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Volumn 52, Issue 3, 2012, Pages 296-304

Inhibitory effects of melatonin on the lipopolysaccharide-induced CC chemokine expression in BV2 murine microglial cells are mediated by suppression of Akt-induced NF-κB and STAT/GAS activity

Author keywords

Akt; CC chemokine; melatonin; NF B; STAT

Indexed keywords

BETA CHEMOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1; MELATONIN; MELATONIN RECEPTOR; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN KINASE B; RANTES; REACTIVE OXYGEN METABOLITE; STAT PROTEIN;

EID: 84858752720     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2011.00943.x     Document Type: Article
Times cited : (49)

References (58)
  • 1
    • 19744380563 scopus 로고    scopus 로고
    • Neuroscience: Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • DOI 10.1126/science.1110647
    • Nimmerjahn A, Kirchhoff F, Helmchen F,. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005; 308: 1314-1318. (Pubitemid 40746128)
    • (2005) Science , vol.308 , Issue.5726 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 2
    • 0027386940 scopus 로고
    • Characterization of microglial reaction after middle cerebral artery occlusion in rat brain
    • DOI 10.1002/cne.903270110
    • Morioka T, Kalehua AN, Streit WJ,. Characterization of microglial reaction after middle cerebral artery occlusion in rat brain. J Comp Neurol 1993; 327: 123-132. (Pubitemid 23006616)
    • (1993) Journal of Comparative Neurology , vol.327 , Issue.1 , pp. 123-132
    • Morioka, T.1    Kalehua, A.N.2    Streit, W.J.3
  • 3
    • 0022644493 scopus 로고
    • Immunocytochemical characterisation of the immune reaction in the central nervous system in multiple sclerosis - Possible role for microglia in lesion growth
    • Woodroofe MN, Bellamy AS, Feldmann M, Davison AN, Cuzner ML,. Immunocytochemical characterisation of the immune reaction in the central nervous system in multiple sclerosis. Possible role for microglia in lesion growth. J Neurol Sci 1986; 74: 135-152. (Pubitemid 16097141)
    • (1986) Journal of the Neurological Sciences , vol.74 , Issue.2-3 , pp. 135-152
    • Woodroofe, M.N.1    Bellamy, A.S.2    Feldmann, M.3
  • 4
    • 0029806757 scopus 로고    scopus 로고
    • Host immune response to vesicular stomatitis virus infection of the central nervous system in C57BL/6 mice
    • Christian AY, Barna M, Bi Z, Reiss CS,. Host immune response to vesicular stomatitis virus infection of the central nervous system in C57BL/6 mice. Viral Immunol 1996; 9: 195-205. (Pubitemid 26353012)
    • (1996) Viral Immunology , vol.9 , Issue.3 , pp. 195-205
    • Christian, A.Y.1    Barna, M.2    Bi, Z.3    Reiss, C.S.4
  • 5
    • 0028299215 scopus 로고
    • Human microglial cell defense against Toxoplasma gondii: The role of cytokines
    • Chao CC, Gekker G, Hu S, Peterson PK,. Human microglial cell defense against Toxoplasma gondii. The role of cytokines. J Immunol 1994; 152: 1246-1252. (Pubitemid 24134352)
    • (1994) Journal of Immunology , vol.152 , Issue.3 , pp. 1246-1252
    • Chao, C.C.1    Gekker, G.2    Hu, S.3    Peterson, P.K.4
  • 7
    • 0031892523 scopus 로고    scopus 로고
    • Cytokine induction of MIP-1α and MIP-1β in human fetal microglia
    • Mcmanus CM, Brosnan CF, Berman JW,. Cytokine induction of MIP-1 alpha and MIP-1 beta in human fetal microglia. J Immunol 1998; 160: 1449-1455. (Pubitemid 28093447)
    • (1998) Journal of Immunology , vol.160 , Issue.3 , pp. 1449-1455
    • McManus, C.M.1    Brosnan, C.F.2    Berman, J.W.3
  • 9
    • 0029121104 scopus 로고
    • Microglia as a unique cellular target in the treatment of stroke: Potential neurotoxic mediators produced by activated microglia
    • Wood PL,. Microglia as a unique cellular target in the treatment of stroke: potential neurotoxic mediators produced by activated microglia. Neurol Res 1995; 17: 242-248.
