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Volumn 22, Issue 4, 2012, Pages 723-736

Acetyl-L-carnitine-mediated neuroprotection during hypoxia is attributed to ERK1/2-Nrf2-regulated mitochondrial biosynthesis

Author keywords

Acetyl L carnitine; Calcium; Hypoxia; Mitochondrial biogenesis; Nuclear factor erythroid 2 related factor 2

Indexed keywords

LEVACECARNINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TRANSCRIPTION FACTOR NRF2;

EID: 84857659914     PISSN: 10509631     EISSN: 10981063     Source Type: Journal    
DOI: 10.1002/hipo.20934     Document Type: Article
Times cited : (80)

References (35)
  • 1
    • 34547841506 scopus 로고    scopus 로고
    • Acetyl-L-carnitine ameliorates hypobaric hypoxic impairment and spatial memory deficits in rats
    • Barhwal K, Singh SB, Hota SK, Jayalakshmi K, Ilavazhagan G. 2007. Acetyl-L-carnitine ameliorates hypobaric hypoxic impairment and spatial memory deficits in rats. Eur J Pharmacol 570: 97-107.
    • (2007) Eur J Pharmacol , vol.570 , pp. 97-107
    • Barhwal, K.1    Singh, S.B.2    Hota, S.K.3    Jayalakshmi, K.4    Ilavazhagan, G.5
  • 2
    • 57049105115 scopus 로고    scopus 로고
    • Hypoxia-induced deactivation of NGF-mediated ERK1/2 signaling in hippocampal cells: Neuroprotection by acetyl-L-carnitine
    • Barhwal K, Hota SK, Prasad D, Singh SB, Ilavazhagan G. 2008. Hypoxia-induced deactivation of NGF-mediated ERK1/2 signaling in hippocampal cells: Neuroprotection by acetyl-L-carnitine. J Neurosci Res 86: 2705-2721.
    • (2008) J Neurosci Res , vol.86 , pp. 2705-2721
    • Barhwal, K.1    Hota, S.K.2    Prasad, D.3    Singh, S.B.4    Ilavazhagan, G.5
  • 3
    • 64549090002 scopus 로고    scopus 로고
    • Isradipine antagonizes hypobaric hypoxia induced CA1 damage and memory impairment: Complementary roles of L-type calcium channel and NMDA receptors
    • Barhwal K, Hota SK, Baitharu I, Prasad D, Singh SB, Ilavazhagan G. 2009a. Isradipine antagonizes hypobaric hypoxia induced CA1 damage and memory impairment: Complementary roles of L-type calcium channel and NMDA receptors. Neurobiol Disease 34: 230-244.
    • (2009) Neurobiol Disease , vol.34 , pp. 230-244
    • Barhwal, K.1    Hota, S.K.2    Baitharu, I.3    Prasad, D.4    Singh, S.B.5    Ilavazhagan, G.6
  • 4
    • 67349275597 scopus 로고    scopus 로고
    • Acetyl-L-carnitine prevents hypobaric hypoxia-induced spatial memory impairment through extracellular related kinase-mediated nuclear factor erythroid 2-related factor 2 phosphorylation
    • Barhwal K, Hota SK, Jain V, Prasad D, Singh SB, Ilavazhagan G. 2009b. Acetyl-L-carnitine prevents hypobaric hypoxia-induced spatial memory impairment through extracellular related kinase-mediated nuclear factor erythroid 2-related factor 2 phosphorylation. Neuroscience 161: 501-514.
    • (2009) Neuroscience , vol.161 , pp. 501-514
    • Barhwal, K.1    Hota, S.K.2    Jain, V.3    Prasad, D.4    Singh, S.B.5    Ilavazhagan, G.6
  • 5
    • 0034798348 scopus 로고    scopus 로고
    • Reduction and restoration of mitochondrial DNA content after focal cerebral ischemia/reperfusion
    • Chen H, Hu CJ, He YY, Yang DI, Xu J, Hsu CY. 2001. Reduction and restoration of mitochondrial DNA content after focal cerebral ischemia/reperfusion. Stroke 32: 2382-2387.
    • (2001) Stroke , vol.32 , pp. 2382-2387
