoxia is attributed to ERL1/2-Nrf2-regulated mitochondrial biosynthesis
    • Hota K.B., Hota S.K., Chaurasia O.O.P., Singh S.B. Aceyl-L-carnitine-mediated neuroprotection during hypoxia is attributed to ERL1/2-Nrf2-regulated mitochondrial biosynthesis. Hippocampus 2012, 22:723-736.
    • (2012) Hippocampus , vol.22 , pp. 723-736
    • Hota, K.B.1    Hota, S.K.2    Chaurasia, O.O.P.3    Singh, S.B.4
  • 51
    • 47249136923 scopus 로고    scopus 로고
    • Melatonin decreases TLR3-mediated inflammatory factor expression via inhibition of NF-kappa B activation in respiratory syncytial virus-infected RAW264.7 macrophages
    • Huang S.H., Cao X.J., Wei W. Melatonin decreases TLR3-mediated inflammatory factor expression via inhibition of NF-kappa B activation in respiratory syncytial virus-infected RAW264.7 macrophages. J. Pineal Res 2008, 45:93-100.
    • (2008) J. Pineal Res , vol.45 , pp. 93-100
    • Huang, S.H.1    Cao, X.J.2    Wei, W.3
  • 52
    • 0030959304 scopus 로고    scopus 로고
    • Bcl-2 phosphorylation required for anti-apoptosis function
    • Ito T., Deng X., Carr B., May W.S. Bcl-2 phosphorylation required for anti-apoptosis function. J. Biol. Chem 1997, 272:11671-11673.
    • (1997) J. Biol. Chem , vol.272 , pp. 11671-11673
    • Ito, T.1    Deng, X.2    Carr, B.3    May, W.S.4
  • 55
    • 84867777145 scopus 로고    scopus 로고
    • The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases
    • Joshi G., Johnson J.A. The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases. Recent Pat. CNS Drug Discov 2012, 7:218-229.
    • (2012) Recent Pat. CNS Drug Discov , vol.7 , pp. 218-229
    • Joshi, G.1    Johnson, J.A.2
  • 57
    • 84922330389 scopus 로고    scopus 로고
    • Melatonin decreases levels of S100β and NFKβ, increases levels of synaptophysin in a rat model of Alzheimer's disease
    • Jun Z., Li Z., Fang W., Fengzhen Y., Puyuan W., Wenwen L., et al. Melatonin decreases levels of S100β and NFKβ, increases levels of synaptophysin in a rat model of Alzheimer's disease. Curr. Aging Sci 2013, 36:152-163.
    • (2013) Curr. Aging Sci , vol.36 , pp. 152-163
    • Jun, Z.1    Li, Z.2    Fang, W.3    Fengzhen, Y.4    Puyuan, W.5    Wenwen, L.6
  • 58
    • 68249112961 scopus 로고    scopus 로고
    • Melatonin downregulates nuclear erythroid 2-related factor and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model
    • Jung K.H., Hong S.W., Zheng H.M., Lee D.H., Hong S.S. Melatonin downregulates nuclear erythroid 2-related factor and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model. J. Pineal Res 2009, 47:173-183.
    • (2009) J. Pineal Res , vol.47 , pp. 173-183
    • Jung, K.H.1    Hong, S.W.2    Zheng, H.M.3    Lee, D.H.4    Hong, S.S.5
  • 59
    • 77749310344 scopus 로고    scopus 로고
    • Melatonin ameliorates cerulean-induced pancreatitis by the modulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats
    • Jung K.H., Hong S.W., Zheng H.M., Lee H.S., Lee H., Lee D.H., et al. Melatonin ameliorates cerulean-induced pancreatitis by the modulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats. J. Pineal Res 2010, 48:239-250.
    • (2010) J. Pineal Res , vol.48 , pp. 239-250
    • Jung, K.H.1    Hong, S.W.2    Zheng, H.M.3    Lee, H.S.4    Lee, H.5    Lee, D.H.6
  • 60
    • 84858739354 scopus 로고    scopus 로고
    • Regulation of NF-κB by ubiquitination and degradation of the IkBs
    • Kanarek N., Ben-Neriah Y. Regulation of NF-κB by ubiquitination and degradation of the IkBs. Immunol. Rev 2012, 246:77-94.
    • (2012) Immunol. Rev , vol.246 , pp. 77-94
    • Kanarek, N.1    Ben-Neriah, Y.2
  • 61
    • 84872136337 scopus 로고    scopus 로고
    • Melatonin suppresses ciplatin-induced nephrotoxicity via activation of Nrf-2/Ho-1 pathway
    • Kilic U., Kilic E., Tuzcu Z., Tuzcu M., Ozercan I., Yilmaz O., et al. Melatonin suppresses ciplatin-induced nephrotoxicity via activation of Nrf-2/Ho-1 pathway. Nutr. Metab 2013, 10:7. 10.1186/1743-7075-10-7.