    • (1995) Neurol Res , vol.17 , pp. 242-248
    • Wood, P.L.1
  • 11
    • 0032904130 scopus 로고    scopus 로고
    • Microglia and Alzheimer's disease
    • DOI 10.1097/00062752-199901000-00004
    • Kalaria RN,. Microglia and Alzheimer's disease. Curr Opin Hematol 1999; 6: 15-24. (Pubitemid 29069007)
    • (1999) Current Opinion in Hematology , vol.6 , Issue.1 , pp. 15-24
    • Kalaria, R.N.1
  • 12
    • 79960360982 scopus 로고    scopus 로고
    • A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases
    • Stehle JH, Saade A, Rawashdeh O, et al., A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases. J Pineal Res 2011; 51: 17-43.
    • (2011) J Pineal Res , vol.51 , pp. 17-43
    • Stehle, J.H.1    Saade, A.2    Rawashdeh, O.3
  • 13
    • 0024363168 scopus 로고
    • Melatonin and its generating system in vertebrate retina: Circadian rhythm, effect of environmental lighting and interaction with dopamine
    • DOI 10.1016/0197-0186(89)90027-2
    • Nowak JZ, E ZU, Zawilska J,. Melatonin and its generating system in vertebrate retina: circadian rhythm, effect of environmental lighting and interaction with dopamine. Neurochem Int 1989; 14: 397-406. (Pubitemid 19166749)
    • (1989) Neurochemistry International , vol.14 , Issue.4 , pp. 397-406
    • Nowak, J.Z.1    Zurawaska, E.2    Zawilska, J.3
  • 14
    • 0025758136 scopus 로고
    • Pineal melatonin: Cell biology of its synthesis and of its physiological interactions
    • Reiter RJ,. Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocr Rev 1991; 12: 151-180.
    • (1991) Endocr Rev , vol.12 , pp. 151-180
    • Reiter, R.J.1
  • 15
    • 0030010625 scopus 로고    scopus 로고
    • Metabolism of serotonin to N-acetylserotonin, melatonin, and 5-methoxytryptamine in hamster skin culture
    • Slominski A, Baker J, Rosano TG, et al., Metabolism of serotonin to N-acetylserotonin, melatonin, and 5-methoxytryptamine in hamster skin culture. J Biol Chem 1996; 271: 12281-12286.
    • (1996) J Biol Chem , vol.271 , pp. 12281-12286
    • Slominski, A.1    Baker, J.2    Rosano, T.G.3
  • 16
    • 0024235361 scopus 로고
    • Serotonin and melatonin synthesis in peripheral blood mononuclear cells: stimulation by interferon-γ as part of an immunomodulatory pathway
    • Finocchiaro LM, Arzt ES, Fernandez-Castelo S, Criscuolo M, Finkielman S, Nahmod VE,. Serotonin and melatonin synthesis in peripheral blood mononuclear cells: stimulation by interferon-gamma as part of an immunomodulatory pathway. J Interferon Res 1988; 8: 705-716. (Pubitemid 19042691)
    • (1988) Journal of Interferon Research , vol.8 , Issue.6 , pp. 705-716
    • Finocchiaro, L.M.E.1    Arzt, E.S.2    Fernandez-Castelo, S.3    Criscuolo, M.4    Finkielman, S.5    Nahmod, V.E.6
  • 17
    • 41749116214 scopus 로고    scopus 로고
    • Blood pressure modulation and cardiovascular protection by melatonin: Potential mechanisms behind
    • Paulis L, Simko F,. Blood pressure modulation and cardiovascular protection by melatonin: potential mechanisms behind. Physiol Res 2007; 56: 671-684.
    • (2007) Physiol Res , vol.56 , pp. 671-684
    • Paulis, L.1    Simko, F.2
  • 18
    • 0032085641 scopus 로고    scopus 로고
    • Exogenous Melatonin Enhances Cell-Mediated, but Not Humoral, Immune Function in Adult Male Deer Mice (Peromyscus maniculatus)
    • Demas GE, Nelson RJ,. Exogenous melatonin enhances cell-mediated, but not humoral, immune function in adult male deer mice (Peromyscus maniculatus). J Biol Rhythms 1998; 13: 245-252. (Pubitemid 128477542)
    • (1998) Journal of Biological Rhythms , vol.13 , Issue.3 , pp. 245-252
    • Demas, G.E.1    Nelson, R.J.2
  • 19
    • 60849096964 scopus 로고    scopus 로고
    • Circadian rhythm and the immune response: A review
    • Habbal OA, Al-Jabri AA,. Circadian rhythm and the immune response: a review. Int Rev Immunol 2009; 28: 93-108.
