-
1
-
-
0036017506
-
Expression of MDR1/P-glycoprotein, the multidrug resistance protein MRP, the lung-resistance protein LRP in multiple myeloma
-
Schwarzenbach, H. Expression of MDR1/P-glycoprotein, the multidrug resistance protein MRP, the lung-resistance protein LRP in multiple myeloma. Med. Oncol, 2002, 19, 87-104.
-
(2002)
Med. Oncol
, vol.19
, pp. 87-104
-
-
Schwarzenbach, H.1
-
2
-
-
35748932956
-
Management of relapsed and relapsed refractory myeloma
-
Kastritis, E.; Mitsiades, C.S.; Dimopoulos, M.A.; Richardson, PG. Management of relapsed and relapsed refractory myeloma. Hematol. Oncol. Clin. N. Am., 2007, 21, 1175-1215.
-
(2007)
Hematol. Oncol. Clin. N. Am
, vol.21
, pp. 1175-1215
-
-
Kastritis, E.1
Mitsiades, C.S.2
Dimopoulos, M.A.3
Richardson, P.G.4
-
3
-
-
0033105537
-
Cell adhesion mediated drug resistance (CAM-DR): Role of integrins and resistance to apoptosis in human myeloma cell lines
-
Damiano, J.S.; Cress, A.E.; Hazlehurst, L.A.; Shtil, A.A.; Dalton, W.S. Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines. Blood, 1999, 93, 1658-1667.
-
(1999)
Blood
, vol.93
, pp. 1658-1667
-
-
Damiano, J.S.1
Cress, A.E.2
Hazlehurst, L.A.3
Shtil, A.A.4
Dalton, W.S.5
-
4
-
-
0034618384
-
Adhesion to fibronectin via (31 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR)
-
Hazlehurst, L.A.; Damiano, J.S.; Buyuksal, I; Pledger, W.U.; Dalton, WS. Adhesion to fibronectin via (31 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR). Oncogene, 2000, 19, 4319-4327.
-
(2000)
Oncogene
, vol.19
, pp. 4319-4327
-
-
Hazlehurst, L.A.1
Damiano, J.S.2
Buyuksal, I.3
Pledger, W.U.4
Dalton, W.S.5
-
5
-
-
0034548453
-
The phosphatidylinositol 3-kinase/AKT kinase pathway in multiple myeloma plasma cells: Roles in cytokine-dependent survival and proliferative responses
-
Tu, Y.; Gardner, A.; Lichtenstein A. The phosphatidylinositol 3-kinase/AKT kinase pathway in multiple myeloma plasma cells: roles in cytokine-dependent survival and proliferative responses. Cancer Res., 2000, 60, 6763-6770.
-
(2000)
Cancer Res
, vol.60
, pp. 6763-6770
-
-
Tu, Y.1
Gardner, A.2
Lichtenstein, A.3
-
6
-
-
0035921689
-
Biologic sequelae of interleukin-6 induced PI3K/Akt signaling in multiple myeloma
-
Hideshima, T.; Nakamura, N; Chauhan, D.; Anderson, K.C. Biologic sequelae of interleukin-6 induced PI3K/Akt signaling in multiple myeloma. Oncogene, 2001, 20, 5991-6000.
-
(2001)
Oncogene
, vol.20
, pp. 5991-6000
-
-
Hideshima, T.1
Nakamura, N.2
Chauhan, D.3
Anderson, K.C.4
-
7
-
-
0037158513
-
Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: Therapeutic implications
-
Mitsiades, C.S.; Mitsiades, N; Poulaki, V.; Schlossman, R.; Akiyama, M.; Chauhan, D.; Fanourakis, G.; Gu, X.; Bailey, C; Joseph, M.; Libermann, T.A.; Schlossman, R.; Munshi, N.C.; Hideshima, T.; Anderson, K.C. Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications. Oncogene, 2002, 21, 5673-5683.