    • (2013) Nutr. Metab , vol.10 , pp. 7
    • Kilic, U.1    Kilic, E.2    Tuzcu, Z.3    Tuzcu, M.4    Ozercan, I.5    Yilmaz, O.6
  • 62
    • 0242721624 scopus 로고    scopus 로고
    • Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway
    • Kwak M.K., Wakabayashi N., Greenlaw J.L., Yamamoto M., Kensler T.W. Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway. Mol. Cell. Biol 2003, 23:8786-8794.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 8786-8794
    • Kwak, M.K.1    Wakabayashi, N.2    Greenlaw, J.L.3    Yamamoto, M.4    Kensler, T.W.5
  • 63
    • 84882789341 scopus 로고    scopus 로고
    • Melatonin: the watchdog of villous trophoblast homeostasis against hypoxia/reoxygenation-induced oxidative stress and apoptosis
    • Lanoix D., Lacasse A.A., Reiter R.J., Vaillancourt C. Melatonin: the watchdog of villous trophoblast homeostasis against hypoxia/reoxygenation-induced oxidative stress and apoptosis. Mol. Cell. Endocrinol 2013, 381:35-45.
    • (2013) Mol. Cell. Endocrinol , vol.381 , pp. 35-45
    • Lanoix, D.1    Lacasse, A.A.2    Reiter, R.J.3    Vaillancourt, C.4
  • 65
    • 70349970493 scopus 로고    scopus 로고
    • Keap1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta
    • Lee D.F., Kuo H.P., Liu M., Chou C.K., Xia W., Du Y., et al. Keap1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. Mol. Cell 2009, 36:131-140.
    • (2009) Mol. Cell , vol.36 , pp. 131-140
    • Lee, D.F.1    Kuo, H.P.2    Liu, M.3    Chou, C.K.4    Xia, W.5    Du, Y.6
  • 66
    • 77956301403 scopus 로고    scopus 로고
    • Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1)
    • Leja-Szpak A., Jaworek J., Pierzchalski P., Reiter R.J. Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1). J. Pineal Res 2010, 49:248-255.
    • (2010) J. Pineal Res , vol.49 , pp. 248-255
    • Leja-Szpak, A.1    Jaworek, J.2    Pierzchalski, P.3    Reiter, R.J.4
  • 67
    • 84904502234 scopus 로고    scopus 로고
    • Alterations in the time course of the Nox family in the brain in a rat experimental cerebral ischemia and reperfusion model; effects of melatonin
    • Li H., Wang Y., Feng D., Liu Y., Xu M., Gao A., et al. Alterations in the time course of the Nox family in the brain in a rat experimental cerebral ischemia and reperfusion model; effects of melatonin. J. Pineal Res 2014, 57:110-119.
    • (2014) J. Pineal Res , vol.57 , pp. 110-119
    • Li, H.1    Wang, Y.2    Feng, D.3    Liu, Y.4    Xu, M.5    Gao, A.6
  • 68
    • 25644449484 scopus 로고    scopus 로고
    • Melatonin reduces inflammatory injury through inhibiting NF-kappaB activation in rats with colitis
    • Li J.H., Yu J.P., Yu H.G., Xu X.M., Yu L.L., Liu J., et al. Melatonin reduces inflammatory injury through inhibiting NF-kappaB activation in rats with colitis. Mediators Inflamm 2005, 31:185-193.
    • (2005) Mediators Inflamm , vol.31 , pp. 185-193
    • Li, J.H.1    Yu, J.P.2    Yu, H.G.3    Xu, X.M.4    Yu, L.L.5    Liu, J.6
  • 69
    • 0141706672 scopus 로고    scopus 로고
    • Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells
    • Ling Y.H., Liebes L., Zou Y., Perez-Solar R. Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. J. Biol. Chem 2003, 278:33714-33723.
    • (2003) J. Biol. Chem , vol.278 , pp. 33714-33723
    • Ling, Y.H.1    Liebes, L.2    Zou, Y.3    Perez-Solar, R.4
  • 70
    • 79958007234 scopus 로고    scopus 로고
    • Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway
    • Macari E.R., Lowrey C.H. Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway. Blood 2011, 117:5987-5997.
    • (2011) Blood , vol.117 , pp. 5987-5997
    • Macari, E.R.1    Lowrey, C.H.2
  • 71
    • 0035284812 scopus 로고    scopus 로고
    • Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells
    • Marshansky V., Wang X., Bertrand R., Luo H., Duguid W., Chinnadurai G., et al. Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells. J. Immunol 2001, 166:3130-3142.
    • (2001) J. Immunol , vol.166 , pp. 3130-3142
    • Marshansky, V.1    Wang, X.2    Bertrand, R.3    Luo, H.4    Duguid, W.5    Chinnadurai, G.6
  • 72
    • 84868139128 scopus 로고    scopus 로고
    • RNAi screening reveals proteasome- and cullin3-dependent stages in vaccinia virus infection
    • Mercer J., Snijder B., Sacher R., Burkard C., Bleck C.K., Stahlberg H., et al. RNAi screening reveals proteasome- and cullin3-dependent stages in vaccinia virus infection. Cell Rep 2012, 2:1036-1047.
