메뉴 건너뛰기




Volumn 57, Issue 2, 2014, Pages 131-146

Melatonin: A well-documented antioxidant with conditional pro-oxidant actions

Author keywords

antioxidant; free radicals; melatonin; mitochondria; pro oxidant; reactive nitrogen species; reactive oxygen species

Indexed keywords

CALMODULIN; DNA; FREE RADICAL; LIPID; MELATONIN; REACTIVE OXYGEN METABOLITE; UBIQUINOL CYTOCHROME C REDUCTASE; ANTIOXIDANT; REACTIVE NITROGEN SPECIES;

EID: 84925835510     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/jpi.12162     Document Type: Review
Times cited : (684)

References (214)
  • 1
    • 33947460818 scopus 로고
    • Isolation of melatonin, the pineal gland factor that lightens melanocytes
    • Lerner AB, Case JD, Takahashi Y, et al. Isolation of melatonin, the pineal gland factor that lightens melanocytes. J Am Chem Soc 1958; 80: 2587.
    • (1958) J Am Chem Soc , vol.80 , pp. 2587
    • Lerner, A.B.1    Case, J.D.2    Takahashi, Y.3
  • 2
    • 84876850102 scopus 로고    scopus 로고
    • The universal nature, unequal distribution and antioxidant functions of melatonin and its derivatives
    • Reiter RJ, Tan DX, Rosales-Corral S, et al. The universal nature, unequal distribution and antioxidant functions of melatonin and its derivatives. Mini Rev Med Chem 2013; 13: 373-384.
    • (2013) Mini Rev Med Chem , vol.13 , pp. 373-384
    • Reiter, R.J.1    Tan, D.X.2    Rosales-Corral, S.3
  • 4
    • 0013774130 scopus 로고
    • Sleep induced by the administration of melatonin (5-methoxyn- acetyltryptamine) to the hypothalamus in unrestrained cats
    • Marczynski TJ, Yamaguchi N, Ling GM, et al. Sleep induced by the administration of melatonin (5-methoxyn-acetyltryptamine) to the hypothalamus in unrestrained cats. Experientia 1964; 20: 435-437.
    • (1964) Experientia , vol.20 , pp. 435-437
    • Marczynski, T.J.1    Yamaguchi, N.2    Ling, G.M.3
  • 5
    • 0025915557 scopus 로고
    • Melatonin: The chemical expression of darkness
    • Reiter RJ,. Melatonin: the chemical expression of darkness. Mol Cell Endocrinol 1991; 79: C153-C158.
    • (1991) Mol Cell Endocrinol , vol.79
    • Reiter, R.J.1
  • 6
    • 0025758136 scopus 로고
    • Pineal melatonin: Cell biology of its synthesis and of its physiological interactions
    • Reiter RJ,. Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocr Rev 1991; 12: 151-180.
    • (1991) Endocr Rev , vol.12 , pp. 151-180
    • Reiter, R.J.1
  • 7
    • 0027210003 scopus 로고
    • The melatonin rhythm: Both a clock and a calendar
    • Reiter RJ,. The melatonin rhythm: both a clock and a calendar. Experientia 1993; 49: 654-664. (Pubitemid 23256791)
    • (1993) Experientia , vol.49 , Issue.8 , pp. 654-664
    • Reiter, R.J.1
  • 8
    • 0037198063 scopus 로고    scopus 로고
    • Reactive oxygen and nitrogen species and cellular and organismal decline: Amelioration with melatonin
    • DOI 10.1016/S0047-6374(01)00384-0, PII S0047637401003840
    • Reiter RJ, Tan DX, Burkhardt S,. Reactive oxygen and nitrogen species and cellular and organismal decline: amelioration with melatonin. Mech Ageing Dev 2002; 123: 1007-1019. (Pubitemid 34603084)
    • (2002) Mechanisms of Ageing and Development , vol.123 , Issue.8 , pp. 1007-1019
    • Reiter, R.J.1    Tan, D.-X.2    Burkhardt, S.3
  • 9
    • 33845536018 scopus 로고    scopus 로고
    • One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species?
    • DOI 10.1111/j.1600-079X.2006.00407.x
    • Tan DX, Manchester LC, Terron MP, et al. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 2007; 42: 28-42. (Pubitemid 44924323)
    • (2007) Journal of Pineal Research , vol.42 , Issue.1 , pp. 28-42
    • Tan, D.-X.1    Manchester, L.C.2    Terron, M.P.3    Flores, L.J.4    Reiter, R.J.5
  • 11
    • 0029032902 scopus 로고
    • Melatonin stimulates brain glutathione peroxidase activity
    • Barlow-Walden LR, Reiter RJ, Abe M, et al. Melatonin stimulates brain glutathione peroxidase activity. Neurochem Int 1995; 26: 497-502.
    • (1995) Neurochem Int , vol.26 , pp. 497-502
    • Barlow-Walden, L.R.1    Reiter, R.J.2    Abe, M.3
  • 12
    • 0025275926 scopus 로고
    • Melatonin receptors: Current status, facts, and hypotheses
    • DOI 10.1016/0024-3205(90)90020-R
    • Stankov B, Reiter RJ,. Melatonin receptors: current status, facts, and hypotheses. Life Sci 1990; 46: 971-982. (Pubitemid 20150552)
    • (1990) Life Sciences , vol.46 , Issue.14 , pp. 971-982
    • Stankov, B.1    Reiter, R.J.2
  • 13
    • 27644449587 scopus 로고    scopus 로고
    • 2 melatonin receptors in mammals
    • DOI 10.1385/ENDO:27:2:101
    • Dubocovich ML, Markowska M,. Functional MT1 and MT2 melatonin receptors in mammals. Endocrine 2005; 27: 101-110. (Pubitemid 41558442)
    • (2005) Endocrine , vol.27 , Issue.2 , pp. 101-110
    • Dubocovich, M.L.1    Markowska, M.2
  • 14
    • 27644466592 scopus 로고    scopus 로고
    • A review of the multiple actions of melatonin on the immune system
    • DOI 10.1385/ENDO:27:2:189
    • Carrillo-Vico A, Guerrero JM, Lardone PJ, et al. A review of the multiple actions of melatonin on the immune system. Endocrine 2005; 27: 189-200. (Pubitemid 41558451)
    • (2005) Endocrine , vol.27 , Issue.2 , pp. 189-200
    • Carrillo-Vico, A.1    Guerrero, J.M.2    Lardone, P.J.3    Reiter, R.J.4
  • 15
    • 34848928810 scopus 로고    scopus 로고
    • 3 melatonin membrane receptor: Hypothesis and significance
    • DOI 10.1111/j.1600-079X.2007.00513.x
    • Tan DX, Manchester LC, Terron MP, et al. Melatonin as a naturally occurring co-substrate of quinone reductase-2, the putative MT3 melatonin membrane receptor: hypothesis and significance. J Pineal Res 2007; 43: 317-320. (Pubitemid 47512273)
    • (2007) Journal of Pineal Research , vol.43 , Issue.4 , pp. 317-320
    • Tan, D.-X.1    Manchester, L.C.2    Terron, M.P.3    Flores, L.J.4    Tamura, H.5    Reiter, R.J.6
  • 16
    • 77957827874 scopus 로고    scopus 로고
    • Melatonin signaling and cell protection function
    • Luchetti F, Canonico B, Betti M, et al. Melatonin signaling and cell protection function. FASEB J 2010; 24: 3603-3624.
    • (2010) FASEB J , vol.24 , pp. 3603-3624
    • Luchetti, F.1    Canonico, B.2    Betti, M.3
  • 17
    • 67349171366 scopus 로고    scopus 로고
    • Lipoxygenase-mediated pro-radical effect of melatonin via stimulation of arachidonic acid metabolism
    • Radogna F, Sestili P, Martinelli C, et al. Lipoxygenase-mediated pro-radical effect of melatonin via stimulation of arachidonic acid metabolism. Toxicol Appl Pharmacol 2009; 238: 170-177.
    • (2009) Toxicol Appl Pharmacol , vol.238 , pp. 170-177
    • Radogna, F.1    Sestili, P.2    Martinelli, C.3
  • 19
    • 33645027389 scopus 로고    scopus 로고
    • Melatonin cytotoxicity in human leukemia cells: Relation with its pro-oxidant effect
    • Buyukavci M, Ozdemir O, Buck S, et al. Melatonin cytotoxicity in human leukemia cells: relation with its pro-oxidant effect. Fundam Clin Pharmacol 2006; 20: 73-79.
    • (2006) Fundam Clin Pharmacol , vol.20 , pp. 73-79
    • Buyukavci, M.1    Ozdemir, O.2    Buck, S.3
  • 20
    • 0035826874 scopus 로고    scopus 로고
    • Melatonin acts as antioxidant and pro-oxidant in an organotypic slice culture model of Alzheimer's disease
    • Clapp-Lilly KL, Smith MA, Perry G, et al. Melatonin acts as antioxidant and pro-oxidant in an organotypic slice culture model of Alzheimer's disease. NeuroReport 2001; 12: 1277-1280. (Pubitemid 32374758)
    • (2001) NeuroReport , vol.12 , Issue.6 , pp. 1277-1280
    • Clapp-Lilly, K.L.1    Smith, M.A.2    Perry, G.3    Harris, P.L.4    Zhu, X.5    Duffy, L.K.6
  • 21
    • 67650690555 scopus 로고    scopus 로고
    • Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes
    • Radogna F, Paternoster L, De Nicola M, et al. Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes. Toxicol Appl Pharmacol 2009; 239: 37-45.
    • (2009) Toxicol Appl Pharmacol , vol.239 , pp. 37-45
    • Radogna, F.1    Paternoster, L.2    De Nicola, M.3
  • 22
    • 84881552543 scopus 로고    scopus 로고
    • Melatonin elevates apoptosis in human platelets via ROS mediated mitochondrial damage
    • Girish KS, Paul M, Thushara RM, et al. Melatonin elevates apoptosis in human platelets via ROS mediated mitochondrial damage. Biochem Biophys Res Commun 2013; 438: 198-204.
    • (2013) Biochem Biophys Res Commun , vol.438 , pp. 198-204
    • Girish, K.S.1    Paul, M.2    Thushara, R.M.3
  • 23
    • 78650079873 scopus 로고    scopus 로고
    • The role of mitochondrial complex III in melatonin-induced ROS production in cultured mesangial cells
    • Zhang HM, Zhang Y, Zhang BX,. The role of mitochondrial complex III in melatonin-induced ROS production in cultured mesangial cells. J Pineal Res 2011; 50: 78-82.
    • (2011) J Pineal Res , vol.50 , pp. 78-82
    • Zhang, H.M.1    Zhang, Y.2    Zhang, B.X.3
  • 24
    • 80053186332 scopus 로고    scopus 로고
    • Impaired mitochondrial complex III and melatonin responsive reactive oxygen species generation in kidney mitochondria of db/db mice
    • Zhang H, Zhang HM, Wu LP, et al. Impaired mitochondrial complex III and melatonin responsive reactive oxygen species generation in kidney mitochondria of db/db mice. J Pineal Res 2011; 51: 338-344.