-
(2002)
Oncogene
, vol.21
, pp. 5673-5683
-
-
Mitsiades, C.S.1
Mitsiades, N.2
Poulaki, V.3
Schlossman, R.4
Akiyama, M.5
Chauhan, D.6
Fanourakis, G.7
Gu, X.8
Bailey, C.9
Joseph, M.10
Libermann, T.A.11
Schlossman, R.12
Munshi, N.C.13
Hideshima, T.14
Anderson, K.C.15
-
8
-
-
0036884062
-
Molecular mechanisms of novel therapeutic approaches for multiple myeloma
-
Hideshima, T.; Anderson, K.C. Molecular mechanisms of novel therapeutic approaches for multiple myeloma. Nat. Rev. Cancer, 2002, 2, 927-937.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 927-937
-
-
Hideshima, T.1
Anderson, K.C.2
-
9
-
-
34447134867
-
Targeting the phosphatidylinositol 3-kinase pathway in multiple myeloma
-
Younes H, Leleu X.; Hatjiharissi, E.; Moreau, A.S.; Hideshima, T.; Richardson, P.; Anderson, K.C; Ghobrial, I.M. Targeting the phosphatidylinositol 3-kinase pathway in multiple myeloma. Clin. Cancer Res., 2007, 13, 3771-3775.
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 3771-3775
-
-
Younes, H.1
Leleu, X.2
Hatjiharissi, E.3
Moreau, A.S.4
Hideshima, T.5
Richardson, P.6
Anderson, K.C.7
Ghobrial, I.M.8
-
10
-
-
33845348577
-
The JAK-STAT pathway: A therapeutic target in hematological malignancies
-
Ferrajoli, A.; Faderl, S.; Ravandi, F.; Estrov, Z. The JAK-STAT pathway: a therapeutic target in hematological malignancies. Curr. Cancer Drug Targets, 2006, 6, 671-679.
-
(2006)
Curr. Cancer Drug Targets
, vol.6
, pp. 671-679
-
-
Ferrajoli, A.1
Faderl, S.2
Ravandi, F.3
Estrov, Z.4
-
11
-
-
50149116996
-
Cantharidin induces apoptosis of human multiple myeloma cells via inhibition of the JAK/STAT pathway
-
Sagawa, M.; Nakazato, T; Uchida, H; Ikeda, Y; Kizaki, M. Cantharidin induces apoptosis of human multiple myeloma cells via inhibition of the JAK/STAT pathway. Cancer Sci., 2008, 99, 1820-1826.
-
(2008)
Cancer Sci
, vol.99
, pp. 1820-1826
-
-
Sagawa, M.1
Nakazato, T.2
Uchida, H.3
Ikeda, Y.4
Kizaki, M.5
-
12
-
-
9344245148
-
Transforming growth factor beta receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment
-
Hayashi, T.; Hideshima, T.; Nguyen, A.N.; Munoz, O.; Podar, K.; Hamasaki, M.; Ishitsuka, K.; Yasui, H.; Richardson, P.; Chakravarty, S.; Murphy, A.; Chauhan, D.; Higgins, L.S.; Anderson, K.C. Transforming growth factor beta receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment. Clin. Cancer Res., 2004, 10, 7540-7546.
-
(2004)
Clin. Cancer Res
, vol.10
, pp. 7540-7546
-
-
Hayashi, T.1
Hideshima, T.2
Nguyen, A.N.3
Munoz, O.4
Podar, K.5
Hamasaki, M.6
Ishitsuka, K.7
Yasui, H.8
Richardson, P.9
Chakravarty, S.10
Murphy, A.11
Chauhan, D.12
Higgins, L.S.13
Anderson, K.C.14
-
13
-
-
0030026437
-
Transforming growth factor-beta1: Differential effects on multiple myeloma versus normal B cells
-
Urashima, M.; Ogata, A.; Chauhan, D.; Hatziyanni, M.; Vidriales, M.B.; Dedera, D.A.; Schlossman R.L.; Anderson, K.C. Transforming growth factor-beta1: differential effects on multiple myeloma versus normal B cells. Blood, 1996, 87, 1928-1938.