    • (2012) Cell Rep , vol.2 , pp. 1036-1047
    • Mercer, J.1    Snijder, B.2    Sacher, R.3    Burkard, C.4    Bleck, C.K.5    Stahlberg, H.6
  • 73
    • 84858752720 scopus 로고    scopus 로고
    • Inhibitory effects of melatonin on the lipopolysaccharide-induced CC chemokine expression in BV2 murine microglial cells are mediated by suppression of AKT-induced NF-κB and STAT/GAS activity
    • Min K.J., Jang J.H., Kwon T.K. Inhibitory effects of melatonin on the lipopolysaccharide-induced CC chemokine expression in BV2 murine microglial cells are mediated by suppression of AKT-induced NF-κB and STAT/GAS activity. J. Pineal Res 2012, 52:296-304.
    • (2012) J. Pineal Res , vol.52 , pp. 296-304
    • Min, K.J.1    Jang, J.H.2    Kwon, T.K.3
  • 74
    • 84872266626 scopus 로고    scopus 로고
    • Melatonin may play a role in modulation of bax and bcl-2 expression levels to protect rat peripheral blood lymphocytes from gamma irradiation-induced apoptosis
    • Mohseni M., Mihandoost E., Shirazi A., Sepehrizadeh Z., Bazzaz J.T., Ghazi-khansari M. Melatonin may play a role in modulation of bax and bcl-2 expression levels to protect rat peripheral blood lymphocytes from gamma irradiation-induced apoptosis. Mutat. Res 2012, 738-739:19-27.
    • (2012) Mutat. Res , pp. 19-27
    • Mohseni, M.1    Mihandoost, E.2    Shirazi, A.3    Sepehrizadeh, Z.4    Bazzaz, J.T.5    Ghazi-khansari, M.6
  • 75
    • 33845515283 scopus 로고    scopus 로고
    • Antioxidant effects of melatonin in rats during chronic exposure to hyperbaric oxygen
    • Mollaoglu H., Topal T., Ozler M., Uysal B., Reiter R.J., Korkmaz A., et al. Antioxidant effects of melatonin in rats during chronic exposure to hyperbaric oxygen. J. Pineal Res 2007, 42:50-54.
    • (2007) J. Pineal Res , vol.42 , pp. 50-54
    • Mollaoglu, H.1    Topal, T.2    Ozler, M.3    Uysal, B.4    Reiter, R.J.5    Korkmaz, A.6
  • 76
    • 0029553170 scopus 로고
    • The neurohormone melatonin inhibits cytokine, mitogen and ionizing radiation induced NF-kappa B
    • Natarajan M., Sadeghi K., Reiter R.J., Meltz M.L. The neurohormone melatonin inhibits cytokine, mitogen and ionizing radiation induced NF-kappa B. Biochem. Mol. Biol. Int 1995, 37:1063-1070.
    • (1995) Biochem. Mol. Biol. Int , vol.37 , pp. 1063-1070
    • Natarajan, M.1    Sadeghi, K.2    Reiter, R.J.3    Meltz, M.L.4
  • 77
    • 45149090556 scopus 로고    scopus 로고
    • Nuclear ubiquitin ligases, NF-κB degradation, and the control of inflammation
    • Natoli G., Chiocca S. Nuclear ubiquitin ligases, NF-κB degradation, and the control of inflammation. Sci. Signal 2008, 1:pe1.
    • (2008) Sci. Signal , vol.1 , pp. pe1
    • Natoli, G.1    Chiocca, S.2
  • 78
    • 79951642115 scopus 로고    scopus 로고
    • Melatonin modulates neuroinflammation and oxidative stress in experimental diabetic neuropathy: effects on NF-κB and Nrf2 cascades
    • Negi G., Kumar A., Sharma S.S. Melatonin modulates neuroinflammation and oxidative stress in experimental diabetic neuropathy: effects on NF-κB and Nrf2 cascades. J. Pineal Res 2011, 50:124-131.
    • (2011) J. Pineal Res , vol.50 , pp. 124-131
    • Negi, G.1    Kumar, A.2    Sharma, S.S.3
  • 79
    • 0013282861 scopus 로고    scopus 로고
    • Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26S proteasome
    • Nguyen T., Sherratt P.J., Huang H.C., Yang C.S., Pickett C.B. Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26S proteasome. J. Biol. Chem 2003, 278:4536-4541.
    • (2003) J. Biol. Chem , vol.278 , pp. 4536-4541
    • Nguyen, T.1    Sherratt, P.J.2    Huang, H.C.3    Yang, C.S.4    Pickett, C.B.5
  • 80
    • 79951670106 scopus 로고    scopus 로고
    • Nrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis
    • Niture S.K., Jaiswal A.K. Nrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis. Cell Death Differ 2011, 18:439-451.
