Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation

Chronobiology International

Volumn 31, Issue 1, 2014, Pages 144-150

  Schwimmer, Hagit ^a   Metzer, Avishag ^a   Pilosof, Yonit ^a   Szyf, Moshe ^b   Machnes, Ziv M ^b   Fares, Fuad ^a   Harel, Orna ^a   Haim, Abraham ^a  

^a UNIVERSITY OF HAIFA   (Israel)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Breast cancer; Epigenetic modifications; Global methylation state; Light at night; Melatonin

Indexed keywords

6 HYDROXYMELATONIN O SULFATE; 6-SULFATOXYMELATONIN; DRUG DERIVATIVE; MELATONIN;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; CANCER TRANSPLANTATION; CIRCADIAN RHYTHM; DNA METHYLATION; EXPERIMENTAL MAMMARY NEOPLASM; FEMALE; GENETIC EPIGENESIS; LIGHT; METABOLISM; MOUSE; PATHOLOGY; PHOTOPERIODICITY; PINEAL BODY; SIGNAL TRANSDUCTION; URINE;

ANIMALS; CIRCADIAN RHYTHM; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; LIGHT; MAMMARY NEOPLASMS, EXPERIMENTAL; MELATONIN; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; PHOTOPERIOD; PINEAL GLAND; SIGNAL TRANSDUCTION;

EID: 84892420352     PISSN: 07420528     EISSN: 15256073     Source Type: Journal    
DOI: 10.3109/07420528.2013.842925     Document Type: Article

References (42)