-
(1996)
Blood
, vol.87
, pp. 1928-1938
-
-
Urashima, M.1
Ogata, A.2
Chauhan, D.3
Hatziyanni, M.4
Vidriales, M.B.5
Dedera, D.A.6
Schlossman, R.L.7
Anderson, K.C.8
-
14
-
-
0346363760
-
The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
-
Tian, E.; Zhan, F.; Walker, R.; Rasmussen, E.; Ma, Y.; Barlogie, B.; Shaughnessy, J.D. Jr. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl. J. Med, 2003, 349, 2483-2494.
-
(2003)
N Engl. J. Med
, vol.349
, pp. 2483-2494
-
-
Tian, E.1
Zhan, F.2
Walker, R.3
Rasmussen, E.4
Ma, Y.5
Barlogie, B.6
Shaughnessy Jr., J.D.7
-
15
-
-
33750704287
-
Wnt antagonism in multiple myeloma: A potential cause of uncoupled bone remodeling
-
Pearse, R.N. Wnt antagonism in multiple myeloma: a potential cause of uncoupled bone remodeling. Clin. Cancer Res., 2006, 12(20, Pt 2), 6274s-6278s.
-
(2006)
Clin. Cancer Res
, vol.12
, Issue.20 Pt 2
-
-
Pearse, R.N.1
-
16
-
-
11144358653
-
Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells
-
Jundt, F.; Pröbsting, KS.; Anagnostopoulos, I.; Muehlinghaus, G.; Chatterjee, M.; Mathas, S.; Bargou, R.C.; Manz, R.; Stein, H.; Dörken, B. Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells. Blood, 2004, 103, 3511-3515.
-
(2004)
Blood
, vol.103
, pp. 3511-3515
-
-
Jundt, F.1
Pröbsting, K.S.2
Anagnostopoulos, I.3
Muehlinghaus, G.4
Chatterjee, M.5
Mathas, S.6
Bargou, R.C.7
Manz, R.8
Stein, H.9
Dörken, B.10
-
17
-
-
1942425110
-
Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines
-
Nefedova, Y.; Cheng, P.; Alsina, M.; Dalton, W.S.; Gabrilovich, D.I. Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines. Blood, 2004, 103, 3503-3510.
-
(2004)
Blood
, vol.103
, pp. 3503-3510
-
-
Nefedova, Y.1
Cheng, P.2
Alsina, M.3
Dalton, W.S.4
Gabrilovich, D.I.5
-
18
-
-
0027303072
-
Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226
-
Freund, G.G.; Kulas, D.T.; Mooney, R.A. Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226. J. Immunol, 1993, 151, 1811-1820.
-
(1993)
J. Immunol
, vol.151
, pp. 1811-1820
-
-
Freund, G.G.1
Kulas, D.T.2
Mooney, R.A.3
-
19
-
-
12144290914
-
Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors
-
Mitsiades, C.S.; Mitsiades, N.S.; McMullan, C.J.; Poulaki, V.; Shringarpure, R.; Akiyama, M.; Hideshima, T.; Chauhan, D.; Joseph, M.; Libermann, T.A.; García-Echeverría, C; Pearson, M.A.; Hofmann, F.; Anderson, K.C.; Kung, A.L. Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Cancer Cell, 2004, 5, 221-230.
-
(2004)
Cancer Cell
, vol.5
, pp. 221-230
-
-
Mitsiades, C.S.1
Mitsiades, N.S.2
McMullan, C.J.3
Poulaki, V.4
Shringarpure, R.5
Akiyama, M.6
Hideshima, T.7
Chauhan, D.8
Joseph, M.9
Libermann, T.A.10
García-Echeverría, C.11
Pearson, M.A.12
Hofmann, F.13
Anderson, K.C.14
Kung, A.L.15
-
20
-
-
34347371570
-
Pleiotrophin is highly expressed by myeloma cells and promotes myeloma tumor growth
-
Chen, H.; Gordon, M.S.; Campbell, R.A.; Li, M.; Wang, C.S.; Lee, H.J.; Sanchez, E.; Manyak, S.J.; Gui, D.; Shalitin, D.; Said, J.; Chang, Y.; Deuel, T.F.; Baritaki, S.; Bonavida, B.; Berenson, J.R. Pleiotrophin is highly expressed by myeloma cells and promotes myeloma tumor growth. Blood, 2007, 110, 287-295.