    • (2011) Cell Death Differ , vol.18 , pp. 439-451
    • Niture, S.K.1    Jaiswal, A.K.2
  • 81
    • 84455192645 scopus 로고    scopus 로고
    • Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phophoglycerate mutase 5 and controls cellular apoptosis
    • Niture S.K., Jaiswal A.K. Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phophoglycerate mutase 5 and controls cellular apoptosis. J. Biol. Chem 2011, 286:44542-44556.
    • (2011) J. Biol. Chem , vol.286 , pp. 44542-44556
    • Niture, S.K.1    Jaiswal, A.K.2
  • 82
    • 0031975809 scopus 로고    scopus 로고
    • Rhythms of glutathione peroxidase and glutathione reductase in brain of chick and their inhibition by light
    • Pablos M.I., Reiter R.J., Ortiz G.G., Guerrero J.M., Agapito M.T., Chuang J.I., et al. Rhythms of glutathione peroxidase and glutathione reductase in brain of chick and their inhibition by light. Neurochem. Int 1998, 32:69-75.
    • (1998) Neurochem. Int , vol.32 , pp. 69-75
    • Pablos, M.I.1    Reiter, R.J.2    Ortiz, G.G.3    Guerrero, J.M.4    Agapito, M.T.5    Chuang, J.I.6
  • 83
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-kappaB transcription factors
    • Pahl H.L. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 1999, 18:6853-6866.
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 84
    • 84890125260 scopus 로고    scopus 로고
    • Transcriptional and post-translational regulation of Bim controls apoptosis in melatonin-treated human renal cancer Caki cells
    • Park E.J., Woo S.M., Min K.J., Kwon T.K. Transcriptional and post-translational regulation of Bim controls apoptosis in melatonin-treated human renal cancer Caki cells. J. Pineal Res 2014, 56:97-106.
    • (2014) J. Pineal Res , vol.56 , pp. 97-106
    • Park, E.J.1    Woo, S.M.2    Min, K.J.3    Kwon, T.K.4
  • 85
    • 33845768987 scopus 로고    scopus 로고
    • Integrating cell-signalling pathways with NF-κB and IKK function
    • Perkins N. Integrating cell-signalling pathways with NF-κB and IKK function. Nat. Rev. Mol. Cell Biol 2007, 8:49-62.
    • (2007) Nat. Rev. Mol. Cell Biol , vol.8 , pp. 49-62
    • Perkins, N.1
  • 86
    • 58149328569 scopus 로고    scopus 로고
    • Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1
    • Piantadosi C.A., Carraway M.S., Babiker A., Suliman H.B. Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circ. Res 2008, 103:1232-1240.
    • (2008) Circ. Res , vol.103 , pp. 1232-1240
    • Piantadosi, C.A.1    Carraway, M.S.2    Babiker, A.3    Suliman, H.B.4
  • 87
    • 84900468337 scopus 로고    scopus 로고
    • Proteasome inhibition induces both antioxidant and hb f response in sickle cell disease via the nrf2 pathway
    • Pullarkat V., Meng Z., Tahara S.M., Johnson C.S., Kalra V.K. Proteasome inhibition induces both antioxidant and hb f response in sickle cell disease via the nrf2 pathway. Hemoglobin 2014, 38:188-195.
    • (2014) Hemoglobin , vol.38 , pp. 188-195
    • Pullarkat, V.1    Meng, Z.2    Tahara, S.M.3    Johnson, C.S.4    Kalra, V.K.5
  • 88
    • 84866303931 scopus 로고    scopus 로고
    • Melatonin inhibits IL 1β-induced MMP9 expression and activity in human umbilical vein endothelial cells by suppressing NF-κB activation
    • Qin W., Lu W., Li H., Yuan X., Li B., Zhang Q., et al. Melatonin inhibits IL 1β-induced MMP9 expression and activity in human umbilical vein endothelial cells by suppressing NF-κB activation. J. Endocrinol 2012, 214:145-153.
    • (2012) J. Endocrinol , vol.214 , pp. 145-153
    • Qin, W.1    Lu, W.2    Li, H.3    Yuan, X.4    Li, B.5    Zhang, Q.6
  • 90
    • 0029055175 scopus 로고
    • Oxidative processes and antioxidative defense mechanisms in the aging brain
    • Reiter R.J. Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J. 1995, 9:526-533.
    • (1995) FASEB J. , vol.9 , pp. 526-533
    • Reiter, R.J.1
  • 91
    • 0029902553 scopus 로고    scopus 로고
    • Functional aspects of the pineal hormone melatonin in combating cell and tissue damage induced by free radicals
    • Reiter R.J. Functional aspects of the pineal hormone melatonin in combating cell and tissue damage induced by free radicals. Eur. J. Endocrinol 1996, 134:412-420.
    • (1996) Eur. J. Endocrinol , vol.134 , pp. 412-420
    • Reiter, R.J.1
  • 92
    • 84876850102 scopus 로고    scopus 로고
    • The universal nature, unequal distribution and antioxidant functions of melatonin and its derivatives
    • Reiter R.J., Tan D.X., Rosales-Corral S., Manchester L.C. The universal nature, unequal distribution and antioxidant functions of melatonin and its derivatives. Mini Rev. Med. Chem 2013, 13:373-384.