    • (2011) J Pineal Res , vol.51 , pp. 338-344
    • Zhang, H.1    Zhang, H.M.2    Wu, L.P.3
  • 25
    • 78650219691 scopus 로고    scopus 로고
    • Pro-oxidant effect of melatonin in tumour leucocytes: Relation with its cytotoxic and pro-apoptotic effects
    • Bejarano I, Espino J, Barriga C, et al. Pro-oxidant effect of melatonin in tumour leucocytes: relation with its cytotoxic and pro-apoptotic effects. Basic Clin Pharmacol Toxicol 2011; 108: 14-20.
    • (2011) Basic Clin Pharmacol Toxicol , vol.108 , pp. 14-20
    • Bejarano, I.1    Espino, J.2    Barriga, C.3
  • 26
    • 0032708134 scopus 로고    scopus 로고
    • Pro-oxidating properties of melatonin in the in vitro interaction with the singlet oxygen
    • Medina-Navarro R, Duran-Reyes G, Hicks JJ,. Pro-oxidating properties of melatonin in the in vitro interaction with the singlet oxygen. Endocr Res 1999; 25: 263-280.
    • (1999) Endocr Res , vol.25 , pp. 263-280
    • Medina-Navarro, R.1    Duran-Reyes, G.2    Hicks, J.J.3
  • 27
    • 0035800628 scopus 로고    scopus 로고
    • Prooxidant activity of melatonin promotes fas-induced cell death in human leukemic Jurkat cells
    • DOI 10.1016/S0014-5793(01)02680-1, PII S0014579301026801
    • Wolfler A, Caluba HC, Abuja PM, et al. Prooxidant activity of melatonin promotes fas-induced cell death in human leukemic Jurkat cells. FEBS Lett 2001; 502: 127-131. (Pubitemid 32728274)
    • (2001) FEBS Letters , vol.502 , Issue.3 , pp. 127-131
    • Wolfler, A.1    Caluba, H.-C.2    Abuja, P.M.3    Dohr, G.4    Schauenstein, K.5    Liebmann, P.M.6
  • 28
    • 0034672108 scopus 로고    scopus 로고
    • Evidence of prooxidant and antioxidant action of melatonin on human liver cell line HepG2
    • DOI 10.1016/S0024-3205(00)00955-3, PII S0024320500009553
    • Osseni RA, Rat P, Bogdan A, et al. Evidence of prooxidant and antioxidant action of melatonin on human liver cell line HepG2. Life Sci 2000; 68: 387-399. (Pubitemid 32011892)
    • (2000) Life Sciences , vol.68 , Issue.4 , pp. 387-399
    • Osseni, R.A.1    Rat, P.2    Bogdan, A.3    Warnet, J.-M.4    Touitou, Y.5
  • 30
    • 0034626735 scopus 로고    scopus 로고
    • Oxidants, oxidative stress and the biology of ageing
    • Finkel T, Holbrook NJ,. Oxidants, oxidative stress and the biology of ageing. Nature 2000; 408: 239-247.
    • (2000) Nature , vol.408 , pp. 239-247
    • Finkel, T.1    Holbrook, N.J.2
  • 31
    • 0035754146 scopus 로고    scopus 로고
    • Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: A review of the evidence
    • DOI 10.1385/CBB:34:2:237
    • Reiter RJ, Tan DX, Manchester LC, et al. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence. Cell Biochem Biophys 2001; 34: 237-256. (Pubitemid 33615836)
    • (2001) Cell Biochemistry and Biophysics , vol.34 , Issue.2 , pp. 237-256
    • Reiter, R.J.1    Tan, D.-X.2    Manchester, L.C.3    Qi, W.4
  • 33
    • 84902205907 scopus 로고    scopus 로고
    • Focusing at the double edged sword of redox imbalance: Signals for cell survival or for cell death?
    • Malorni W, Pietraforte D,. Focusing at the double edged sword of redox imbalance: signals for cell survival or for cell death? Antioxid Redox Signal 2014; 21: 52-55.
    • (2014) Antioxid Redox Signal , vol.21 , pp. 52-55
    • Malorni, W.1    Pietraforte, D.2
  • 34
    • 0033805296 scopus 로고    scopus 로고
    • Triggering and modulation of apoptosis by oxidative stress
    • Chandra J, Samali A, Orrenius S,. Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol Med 2000; 29: 323-333.
    • (2000) Free Radic Biol Med , vol.29 , pp. 323-333
    • Chandra, J.1    Samali, A.2    Orrenius, S.3
  • 35
    • 84879165160 scopus 로고    scopus 로고
    • Oxidative stress: The mitochondria-dependent and mitochondria-independent pathways of apoptosis
    • Sinha K, Das J, Pal PB, et al. Oxidative stress: the mitochondria- dependent and mitochondria-independent pathways of apoptosis. Arch Toxicol 2013; 87: 1157-1180.
    • (2013) Arch Toxicol , vol.87 , pp. 1157-1180
    • Sinha, K.1    Das, J.2    Pal, P.B.3
  • 36
    • 43049163718 scopus 로고    scopus 로고
    • Free radicals and senescence
    • Lu T, Finkel T,. Free radicals and senescence. Exp Cell Res 2008; 314: 1918-1922.
    • (2008) Exp Cell Res , vol.314 , pp. 1918-1922
    • Lu, T.1    Finkel, T.2
  • 37
    • 0029918901 scopus 로고    scopus 로고
    • Role of oxygen free radicals in cancer development
    • Dreher D, Junod AF,. Role of oxygen free radicals in cancer development. Eur J Cancer 1996; 32A: 30-38.
    • (1996) Eur J Cancer , vol.32 A , pp. 30-38
    • Dreher, D.1    Junod, A.F.2
  • 38
    • 38949098182 scopus 로고    scopus 로고
    • Autophagy as a second level protective process in conferring resistance to environmentally-induced oxidative stress
    • Moore MN,. Autophagy as a second level protective process in conferring resistance to environmentally-induced oxidative stress. Autophagy 2008; 4: 254-256. (Pubitemid 351231195)
    • (2008) Autophagy , vol.4 , Issue.2 , pp. 254-256
    • Moore, M.N.1
  • 39
    • 34250900982 scopus 로고    scopus 로고
    • Base-excision repair of oxidative DNA damage
    • DOI 10.1038/nature05978, PII NATURE05978
    • David SS, O'shea VL, Kundu S,. Base-excision repair of oxidative DNA damage. Nature 2007; 447: 941-950. (Pubitemid 46975761)
    • (2007) Nature , vol.447 , Issue.7147 , pp. 941-950
    • David, S.S.1    O'Shea, V.L.2    Kundu, S.3
  • 40
    • 33645573723 scopus 로고    scopus 로고
    • Reactive oxygen species-(ROS) pathogens or sources of vital energy? Part 1. ROS in normal and pathologic physiology of living systems
    • Voeikov VL,. Reactive oxygen species-(ROS) pathogens or sources of vital energy? Part 1. ROS in normal and pathologic physiology of living systems. J Altern Complement Med 2006; 12: 111-118.
    • (2006) J Altern Complement Med , vol.12 , pp. 111-118
    • Voeikov, V.L.1
  • 42
    • 0022724167 scopus 로고
    • The role of the respiratory burst of phagocytes in host defense
    • Shepherd VL,. The role of the respiratory burst of phagocytes in host defense. Semin Respir Infect 1986; 1: 99-106.
    • (1986) Semin Respir Infect , vol.1 , pp. 99-106
    • Shepherd, V.L.1
  • 43
    • 0026034432 scopus 로고
    • Role of nitric oxide synthesis in macrophage antimicrobial activity
    • Nathan CF, Hibbs JB Jr,. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol 1991; 3: 65-70.
    • (1991) Curr Opin Immunol , vol.3 , pp. 65-70
    • Nathan, C.F.1    Hibbs, Jr.J.B.2
  • 44
    • 34648813720 scopus 로고    scopus 로고
    • ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis
    • DOI 10.1038/nrm2256, PII NRM2256
    • D'Autreaux B, Toledano MB,. ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat Rev Mol Cell Biol 2007; 8: 813-824. (Pubitemid 47462134)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.10 , pp. 813-824
    • D'Autreaux, B.1    Toledano, M.B.2
  • 45
    • 0033963704 scopus 로고    scopus 로고
    • Oxidative stress and gene regulation
    • DOI 10.1016/S0891-5849(99)00242-7, PII S0891584999002427
    • Allen RG, Tresini M,. Oxidative stress and gene regulation. Free Radic Biol Med 2000; 28: 463-499. (Pubitemid 30110662)
    • (2000) Free Radical Biology and Medicine , vol.28 , Issue.3 , pp. 463-499
    • Allen, R.G.1    Tresini, M.2
  • 46
    • 33750915802 scopus 로고    scopus 로고
    • Regulation of signal transduction through protein cysteine oxidation
    • DOI 10.1089/ars.2006.8.1819
    • Cross JV, Templeton DJ,. Regulation of signal transduction through protein cysteine oxidation. Antioxid Redox Signal 2006; 8: 1819-1827. (Pubitemid 44726354)
    • (2006) Antioxidants and Redox Signaling , vol.8 , Issue.9-10 , pp. 1819-1827
    • Cross, J.V.1    Templeton, D.J.2
  • 47
    • 0028320894 scopus 로고
    • Regulation of cytosolic guanylyl cyclase by nitric oxide: The NO-cyclic GMP signal transduction system
    • Murad F,. Regulation of cytosolic guanylyl cyclase by nitric oxide: the NO-cyclic GMP signal transduction system. Adv Pharmacol 1994; 26: 19-33.
    • (1994) Adv Pharmacol , vol.26 , pp. 19-33
    • Murad, F.1
  • 48
    • 0029928445 scopus 로고    scopus 로고
    • Paraquat toxicity and oxidative damage. Reduction by melatonin
    • Melchiorri D, Reiter RJ, Sewerynek E, et al. Paraquat toxicity and oxidative damage. Reduction by melatonin. Biochem Pharmacol 1996; 51: 1095-1099.
    • (1996) Biochem Pharmacol , vol.51 , pp. 1095-1099
    • Melchiorri, D.1    Reiter, R.J.2    Sewerynek, E.3
  • 49
    • 0002979059 scopus 로고
    • Melatonin: A potent endogenous hydroxyl radical scavenger
    • Tan DX, Chen LD, Poeggeler B, et al. Melatonin: a potent endogenous hydroxyl radical scavenger. Endocr J 1993; 1: 57-60.