-
(2007)
Blood
, vol.110
, pp. 287-295
-
-
Chen, H.1
Gordon, M.S.2
Campbell, R.A.3
Li, M.4
Wang, C.S.5
Lee, H.J.6
Sanchez, E.7
Manyak, S.J.8
Gui, D.9
Shalitin, D.10
Said, J.11
Chang, Y.12
Deuel, T.F.13
Baritaki, S.14
Bonavida, B.15
Berenson, J.R.16
-
21
-
-
33947537205
-
Relevance of Ras gene mutations in the context of the molecular heterogeneity of multiple myeloma
-
Intini, D.; Agnelli, L.; Ciceri, G.; Ronchetti, D.; Fabris, S.; Nobili, L.; Lambertenghi-Deliliers, G.; Lombardi, L.; Neri, A. Relevance of Ras gene mutations in the context of the molecular heterogeneity of multiple myeloma. Hematol.Oncol, 2007, 25, 6-10.
-
(2007)
Hematol.Oncol
, vol.25
, pp. 6-10
-
-
Intini, D.1
Agnelli, L.2
Ciceri, G.3
Ronchetti, D.4
Fabris, S.5
Nobili, L.6
Lambertenghi-Deliliers, G.7
Lombardi, L.8
Neri, A.9
-
22
-
-
0034876702
-
High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis
-
Bezieau, S.; Devilder, M.C.; Avet-Loiseau, H.; Mellerin, M.P.; Puthier, D.; Pennarun, E.; Rapp, M.J., Harousseau, J.L.; Moisan, J.P.; Bataille, R High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis. Hum. Mutat, 2001, 18, 212-224.
-
(2001)
Hum. Mutat
, vol.18
, pp. 212-224
-
-
Bezieau, S.1
Devilder, M.C.2
Avet-Loiseau, H.3
Mellerin, M.P.4
Puthier, D.5
Pennarun, E.6
Rapp, M.J.7
Harousseau, J.L.8
Moisan, J.P.9
Bataille, R.10
-
23
-
-
0035207110
-
The role of nuclear factor-kappaB in the biology and treatment of multiple myeloma
-
Berenson, J.R.; Ma, H.M.; Vescio, R. The role of nuclear factor-kappaB in the biology and treatment of multiple myeloma. Semin.Oncol, 2001, 28, 626-633.
-
(2001)
Semin.Oncol
, vol.28
, pp. 626-633
-
-
Berenson, J.R.1
Ma, H.M.2
Vescio, R.3
-
24
-
-
14644413996
-
Regulation of NF-κB in multiple myeloma: Therapeutic implications
-
Feinman, R.; Siegel, D.S.; Berenson, J. Regulation of NF-κB in multiple myeloma: therapeutic implications. Clin. Adv. Hematol. Oncol, 2004, 2, 162-166.
-
(2004)
Clin. Adv. Hematol. Oncol
, vol.2
, pp. 162-166
-
-
Feinman, R.1
Siegel, D.S.2
Berenson, J.3
-
25
-
-
34547562418
-
Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma
-
Annunziata, CM.; Davis, R.E.; Demchenko, Y.; Bellamy, W.; Gabrea, A.; Zhan, F.; Lenz, G.; Hanamura, I.; Wright, G.; Xiao, W.; Dave, S.; Hurt, E.M.; Tan, B.; Zhao, H.; Stephens, O.; Santra, M.; Williams, D.R; Dang, L.; Barlogie, B.; Shaughnessy, J.D. Jr.; Kuehl, W.M.; Staudt, L.M. Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell, 2007, 12, 115-130.