    • (2013) Mini Rev. Med. Chem , vol.13 , pp. 373-384
    • Reiter, R.J.1    Tan, D.X.2    Rosales-Corral, S.3    Manchester, L.C.4
  • 93
    • 84949117036 scopus 로고    scopus 로고
    • Melatonin reduces lipid peroxidation and membrane viscosity
    • article 377
    • Reiter R.J., Tan D.X., Galano A. Melatonin reduces lipid peroxidation and membrane viscosity. Front. Physiol 2014, 5. article 377.
    • (2014) Front. Physiol , vol.5
    • Reiter, R.J.1    Tan, D.X.2    Galano, A.3
  • 95
    • 84889600643 scopus 로고    scopus 로고
    • The effect of melatonin on plasma markers of inflammation and on expression of nuclear factor-kappa beta in acetic acid-induced colitis in the rat
    • Sayyed H.G., Jaumdally R.J., Idriss N.K., El Sers D.A., Blann A. The effect of melatonin on plasma markers of inflammation and on expression of nuclear factor-kappa beta in acetic acid-induced colitis in the rat. Dig. Dis. Sci 2013, 58:3156-3164.
    • (2013) Dig. Dis. Sci , vol.58 , pp. 3156-3164
    • Sayyed, H.G.1    Jaumdally, R.J.2    Idriss, N.K.3    El Sers, D.A.4    Blann, A.5
  • 96
    • 84892420352 scopus 로고    scopus 로고
    • Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation
    • Schwimmer H., Metzer A., Pilosof Y., Szyf M., Machnes Z.M., Fares F., et al. Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation. Chronobiol. Int 2014, 31:144-150.
    • (2014) Chronobiol. Int , vol.31 , pp. 144-150
    • Schwimmer, H.1    Metzer, A.2    Pilosof, Y.3    Szyf, M.4    Machnes, Z.M.5    Fares, F.6
  • 97
    • 0242362280 scopus 로고    scopus 로고
    • An inhibitor of mitochondrial complex I, rotenone, inactivates proteasome by oxidative modification and induces aggregation of oxidized proteins in SH-SY5Y cells
    • Shamoto-Nagai M., Maruyama W., Kato Y., Osobe K., Tanaka M., Naoi M., et al. An inhibitor of mitochondrial complex I, rotenone, inactivates proteasome by oxidative modification and induces aggregation of oxidized proteins in SH-SY5Y cells. J. Neurosci. Res 2003, 74:589-597.
    • (2003) J. Neurosci. Res , vol.74 , pp. 589-597
    • Shamoto-Nagai, M.1    Maruyama, W.2    Kato, Y.3    Osobe, K.4    Tanaka, M.5    Naoi, M.6
  • 98
    • 79957933700 scopus 로고    scopus 로고
    • Ubiquitin-proteasome pathway and cellular responses to oxidative stress
    • Shang F., Taylor A. Ubiquitin-proteasome pathway and cellular responses to oxidative stress. Free Radic. Biol. Med 2011, 51:5-16.
    • (2011) Free Radic. Biol. Med , vol.51 , pp. 5-16
    • Shang, F.1    Taylor, A.2
  • 99
    • 84864977145 scopus 로고    scopus 로고
    • Melatonin suppresses proinflammatory mediators in lipopolysaccharide-stimulated CRL 1999 cells via targeting MAPK, NF-κB, c/EBPβ, and p300 signaling
    • Shi D., Xiao X., Wang J., Liu L., Chen W., Fu L., et al. Melatonin suppresses proinflammatory mediators in lipopolysaccharide-stimulated CRL 1999 cells via targeting MAPK, NF-κB, c/EBPβ, and p300 signaling. J. Pineal Res 2012, 53:154-165.
    • (2012) J. Pineal Res , vol.53 , pp. 154-165
    • Shi, D.1    Xiao, X.2    Wang, J.3    Liu, L.4    Chen, W.5    Fu, L.6
  • 100
    • 77958004285 scopus 로고    scopus 로고
    • Nrf2-ARE stress response mechanism: a control point in oxidative stress-mediated dysfunctions and inflammatory diseases
    • Singh S., Vrishni S., Singh B.K., Rahman I., Kakkar P. Nrf2-ARE stress response mechanism: a control point in oxidative stress-mediated dysfunctions and inflammatory diseases. Free Radic. Res 2010, 44:1267-1288.
    • (2010) Free Radic. Res , vol.44 , pp. 1267-1288
    • Singh, S.1    Vrishni, S.2    Singh, B.K.3    Rahman, I.4    Kakkar, P.5
  • 101
    • 34548772935 scopus 로고    scopus 로고
    • Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2
    • Sun Z., Zhang S., Chan J.Y., Zhang D.D. Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2. Mol. Cell. Biol 2007, 27:6334-6349.
