Exogenous melatonin supplementation prevents oxidative stress-evoked DNA damage in human spermatozoa

Journal of Pineal Research

Volumn 57, Issue 3, 2014, Pages 333-339

  Bejarano, Ignacio ^a   Monllor, Fabian ^b   Marchena, Ana María ^a   Ortiz, Agueda ^b   Lozano, Graciela ^b   Jiménez, Maria Isabel ^b   Gaspar, Pilar ^b   García, Juan F ^b   Pariente, Jose A ^a   Rodríguez, Ana B ^a   Espino, Javier ^a  

^a UNIVERSITY OF EXTREMADURA   (Spain)

^b Infantile Hospital   (Spain)

Author keywords

apoptosis; DNA fragmentation; embryo quality; melatonin; sperm quality

Indexed keywords

6 HYDROXYMELATONIN O SULFATE; MELATONIN;

ADULT; ANTIOXIDANT ACTIVITY; ANTIOXIDANT ASSAY; ARTICLE; BLASTOMA; CANCER STAGING; CYTOPLASM; DNA DAMAGE; DNA FRAGMENTATION; EMBRYO DEVELOPMENT; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; HORMONE BLOOD LEVEL; HUMAN; HUMAN CELL; LONG TERM CARE; MALE; MALE INFERTILITY; OUTCOME ASSESSMENT; OXIDATIVE STRESS; REPRODUCTION; SEMEN ANALYSIS; SPERM QUALITY; SPERMATOGENESIS; SPERMATOZOON; SUPPLEMENTATION; TUMOR VOLUME; URINALYSIS; DRUG EFFECTS;

DNA DAMAGE; HUMANS; MALE; MELATONIN; OXIDATIVE STRESS; SPERMATOZOA;

EID: 84922328489     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/jpi.12172     Document Type: Article

References (52)