    • (1993) Endocr J , vol.1 , pp. 57-60
    • Tan, D.X.1    Chen, L.D.2    Poeggeler, B.3
  • 50
    • 79960380554 scopus 로고    scopus 로고
    • Melatonin as a natural ally against oxidative stress: A physicochemical examination
    • Galano A, Tan DX, Reiter RJ,. Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res 2011; 51: 1-16.
    • (2011) J Pineal Res , vol.51 , pp. 1-16
    • Galano, A.1    Tan, D.X.2    Reiter, R.J.3
  • 51
    • 84874949228 scopus 로고    scopus 로고
    • On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK
    • Galano A, Tan DX, Reiter RJ,. On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK. J Pineal Res 2013; 54: 245-257.
    • (2013) J Pineal Res , vol.54 , pp. 245-257
    • Galano, A.1    Tan, D.X.2    Reiter, R.J.3
  • 54
    • 0001327186 scopus 로고
    • Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum
    • DOI 10.1016/0024-3205(94)00532-X
    • Pozo D, Reiter RJ, Calvo JR, et al. Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum. Life Sci 1994; 55: PL455-PL460. (Pubitemid 24347808)
    • (1994) Life Sciences , vol.55 , Issue.24
    • Pozo, D.1    Reiter, R.J.2    Calvo, J.R.3    Guerrero, J.M.4
  • 55
    • 0030930937 scopus 로고    scopus 로고
    • Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin
    • DOI 10.1002/(SICI)1097-4644(19970601)65:3<430::AID-JCB12>3.0.CO;2-J
    • Pozo D, Reiter RJ, Calvo JR, et al. Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin. J Cell Biochem 1997; 65: 430-442. (Pubitemid 27190697)
    • (1997) Journal of Cellular Biochemistry , vol.65 , Issue.3 , pp. 430-442
    • Pozo, D.1    Reiter, R.J.2    Calvo, J.R.3    Guerrero, J.M.4
  • 59
  • 60
    • 0027725205 scopus 로고
    • Distribution of melatonin in mammalian tissues: The relative importance of nuclear versus cytosolic localization
    • Menendez-Pelaez A, Reiter RJ,. Distribution of melatonin in mammalian tissues: the relative importance of nuclear versus cytosolic localization. J Pineal Res 1993; 15: 59-69. (Pubitemid 24028611)
    • (1993) Journal of Pineal Research , vol.15 , Issue.2 , pp. 59-69
    • Menendez-Pelaez, A.1    Reiter, R.J.2
  • 62
    • 84856693660 scopus 로고    scopus 로고
    • Extrapineal melatonin: Analysis of its subcellular distribution and daily fluctuations
    • Venegas C, Garcia JA, Escames G, et al. Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations. J Pineal Res 2012; 52: 217-227.
    • (2012) J Pineal Res , vol.52 , pp. 217-227
    • Venegas, C.1    Garcia, J.A.2    Escames, G.3
  • 63
    • 0028618440 scopus 로고
    • Melatonin-a highly potent endogenous radical scavenger and electron donor: New aspects of the oxidation chemistry of this indole accessed in vitro
    • Poeggeler B, Saarela S, Reiter RJ, et al. Melatonin-a highly potent endogenous radical scavenger and electron donor: new aspects of the oxidation chemistry of this indole accessed in vitro. Ann N Y Acad Sci 1994; 738: 419-420.
    • (1994) Ann N y Acad Sci , vol.738 , pp. 419-420
    • Poeggeler, B.1    Saarela, S.2    Reiter, R.J.3
  • 64
    • 0030986012 scopus 로고    scopus 로고
    • Reaction of melatonin and related indoles with hydroxyl radicals: EPR and spin trapping investigations
    • DOI 10.1016/S0891-5849(96)00614-4, PII S0891584996006144
    • Matuszak Z, Reszka K, Chignell CF,. Reaction of melatonin and related indoles with hydroxyl radicals: EPR and spin trapping investigations. Free Radic Biol Med 1997; 23: 367-372. (Pubitemid 27276772)
    • (1997) Free Radical Biology and Medicine , vol.23 , Issue.3 , pp. 367-372
    • Matuszak, Z.1    Reszka, K.J.2    Chignell, C.F.3
  • 65
    • 0031172139 scopus 로고    scopus 로고
    • Potent protective effect of melatonin on chromium(VI)-induced DNA single-strand breaks, cytotoxicity, and lipid peroxidation in primary cultures of rat hepatocytes
    • DOI 10.1006/taap.1997.8151
    • Susa N, Ueno S, Furukawa Y, et al. Potent protective effect of melatonin on chromium(VI)-induced DNA single-strand breaks, cytotoxicity, and lipid peroxidation in primary cultures of rat hepatocytes. Toxicol Appl Pharmacol 1997; 144: 377-384. (Pubitemid 27268360)
    • (1997) Toxicology and Applied Pharmacology , vol.144 , Issue.2 , pp. 377-384
    • Susa, N.1    Ueno, S.2    Furukawa, Y.3    Ueda, J.4    Sugiyama, M.5
  • 66
    • 0031823823 scopus 로고    scopus 로고
    • Melatonin as a hydroxyl radical scavenger
    • DOI 10.1111/j.1600-079X.1998.tb00387.x
    • Stasica P, Ulanski P, Rosiak JM,. Melatonin as a hydroxyl radical scavenger. J Pineal Res 1998; 25: 65-66. (Pubitemid 28319918)
    • (1998) Journal of Pineal Research , vol.25 , Issue.1 , pp. 65-66
    • Stasica, P.1    Ulanski, P.2    Rosiak, J.M.3
  • 69
    • 0031981238 scopus 로고    scopus 로고
    • Comparison of the antioxidant activity of melatonin and pinoline in vitro
    • DOI 10.1111/j.1600-079X.1998.tb00373.x
    • Pahkla R, Zilmer M, Kullisaar T, et al. Comparison of the antioxidant activity of melatonin and pinoline in vitro. J Pineal Res 1998; 24: 96-101. (Pubitemid 28168321)
    • (1998) Journal of Pineal Research , vol.24 , Issue.2 , pp. 96-101
    • Pahkla, R.1    Zilmer, M.2    Kullisaar, T.3    Rago, L.4
  • 70
    • 0030752205 scopus 로고    scopus 로고
    • Melatonin decreases production of hydroxyl radical during cerebral ischemia-reperfusion
    • Li XJ, Zhang LM, Gu J, et al. Melatonin decreases production of hydroxyl radical during cerebral ischemia-reperfusion. Zhongguo Yao Li Xue Bao 1997; 18: 394-396. (Pubitemid 27389438)
    • (1997) Acta Pharmacologica Sinica , vol.18 , Issue.5 , pp. 394-396
    • Li, X.-J.1    Zhang, L.-M.2    Gu, J.3    Zhang, A.-Z.4    Sun, F.-Y.5
  • 71
    • 0033790186 scopus 로고    scopus 로고
    • Scavenging effect of melatonin on hydroxyl radicals generated by alloxan
    • Bromme HJ, Morke W, Peschke D, et al. Scavenging effect of melatonin on hydroxyl radicals generated by alloxan. J Pineal Res 2000; 29: 201-208.
    • (2000) J Pineal Res , vol.29 , pp. 201-208
    • Bromme, H.J.1    Morke, W.2    Peschke, D.3
  • 72
    • 84899888264 scopus 로고    scopus 로고
    • Cyclic-3-hydroxymelatonin (C3HOM), a potent antioxidant, scavenges free radicals and suppresses oxidative reactions
    • Tan DX, Hardeland R, Manchester LC, et al. Cyclic-3-hydroxymelatonin (C3HOM), a potent antioxidant, scavenges free radicals and suppresses oxidative reactions. Curr Med Chem 2014; 21: 1557-1565.
    • (2014) Curr Med Chem , vol.21 , pp. 1557-1565
    • Tan, D.X.1    Hardeland, R.2    Manchester, L.C.3
  • 73
    • 84891791781 scopus 로고    scopus 로고
    • Cyclic 3-hydroxymelatonin, a key metabolite enhancing the peroxyl radical scavenging activity of melatonin
    • Galano A, Tan DX, Reiter RJ,. Cyclic 3-hydroxymelatonin, a key metabolite enhancing the peroxyl radical scavenging activity of melatonin. Roy Soc Chem Adv 2014; 4: 5220-5227.
    • (2014) Roy Soc Chem Adv , vol.4 , pp. 5220-5227
    • Galano, A.1    Tan, D.X.2    Reiter, R.J.3
  • 75
    • 0033000928 scopus 로고    scopus 로고
    • Cyclic 3-hydroxymelatonin: A melatonin metabolite generated as a result of hydroxyl radical scavenging
    • Tan DX, Manchester LC, Reiter RJ, et al. Cyclic 3-hydroxymelatonin: a melatonin metabolite generated as a result of hydroxyl radical scavenging. Biol Signals Recept 1999; 8: 70-74. (Pubitemid 29132385)
    • (1999) Biological Signals and Receptors , vol.8 , Issue.1-2 , pp. 70-74
    • Tan, D.-X.1    Manchester, L.C.2    Reiter, R.J.3    Plummer, B.F.4
  • 76
    • 0015944572 scopus 로고
    • In vitro and in vivo formation of two new metabolites of melatonin
    • Hirata F, Hayaishi O, Tokuyama T, et al. In vitro and in vivo formation of two new metabolites of melatonin. J Biol Chem 1974; 249: 1311-1313.
    • (1974) J Biol Chem , vol.249 , pp. 1311-1313
    • Hirata, F.1    Hayaishi, O.2    Tokuyama, T.3
  • 77
    • 0034564392 scopus 로고    scopus 로고
    • Melatonin directly scavenges hydrogen peroxide: A potentially new metabolic pathway of melatonin biotransformation
    • Tan DX, Manchester LC, Reiter RJ, et al. Melatonin directly scavenges hydrogen peroxide: a potentially new metabolic pathway of melatonin biotransformation. Free Radic Biol Med 2000; 29: 1177-1185.
    • (2000) Free Radic Biol Med , vol.29 , pp. 1177-1185
    • Tan, D.X.1    Manchester, L.C.2    Reiter, R.J.3
  • 78
    • 0035487508 scopus 로고    scopus 로고
    • N1-acetyl-N2-formyl-5-methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant
    • Tan DX, Manchester LC, Burkhardt S, et al. N1-acetyl-N2-formyl-5- methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant. FASEB J 2001; 15: 2294-2296.