    • Chen, H.1    Hu, C.J.2    He, Y.Y.3    Yang, D.I.4    Xu, J.5    Hsu, C.Y.6
  • 6
    • 13444306450 scopus 로고    scopus 로고
    • Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators
    • Gleyzer N, Vercauteren K, Scarpulla RC. 2005. Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators. Mol Cell Biol 25: 1354-66.
    • (2005) Mol Cell Biol , vol.25 , pp. 1354-1366
    • Gleyzer, N.1    Vercauteren, K.2    Scarpulla, R.C.3
  • 7
    • 3442886811 scopus 로고    scopus 로고
    • The pathophysiology of mitochondrial cell death
    • Green DR, Kroemer G. 2004. The pathophysiology of mitochondrial cell death. Science 305: 626-629.
    • (2004) Science , vol.305 , pp. 626-629
    • Green, D.R.1    Kroemer, G.2
  • 8
    • 0021895138 scopus 로고
    • 2+ indicators with greatly improved fluorescence properties
    • 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450.
    • (1985) J Biol Chem , vol.260 , pp. 3440-3450
    • Grynkiewicz, G.1    Poenie, M.2    Tsien, R.Y.3
  • 9
    • 39849094082 scopus 로고    scopus 로고
    • Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism
    • Gutsaeva DR, Carraway MS, Suliman HB, Demchenko IT, Shitara H, Yonekawa H, Piantadosi CA. 2008. Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism. J Neurosci 28: 2015-24.
    • (2008) J Neurosci , vol.28 , pp. 2015-2024
    • Gutsaeva, D.R.1    Carraway, M.S.2    Suliman, H.B.3    Demchenko, I.T.4    Shitara, H.5    Yonekawa, H.6    Piantadosi, C.A.7
  • 10
    • 70349786427 scopus 로고    scopus 로고
    • Ascorbic acid attenuates scopolamine-induced spatial learning deficits in the water maze
    • Harrison FE, Hosseini AH, Dawes SM, Weaver S, May JM. 2009. Ascorbic acid attenuates scopolamine-induced spatial learning deficits in the water maze. Behav Brain Res 205: 550-558.
    • (2009) Behav Brain Res , vol.205 , pp. 550-558
    • Harrison, F.E.1    Hosseini, A.H.2    Dawes, S.M.3    Weaver, S.4    May, J.M.5
  • 11
    • 41149155394 scopus 로고    scopus 로고
    • NR1 and GluR2 expression mediates excitotoxicity in chronic hypobaric hypoxia
    • Hota SK, Barhwal K, Singh SB, Sairam M, Ilavazhagan G. 2008. NR1 and GluR2 expression mediates excitotoxicity in chronic hypobaric hypoxia. J Neurosci Res 86: 1142-1152.
    • (2008) J Neurosci Res , vol.86 , pp. 1142-1152
    • Hota, S.K.1    Barhwal, K.2    Singh, S.B.3    Sairam, M.4    Ilavazhagan, G.5
  • 12
    • 77953542391 scopus 로고    scopus 로고
    • Oxidative stress induced alterations in Sp factors mediate transcriptional regulation of NR1 subunit in hippocampus during hypoxia
    • Hota SK, Hota BK, Prasad D, Ilavazhagan G, Singh SB. 2010. Oxidative stress induced alterations in Sp factors mediate transcriptional regulation of NR1 subunit in hippocampus during hypoxia. Free Radic Biol Med 49: 178-191.
    • (2010) Free Radic Biol Med , vol.49 , pp. 178-191
    • Hota, S.K.1    Hota, B.K.2    Prasad, D.3    Ilavazhagan, G.4    Singh, S.B.5
  • 13
    • 34547545892 scopus 로고    scopus 로고
    • AMP-activated protein kinase action in skeletal muscle via direct phosphorylation of PGC-1
    • Jager S, Handschin C, St.-Pierre J, Spiegelman BM. 2007. AMP-activated protein kinase action in skeletal muscle via direct phosphorylation of PGC-1. Proc Natl Acad Sci 104: 12017-12022.
    • (2007) Proc Natl Acad Sci , vol.104 , pp. 12017-12022