    • (2009) Int Rev Immunol , vol.28 , pp. 93-108
    • Habbal, O.A.1    Al-Jabri, A.A.2
  • 20
    • 75149174756 scopus 로고    scopus 로고
    • Antidepressant action of melatonin in the treatment of delayed sleep phase syndrome
    • Rahman SA, Kayumov L, Shapiro CM,. Antidepressant action of melatonin in the treatment of delayed sleep phase syndrome. Sleep Med 2010; 11: 131-136.
    • (2010) Sleep Med , vol.11 , pp. 131-136
    • Rahman, S.A.1    Kayumov, L.2    Shapiro, C.M.3
  • 21
    • 71549154751 scopus 로고    scopus 로고
    • Sirtuins, melatonin and circadian rhythms: Building a bridge between aging and cancer
    • Jung-Hynes B, Reiter RJ, Ahmad N,. Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer. J Pineal Res 2010; 48: 9-19.
    • (2010) J Pineal Res , vol.48 , pp. 9-19
    • Jung-Hynes, B.1    Reiter, R.J.2    Ahmad, N.3
  • 22
    • 79960380554 scopus 로고    scopus 로고
    • Melatonin as a natural ally against oxidative stress: A physicochemical examination
    • Galano A, Tan DX, Reiter RJ,. Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res 2011; 51: 1-16.
    • (2011) J Pineal Res , vol.51 , pp. 1-16
    • Galano, A.1    Tan, D.X.2    Reiter, R.J.3
  • 23
    • 77953808415 scopus 로고    scopus 로고
    • Effect of melatonin on neuroinflammation and acetylcholinesterase activity induced by LPS in rat brain
    • Tyagi E, Agrawal R, Nath C, Shukla R,. Effect of melatonin on neuroinflammation and acetylcholinesterase activity induced by LPS in rat brain. Eur J Pharmacol 2010; 640: 206-210.
    • (2010) Eur J Pharmacol , vol.640 , pp. 206-210
    • Tyagi, E.1    Agrawal, R.2    Nath, C.3    Shukla, R.4
  • 24
    • 33847653731 scopus 로고    scopus 로고
    • Suppressive Effects of Melatonin on Amyloid-β-induced Glial Activation in Rat Hippocampus
    • DOI 10.1016/j.arcmed.2006.10.007, PII S0188440906003766
    • Shen Y, Zhang G, Liu L, Xu S,. Suppressive effects of melatonin on amyloid-beta-induced glial activation in rat hippocampus. Arch Med Res 2007; 38: 284-290. (Pubitemid 46366081)
    • (2007) Archives of Medical Research , vol.38 , Issue.3 , pp. 284-290
    • Shen, Y.1    Zhang, G.2    Liu, L.3    Xu, S.4
  • 25
    • 33847654606 scopus 로고    scopus 로고
    • Intravenous administration of melatonin reduces the intracerebral cellular inflammatory response following transient focal cerebral ischemia in rats
    • Lee MY, Kuan YH, Chen HY, et al., Intravenous administration of melatonin reduces the intracerebral cellular inflammatory response following transient focal cerebral ischemia in rats. J Pineal Res 2007; 42: 297-309.
    • (2007) J Pineal Res , vol.42 , pp. 297-309
    • Lee, M.Y.1    Kuan, Y.H.2    Chen, H.Y.3
  • 26
    • 77956333316 scopus 로고    scopus 로고
    • Melatonin plus exercise-based neurorehabilitative therapy for spinal cord injury
    • Hong Y, Palaksha KJ, Park K, et al., Melatonin plus exercise-based neurorehabilitative therapy for spinal cord injury. J Pineal Res 2010; 49: 201-209.