-
(2007)
Cancer Cell
, vol.12
, pp. 115-130
-
-
Annunziata, C.M.1
Davis, R.E.2
Demchenko, Y.3
Bellamy, W.4
Gabrea, A.5
Zhan, F.6
Lenz, G.7
Hanamura, I.8
Wright, G.9
Xiao, W.10
Dave, S.11
Hurt, E.M.12
Tan, B.13
Zhao, H.14
Stephens, O.15
Santra, M.16
Williams, D.R.17
Dang, L.18
Barlogie, B.19
Shaughnessy Jr., J.D.20
Kuehl, W.M.21
Staudt, L.M.22
more..
-
26
-
-
34547660308
-
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma
-
Keats, J.J.; Fonseca, R.; Chesi, M.; Schop, R.; Baker, A.; Chng, W.J.; Van Wier, S.; Tiedemann, R.; Shi, C.X.; Sebag, M.; Braggio, E.; Henry, T; Zhu, Y.X.; Fogle, H.; Price-Troska, T; Ahmann, G.; Mancini, C; Brents, L.A.; Kumar, S.; Greipp, P.; Dispenzieri, A.; Bryant, B.; Mulligan, G; Bruhn, L.; Barrett, M.; Valdez, R.; Trent, J.; Stewart, A.K.; Carpten, J.; Bergsagel, PL. Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. Cancer Cell, 2007, 12, 131-144.
-
(2007)
Cancer Cell
, vol.12
, pp. 131-144
-
-
Keats, J.J.1
Fonseca, R.2
Chesi, M.3
Schop, R.4
Baker, A.5
Chng, W.J.6
van Wier, S.7
Tiedemann, R.8
Shi, C.X.9
Sebag, M.10
Braggio, E.11
Henry, T.12
Zhu, Y.X.13
Fogle, H.14
Price-Troska, T.15
Ahmann, G.16
Mancini, C.17
Brents, L.A.18
Kumar, S.19
Greipp, P.20
Dispenzieri, A.21
Bryant, B.22
Mulligan, G.23
Bruhn, L.24
Barrett, M.25
Valdez, R.26
Trent, J.27
Stewart, A.K.28
Carpten, J.29
Bergsagel, P.L.30
more..
-
27
-
-
78650176111
-
NF-κB localization in multiple myeloma plasma cells and mesenchymal cells
-
Conticello, C; Giuffrida, R.; Adamo, L.; Anastasi, G.; Martinetti, D.; Salomone, E.; Colarossi, C; Amato, G.; Gorgone, A.; Romano, A.; Iannolo, G.; De Maria, R.; Giustolisi, R.; Gulisano, M.; Di Raimondo, F. NF-κB localization in multiple myeloma plasma cells and mesenchymal cells. Leuk. Res., 2011, 35, 52-60.
-
(2011)
Leuk. Res
, vol.35
, pp. 52-60
-
-
Conticello, C.1
Giuffrida, R.2
Adamo, L.3
Anastasi, G.4
Martinetti, D.5
Salomone, E.6
Colarossi, C.7
Amato, G.8
Gorgone, A.9
Romano, A.10
Iannolo, G.11
de Maria, R.12
Giustolisi, R.13
Gulisano, M.14
Di Raimondo, F.15
-
28
-
-
0035211881
-
Novel therapies targeting the myeloma cell and its bone marrow microenvironment
-
Hideshima, T; Chauhan, D.; Podar, K.; Schlossman, R.L.; Richardson, P.; Anderson, K.C. Novel therapies targeting the myeloma cell and its bone marrow microenvironment. Semin. Oncol, 2001, 28, 607-612.
-
(2001)
Semin. Oncol
, vol.28
, pp. 607-612
-
-
Hideshima, T.1
Chauhan, D.2
Podar, K.3
Schlossman, R.L.4
Richardson, P.5
Anderson, K.C.6
-
29
-
-
78149361152
-
Toll-like receptors: Expression and involvement in multiple myeloma
-
Chiron, D.; Jego, G.; Pellat-Deuceunynck, C. Toll-like receptors: expression and involvement in multiple myeloma. Leuk.Res., 2010, 34, 1545-1550.