    • (2007) Mol. Cell. Biol , vol.27 , pp. 6334-6349
    • Sun, Z.1    Zhang, S.2    Chan, J.Y.3    Zhang, D.D.4
  • 102
    • 56249106571 scopus 로고    scopus 로고
    • Nfr2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals
    • Surh Y.J., Kundu J.K., Na H.K. Nfr2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Med 2008, 74:1526-1539.
    • (2008) Planta Med , vol.74 , pp. 1526-1539
    • Surh, Y.J.1    Kundu, J.K.2    Na, H.K.3
  • 103
    • 78751703950 scopus 로고    scopus 로고
    • Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
    • Taguchi K., Motohashi H., Yamamoto M. Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells 2011, 16:123-140.
    • (2011) Genes Cells , vol.16 , pp. 123-140
    • Taguchi, K.1    Motohashi, H.2    Yamamoto, M.3
  • 105
    • 23744485610 scopus 로고    scopus 로고
    • Interactions between melatonin and nicotinamide nucleotide: NADH preservation in cells and in cell-free systems by melatonin
    • Tan D.X., Manchester L.C., Sainz R.M., Mayo J.C., Leon J., Hardeland R., et al. Interactions between melatonin and nicotinamide nucleotide: NADH preservation in cells and in cell-free systems by melatonin. J. Pineal Res 2005, 39:185-194.
    • (2005) J. Pineal Res , vol.39 , pp. 185-194
    • Tan, D.X.1    Manchester, L.C.2    Sainz, R.M.3    Mayo, J.C.4    Leon, J.5    Hardeland, R.6
  • 106
    • 84897954689 scopus 로고    scopus 로고
    • Melatonin attenuates hippocampal neuron apoptosis and oxidative stress during chronic intermittent hypoxia via up-regulating B-cell lymphoma-2 and down-regulating C-cell lymphoma-2 associated X protein
    • Tan X., Guo X., Liu H. Melatonin attenuates hippocampal neuron apoptosis and oxidative stress during chronic intermittent hypoxia via up-regulating B-cell lymphoma-2 and down-regulating C-cell lymphoma-2 associated X protein. Saudi Med. J. 2013, 34:701-708.
    • (2013) Saudi Med. J. , vol.34 , pp. 701-708
    • Tan, X.1    Guo, X.2    Liu, H.3
  • 107
    • 80053352130 scopus 로고    scopus 로고
    • Mitochondrial quality control by the ubiquitin-proteasome system
    • Taylor E.B., Rutter J. Mitochondrial quality control by the ubiquitin-proteasome system. Biochem. Soc. Trans 2011, 39:1509-1513.
    • (2011) Biochem. Soc. Trans , vol.39 , pp. 1509-1513
    • Taylor, E.B.1    Rutter, J.2
  • 108
    • 84865280525 scopus 로고    scopus 로고
    • Keap1: one stone kills three birds Nrf2, IKKβ, and Bcl-2/Bcl-xL
    • Tian H., Zhang B., Di J., Jiang G., Chen F., Li H., et al. Keap1: one stone kills three birds Nrf2, IKKβ, and Bcl-2/Bcl-xL. Cancer Lett 2012, 325:26-34.
    • (2012) Cancer Lett , vol.325 , pp. 26-34
    • Tian, H.1    Zhang, B.2    Di, J.3    Jiang, G.4    Chen, F.5    Li, H.6
  • 109
    • 23744513206 scopus 로고    scopus 로고
    • A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes
    • Tomas-Zapico C., Coto-Montes A. A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes. J. Pineal Res 2005, 39:366-375.
    • (2005) J. Pineal Res , vol.39 , pp. 366-375
    • Tomas-Zapico, C.1    Coto-Montes, A.2
  • 110
    • 0028148227 scopus 로고
    • A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B
    • Traenchner E.B., Wilk S., Baeuerle P.A. A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B. EMBO J. 1994, 13:5433-5441.
    • (1994) EMBO J. , vol.13 , pp. 5433-5441
    • Traenchner, E.B.1    Wilk, S.2    Baeuerle, P.A.3
  • 111
    • 84919772749 scopus 로고    scopus 로고
    • Isoform-specific SCFFbw7 ubiquitination mediates differential regulation of PGC-1α
    • (in press), [epub ahead of print]
    • Trausch-Azar J.S., Abed M., Orian A., Schwartz A.L. Isoform-specific SCFFbw7 ubiquitination mediates differential regulation of PGC-1α. J. Cell. Physiol 2014, (in press), [epub ahead of print].
    • (2014) J. Cell. Physiol
    • Trausch-Azar, J.S.1    Abed, M.2    Orian, A.3    Schwartz, A.L.4
  • 112
    • 77950648335 scopus 로고    scopus 로고
    • Effect of melatonin on the expression of Nrf2 and NF-kappaB during cyclophosphamide induced urinary bladder injury in rat
    • Tripathi D.N., Jena G.B. Effect of melatonin on the expression of Nrf2 and NF-kappaB during cyclophosphamide induced urinary bladder injury in rat. J. Pineal Res 2010, 48:324-331.