    • (2010) J Pineal Res , vol.49 , pp. 201-209
    • Hong, Y.1    Palaksha, K.J.2    Park, K.3
  • 27
    • 0034144269 scopus 로고    scopus 로고
    • Chemokines: A new classification system and their role in immunity
    • Zlotnik A, Yoshie O,. Chemokines: a new classification system and their role in immunity. Immunity 2000; 12: 121-127. (Pubitemid 30398626)
    • (2000) Immunity , vol.12 , Issue.2 , pp. 121-127
    • Zlotnik, A.1    Yoshie, O.2
  • 29
    • 30344437881 scopus 로고    scopus 로고
    • The expression and function of chemokines involved in CNS inflammation
    • DOI 10.1016/j.tips.2005.11.002, PII S0165614705003044
    • Ubogu EE, Cossoy MB, Ransohoff RM,. The expression and function of chemokines involved in CNS inflammation. Trends Pharmacol Sci 2006; 27: 48-55. (Pubitemid 43063124)
    • (2006) Trends in Pharmacological Sciences , vol.27 , Issue.1 , pp. 48-55
    • Ubogu, E.E.1    Cossoy, M.B.2    Ransohoff, R.M.3
  • 31
    • 2942551122 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 are involved in both excitotoxin-induced neurodegeneration and regeneration
    • DOI 10.1016/j.yexcr.2004.02.031, PII S0014482704001417
    • Kalehua AN, Nagel JE, Whelchel LM, et al., Monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 are involved in both excitotoxin-induced neurodegeneration and regeneration. Exp Cell Res 2004; 297: 197-211. (Pubitemid 38759573)
    • (2004) Experimental Cell Research , vol.297 , Issue.1 , pp. 197-211
    • Kalehua, A.N.1    Nagel, J.E.2    Whelchel, L.M.3    Gides, J.J.4    Pyle, R.S.5    Smith, R.J.6    Kusiak, J.W.7    Taub, D.D.8
  • 33
    • 0026554428 scopus 로고
    • Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress
    • Lebel CP, Ischiropoulos H, Bondy SC,. Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol 1992; 5: 227-231.
    • (1992) Chem Res Toxicol , vol.5 , pp. 227-231
    • Lebel, C.P.1    Ischiropoulos, H.2    Bondy, S.C.3
  • 35
    • 53149124406 scopus 로고    scopus 로고
    • Differential migration, LPS-induced cytokine, chemokine, and NO expression in immortalized BV-2 and HAPI cell lines and primary microglial cultures
    • Horvath RJ, Nutile-Mcmenemy N, Alkaitis MS, Deleo JA,. Differential migration, LPS-induced cytokine, chemokine, and NO expression in immortalized BV-2 and HAPI cell lines and primary microglial cultures. J Neurochem 2008; 107: 557-569.
    • (2008) J Neurochem , vol.107 , pp. 557-569
    • Horvath, R.J.1    Nutile-Mcmenemy, N.2    Alkaitis, M.S.3    Deleo, J.A.4
  • 36
    • 78650159113 scopus 로고    scopus 로고
    • Oral melatonin attenuates lung inflammation and airway hyperreactivity induced by inhalation of aerosolized pancreatic fluid in rats
    • Chen CF, Wang D, Reiter RJ, Yeh DY,. Oral melatonin attenuates lung inflammation and airway hyperreactivity induced by inhalation of aerosolized pancreatic fluid in rats. J Pineal Res 2011; 50: 46-53.
    • (2011) J Pineal Res , vol.50 , pp. 46-53
    • Chen, C.F.1    Wang, D.2    Reiter, R.J.3    Yeh, D.Y.4
  • 37
    • 0031226491 scopus 로고    scopus 로고
    • Protective effect of melatonin in carrageenan-induced models of local inflammation: Relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity
    • Cuzzocrea S, Zingarelli B, Gilad E, Hake P, Salzman AL, Szabo C,. Protective effect of melatonin in carrageenan-induced models of local inflammation: relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity. J Pineal Res 1997; 23: 106-116. (Pubitemid 127731745)
    • (1997) Journal of Pineal Research , vol.23 , Issue.2 , pp. 106-116
    • Cuzzocrea, S.1    Zingarelli, B.2    Gilad, E.3    Hake, P.4    Salzman, A.L.5    Szabo, C.6
  • 38
    • 77957827874 scopus 로고    scopus 로고
    • Melatonin signaling and cell protection function
    • Luchetti F, Canonico B, Betti M, et al., Melatonin signaling and cell protection function. FASEB J 2010; 24: 3603-3624.
    • (2010) FASEB J , vol.24 , pp. 3603-3624
    • Luchetti, F.1    Canonico, B.2    Betti, M.3
  • 39
    • 80053616414 scopus 로고    scopus 로고
    • Reciprocal regulation of NADPH oxidases and the cyclooxygenase-2 pathway
    • Sancho P, Martin-Sanz P, Fabregat I,. Reciprocal regulation of NADPH oxidases and the cyclooxygenase-2 pathway. Free Radic Biol Med 2011; 51: 1789-1798.