1. Sikka SC, Rajasekaran M, Hellstrom WJ,. Role of oxidative stress and antioxidants in male infertility. J Androl 1995; 16: 464-468.
2. Farrugia G, Balzan R,. Oxidative stress and programmed cell death in yeast. Front Oncol 2012; 2: 64.
3. Kothari S, Thompson A, Agarwal A, et al. Free radicals: their beneficial and detrimental effects on sperm function. Indian J Exp Biol 2010; 48: 425-435.
4. Aitken RJ, Clarkson JS,. Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa. J Reprod Fertil 1987; 81: 459-469.
5. Kodama H, Yamaguchi R, Fukuda J, et al. Increased oxidative deoxyribonucleic acid damage in the spermatozoa of infertile male patients. Fertil Steril 1997; 65: 519-524.
6. Zini A, de Lamirande E, Gagnon C,. Reactive oxygen species in semen of infertile patients: levels of superoxide dismutase- and catalase-like activities in seminal plasma and spermatozoa. Int J Androl 1993; 16: 183-188.
7. Aitken RJ, de Iuliis GN, McLachlan RI,. Biological and clinical significance of DNA damage in the male germ line. Int J Androl 2009; 32: 46-56.
8. Jones R, Mann T, Sherins RJ,. Peroxidative breakdown of phospholipids in human spermatozoa: spermicidal effects of fatty acid peroxides and protective action of seminal plasma. Fertil Steril 1979; 31: 531-537.
9. Bejarano I, Lozano GM, Ortiz A, et al. Caspase-3 activation in human spermatozoa in response to hydrogen peroxide and progesterone. Fertil Steril 2008; 90: 1340-1347.
10. Tan DX, Chen LD, Poeggeler B, et al. Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocr J 1993; 1: 57-60.
11. Galano A, Tan DX, Reiter RJ,. Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res 2011; 51: 1-16.
12. Galano A, Tan DX, Reiter RJ,. On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK. J Pineal Res 2013; 54: 245-257.
13. Galano A, Tan DX, Reiter RJ,. Cyclic 3-hydroxymelatonin, a key metabolite enhancing the peroxyl radical scavenging activity of melatonin. Royal Soc Chem Adv 2014; 4: 5220-5227.
14. Rodriguez C, Mayo JC, Sainz RM, et al. Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 2004; 36: 1-9.
15. Fischer TW, Slominski A, Zmijewski MA, et al. Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair. Exp Dermatol 2008; 17: 713-730.
16. du Plessis SS, Hagenaar K, Lampiao F,. The in vitro effects of melatonin on human sperm function and its scavenging activities on NO and ROS. Andrologia 2010; 42: 112-116.
17. Ortiz A, Espino J, Bejarano I, et al. High endogenous melatonin concentrations enhance sperm quality and short-term in vitro exposure to melatonin improves aspects of sperm motility. J Pineal Res 2011; 50: 132-139.
18. Espino J, Bejarano I, Ortiz A, et al. Melatonin as a potential tool against oxidative damage and apoptosis in ejaculated human spermatozoa. Fertil Steril 2010; 94: 1915-1917.
19. Espino J, Ortiz A, Bejarano I, et al. Melatonin protects human spermatozoa from apoptosis via melatonin receptor- and extracellular-regulated kinase-mediated pathways. Fertil Steril 2011; 95: 2290-2296.
20. World Health Organization (WHO). Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction. Cambridge University Press, London, 1999.
21. Klante G, Brinschwitz T, Secci K, et al. Creatinine is an appropriate reference for urinary sulphatoxymelatonin of laboratory animals and humans. J Pineal Res 1997; 23: 191-197.
22. Heatwole VM,. TUNEL assay for apoptotic cells. Methods Mol Biol 1999; 115: 141-148.
23. Ramos L, Wetzels AM,. Low rates of DNA fragmentation in selected motile human spermatozoa assessed by the TUNEL assay. Hum Reprod 2001; 16: 1703-1707.
24. Torelló MJ, Ardoy M, Calderón G, et al. Criterios ASEBIR de valoración morfológica de Oocitos, Embriones tempranos y Blastocistos. ASEBIR Congress, Zaragoza, 2005.
25. Poeggeler B,. Melatonin, aging, and age-related diseases: perspectives for prevention, intervention, and therapy. Endocrine 2005; 27: 201-212.
26. Benot S, Goberna R, Reiter RJ, et al. Physiological levels of melatonin contribute to the antioxidant capacity of human serum. J Pineal Res 1999; 27: 59-64.
27. Tawadrous GA, Aziz AA, Mostafa T,. Seminal soluble fas relationship with oxidative stress in infertile men with varicocele. Urology 2013; 82: 820-823.
28. Turner TT, Lysiak JJ,. Oxidative stress: a common factor in testicular dysfunction. J Androl 2008; 29: 488-498.
29. Aitken RJ, Koppers AJ,. Apoptosis and DNA damage in human spermatozoa. Asian J Androl 2011; 13: 36-42.
30. Shukla KK, Mahdi AA, Rajender S,. Apoptosis, spermatogenesis and male infertility. Front Biosci (Elite Ed) 2012; 4: 746-754.
31. Shang X, Huang Y, Ye Z, et al. Protection of melatonin against damage of sperm mitochondrial function induced by reactive oxygen species. Zhonghua Nan Ke Xue 2004; 10: 604-607.
32. Shamsi MB, Venkatesh S, Tanwar M, et al. DNA integrity and semen quality in men with low seminal antioxidant levels. Mutat Res 2009; 665: 29-36.
33. Reiter RJ, Paredes SD, Manchester LC, et al. Reducing oxidative/nitrosative oxidative stress: a newly-discovered genre for melatonin. Crit Rev Biochem Mol Biol 2009; 44: 175-200.
34. Reiter RJ, Rosales-Corral SA, Manchester LC, et al. Peripheral reproductive organ health and melatonin: ready for prime time. Int J Mol Sci 2013; 14: 7231-7272.
35. Tamura H, Takasaki A, Miwa I, et al. Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rates. J Pineal Res 2008; 44: 280-287.
36. Zini A, Al-Hathal N,. Antioxidant therapy in male infertility: fact or fiction? Asian J Androl 2011; 13: 374-381.
37. Zareba P, Colaci DS, Afeiche M, et al. Semen quality in relation to antioxidant intake in a healthy male population. Fertil Steril 2013; 100: 1572-1579.
38. Ahmadi A, Ng SC,. Fertilizing ability of DNA-damaged spermatozoa. J Exp Zool 1999; 284: 696-704.
39. Fatehi AN, Bevers MM, Schoevers E, et al. DNA damage in bovine sperm does not block fertilization and early embryonic development but induces apoptosis after the first cleavages. J Androl 2006; 27: 176-188.
40. Aitken RJ, Krausz C,. Oxidative stress, DNA damage and the Y chromosome. Reproduction 2001; 122: 497-506.
41. Benchaib M, Braun V, Lornage J, et al. Sperm DNA fragmentation decreases the pregnancy rate in an assisted reproductive technique. Hum Reprod 2003; 18: 1023-1028.
42. Borini A, Tarozzi N, Bizzaro D, et al. Sperm DNA fragmentation: paternal effect on early post-implantation embryo development in ART. Hum Reprod 2006; 21: 2876-2881.
43. Zini A, Jamal W, Cowan L, et al. Is sperm DNA damage associated with IVF embryo quality? A systematic review. J Assist Reprod Genet 2011; 28: 391-397.
44. Schmid TE, Eskenazi B, Marchetti F, et al. Micronutrients intake is associated with improved sperm DNA quality in older men. Fertil Steril 2012; 98: 1130-1137.
45. Hawkes WC, Alkan Z, Wong K,. Selenium supplementation does not affect testicular selenium status or semen quality in North American men. J Androl 2009; 30: 525-533.
46. Mínguez-Alarcón L, Mendiola J, López-Espín JJ, et al. Dietary intake of antioxidant nutrients is associated with semen quality in young university students. Hum Reprod 2012; 27: 2807-2814.
47. Greco E, Iacobelli M, Rienzi L, et al. Reduction of the incidence of sperm DNA fragmentation by oral antioxidant treatment. J Androl 2005; 26: 349-353.
48. Lewis SE, Aitken RJ,. DNA damage to spermatozoa has impacts on fertilization and pregnancy. Cell Tissue Res 2005; 322: 33-41.
49. Agarwal A, Makker K, Sharma R,. Clinical relevance of oxidative stress in male factor infertility: an update. Am J Reprod Immunol 2008; 59: 2-11.
50. Vargas A, Bustos-Obregón E, Hartley R,. Effects of hypoxia on epididymal sperm parameters and protective role of ibuprofen and melatonin. Biol Res 2011; 44: 161-167.
51. Jang HY, Kim YH, Kim BW, et al. Ameliorative effects of melatonin against hydrogen peroxide-induced oxidative stress on boar sperm characteristics and subsequent in vitro embryo development. Reprod Domest Anim 2010; 45: 943-950.
52. Fujinoki M,. Melatonin-enhanced hyperactivation of hamster sperm. Reproduction 2008; 136: 533-541.