    • (2001) FASEB J , vol.15 , pp. 2294-2296
    • Tan, D.X.1    Manchester, L.C.2    Burkhardt, S.3
  • 81
    • 25144447579 scopus 로고    scopus 로고
    • 1-acetyl-5- methoxykynuramine) with reactive nitrogen species: Formation of novel compounds, 3-acetamidomethyl-6-methoxycinnolinone and 3-nitro-AMK
    • DOI 10.1111/j.1600-079X.2005.00242.x
    • Guenther AL, Schmidt SI, Laatsch H, et al. Reactions of the melatonin metabolite AMK (N1-acetyl-5-methoxykynuramine) with reactive nitrogen species: formation of novel compounds, 3-acetamidomethyl-6-methoxycinnolinone and 3-nitro-AMK. J Pineal Res 2005; 39: 251-260. (Pubitemid 41337805)
    • (2005) Journal of Pineal Research , vol.39 , Issue.3 , pp. 251-260
    • Guenther, A.L.1    Schmidt, S.I.2    Laatsch, H.3    Fotso, S.4    Ness, H.5    Ressmeyer, A.-R.6    Poeggeler, B.7    Hardeland, R.8
  • 82
    • 0036482282 scopus 로고    scopus 로고
    • Chemical and physical properties and potential mechanisms: Melatonin as a broad spectrum antioxidant and free radical scavenger
    • Tan DX, Reiter RJ, Manchester LC, et al. Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger. Curr Top Med Chem 2002; 2: 181-197.
    • (2002) Curr Top Med Chem , vol.2 , pp. 181-197
    • Tan, D.X.1    Reiter, R.J.2    Manchester, L.C.3
  • 83
    • 70349577367 scopus 로고    scopus 로고
    • Reducing oxidative/nitrosative stress: A newly-discovered genre for melatonin
    • Reiter RJ, Paredes SD, Manchester LC, et al. Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin. Crit Rev Biochem Mol Biol 2009; 44: 175-200.
    • (2009) Crit Rev Biochem Mol Biol , vol.44 , pp. 175-200
    • Reiter, R.J.1    Paredes, S.D.2    Manchester, L.C.3
  • 84
    • 79954509582 scopus 로고    scopus 로고
    • Melatonin: Helping cells cope with oxidative disaster
    • Paredes SD, Reiter RJ,. Melatonin: helping cells cope with oxidative disaster. Cell Membr Free Radic Res 2010; 2: 99-111.
    • (2010) Cell Membr Free Radic Res , vol.2 , pp. 99-111
    • Paredes, S.D.1    Reiter, R.J.2
  • 85
    • 0033006251 scopus 로고    scopus 로고
    • Antioxidant properties of melatonin: A pulse radiolysis study
    • DOI 10.1016/S0891-5849(98)00226-3, PII S0891584998002263
    • Mahal HS, Sharma HS, Mukherjee T,. Antioxidant properties of melatonin: a pulse radiolysis study. Free Radic Biol Med 1999; 26: 557-565. (Pubitemid 29146258)
    • (1999) Free Radical Biology and Medicine , vol.26 , Issue.5-6 , pp. 557-565
    • Mahal, H.S.1    Sharma, H.S.2    Mukherjee, T.3
  • 86
    • 0029398053 scopus 로고
    • Exploratory laser flash photolysis study of free radical reactions and magnetic field effects in melatonin chemistry
    • Scaiano JC,. Exploratory laser flash photolysis study of free radical reactions and magnetic field effects in melatonin chemistry. J Pineal Res 1995; 19: 189-195.
    • (1995) J Pineal Res , vol.19 , pp. 189-195
    • Scaiano, J.C.1
  • 87
    • 0032500821 scopus 로고    scopus 로고
    • The reaction of melatonin with peroxynitrite: Formation of melatonin radical cation and absence of stable nitrated products
    • DOI 10.1006/bbrc.1998.9426
    • Zhang H, Squadrito GL, Pryor WA,. The reaction of melatonin with peroxynitrite: formation of melatonin radical cation and absence of stable nitrated products. Biochem Biophys Res Commun 1998; 251: 83-87. (Pubitemid 28498067)
    • (1998) Biochemical and Biophysical Research Communications , vol.251 , Issue.1 , pp. 83-87
    • Zhang, H.1    Squadrito, G.L.2    Pryor, W.A.3
  • 88
  • 91
    • 0029295723 scopus 로고
    • Melatonin protects neurons from singlet oxygen-induced apoptosis
    • Cagnoli CM, Atabay C, Kharlamova E, et al. Melatonin protects neurons from singlet oxygen-induced apoptosis. J Pineal Res 1995; 18: 222-226.
    • (1995) J Pineal Res , vol.18 , pp. 222-226
    • Cagnoli, C.M.1    Atabay, C.2    Kharlamova, E.3
  • 92
    • 0032831961 scopus 로고    scopus 로고
    • Melatonin and its precursors scavenge nitric oxide
    • DOI 10.1111/j.1600-079X.1999.tb00611.x
    • Noda Y, Mori A, Liburdy R, et al. Melatonin and its precursors scavenge nitric oxide. J Pineal Res 1999; 27: 159-163. (Pubitemid 29487960)
    • (1999) Journal of Pineal Research , vol.27 , Issue.3 , pp. 159-163
    • Noda, Y.1    Mori, A.2    Liburdy, R.3    Packer, L.4
  • 93
    • 0033815088 scopus 로고    scopus 로고
    • Nitrosation of melatonin by nitric oxide and peroxynitrite
    • Blanchard B, Pompon D, Ducrocq C,. Nitrosation of melatonin by nitric oxide and peroxynitrite. J Pineal Res 2000; 29: 184-192.
    • (2000) J Pineal Res , vol.29 , pp. 184-192
    • Blanchard, B.1    Pompon, D.2    Ducrocq, C.3
  • 95
    • 0037402887 scopus 로고    scopus 로고
    • Oxidative damage to catalase induced by peroxyl radicals: Functional protection by melatonin and other antioxidants
    • DOI 10.1080/1071576031000083206
    • Mayo JC, Tan DX, Sainz RM, et al. Oxidative damage to catalase induced by peroxyl radicals: functional protection by melatonin and other antioxidants. Free Radic Res 2003; 37: 543-553. (Pubitemid 36410896)
    • (2003) Free Radical Research , vol.37 , Issue.5 , pp. 543-553
    • Mayo, J.C.1    Tan, D.-X.2    Sainz, R.M.3    Lopez-Burillo, S.4    Reiter, R.J.5
  • 96
    • 0031853670 scopus 로고    scopus 로고
    • Protective effect of melatonin in a non-septic shock model induced by zymosan in the rat
    • DOI 10.1111/j.1600-079X.1998.tb00382.x
    • Cuzzocrea S, Zingarelli B, Costantino G, et al. Protective effect of melatonin in a non-septic shock model induced by zymosan in the rat. J Pineal Res 1998; 25: 24-33. (Pubitemid 28319913)
    • (1998) Journal of Pineal Research , vol.25 , Issue.1 , pp. 24-33
    • Cuzzocrea, S.1    Zingarelli, B.2    Costantino, G.3    Caputi, A.P.4
  • 97
    • 0031823039 scopus 로고    scopus 로고
    • Protective effect of melatonin on cellular energy depletion mediated by peroxynitrite and poly (ADP-ribose) synthetase activation in a non-septic shock model induced by zymosan in the rat
    • Cuzzocrea S, Costantino G, Caputi AP,. Protective effect of melatonin on cellular energy depletion mediated by peroxynitrite and poly (ADP-ribose) synthetase activation in a non-septic shock model induced by zymosan in the rat. J Pineal Res 1998; 25: 78-85. (Pubitemid 28392103)
    • (1998) Journal of Pineal Research , vol.25 , Issue.2 , pp. 78-85
    • Cuzzocrea, S.1    Costantino, G.2    Caputi, A.P.3
  • 98
    • 0033227020 scopus 로고    scopus 로고
    • Role of melatonin in reduction of lipid peroxidation and peroxynitrite formation in non-septic shock induced by zymosan
    • El-Sokkary GH, Reiter RJ, Cuzzocrea S, et al. Role of melatonin in reduction of lipid peroxidation and peroxynitrite formation in non-septic shock induced by zymosan. Shock 1999; 12: 402-408.
    • (1999) Shock , vol.12 , pp. 402-408
    • El-Sokkary, G.H.1    Reiter, R.J.2    Cuzzocrea, S.3
  • 99
    • 0034937764 scopus 로고    scopus 로고
    • Effect of melatonin on cellular energy depletion mediated by peroxynitrite and poly (ADP-ribose) synthetase activation in an acute model of inflammation
    • DOI 10.1034/j.1600-079X.2001.310111.x
    • Dugo L, Serraino I, Fulia F, et al. Effect of melatonin on cellular energy depletion mediated by peroxynitrite and poly (ADP-ribose) synthetase activation in an acute model of inflammation. J Pineal Res 2001; 31: 76-84. (Pubitemid 32626049)
    • (2001) Journal of Pineal Research , vol.31 , Issue.1 , pp. 76-84
    • Dugo, L.1    Serraino, I.2    Fulia, F.3    De Sarro, A.4    Caputi, A.P.5    Cuzzocrea, S.6
  • 100
    • 33746560617 scopus 로고    scopus 로고
    • Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain
    • DOI 10.1111/j.1600-079X.2006.00343.x
    • Yin J, Liu YH, Xu YF, et al. Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain. J Pineal Res 2006; 41: 124-129. (Pubitemid 44141746)
    • (2006) Journal of Pineal Research , vol.41 , Issue.2 , pp. 124-129
    • Yin, J.1    Liu, Y.-H.2    Xu, Y.-F.3    Zhang, Y.-J.4    Chen, J.-G.5    Shu, B.-H.6    Wang, J.-Z.7
  • 103
    • 0001155209 scopus 로고    scopus 로고
    • Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments
    • DOI 10.1002/(SICI)1097-4547(19980901)53:5<593::AID-JNR9>3.0.CO;2-4
    • Tang YP, Ma YL, Chao CC, et al. Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments. J Neurosci Res 1998; 53: 593-604. (Pubitemid 28380800)
    • (1998) Journal of Neuroscience Research , vol.53 , Issue.5 , pp. 593-604
    • Tang, Y.P.1    Ma, Y.L.2    Chao, C.C.3    Chen, K.Y.4    Lee, E.H.Y.5
  • 104
    • 10344239385 scopus 로고    scopus 로고
    • Pro-oxidant activity of aluminum in the rat hippocampus: Gene expression of antioxidant enzymes after melatonin administration
    • DOI 10.1016/j.freeradbiomed.2004.10.009, PII S0891584904008111
    • Gomez M, Esparza JL, Nogues MR, et al. Pro-oxidant activity of aluminum in the rat hippocampus: gene expression of antioxidant enzymes after melatonin administration. Free Radic Biol Med 2005; 38: 104-111. (Pubitemid 39626915)
    • (2005) Free Radical Biology and Medicine , vol.38 , Issue.1 , pp. 104-111
    • Gomez, M.1    Esparza, J.L.2    Nogues, M.R.3    Giralt, M.4    Cabre, M.5    Domingo, J.L.6
  • 105
    • 23744457490 scopus 로고    scopus 로고
    • Melatonin reduces oxidative stress and increases gene expression in the cerebral cortex and cerebellum of aluminum-exposed rats
    • DOI 10.1111/j.1600-079X.2005.00225.x
    • Esparza JL, Gomez M, Rosa Nogues M, et al. Melatonin reduces oxidative stress and increases gene expression in the cerebral cortex and cerebellum of aluminum-exposed rats. J Pineal Res 2005; 39: 129-136. (Pubitemid 41140750)
    • (2005) Journal of Pineal Research , vol.39 , Issue.2 , pp. 129-136
    • Esparza, J.L.1    Gomez, M.2    Nogues, M.R.3    Paternain, J.L.4    Mallol, J.5    Domingo, J.L.6
  • 107
    • 84874825677 scopus 로고    scopus 로고
    • Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-deoxyguanosine) in ex vivo human skin
    • Fischer TW, Kleszczynski K, Hardkop LH, et al. Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2-deoxyguanosine) in ex vivo human skin. J Pineal Res 2013; 54: 303-312.