    • (2011) Free Radic Biol Med , vol.51 , pp. 1789-1798
    • Sancho, P.1    Martin-Sanz, P.2    Fabregat, I.3
  • 40
    • 38949111009 scopus 로고    scopus 로고
    • Sphingosine kinase, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 are required for CCL5 production in Mycobacterium bovis Bacillus Calmette-Guerin (BCG)-infected epithelial cells
    • Mendez-Samperio P, Perez A, Trejo A,. Sphingosine kinase, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 are required for CCL5 production in Mycobacterium bovis Bacillus Calmette-Guerin (BCG)-infected epithelial cells. Cell Immunol 2007; 249: 94-100.
    • (2007) Cell Immunol , vol.249 , pp. 94-100
    • Mendez-Samperio, P.1    Perez, A.2    Trejo, A.3
  • 41
    • 29144473003 scopus 로고    scopus 로고
    • IL-18 induces monocyte chemotactic protein-1 production in macrophages through the phosphatidylinositol 3-kinase/Akt and MEK/ERK1/2 pathways
    • Yoo JK, Kwon H, Khil LY, Zhang L, Jun HS, Yoon JW,. IL-18 induces monocyte chemotactic protein-1 production in macrophages through the phosphatidylinositol 3-kinase/Akt and MEK/ERK1/2 pathways. J Immunol 2005; 175: 8280-8286. (Pubitemid 41798393)
    • (2005) Journal of Immunology , vol.175 , Issue.12 , pp. 8280-8286
    • Yoo, J.K.1    Kwon, H.2    Khil, L.-Y.3    Zhang, L.4    Jun, H.-S.5    Yoon, J.-W.6
  • 42
    • 36849041566 scopus 로고    scopus 로고
    • Intracellular signaling pathways involved in cell growth inhibition of human umbilical vein endothelial cells by melatonin
    • DOI 10.1111/j.1600-079X.2007.00496.x
    • Cui P, Yu M, Luo Z, et al., Intracellular signaling pathways involved in cell growth inhibition of human umbilical vein endothelial cells by melatonin. J Pineal Res 2008; 44: 107-114. (Pubitemid 350231103)
    • (2008) Journal of Pineal Research , vol.44 , Issue.1 , pp. 107-114
    • Cui, P.1    Yu, M.2    Luo, Z.3    Dai, M.4    Han, J.5    Xiu, R.6    Yang, Z.7
  • 43
    • 68049083543 scopus 로고    scopus 로고
    • Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-3 through NFkB and MAPK dependent pathways in rat astrocytes [corrected]
    • Thompson WL, Van Eldik LJ,. Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-3 through NFkB and MAPK dependent pathways in rat astrocytes [corrected]. Brain Res 2009; 1287: 47-57.
    • (2009) Brain Res , vol.1287 , pp. 47-57
    • Thompson, W.L.1    Van Eldik, L.J.2
  • 45
    • 0030272628 scopus 로고    scopus 로고
    • Effect of melatonin on NF-κB DNA-binding activity in the rat spleen
    • DOI 10.1006/cbir.1996.0091
    • Chuang JI, Mohan N, Meltz ML, Reiter RJ,. Effect of melatonin on NF-kappa-B DNA-binding activity in the rat spleen. Cell Biol Int 1996; 20: 687-692. (Pubitemid 26402163)
    • (1996) Cell Biology International , vol.20 , Issue.10 , pp. 687-692
    • Chuang, J.-I.1    Mohan, N.2    Meltz, M.L.3    Reiter, R.J.4
  • 47
    • 0035930550 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced expression of interferon-beta mediates the timing of inducible nitric-oxide synthase induction in RAW 264.7 macrophages
    • Jacobs AT, Ignarro LJ,. Lipopolysaccharide-induced expression of interferon-beta mediates the timing of inducible nitric-oxide synthase induction in RAW 264.7 macrophages. J Biol Chem 2001; 276: 47950-47957.