    • Jager, S.1    Handschin, C.2    St -Pierre, J.3    Spiegelman, B.M.4
  • 14
    • 39149113157 scopus 로고    scopus 로고
    • Sustained hypoxia modulates mitochondrial DNA content in the neonatal rat brain
    • Lee HM, Greeley GHJr, Englander EW. 2008. Sustained hypoxia modulates mitochondrial DNA content in the neonatal rat brain. Free Radic Biol Med 44: 807-14.
    • (2008) Free Radic Biol Med , vol.44 , pp. 807-814
    • Lee, H.M.1    Greeley Jr., G.H.2    Englander, E.W.3
  • 16
    • 0033495895 scopus 로고    scopus 로고
    • Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion
    • Matsumoto S, Friberg H, Ferrand-Drake M, Wieloch T. 1999. Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab 19: 736-741.
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 736-741
    • Matsumoto, S.1    Friberg, H.2    Ferrand-Drake, M.3    Wieloch, T.4
  • 17
    • 0021173996 scopus 로고
    • Development of a water maze procedure for studying spatial learning the rat
    • Morris RGM. 1984. Development of a water maze procedure for studying spatial learning the rat. J Neurosci Methods 11: 47-60.
    • (1984) J Neurosci Methods , vol.11 , pp. 47-60
    • Morris, R.G.M.1
  • 18
    • 0019957779 scopus 로고
    • Place navigation impaired in rats with hippocampal lesions
    • Morris RGM, Grrud P, Rawlins JNP, O'Keefe J. 1982. Place navigation impaired in rats with hippocampal lesions. Nature 297: 681-683.
    • (1982) Nature , vol.297 , pp. 681-683
    • Morris, R.G.M.1    Grrud, P.2    Rawlins, J.N.P.3    O'Keefe, J.4
  • 21
    • 77952359875 scopus 로고    scopus 로고
    • Acetyl-L-carnitine supplementation to old rats partially reverts the age-related mitochondrial decay of soleus muscle by activating peroxisome proliferator-activated receptor gamma coactivator-1alpha-dependent mitochondrial biogenesis
    • Pesce V, Fracasso F, Cassano P, Lezza AM, Cantatore P, Gadaleta MN. 2010. Acetyl-L-carnitine supplementation to old rats partially reverts the age-related mitochondrial decay of soleus muscle by activating peroxisome proliferator-activated receptor gamma coactivator-1alpha-dependent mitochondrial biogenesis. Rejuvenation Res 13: 148-151.
    • (2010) Rejuvenation Res , vol.13 , pp. 148-151
    • Pesce, V.1    Fracasso, F.2    Cassano, P.3    Lezza, A.M.4    Cantatore, P.5    Gadaleta, M.N.6
  • 22
    • 30044447187 scopus 로고    scopus 로고
    • Oxygen tension regulates mitochondrial DNA-encoded complex I gene expression
    • Piruat JI, Lopez-Barneo J. 2005. Oxygen tension regulates mitochondrial DNA-encoded complex I gene expression. J Biol Chem 280: 42676-42684.
    • (2005) J Biol Chem , vol.280 , pp. 42676-42684
    • Piruat, J.I.1    Lopez-Barneo, J.2
  • 23
    • 33745215883 scopus 로고    scopus 로고
    • The role of AMP-activated protein kinase in mitochondrial biogenesis
    • Reznick RM, Shulman GI. 2006. The role of AMP-activated protein kinase in mitochondrial biogenesis. J Physiol 574: 33-39.
    • (2006) J Physiol , vol.574 , pp. 33-39
    • Reznick, R.M.1    Shulman, G.I.2
  • 25
    • 0035375261 scopus 로고    scopus 로고
    • Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth
    • Sapkota GP, Kieloch A, Lizcano JM, Lain S, Arthur JS, Williams MR, Morrice N, Deak M, Alessi DR. 2001. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth. J Biol Chem 276: 19469-19482.