    • (2013) J Pineal Res , vol.54 , pp. 303-312
    • Fischer, T.W.1    Kleszczynski, K.2    Hardkop, L.H.3
  • 108
    • 84883742089 scopus 로고    scopus 로고
    • Melatonin promotes the in vitro development of pronuclear embryos and increases the efficiency of blastocyst implantation in murine
    • Wang F, Tian X, Zhang L, et al. Melatonin promotes the in vitro development of pronuclear embryos and increases the efficiency of blastocyst implantation in murine. J Pineal Res 2013; 55: 267-274.
    • (2013) J Pineal Res , vol.55 , pp. 267-274
    • Wang, F.1    Tian, X.2    Zhang, L.3
  • 109
    • 84892640329 scopus 로고    scopus 로고
    • Rescue of proinflammatory cytokine-inhibited chondrogenesis by the antiarthritic effect of melatonin in synovium mesenchymal stem cells via suppression of reactive oxygen species and matrix metalloproteinases
    • Liu X, Xu Y, Chen S, et al. Rescue of proinflammatory cytokine-inhibited chondrogenesis by the antiarthritic effect of melatonin in synovium mesenchymal stem cells via suppression of reactive oxygen species and matrix metalloproteinases. Free Radic Biol Med 2014; 68: 234-246.
    • (2014) Free Radic Biol Med , vol.68 , pp. 234-246
    • Liu, X.1    Xu, Y.2    Chen, S.3
  • 113
    • 33748042003 scopus 로고    scopus 로고
    • Inhibition of neuronal nitric oxide synthase activity by N1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin
    • Leon J, Escames G, Rodriguez MI, et al. Inhibition of neuronal nitric oxide synthase activity by N1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin. J Neurochem 2006; 98: 2023-2933.
    • (2006) J Neurochem , vol.98 , pp. 2023-2933
    • Leon, J.1    Escames, G.2    Rodriguez, M.I.3
  • 114
    • 0344131940 scopus 로고    scopus 로고
    • Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats
    • Crespo E, Macias M, Pozo D, et al. Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats. FASEB J 1999; 13: 1537-1546. (Pubitemid 29411787)
    • (1999) FASEB Journal , vol.13 , Issue.12 , pp. 1537-1546
    • Crespo, E.1    Macias, M.2    Pozo, D.3    Escames, G.4    Martin, M.5    Vives, F.6    Guerrero, J.M.7    Acuna-Castroviejo, D.8
  • 115
    • 23744513206 scopus 로고    scopus 로고
    • A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes
    • DOI 10.1111/j.1600-079X.2005.00248.x
    • Tomas-Zapico C, Coto-Montes A,. A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes. J Pineal Res 2005; 39: 99-104. (Pubitemid 41140746)
    • (2005) Journal of Pineal Research , vol.39 , Issue.2 , pp. 99-104
    • Tomas-Zapico, C.1    Coto-Montes, A.2
  • 116
    • 57149136250 scopus 로고    scopus 로고
    • Melatonin combats molecular terrorism at the mitochondrial level
    • Reiter RJ, Paredes SD, Korkmaz A, et al. Melatonin combats molecular terrorism at the mitochondrial level. Interdiscip Toxicol 2008; 1: 137-149.
    • (2008) Interdiscip Toxicol , vol.1 , pp. 137-149
    • Reiter, R.J.1    Paredes, S.D.2    Korkmaz, A.3
  • 120
    • 84873458408 scopus 로고    scopus 로고
    • Mitochondria and chloroplasts as the original sites of melatonin synthesis: A hypothesis related to melatonin's primary function and evolution in eukaryotes
    • Tan DX, Manchester LC, Liu X, et al. Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes. J Pineal Res 2013; 54: 127-238.
    • (2013) J Pineal Res , vol.54 , pp. 127-238
    • Tan, D.X.1    Manchester, L.C.2    Liu, X.3
  • 121
    • 0036479802 scopus 로고    scopus 로고
    • Melatonin, mitochondrial homeostasis and mitochondrial-related diseases
    • Acuna-Castroviejo D, Escames G, Carazo A, et al. Melatonin, mitochondrial homeostasis and mitochondrial-related diseases. Curr Top Med Chem 2002; 2: 133-151.
    • (2002) Curr Top Med Chem , vol.2 , pp. 133-151
    • Acuna-Castroviejo, D.1    Escames, G.2    Carazo, A.3
  • 122
    • 27644507326 scopus 로고    scopus 로고
    • Melatonin and nitric oxide: Two required antagonists for mitochondrial homeostasis
    • DOI 10.1385/ENDO:27:2:159
    • Acuna-Castroviejo D, Escames G, Lopez LC, et al. Melatonin and nitric oxide: two required antagonists for mitochondrial homeostasis. Endocrine 2005; 27: 159-168. (Pubitemid 41558448)
    • (2005) Endocrine , vol.27 , Issue.2 , pp. 159-168
    • Acuna-Castroviejo, D.1    Escames, G.2    Lopez, L.C.3    Hitos, A.B.4    Leon, J.5
  • 123
    • 79955622602 scopus 로고    scopus 로고
    • Melatonin and steroid hormones activate intermembrane Cu,Zn-superoxide dismutase by means of mitochondrial cytochrome P450
    • Inarrea P, Casanova A, Alava MA, et al. Melatonin and steroid hormones activate intermembrane Cu,Zn-superoxide dismutase by means of mitochondrial cytochrome P450. Free Radic Biol Med 2011; 50: 1575-1581.
    • (2011) Free Radic Biol Med , vol.50 , pp. 1575-1581
    • Inarrea, P.1    Casanova, A.2    Alava, M.A.3
  • 125
    • 0035113875 scopus 로고    scopus 로고
    • Evidence for a direct effect of melatonin on mitochondrial genome expression of Siberian hamster brown adipocytes
    • DOI 10.1034/j.1600-079X.2001.300206.x
    • Prunet-Marcassus B, Ambid L, Viguerie-Bascands N, et al. Evidence for a direct effect of melatonin on mitochondrial genome expression of Siberian hamster brown adipocytes. J Pineal Res 2001; 30: 108-115. (Pubitemid 32176213)
    • (2001) Journal of Pineal Research , vol.30 , Issue.2 , pp. 108-115
    • Prunet-Marcassus, B.1    Ambid, L.2    Viguerie-Bascands, N.3    Penicaud, L.4    Casteilla, L.5
  • 126
    • 3142713361 scopus 로고    scopus 로고
    • Direct inhibition of the mitochondrial permeability transition pore: A possible mechanism responsible for anti-apoptotic effects of melatonin
    • Andrabi SA, Sayeed I, Siemen D, et al. Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin. FASEB J 2004; 18: 869-871.
    • (2004) FASEB J , vol.18 , pp. 869-871
    • Andrabi, S.A.1    Sayeed, I.2    Siemen, D.3
  • 127
    • 79954420629 scopus 로고    scopus 로고
    • 2+ stress in astrocyte
    • 2+ stress in astrocyte. J Pineal Res 2011; 50: 427-435.
    • (2011) J Pineal Res , vol.50 , pp. 427-435
    • Jou, M.J.1
  • 129
    • 79960356607 scopus 로고    scopus 로고
    • Melatonin treatment restores mitochondrial function in Alzheimer's mice: A mitochondrial protective role of melatonin membrane receptor signaling
    • Dragicevic N, Copes N, O'Neal-Moffitt G, et al. Melatonin treatment restores mitochondrial function in Alzheimer's mice: a mitochondrial protective role of melatonin membrane receptor signaling. J Pineal Res 2011; 51: 75-86.
    • (2011) J Pineal Res , vol.51 , pp. 75-86
    • Dragicevic, N.1    Copes, N.2    O'Neal-Moffitt, G.3
  • 130
    • 84904157724 scopus 로고    scopus 로고
    • Activity of melatonin against Leishmania infantum promastigotes by mitochondrial dependent pathway
    • Elmahallawy EK, Jimenez-Aranda A, Martinez AS, et al. Activity of melatonin against Leishmania infantum promastigotes by mitochondrial dependent pathway. Chem Biol Interact 2014; 220: 84-93.
    • (2014) Chem Biol Interact , vol.220 , pp. 84-93
    • Elmahallawy, E.K.1    Jimenez-Aranda, A.2    Martinez, A.S.3
  • 131
    • 84887972761 scopus 로고    scopus 로고
    • Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: A review
    • Bizzarri M, Proietti S, Cucina A, et al. Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review. Expert Opin Ther Targets 2013; 17: 1483-1496.
    • (2013) Expert Opin Ther Targets , vol.17 , pp. 1483-1496
    • Bizzarri, M.1    Proietti, S.2    Cucina, A.3
  • 132
    • 84875458202 scopus 로고    scopus 로고
    • Mechanisms involved in the pro-apoptotic effect of melatonin in cancer cells
    • Rodriguez C, Martin V, Herrera F, et al. Mechanisms involved in the pro-apoptotic effect of melatonin in cancer cells. Int J Mol Sci 2013; 14: 6597-6613.
    • (2013) Int J Mol Sci , vol.14 , pp. 6597-6613
    • Rodriguez, C.1    Martin, V.2    Herrera, F.3
  • 133
    • 0034624312 scopus 로고    scopus 로고
    • Renal toxicity of the carcinogen delta-aminolevulinic acid: Antioxidant effects of melatonin
    • Karbownik M, Tan D, Manchester LC, et al. Renal toxicity of the carcinogen delta-aminolevulinic acid: antioxidant effects of melatonin. Cancer Lett 2000; 161: 1-7.