    • (2001) J Biol Chem , vol.276 , pp. 47950-47957
    • Jacobs, A.T.1    Ignarro, L.J.2
  • 49
    • 2642617812 scopus 로고    scopus 로고
    • IFN-γ induction of the human monocyte chemoattractant protein (hMCP)-1 gene in astrocytoma cells: Functional interaction between an IFN-γ-activated site and a GC-Rich element
    • Zhou ZH, Chaturvedi P, Han YL, et al., IFN-gamma induction of the human monocyte chemoattractant protein (hMCP)-1 gene in astrocytoma cells: functional interaction between an IFN-gamma-activated site and a GC-rich element. J Immunol 1998; 160: 3908-3916. (Pubitemid 28176097)
    • (1998) Journal of Immunology , vol.160 , Issue.8 , pp. 3908-3916
    • Zhou, Z.-H.L.1    Chaturvedi, P.2    Han, Y.-L.3    Aras, S.4    Li, Y.-S.5    Kolattukudy, P.E.6    Ping, D.7    Boss, J.M.8    Ransohoff, R.M.9
  • 50
    • 80051671405 scopus 로고    scopus 로고
    • Melatonin attenuates brain contusion-induced oxidative insult, inactivation of signal transducers and activators of transcription 1, and upregulation of suppressor of cytokine signaling-3 in rats
    • Tsai MC, Chen WJ, Tsai MS, Ching CH, Chuang JI,. Melatonin attenuates brain contusion-induced oxidative insult, inactivation of signal transducers and activators of transcription 1, and upregulation of suppressor of cytokine signaling-3 in rats. J Pineal Res 2011; 51: 233-245.
    • (2011) J Pineal Res , vol.51 , pp. 233-245
    • Tsai, M.C.1    Chen, W.J.2    Tsai, M.S.3    Ching, C.H.4    Chuang, J.I.5
  • 51
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell JE Jr, Kerr IM, Stark GR,. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994; 264: 1415-1421. (Pubitemid 24217131)
    • (1994) Science , vol.264 , Issue.5164 , pp. 1415-1421
    • Darnell Jr., J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 52
    • 44649122048 scopus 로고    scopus 로고
    • Melatonin inhibits amphetamine-induced nitric oxide synthase mRNA overexpression in microglial cell lines
    • Tocharus J, Chongthammakun S, Govitrapong P,. Melatonin inhibits amphetamine-induced nitric oxide synthase mRNA overexpression in microglial cell lines. Neurosci Lett 2008; 439: 134-137.
    • (2008) Neurosci Lett , vol.439 , pp. 134-137
    • Tocharus, J.1    Chongthammakun, S.2    Govitrapong, P.3
  • 53
    • 77950644583 scopus 로고    scopus 로고
    • Melatonin attenuates methamphetamine-induced overexpression of pro-inflammatory cytokines in microglial cell lines
    • Tocharus J, Khonthun C, Chongthammakun S, Govitrapong P,. Melatonin attenuates methamphetamine-induced overexpression of pro-inflammatory cytokines in microglial cell lines. J Pineal Res 2010; 48: 347-352.
    • (2010) J Pineal Res , vol.48 , pp. 347-352
    • Tocharus, J.1    Khonthun, C.2    Chongthammakun, S.3    Govitrapong, P.4
  • 54
    • 49549092451 scopus 로고    scopus 로고
    • Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid-beta1-42
    • Zhou J, Zhang S, Zhao X, Wei T,. Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid-beta1-42. J Pineal Res 2008; 45: 157-165.
    • (2008) J Pineal Res , vol.45 , pp. 157-165
    • Zhou, J.1    Zhang, S.2    Zhao, X.3    Wei, T.4
  • 56
    • 79951606158 scopus 로고    scopus 로고
    • Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway: A possible role in neuroprotection
    • Kwon KJ, Kim JN, Kim MK, et al., Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway: a possible role in neuroprotection. J Pineal Res 2011; 50: 110-123.
    • (2011) J Pineal Res , vol.50 , pp. 110-123
    • Kwon, K.J.1    Kim, J.N.2    Kim, M.K.3
  • 57
    • 77955169904 scopus 로고    scopus 로고
    • Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH-SY5Y neuroblastoma cells
    • Romero A, Egea J, Garcia AG, Lopez MG,. Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH-SY5Y neuroblastoma cells. J Pineal Res 2010; 49: 141-148.
    • (2010) J Pineal Res , vol.49 , pp. 141-148
    • Romero, A.1    Egea, J.2    Garcia, A.G.3    Lopez, M.G.4
  • 58
    • 44349111685 scopus 로고    scopus 로고
    • Melatonin induces Akt phosphorylation through melatonin receptor- and PI3K-dependent pathways in primary astrocytes
    • Kong PJ, Byun JS, Lim SY, et al., Melatonin induces Akt phosphorylation through melatonin receptor- and PI3K-dependent pathways in primary astrocytes. Korean J Physiol Pharmacol 2008; 12: 37-41.
    • (2008) Korean J Physiol Pharmacol , vol.12 , pp. 37-41
    • Kong, P.J.1    Byun, J.S.2    Lim, S.Y.3


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