    • (2010) J. Pineal Res , vol.48 , pp. 324-331
    • Tripathi, D.N.1    Jena, G.B.2
  • 113
  • 114
    • 77958115724 scopus 로고    scopus 로고
    • Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin-proteasome system: an insight into cullin-ring ubiquitin ligases
    • Villeneuve N.F., Lau A., Zhang D.D. Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin-proteasome system: an insight into cullin-ring ubiquitin ligases. Antioxid. Redox Signal 2010, 13:1699-1712.
    • (2010) Antioxid. Redox Signal , vol.13 , pp. 1699-1712
    • Villeneuve, N.F.1    Lau, A.2    Zhang, D.D.3
  • 115
    • 84866333520 scopus 로고    scopus 로고
    • The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism
    • Vomhof-DeKrey E.E., Picklo M.J. The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism. J. Nutr. Biochem 2012, 1201-1206.
    • (2012) J. Nutr. Biochem , pp. 1201-1206
    • Vomhof-DeKrey, E.E.1    Picklo, M.J.2
  • 116
    • 84908042241 scopus 로고    scopus 로고
    • Melatonin as a proteasome inhibitor. Is there any clinical evidence?
    • Vriend J., Reiter R.J. Melatonin as a proteasome inhibitor. Is there any clinical evidence?. Life Sci 2014, 115:8-14.
    • (2014) Life Sci , vol.115 , pp. 8-14
    • Vriend, J.1    Reiter, R.J.2
  • 117
    • 84901433308 scopus 로고    scopus 로고
    • APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction
    • Wan L., Tan M., Yang J., Inzuka H., Dai X., Wu T., et al. APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction. Dev. Cell 2014, 27:377-391.
    • (2014) Dev. Cell , vol.27 , pp. 377-391
    • Wan, L.1    Tan, M.2    Yang, J.3    Inzuka, H.4    Dai, X.5    Wu, T.6
  • 118
    • 84882370702 scopus 로고    scopus 로고
    • Protective effect of melatonin on bone marrow mesenchymal stem cells against hydrogen peroxide-induced apoptosis in vitro
    • Wang F.W., Wang Z., Zhang Y.M., Du Z.X., Zhang X.L., Liu Q., et al. Protective effect of melatonin on bone marrow mesenchymal stem cells against hydrogen peroxide-induced apoptosis in vitro. J. Cell. Biochem 2013, 114:2346-2355.
    • (2013) J. Cell. Biochem , vol.114 , pp. 2346-2355
    • Wang, F.W.1    Wang, Z.2    Zhang, Y.M.3    Du, Z.X.4    Zhang, X.L.5    Liu, Q.6
  • 119
    • 84897494376 scopus 로고    scopus 로고
    • Ectromelia virus encodes a BTB/kelch protein, EVM150, that inhibits NF-κB signaling
    • Wang Q., Burles K., Couturier B., Randall C.M., Shisler J., Barry M. Ectromelia virus encodes a BTB/kelch protein, EVM150, that inhibits NF-κB signaling. J. Virol 2014, 88:4853-4865.
    • (2014) J. Virol , vol.88 , pp. 4853-4865
    • Wang, Q.1    Burles, K.2    Couturier, B.3    Randall, C.M.4    Shisler, J.5    Barry, M.6
  • 120
    • 0031985626 scopus 로고    scopus 로고
    • Role of proteasomes in T cell activation and proliferation
    • Wang X., Luo H., Chen H., Duguid W., Wu J. Role of proteasomes in T cell activation and proliferation. J. Immunol 1998, 160:788-801.
    • (1998) J. Immunol , vol.160 , pp. 788-801
    • Wang, X.1    Luo, H.2    Chen, H.3    Duguid, W.4    Wu, J.5
  • 121
    • 84862217131 scopus 로고    scopus 로고
    • Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model
    • Wang Z., Ma C., Meng C.J., Zhu G.Q., Sun X.B., Huo L., et al. Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model. J. Pineal Res 2012, 53:129-137.
    • (2012) J. Pineal Res , vol.53 , pp. 129-137
    • Wang, Z.1    Ma, C.2    Meng, C.J.3    Zhu, G.Q.4    Sun, X.B.5    Huo, L.6
  • 122
    • 84878875514 scopus 로고    scopus 로고
    • Where ubiquitin meets NF-kB: a trove for anti-cancer drug development
    • Wu Z., Shi Y. Where ubiquitin meets NF-kB: a trove for anti-cancer drug development. Curr. Pharm. Des 2013, 19:3263-3675.
    • (2013) Curr. Pharm. Des , vol.19 , pp. 3263-3675
    • Wu, Z.1    Shi, Y.2
  • 123
    • 0033538473 scopus 로고    scopus 로고
    • Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
    • Wu Z., Puigserver P., Andersson U., Zhang C., Adelmant G., Mootha V., et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 1999, 98:115-124.