    • (2000) Cancer Lett , vol.161 , pp. 1-7
    • Karbownik, M.1    Tan, D.2    Manchester, L.C.3
  • 135
    • 0037200831 scopus 로고    scopus 로고
    • Melatonin attenuates brain mitochondria DNA damage induced by potassium cyanide in vivo and in vitro
    • DOI 10.1016/S0300-483X(02)00244-5, PII S0300483X02002445
    • Yamamoto HA, Mohanan PV,. Melatonin attenuates brain mitochondria DNA damage induced by potassium cyanide in vivo and in vitro. Toxicology 2002; 179: 29-36. (Pubitemid 35245461)
    • (2002) Toxicology , vol.179 , Issue.1-2 , pp. 29-36
    • Yamamoto, H.-A.1    Mohanan, P.V.2
  • 136
    • 22044448363 scopus 로고    scopus 로고
    • Melatonin protects against MPTP/MPP+ -induced mitochondrial DNA oxidative damage in vivo and in vitro
    • Chen LJ, Gao YQ, Li XJ, et al. Melatonin protects against MPTP/MPP+ -induced mitochondrial DNA oxidative damage in vivo and in vitro. J Pineal Res 2005; 39: 34-42.
    • (2005) J Pineal Res , vol.39 , pp. 34-42
    • Chen, L.J.1    Gao, Y.Q.2    Li, X.J.3
  • 137
    • 34848826062 scopus 로고    scopus 로고
    • Melatonin inhibits free radical-mediated mitochondrial-dependent hepatocyte apoptosis and liver damage induced during malarial infection
    • DOI 10.1111/j.1600-079X.2007.00488.x
    • Guha M, Maity P, Choubey V, et al. Melatonin inhibits free radical-mediated mitochondrial-dependent hepatocyte apoptosis and liver damage induced during malarial infection. J Pineal Res 2007; 43: 372-381. (Pubitemid 47512269)
    • (2007) Journal of Pineal Research , vol.43 , Issue.4 , pp. 372-381
    • Guha, M.1    Maity, P.2    Choubey, V.3    Mitra, K.4    Reiter, R.J.5    Bandyopadhyay, U.6
  • 140
    • 84885186463 scopus 로고    scopus 로고
    • Melatonin improved rat cardiac mitochondria and survival rate in septic heart injury
    • Zhang H, Liu D, Wang X, et al. Melatonin improved rat cardiac mitochondria and survival rate in septic heart injury. J Pineal Res 2013; 55: 1-6.
    • (2013) J Pineal Res , vol.55 , pp. 1-6
    • Zhang, H.1    Liu, D.2    Wang, X.3
  • 141
    • 84906309654 scopus 로고    scopus 로고
    • Protective effects of melatonin against mitochondrial injury in a mouse model of multiple sclerosis
    • [Epub ahead of print].
    • Kashani IR, Rajabi Z, Akbari M, et al. Protective effects of melatonin against mitochondrial injury in a mouse model of multiple sclerosis. Exp Brain Res 2014 [Epub ahead of print].
    • (2014) Exp Brain Res
    • Kashani, I.R.1    Rajabi, Z.2    Et Al., A.M.3
  • 142
    • 84867748082 scopus 로고    scopus 로고
    • Melatonin suppresses doxorubicin-induced premature senescence of A549 lung cancer cells by ameliorating mitochondrial dysfunction
    • Song N, Kim AJ, Kim HJ, et al. Melatonin suppresses doxorubicin-induced premature senescence of A549 lung cancer cells by ameliorating mitochondrial dysfunction. J Pineal Res 2012; 53: 335-343.
    • (2012) J Pineal Res , vol.53 , pp. 335-343
    • Song, N.1    Kim, A.J.2    Kim, H.J.3
  • 143
    • 47749113264 scopus 로고    scopus 로고
    • Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice
    • Rodriguez MI, Escames G, Lopez LC, et al. Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice. Exp Gerontol 2008; 43: 749-756.
    • (2008) Exp Gerontol , vol.43 , pp. 749-756
    • Rodriguez, M.I.1    Escames, G.2    Lopez, L.C.3
  • 144
    • 0036227594 scopus 로고    scopus 로고
    • Melatonin protects hepatic mitochondrial respiratory chain activity in senescence-accelerated mice
    • DOI 10.1034/j.1600-079x.2002.1o106.x
    • Okatani Y, Wakatsuki A, Reiter RJ,. Melatonin protects hepatic mitochondrial respiratory chain activity in senescence-accelerated mice. J Pineal Res 2002; 32: 143-148. (Pubitemid 34309880)
    • (2002) Journal of Pineal Research , vol.32 , Issue.3 , pp. 143-148
    • Okatani, Y.1    Wakatsuki, A.2    Reiter, R.J.3
  • 146
    • 54249092854 scopus 로고    scopus 로고
    • Melatonin prevents age-related mitochondrial dysfunction in rat brain via cardiolipin protection
    • Petrosillo G, Fattoretti P, Matera M, et al. Melatonin prevents age-related mitochondrial dysfunction in rat brain via cardiolipin protection. Rejuvenation Res 2008; 11: 935-943.
    • (2008) Rejuvenation Res , vol.11 , pp. 935-943
    • Petrosillo, G.1    Fattoretti, P.2    Matera, M.3
  • 147
    • 68249090104 scopus 로고    scopus 로고
    • Long-term melatonin administration protects brain mitochondria from aging
    • Carretero M, Escames G, Lopez LC, et al. Long-term melatonin administration protects brain mitochondria from aging. J Pineal Res 2009; 47: 192-200.
    • (2009) J Pineal Res , vol.47 , pp. 192-200
    • Carretero, M.1    Escames, G.2    Lopez, L.C.3
  • 148
    • 84863717935 scopus 로고    scopus 로고
    • Melatonin protects lung mitochondria from aging
    • Acuna-Castroviejo D, Carretero M, Doerrier C, et al. Melatonin protects lung mitochondria from aging. Age 2012; 34: 681-692.
    • (2012) Age , vol.34 , pp. 681-692
    • Acuna-Castroviejo, D.1    Carretero, M.2    Doerrier, C.3
  • 149
    • 69249217642 scopus 로고    scopus 로고
    • Melatonin inhibits cardiolipin peroxidation in mitochondria and prevents the mitochondrial permeability transition and cytochrome c release
    • Petrosillo G, Moro N, Ruggiero FM, et al. Melatonin inhibits cardiolipin peroxidation in mitochondria and prevents the mitochondrial permeability transition and cytochrome c release. Free Radic Biol Med 2009; 47: 969-974.
    • (2009) Free Radic Biol Med , vol.47 , pp. 969-974
    • Petrosillo, G.1    Moro, N.2    Ruggiero, F.M.3
  • 150
    • 84885596203 scopus 로고    scopus 로고
    • Decline in cytochrome c oxidase activity in rat-brain mitochondria with aging. Role of peroxidized cardiolipin and beneficial effect of melatonin
    • Petrosillo G, De Benedictis V, Ruggiero FM, et al. Decline in cytochrome c oxidase activity in rat-brain mitochondria with aging. Role of peroxidized cardiolipin and beneficial effect of melatonin. J Bioenerg Biomembr 2013; 45: 431-440.
    • (2013) J Bioenerg Biomembr , vol.45 , pp. 431-440
    • Petrosillo, G.1    De Benedictis, V.2    Ruggiero, F.M.3
  • 153
    • 0004608585 scopus 로고    scopus 로고
    • Melatonin: Lowering the high price of free radicals
    • Reiter RJ,. Melatonin: lowering the high price of free radicals. News Physiol Sci 2000; 15: 246-250.
    • (2000) News Physiol Sci , vol.15 , pp. 246-250
    • Reiter, R.J.1
  • 157
    • 34848919892 scopus 로고    scopus 로고
    • Melatonin protects against common deletion of mitochondrial DNA-augmented mitochondrial oxidative stress and apoptosis
    • Jou MJ, Peng TI, Yu PZ, et al. Melatonin protects against common deletion of mitochondrial DNA-augmented mitochondrial oxidative stress and apoptosis. J Pineal Res 2007; 43: 389-403.
    • (2007) J Pineal Res , vol.43 , pp. 389-403
    • Jou, M.J.1    Peng, T.I.2    Yu, P.Z.3
  • 158
    • 3242664824 scopus 로고    scopus 로고
    • Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress-induced apoptosis of rat brain astrocytes
    • DOI 10.1111/j.1600-079X.2004.00140.x
    • Jou MJ, Peng TI, Reiter RJ, et al. Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress-induced apoptosis of rat brain astrocytes. J Pineal Res 2004; 37: 55-70. (Pubitemid 38969021)
    • (2004) Journal of Pineal Research , vol.37 , Issue.1 , pp. 55-70
    • Jou, M.-J.1    Peng, T.-I.2    Reiter, R.J.3    Jou, S.-B.4    Wu, H.-Y.5    Wen, S.-T.6
  • 159
    • 33947592217 scopus 로고    scopus 로고
    • Melatonin and its metabolites: New findings regarding their production and their radical scavenging actions
    • Reiter RJ, Tan DX, Terron MP, et al. Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions. Acta Biochim Pol 2007; 54: 1-9. (Pubitemid 46481811)
    • (2007) Acta Biochimica Polonica , vol.54 , Issue.1 , pp. 1-9
    • Reiter, R.J.1    Tan, D.-X.2    Terron, M.P.3    Flores, L.J.4    Czarnocki, Z.5
  • 160
    • 79952573098 scopus 로고    scopus 로고
    • Reaction mechanism of melatonin oxidation by reactive oxygen species in vitro
    • Bonnefont-Rousselot D, Collin F, Jore D, et al. Reaction mechanism of melatonin oxidation by reactive oxygen species in vitro. J Pineal Res 2011; 50: 328-335.
    • (2011) J Pineal Res , vol.50 , pp. 328-335
    • Bonnefont-Rousselot, D.1    Collin, F.2    Jore, D.3
  • 163
    • 77955140547 scopus 로고    scopus 로고
    • Analysis of N1-acetyl-N2-formyl-5-methoxykynuramine/N1-acetyl-5-methoxy- kynuramine formation from melatonin in mice
    • Niu S, Li F, Tan DX, et al. Analysis of N1-acetyl-N2-formyl-5- methoxykynuramine/N1-acetyl-5-methoxy-kynuramine formation from melatonin in
    • (2010) J Pineal Res , vol.49 , pp. 106-114
    • Niu, S.1    Li, F.2    Tan, D.X.3
  • 164
    • 68249129060 scopus 로고    scopus 로고
    • Kynuramines, metabolites of melatonin and other indoles: The resurrection of an almost forgotten class of biogenic amines
    • Hardeland R, Tan DX, Reiter RJ,. Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines. J Pineal Res 2009; 47: 109-126.
    • (2009) J Pineal Res , vol.47 , pp. 109-126
    • Hardeland, R.1    Tan, D.X.2    Reiter, R.J.3
  • 167
    • 14344265259 scopus 로고    scopus 로고
    • 2-formyl-5-methoxykynuramine, quercetin or resveratrol
    • DOI 10.1111/j.1600-079X.2004.00180.x
    • Onuki J, Almeida EA, Medeiros MH, et al. Inhibition of 5-aminolevulinic acid-induced DNA damage by melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine, quercetin or resveratrol. J Pineal Res 2005; 38: 107-115. (Pubitemid 40293235)
    • (2005) Journal of Pineal Research , vol.38 , Issue.2 , pp. 107-115
    • Onuki, J.1    Almeida, E.A.2    Medeiros, M.H.G.3    Di Mascio, P.4
  • 168
    • 84904507080 scopus 로고    scopus 로고
    • Melatonin and its metabolites ameliorate UVB-induced damages in human epidermal keratinocytes
    • Janjetovic Z, Nahmias ZP, Hanna S, et al. Melatonin and its metabolites ameliorate UVB-induced damages in human epidermal keratinocytes. J Pineal Res 2014; 57: 90-102.