    • (2001) J Biol Chem , vol.276 , pp. 19469-19482
    • Sapkota, G.P.1    Kieloch, A.2    Lizcano, J.M.3    Lain, S.4    Arthur, J.S.5    Williams, M.R.6    Morrice, N.7    Deak, M.8    Alessi, D.R.9
  • 26
    • 0037314215 scopus 로고    scopus 로고
    • Neuronal degeneration and mitochondrial dysfunction
    • Schon EA, Manfredi G. 2003. Neuronal degeneration and mitochondrial dysfunction. J Clin Invest 111: 303-312.
    • (2003) J Clin Invest , vol.111 , pp. 303-312
    • Schon, E.A.1    Manfredi, G.2
  • 27
    • 1542618348 scopus 로고    scopus 로고
    • The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
    • Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. 2004. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 101: 3329-3335.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3329-3335
    • Shaw, R.J.1    Kosmatka, M.2    Bardeesy, N.3    Hurley, R.L.4    Witters, L.A.5    DePinho, R.A.6    Cantley, L.C.7
  • 28
    • 36649024590 scopus 로고    scopus 로고
    • R-α-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes
    • Shen W, Liu K, Tian C, Yang L, Li X, Ren J, Packer L, Cotman CW, Liu J. 2008. R-α-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes. Diabetologia 51: 165-174.
    • (2008) Diabetologia , vol.51 , pp. 165-174
    • Shen, W.1    Liu, K.2    Tian, C.3    Yang, L.4    Li, X.5    Ren, J.6    Packer, L.7    Cotman, C.W.8    Liu, J.9
  • 30
    • 0028011017 scopus 로고
    • C. Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: A potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis
    • Virbasius JV, Scarpulla R. 1994. C. Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: A potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis. Proc Natl Acad Sci USA 91: 1309-1313.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 1309-1313
    • Virbasius, J.V.1    Scarpulla, R.2
  • 33
    • 55749114205 scopus 로고    scopus 로고
    • Rapidly increased neuronal mitochondrial biogenesis after hypoxic-ischemic brain injury
    • Yin W, Signore AP, Iwai M, Cao G, Gao Y, Chen J. 2008. Rapidly increased neuronal mitochondrial biogenesis after hypoxic-ischemic brain injury. Stroke 39: 3057-3063.
    • (2008) Stroke , vol.39 , pp. 3057-3063
    • Yin, W.1    Signore, A.P.2    Iwai, M.3    Cao, G.4    Gao, Y.5    Chen, J.6
  • 34
    • 77951950272 scopus 로고    scopus 로고
    • Combined R-α-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease
    • Zhang H, Jia H, Liu J, Ao N, Yan B, Shen W, Wang X, Li X, Luo C, Liu J. 2010. Combined R-α-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease. J Cell Mol Med 14: 215-225.
    • (2010) J Cell Mol Med , vol.14 , pp. 215-225
    • Zhang, H.1    Jia, H.2    Liu, J.3    Ao, N.4    Yan, B.5    Shen, W.6    Wang, X.7    Li, X.8    Luo, C.9    Liu, J.10
  • 35
    • 0037058977 scopus 로고    scopus 로고
    • I. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
    • Zong H, Ren JM, Young LH, Pypaert M, Mu J, Birnbaum MJ, Shulman G. 2002. I. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci USA 25: 15983-15987.
    • (2002) Proc Natl Acad Sci USA , vol.25 , pp. 15983-15987
    • Zong, H.1    Ren, J.M.2    Young, L.H.3    Pypaert, M.4    Mu, J.5    Birnbaum, M.J.6    Shulman, G.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.