1. AMA. (2012). AMA adopts new public health policies at annual meeting. Retrieved from: Http://www.cisionwire.com/american-medical-Association/r/ama- Adopts-new-public-healthpolicies- at-Annual-meeting,c9275938
2. Arendt J, Deacon S, English J, et al. (1995). Melatonin and adjustment to phase shift. J Sleep Res. 4:74-9.
3. Bernardino J, Roux C, Almeida A, et al (1997). DNA hypomethylation in breast cancer: An independent parameter of tumor progression? Cancer Genet Cytogenet. 97:83-9.
4. Blask DE, Brainard GC, Dauchy RT, et al. (2005). Melatonindepleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats. Cancer Res. 65:11174-84.
5. Blask DE, Hill SM, Dauchy RT, et al. (2011). Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the consequences of its disruption by light at night. J Pineal Res. 51:259-569.
6. Blask DE, Sauer LA, Dauchy RT. (2002). Melatonin as a chronobiotic/ anticancer agent: Cellular, biochemical, and molecular mechanisms of action and their implications for circadianbased cancer therapy. Curr Top Med Chem. 2:113-32.
7. Blask DE. (2009). Melatonin, sleep disturbance and cancer risk. Sleep Med Rev. 13:257-64.
8. Boyle P, Levin B. (2008). World cancer report 2008. Lyon: International Agency for Research on Cancer.
9. Brainard GC, Rollag MD, Hanifin JP. (1997). Photic regulation of melatonin in humans: Ocular and neural signal transduction. J Biol Rhythms. 12:537-46.
10. Cajochen C, Munch M, Kobialka S, et al. (2005). High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light. J Clin Endocrinol Metab. 90:1311-16.
11. Conti A, Maestroni GJ. (1996). HPLC validation of a circadian melatonin rhythm in the pineal gland of inbred mice. J Pineal Res. 20:138-44.
12. Cos S, Mediavilla D, Martínez-Campa C, et al. (2006). Exposure to light-At-night increases the growth of DMBA-induced mammary adenocarcinomas in rats. Cancer Lett. 235:266-71.
13. Erren TC, Erren M, Lerchl A, Meyer-Rochow VB. (2008). Clockwork blue: On the evolution of non-image-forming retinal photoreceptors in marine and terrestrial vertebrates. Naturwissenschaften. 95:273-9.
14. Esteller M, Fraga MF, Guo M, et al. (2001). DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. Hum Mol Genet. 10:3001-7.
15. Esteller M. (2005). Aberrant DNA methylation as a cancer-inducing mechanism. Annu Rev Pharmacol Toxicol. 45:629-56.
16. Feinberg AP, Tycko B. (2004). The history of cancer epigenetics. Nat Rev Cancer. 4:143-53.
17. Filipski E, Delaunay F, King VM, et al. (2004). Effects of chronic jet lag on tumor progression in mice. Cancer Res. 64:7879-85.
18. Haim A, Kloog I, Rennert HS, Portnov BA. (2011). Authors' response. Chronobiol Int. 28:379-80.
19. Haim A, Portnov BA. (2011). LAN and breast cancer risk: Can we see a forest through the trees?-Response to ''Measurements of Light at Night (LAN) for a Sample of Female School Teachers'' by M. S. Rea, J. A. Brons, and M. G. Figueiro. Chronobiol Int. 28: 734-6.
20. Haim A, Yukler A, Harel O, et al. (2010). Effects of chronobiology on prostate cancer cells growth in vivo. Sleep Sci. 3:32-5.
21. Hoffman AE, Yi CH, Zheng T, et al. (2010). CLOCK in breast tumorigenesis: Genetic, epigenetic, and transcriptional profiling analyses. Cancer Res. 70:1459-68.
22. Karimi M, Johansson S, Stach D, et al. (2006). LUMA (LUminometric Methylation Assay)-A high throughput method to the analysis of genomic DNA methylation. Exp Cell Res. 312:1989-95.
23. Kloog I, Haim A, Stevens RG, et al. (2008). Light at night co-distributes with incident breast but not lung cancer in the female population of Israel. Chronobiol Int. 25:65-81.
24. Kloog I, Portnov BA, Rennert HS, Haim A. (2011). Does the modern urbanized sleeping habitat pose a breast cancer risk? Chronobiol Int. 28:76-80.
25. Kloog I, Stevens RG, Haim A, Portnov B. (2010). Nighttime light level co-distributes with breast cancer incidence worldwide. Cancer Causes Control. 21:2059-68.
26. Korkmaz A, Reiter RJ. (2008). Epigenetic regulation: A new research area for melatonin? J Pineal Res. 44:41-4.
27. Nelson RJ, Drazen DL. (1999). Melatonin mediates seasonal adjustments in immune function. Reprod Nutr Dev. 39:383-98.
28. Portaluppi F, Smolensky M, Touitou Y. (2010). Ethics and methods for biological rhythm research on animals and human beings. Chronobiol Int. 27:1911-29.
29. Redondo P, Idoate M, Galofré JC, Solano T. (2000). Cidofovir inhibits growth of B16 melanoma cells in vivo. Br J Dermatol. 143:741-8.
30. Reiter RJ, Fraschini F. (1969). Endocrine aspects of the mammalian pineal gland: A review. Neuroendocrinology. 5:219-55.
31. Reiter RJ. (2002). Potential biological consequences of excessive light exposure: Melatonin suppression, DNA damage, cancer and neurodegenerative diseases. Neuroendocrinol Lett. 23: 9-13.
32. Schernhammer ES, Laden F, Speizer FE, et al. (2001). Rotating night shifts and risk of breast cancer in women participating in the nurses' health study. J Natl Cancer Inst. 93:1563-8.
33. Shah PN, Mhatre MC, Kothari LS. (1984). Effect of melatonin on mammary carcinogenesis in intact and pinealectomized rats in varying photoperiods. Cancer Res. 44:3403-7.
34. Soares J, Pinto AE, Cunha CV, et al. (1999). Global DNA hypomethylation in breast carcinoma: Correlation with prognostic factors and tumor progression. Cancer. 85:112-18.
35. Srinivasan V, Spence DW, Pandi-Perumal SR, et al. (2008). Therapeutic actions of melatonin in cancer: Possible mechanisms. Integr Cancer Ther. 7:189-203.
36. Stevens RG. (2002). Lighting during the day and night: Possible impact on risk of breast cancer. Neuroendocrinol Lett. 23: 57-60.
37. Stevens RG. (2009). Light-At-night, circadian disruption and breast cancer: Assessment of existing evidence. Int J Epidemiol. 38: 963-70.
38. Subramanian A, Kothari L. (1991). Suppressive effect by melatonin on different phases of 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced rat mammary gland carcinogenesis. Anticancer Drugs. 2:297-303.
39. Szyf M, Pakneshan P, Rabbani SA. (2004). DNA methylation and breast cancer. Biochem Pharmacol. 68:1187-97.
40. Verkasalo PK, Pukkala E, Stevens RG, et al. (1999). Inverse association between breast cancer incidence and degree of visual impairment in Finland. Br J Cancer. 80:1459-60.
41. Vijayalaxmi, Thomas Jr Cr, Reiter RJ, Herman TS. (2002). Melatonin: From basic research to cancer treatment clinics. J Clin Oncol. 20:2575-601.
42. Zubidat AE, Ben-Shlomo R, Haim A. (2007). Thermoregulatory and endocrine responses to light pulses in short-day acclimated social voles (Microtus socialis). Chronobiol Int. 24: 269-88