    • (2014) J Pineal Res , vol.57 , pp. 90-102
    • Janjetovic, Z.1    Nahmias, Z.P.2    Hanna, S.3
  • 169
    • 34147201601 scopus 로고    scopus 로고
    • AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice
    • DOI 10.1111/j.1600-079X.2007.00432.x
    • Manda K, Ueno M, Anzai K,. AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. J Pineal Res 2007; 42: 386-393. (Pubitemid 46581663)
    • (2007) Journal of Pineal Research , vol.42 , Issue.4 , pp. 386-393
    • Manda, K.1    Ueno, M.2    Anzai, K.3
  • 170
    • 57149130854 scopus 로고    scopus 로고
    • The melatonin metabolite N-acetyl-5-methoxykynuramine is a potent singlet oxygen scavenger
    • Schaefer M, Hardeland R,. The melatonin metabolite N-acetyl-5- methoxykynuramine is a potent singlet oxygen scavenger. J Pineal Res 2009; 46: 49-52.
    • (2009) J Pineal Res , vol.46 , pp. 49-52
    • Schaefer, M.1    Hardeland, R.2
  • 171
    • 27644552995 scopus 로고    scopus 로고
    • Antioxidative protection by melatonin: Multiplicity of mechanisms from radical detoxification to radical avoidance
    • DOI 10.1385/ENDO:27:2:119
    • Hardeland R,. Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance. Endocrine 2005; 27: 119-130. (Pubitemid 41558444)
    • (2005) Endocrine , vol.27 , Issue.2 , pp. 119-130
    • Hardeland, R.1
  • 172
    • 68249127673 scopus 로고    scopus 로고
    • Melatonin and its brain metabolite N(1)-acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice
    • Tapias V, Escames G, Lopez LC, et al. Melatonin and its brain metabolite N(1)-acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice. J Neurosci Res 2009; 87: 3002-3010.
    • (2009) J Neurosci Res , vol.87 , pp. 3002-3010
    • Tapias, V.1    Escames, G.2    Lopez, L.C.3
  • 174
    • 78049451374 scopus 로고    scopus 로고
    • Melatonin: A pleiotropic molecule regulating inflammation
    • Radogna F, Diederich M, Ghibelli L,. Melatonin: a pleiotropic molecule regulating inflammation. Biochem Pharmacol 2010; 80: 1844-1852.
    • (2010) Biochem Pharmacol , vol.80 , pp. 1844-1852
    • Radogna, F.1    Diederich, M.2    Ghibelli, L.3
  • 175
    • 84872685423 scopus 로고    scopus 로고
    • A review of the molecular aspects of melatonin's anti-inflammatory actions: Recent insights and new perspectives
    • Mauriz JL, Collado PS, Veneroso C, et al. A review of the molecular aspects of melatonin's anti-inflammatory actions: recent insights and new perspectives. J Pineal Res 2013; 54: 1-14.
    • (2013) J Pineal Res , vol.54 , pp. 1-14
    • Mauriz, J.L.1    Collado, P.S.2    Veneroso, C.3
  • 176
    • 0021277141 scopus 로고
    • N-acetyl-5-methoxy kynurenamine, a brain metabolite of melatonin, is a potent inhibitor of prostaglandin biosynthesis
    • Kelly RW, Amato F, Seamark RF,. N-acetyl-5-methoxy kynurenamine, a brain metabolite of melatonin, is a potent inhibitor of prostaglandin biosynthesis. Biochem Biophys Res Commun 1984; 121: 372-379. (Pubitemid 14117162)
    • (1984) Biochemical and Biophysical Research Communications , vol.121 , Issue.1 , pp. 372-379
    • Kelly, R.W.1    Amato, F.2    Seamark, R.F.3
  • 177
    • 22144498398 scopus 로고    scopus 로고
    • Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages
    • DOI 10.1016/j.jneuroim.2005.05.002, PII S0165572805001724
    • Mayo JC, Sainz RM, Tan DX, et al. Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages. J Neuroimmunol 2005; 165: 139-149. (Pubitemid 40984631)
    • (2005) Journal of Neuroimmunology , vol.165 , Issue.1-2 , pp. 139-149
    • Mayo, J.C.1    Sainz, R.M.2    Tan, D.-X.3    Hardeland, R.4    Leon, J.5    Rodriguez, C.6    Reiter, R.J.7
  • 178
    • 33847635974 scopus 로고    scopus 로고
    • 2-formyl-5-methoxykynuramine modulates the cell cycle of malaria parasites
    • DOI 10.1111/j.1600-079X.2006.00414.x
    • Budu A, Peres R, Bueno VB, et al. N1-acetyl-N2-formyl-5-methoxykynuramine modulates the cell cycle of malaria parasites. J Pineal Res 2007; 42: 261-266. (Pubitemid 46365063)
    • (2007) Journal of Pineal Research , vol.42 , Issue.3 , pp. 261-266
    • Budu, A.1    Peres, R.2    Bueno, V.B.3    Catalani, L.H.4    Garcia, C.R.D.S.5
  • 179
    • 69149105021 scopus 로고    scopus 로고
    • Intracellular prooxidant activity of melatonin induces a survival pathway involving NF-kappaB activation
    • Cristofanon S, Uguccioni F, Cerella C, et al. Intracellular prooxidant activity of melatonin induces a survival pathway involving NF-kappaB activation. Ann N Y Acad Sci 2009; 1171: 472-478.
    • (2009) Ann N y Acad Sci , vol.1171 , pp. 472-478
    • Cristofanon, S.1    Uguccioni, F.2    Cerella, C.3
  • 180
    • 79960343104 scopus 로고    scopus 로고
    • Melatonin promotes proliferation and differentiation of neural stem cells subjected to hypoxia in vitro
    • Fu J, Zhao SD, Liu HJ, et al. Melatonin promotes proliferation and differentiation of neural stem cells subjected to hypoxia in vitro. J Pineal Res 2011; 51: 104-112.
    • (2011) J Pineal Res , vol.51 , pp. 104-112
    • Fu, J.1    Zhao, S.D.2    Liu, H.J.3
  • 181
    • 84856706859 scopus 로고    scopus 로고
    • Melatonin prevents human pancreatic carcinoma cell PANC-1-induced human umbilical vein endothelial cell proliferation and migration by inhibiting vascular endothelial growth factor expression
    • Cui P, Yu M, Peng X, et al. Melatonin prevents human pancreatic carcinoma cell PANC-1-induced human umbilical vein endothelial cell proliferation and migration by inhibiting vascular endothelial growth factor expression. J Pineal Res 2012; 52: 236-243.
    • (2012) J Pineal Res , vol.52 , pp. 236-243
    • Cui, P.1    Yu, M.2    Peng, X.3
  • 182
    • 0030767867 scopus 로고    scopus 로고
    • Effects of melatonin on proliferation, oxidative stress and Cx32 gap junction protein expression in primary cultures of adult rat hepatocytes
    • Kojima T, Mochizuki C, Mitaka T, et al. Effects of melatonin on proliferation, oxidative stress and Cx32 gap junction protein expression in primary cultures of adult rat hepatocytes. Cell Struct Funct 1997; 22: 347-356. (Pubitemid 27365905)
    • (1997) Cell Structure and Function , vol.22 , Issue.3 , pp. 347-356
    • Kojima, T.1    Mochizuki, C.2    Mitaka, T.3    Mochizuki, Y.4
  • 183
    • 0028921581 scopus 로고
    • Calmodulin-binding domains: Just two faced or multi-faceted?
    • James P, Vorherr T, Carafoli E,. Calmodulin-binding domains: just two faced or multi-faceted? Trends Biochem Sci 1995; 20: 38-42.
    • (1995) Trends Biochem Sci , vol.20 , pp. 38-42
    • James, P.1    Vorherr, T.2    Carafoli, E.3
  • 186
    • 80054082654 scopus 로고    scopus 로고
    • Phospholipase A2 enzymes: Physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention
    • Dennis EA, Cao J, Hsu YH, et al. Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chem Rev 2011; 111: 6130-6185.
    • (2011) Chem Rev , vol.111 , pp. 6130-6185
    • Dennis, E.A.1    Cao, J.2    Hsu, Y.H.3
  • 187
    • 0035831490 scopus 로고    scopus 로고
    • Identification of the calmodulin-binding domain of recombinant calcium-independent phospholipase A2beta implications for structure and function
    • Jenkins CM, Wolf MJ, Mancuso DJ, et al. Identification of the calmodulin-binding domain of recombinant calcium-independent phospholipase A2beta. implications for structure and function. J Biol Chem 2001; 276: 7129-7135.
    • (2001) J Biol Chem , vol.276 , pp. 7129-7135
    • Jenkins, C.M.1    Wolf, M.J.2    Mancuso, D.J.3
  • 188
    • 3543128199 scopus 로고    scopus 로고
    • Membrane-bound calmodulin in xenopus laevis oocytes as a novel binding site for melatonin
    • Romero MP, Garcia-Perganeda A, Guerrero JM, et al. Membrane-bound calmodulin in Xenopus laevis oocytes as a novel binding site for melatonin. FASEB J 1998; 12: 1401-1408. (Pubitemid 28475582)
    • (1998) FASEB Journal , vol.12 , Issue.13 , pp. 1401-1408
    • Paz Romero, M.1    Garcia-Perganeda, A.2    Guerrero, J.M.3    Osuna, C.4
  • 189
    • 0031922787 scopus 로고    scopus 로고
    • Modulation of the subcellular distribution of calmodulin by melatonin in MDCK cells
    • DOI 10.1111/j.1600-079X.1998.tb00363.x
    • Anton-Tay F, Martinez I, Tovar R, et al. Modulation of the subcellular distribution of calmodulin by melatonin in MDCK cells. J Pineal Res 1998; 24: 35-42. (Pubitemid 28161019)
    • (1998) Journal of Pineal Research , vol.24 , Issue.1 , pp. 35-42
    • Anton-Tay, F.1    Martinez, I.2    Tovar, R.3    Benitez-King, G.4
  • 191
    • 84878424820 scopus 로고    scopus 로고
    • New evidence for cross talk between melatonin and mitochondria mediated by a circadian-compatible interaction with nitric oxide
    • Sarti P, Magnifico MC, Altieri F, et al. New evidence for cross talk between melatonin and mitochondria mediated by a circadian-compatible interaction with nitric oxide. Int J Mol Sci 2013; 14: 11259-11276.