    • (1999) Cell , vol.98 , pp. 115-124
    • Wu, Z.1    Puigserver, P.2    Andersson, U.3    Zhang, C.4    Adelmant, G.5    Mootha, V.6
  • 124
    • 84923028459 scopus 로고    scopus 로고
    • An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders
    • (in press)
    • Yang Y., Jiang S., Yan J., Li Y., Xin Z., Lin Y., et al. An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders. Cytokine Growth Factor Rev 2014, (in press).
    • (2014) Cytokine Growth Factor Rev
    • Yang, Y.1    Jiang, S.2    Yan, J.3    Li, Y.4    Xin, Z.5    Lin, Y.6
  • 125
    • 84919345872 scopus 로고    scopus 로고
    • A review of melatonin as a suitable antioxidant against myocardial ischemia-reperfusion injury and clinical heart diseases
    • Yang Y., Sun Y., Yi W., Li Y., Fan C., Xin Z., et al. A review of melatonin as a suitable antioxidant against myocardial ischemia-reperfusion injury and clinical heart diseases. J. Pineal Res 2014, 57:357-366.
    • (2014) J. Pineal Res , vol.57 , pp. 357-366
    • Yang, Y.1    Sun, Y.2    Yi, W.3    Li, Y.4    Fan, C.5    Xin, Z.6
  • 126
    • 84877135789 scopus 로고    scopus 로고
    • Expression of heme oxygenase-1 in response to proteasomal inhibition
    • Yerlikaya A. Expression of heme oxygenase-1 in response to proteasomal inhibition. Protein Pept. Lett 2012, 19:1330-1333.
    • (2012) Protein Pept. Lett , vol.19 , pp. 1330-1333
    • Yerlikaya, A.1
  • 127
    • 18544378885 scopus 로고    scopus 로고
    • Melatonin suppresses NO-induced apoptosis via induction of Bcl-2 expression in PGT-β immortalized pineal cells
    • Yoo Y.M., Yim S.V., Kim S.S., Jang H.Y., Lea H.Z., Hwang G.C., et al. Melatonin suppresses NO-induced apoptosis via induction of Bcl-2 expression in PGT-β immortalized pineal cells. J. Pineal Res 2002, 33:146-150.
    • (2002) J. Pineal Res , vol.33 , pp. 146-150
    • Yoo, Y.M.1    Yim, S.V.2    Kim, S.S.3    Jang, H.Y.4    Lea, H.Z.5    Hwang, G.C.6
  • 128
    • 1842861723 scopus 로고    scopus 로고
    • The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib
    • Yu C., Rahmani M., Dent P., Grant S. The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib. Exp. Cell Res 2004, 295:555-566.
    • (2004) Exp. Cell Res , vol.295 , pp. 555-566
    • Yu, C.1    Rahmani, M.2    Dent, P.3    Grant, S.4
  • 129
    • 33845442925 scopus 로고    scopus 로고
    • Mechanistic studies of the Nrf2-Keap1 signaling pathway
    • Zhang D.D. Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab. Rev 2006, 38:769-789.
    • (2006) Drug Metab. Rev , vol.38 , pp. 769-789
    • Zhang, D.D.1
  • 130
    • 84925835510 scopus 로고    scopus 로고
    • Melatonin a well-documented antioxidant with conditional pro-oxidant actions
    • Zhang H.M., Zhang Y. Melatonin a well-documented antioxidant with conditional pro-oxidant actions. J. Pineal Res 2014, 57:131-246.
    • (2014) J. Pineal Res , vol.57 , pp. 131-246
    • Zhang, H.M.1    Zhang, Y.2
  • 131
    • 84870902532 scopus 로고    scopus 로고
    • Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection
    • Zhang M., An C., Gao Y., Leak R.K., Chen J., Zhang F. Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection. Prog. Neurobiol 2013, 100:30-47.
    • (2013) Prog. Neurobiol , vol.100 , pp. 30-47
    • Zhang, M.1    An, C.2    Gao, Y.3    Leak, R.K.4    Chen, J.5    Zhang, F.6
  • 132
    • 84892795491 scopus 로고    scopus 로고
    • Dietary melatonin attenuates age-related changes in morphology and in levels of key proteins in globus pallidus of mouse brain
    • Zhou J., Yang F., Wang J.G., Wen P., Luo H., Li W., et al. Dietary melatonin attenuates age-related changes in morphology and in levels of key proteins in globus pallidus of mouse brain. Brain Res 2014, 1546:1-8.
    • (2014) Brain Res , vol.1546 , pp. 1-8
    • Zhou, J.1    Yang, F.2    Wang, J.G.3    Wen, P.4    Luo, H.5    Li, W.6
  • 133
    • 84877107994 scopus 로고    scopus 로고
    • Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases
    • Zhou W., Wei W., Sun Y. Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases. Cell Res 2013, 23:599-619.
    • (2013) Cell Res , vol.23 , pp. 599-619
    • Zhou, W.1    Wei, W.2    Sun, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.