Melatonin suppresses proinflammatory mediators in lipopolysaccharide- stimulated CRL1999 cells via targeting MAPK, NF-κB, c/EBPβ, and p300 signaling

Journal of Pineal Research

Volumn 53, Issue 2, 2012, Pages 154-165

  Shi, Dingbo ^a   Xiao, Xiangsheng ^a   Wang, Jingshu ^a   Liu, Liqun ^c   Chen, Wangbing ^a   Fu, Lingyi ^a   Xie, Fangyun ^a   Huang, Wenlin ^a,c   Deng, Wuguo ^a,b  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b Guangzhou Double Bioproduct Inc   (China)

^c DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

c EBP ; MAPK; melatonin; NF B; p300; proinflammatory mediator

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; CYCLOOXYGENASE 2; HISTONE ACETYLTRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MELATONIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; PLACEBO; PROSTAGLANDIN E2; PROTEIN P300; ROSCOVITINE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INFLAMMATION; MUTANT; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

BLOTTING, WESTERN; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; E1A-ASSOCIATED P300 PROTEIN; HUMANS; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MELATONIN; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84864977145     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2012.00982.x     Document Type: Article

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