    • (2013) Int J Mol Sci , vol.14 , pp. 11259-11276
    • Sarti, P.1    Magnifico, M.C.2    Altieri, F.3
  • 192
    • 84862766247 scopus 로고    scopus 로고
    • Interactions of melatonin with mammalian mitochondria. Reducer of energy capacity and amplifier of permeability transition
    • Martinis P, Zago L, Maritati M, et al. Interactions of melatonin with mammalian mitochondria. Reducer of energy capacity and amplifier of permeability transition. Amino Acids 2012; 42: 1827-1837.
    • (2012) Amino Acids , vol.42 , pp. 1827-1837
    • Martinis, P.1    Zago, L.2    Maritati, M.3
  • 193
    • 59149094114 scopus 로고    scopus 로고
    • Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production
    • Lopez A, Garcia JA, Escames G, et al. Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production. J Pineal Res 2009; 46: 188-198.
    • (2009) J Pineal Res , vol.46 , pp. 188-198
    • Lopez, A.1    Garcia, J.A.2    Escames, G.3
  • 194
    • 84857313612 scopus 로고    scopus 로고
    • Nanomolar melatonin enhances nNOS expression and controls HaCaT-cells bioenergetics
    • Arese M, Magnifico MC, Mastronicola D, et al. Nanomolar melatonin enhances nNOS expression and controls HaCaT-cells bioenergetics. IUBMB Life 2012; 64: 251-258.
    • (2012) IUBMB Life , vol.64 , pp. 251-258
    • Arese, M.1    Magnifico, M.C.2    Mastronicola, D.3
  • 195
    • 1542409979 scopus 로고    scopus 로고
    • Changes in the Apoptotic and Survival Signaling in Cancer Cells and Their Potential Therapeutic Implications
    • DOI 10.2174/1568009043481551
    • Kabore AF, Johnston JB, Gibson SB,. Changes in the apoptotic and survival signaling in cancer cells and their potential therapeutic implications. Curr Cancer Drug Targets 2004; 4: 147-163. (Pubitemid 38332553)
    • (2004) Current Cancer Drug Targets , vol.4 , Issue.2 , pp. 147-163
    • Kabore, A.F.1    Johnston, J.B.2    Gibson, S.B.3
  • 196
    • 2942593991 scopus 로고    scopus 로고
    • ROS stress in cancer cells and therapeutic implications
    • DOI 10.1016/j.drup.2004.01.004
    • Pelicano H, Carney D, Huang P,. ROS stress in cancer cells and therapeutic implications. Drug Resist Updat 2004; 7: 97-110. (Pubitemid 38736063)
    • (2004) Drug Resistance Updates , vol.7 , Issue.2 , pp. 97-110
    • Pelicano, H.1    Carney, D.2    Huang, P.3
  • 197
    • 77649187905 scopus 로고    scopus 로고
    • The Warburg effect and mitochondrial stability in cancer cells
    • Gogvadze V, Zhivotovsky B, Orrenius S,. The Warburg effect and mitochondrial stability in cancer cells. Mol Aspects Med 2010; 31: 60-74.
    • (2010) Mol Aspects Med , vol.31 , pp. 60-74
    • Gogvadze, V.1    Zhivotovsky, B.2    Orrenius, S.3
  • 200
    • 84892952980 scopus 로고    scopus 로고
    • Production of reactive oxygen species in the diabetic heart. Roles of mitochondria and NADPH oxidase
    • Teshima Y, Takahashi N, Nishio S, et al. Production of reactive oxygen species in the diabetic heart. Roles of mitochondria and NADPH oxidase. Circ J 2014; 78: 300-306.
    • (2014) Circ J , vol.78 , pp. 300-306
    • Teshima, Y.1    Takahashi, N.2    Nishio, S.3
  • 201
    • 0028511448 scopus 로고
    • Inhibitory effect of melatonin on cataract formation in newborn rats: Evidence for an antioxidative role for melatonin
    • Abe M, Reiter RJ, Orhii PB, et al. Inhibitory effect of melatonin on cataract formation in newborn rats: evidence for an antioxidative role for melatonin. J Pineal Res 1994; 17: 94-100.
    • (1994) J Pineal Res , vol.17 , pp. 94-100
    • Abe, M.1    Reiter, R.J.2    Orhii, P.B.3
  • 202
    • 80051667861 scopus 로고    scopus 로고
    • Corrections by melatonin of liver mitochondrial disorders under diabetes and acute intoxication in rats
    • Cheshchevik VT, Dremza IK, Lapshina EA, et al. Corrections by melatonin of liver mitochondrial disorders under diabetes and acute intoxication in rats. Cell Biochem Funct 2011; 29: 481-488.
    • (2011) Cell Biochem Funct , vol.29 , pp. 481-488
    • Cheshchevik, V.T.1    Dremza, I.K.2    Lapshina, E.A.3
  • 203
    • 84865627272 scopus 로고    scopus 로고
    • Obesity and metabolic syndrome: Association with chronodisruption, sleep deprivation, and melatonin suppression
    • Reiter RJ, Tan DX, Korkmaz A, et al. Obesity and metabolic syndrome: association with chronodisruption, sleep deprivation, and melatonin suppression. Ann Med 2012; 44: 564-577.
    • (2012) Ann Med , vol.44 , pp. 564-577
    • Reiter, R.J.1    Tan, D.X.2    Korkmaz, A.3
  • 204
    • 78649836904 scopus 로고    scopus 로고
    • Extended exposure to dietary melatonin reduces tumor number and size in aged male mice
    • Sharman EH, Sharman KG, Bondy SC,. Extended exposure to dietary melatonin reduces tumor number and size in aged male mice. Exp Gerontol 2011; 46: 18-22.
    • (2011) Exp Gerontol , vol.46 , pp. 18-22
    • Sharman, E.H.1    Sharman, K.G.2    Bondy, S.C.3
  • 205
    • 84874948547 scopus 로고    scopus 로고
    • Melatonin suppresses tumor progression by reducing angiogenesis stimulated by HIF-1 in a mouse tumor model
    • Kim KJ, Choi JS, Kang I, et al. Melatonin suppresses tumor progression by reducing angiogenesis stimulated by HIF-1 in a mouse tumor model. J Pineal Res 2013; 54: 264-270.
    • (2013) J Pineal Res , vol.54 , pp. 264-270
    • Kim, K.J.1    Choi, J.S.2    Kang, I.3
  • 206
    • 0038054054 scopus 로고    scopus 로고
    • Protective effect of melatonin against mitochondrial injury induced by ischemia and reperfusion of rat liver
    • DOI 10.1016/S0014-2999(03)01643-1
    • Okatani Y, Wakatsuki A, Reiter RJ, et al. Protective effect of melatonin against mitochondrial injury induced by ischemia and reperfusion of rat liver. Eur J Pharmacol 2003; 469: 145-152. (Pubitemid 36629560)
    • (2003) European Journal of Pharmacology , vol.469 , Issue.1-3 , pp. 145-152
    • Okatani, Y.1    Wakatsuki, A.2    Reiter, R.J.3    Enzan, H.4    Miyahara, Y.5
  • 207
    • 7644221985 scopus 로고    scopus 로고
    • Maternally administered melatonin protects against ischemia and reperfusion-induced oxidative mitochondrial damage in premature fetal rat brain
    • DOI 10.1111/j.1600-079X.2004.00167.x
    • Watanabe K, Wakatsuki A, Shinohara K, et al. Maternally administered melatonin protects against ischemia and reperfusion-induced oxidative mitochondrial damage in premature fetal rat brain. J Pineal Res 2004; 37: 276-280. (Pubitemid 39457049)
    • (2004) Journal of Pineal Research , vol.37 , Issue.4 , pp. 276-280
    • Watanabe, K.1    Wakatsuki, A.2    Shinohara, K.3    Ikenoue, N.4    Yokota, K.5    Fukaya, T.6
  • 208
    • 78149420495 scopus 로고    scopus 로고
    • Role of melatonin in preventing mitochondrial dysfunction in myocardial ischemia-reperfusion injury
    • Dominguez-Rodriguez A, Arroyo-Ucar E, Abreu-Gonzalez P,. Role of melatonin in preventing mitochondrial dysfunction in myocardial ischemia-reperfusion injury. Am J Cardiol 2010; 106: 1521-1522.
    • (2010) Am J Cardiol , vol.106 , pp. 1521-1522
    • Dominguez-Rodriguez, A.1    Arroyo-Ucar, E.2    Abreu-Gonzalez, P.3
  • 209
    • 70349624362 scopus 로고    scopus 로고
    • Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening
    • Petrosillo G, Colantuono G, Moro N, et al. Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening. Am J Physiol Heart Circ Physiol 2009; 297: H1487-H1493.
    • (2009) Am J Physiol Heart Circ Physiol , vol.297
    • Petrosillo, G.1    Colantuono, G.2    Moro, N.3
  • 210
    • 34848911302 scopus 로고    scopus 로고
    • Melatonin in cardiac ischemia/reperfusion-induced mitochondrial adaptive changes
    • DOI 10.2174/187152907781745297
    • Giacomo CG, Antonio M,. Melatonin in cardiac ischemia/reperfusion-induced mitochondrial adaptive changes. Cardiovasc Hematol Disord Drug Targets 2007; 7: 163-169. (Pubitemid 47496573)
    • (2007) Cardiovascular and Hematological Disorders - Drug Targets , vol.7 , Issue.3 , pp. 163-169
    • Giacomo, C.G.1    Antonio, M.2
  • 211
    • 12744273107 scopus 로고    scopus 로고
    • When melatonin gets on your nerves: Its beneficial actions in experimental models of stroke
    • Reiter RJ, Tan DX, Leon J, et al. When melatonin gets on your nerves: its beneficial actions in experimental models of stroke. Exp Biol Med 2005; 230: 104-117.
    • (2005) Exp Biol Med , vol.230 , pp. 104-117
    • Reiter, R.J.1    Tan, D.X.2    Leon, J.3
  • 212
    • 84883739426 scopus 로고    scopus 로고
    • JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury
    • Yang Y, Duan W, Jin Z, et al. JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury. J Pineal Res 2013; 55: 275-286.
    • (2013) J Pineal Res , vol.55 , pp. 275-286
    • Yang, Y.1    Duan, W.2    Jin, Z.3
  • 213
    • 78650672113 scopus 로고    scopus 로고
    • Basic mechanisms involved in the anti-cancer effects of melatonin
    • Mediavilla MD, Sanchez-Barcelo EJ, Tan DX, et al. Basic mechanisms involved in the anti-cancer effects of melatonin. Curr Med Chem 2010; 17: 4462-4481.
    • (2010) Curr Med Chem , vol.17 , pp. 4462-4481
    • Mediavilla, M.D.1    Sanchez-Barcelo, E.J.2    Tan, D.X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.