-
(2010)
Leuk.Res
, vol.34
, pp. 1545-1550
-
-
Chiron, D.1
Jego, G.2
Pellat-Deuceunynck, C.3
-
30
-
-
33947310737
-
Inhibition of VEGF signaling pathways in multiple myeloma and other malignancies
-
Podar, K.; Anderson, K.C. Inhibition of VEGF signaling pathways in multiple myeloma and other malignancies. Cell Cycle, 2007, 6, 538-542.
-
(2007)
Cell Cycle
, vol.6
, pp. 538-542
-
-
Podar, K.1
Anderson, K.C.2
-
31
-
-
77954242446
-
The rafts of the medusa: Cholesterol targeting in cancer therapy
-
Freeman, M.R.; Di Vizio, D.; Solomon, K.R. The rafts of the medusa: cholesterol targeting in cancer therapy. Oncogene, 2010, 29, 3745-3747.
-
(2010)
Oncogene
, vol.29
, pp. 3745-3747
-
-
Freeman, M.R.1
Di Vizio, D.2
Solomon, K.R.3
-
32
-
-
77954237062
-
Lipid raft-targeted therapy in multiple myeloma
-
Mollinedo, F.; de la Iglesia-Vicente, J.; Gajate, C; Estella-Hermoso de Mondoza, A.; Villa-Pulgarin, J.A.; Campanero, M.A.; Blanco-Prieto, M.J. Lipid raft-targeted therapy in multiple myeloma. Oncogene, 2010, 29, 3748-3757.
-
(2010)
Oncogene
, vol.29
, pp. 3748-3757
-
-
Mollinedo, F.1
de la Iglesia-Vicente, J.2
Gajate, C.3
Estella-Hermoso de mondoza, A.4
Villa-Pulgarin, J.A.5
Campanero, M.A.6
Blanco-Prieto, M.J.7
-
33
-
-
1842579486
-
Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis
-
Bharti, A.C.; Shishodia, S.; Reuben, J.M.; Weber, D.; Alexanian, R.; Raj-Vadhan, S.; Estrov, Z.; Talpaz, M.; Aggarwal, B.B. Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. Blood, 2004, 103, 3175-3184.
-
(2004)
Blood
, vol.103
, pp. 3175-3184
-
-
Bharti, A.C.1
Shishodia, S.2
Reuben, J.M.3
Weber, D.4
Alexanian, R.5
Raj-Vadhan, S.6
Estrov, Z.7
Talpaz, M.8
Aggarwal, B.B.9
-
34
-
-
33947197883
-
Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells
-
Bhardwaj A, Sethi, G.; Vadhan-Raj, S.; Bueso-Ramos, C; Takada, Y; Gaur, U.; Nair, A.S.; Shishodia, S.; Aggarwal, B.B. Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood, 2007, 109, 2293-2302.
-
(2007)
Blood
, vol.109
, pp. 2293-2302
-
-
Bhardwaj, A.1
Sethi, G.2
Vadhan-Raj, S.3
Bueso-Ramos, C.4
Takada, Y.5
Gaur, U.6
Nair, A.S.7
Shishodia, S.8
Aggarwal, B.B.9
-
35
-
-
54049149951
-
Simultaneous inhibition of the constitutively activated nuclear factor kappaB and of the interleukin-6 pathways is necessary and sufficient to completely overcome apoptosis resistance of human U266 myeloma cells
-
Malara, N.; Focà, D.; Casadonte, F; Sesto, MF; Macrina, L.; Santoro, L.; Scaramuzzino, M.; Terracciano, R.; Savino, R Simultaneous inhibition of the constitutively activated nuclear factor kappaB and of the interleukin-6 pathways is necessary and sufficient to completely overcome apoptosis resistance of human U266 myeloma cells. Cell Cycle, 2008, 7, 3235-3245.
-
(2008)
Cell Cycle
, vol.7
, pp. 3235-3245
-
-
Malara, N.1
Focà, D.2
Casadonte, F.3
Sesto, M.F.4
Macrina, L.5
Santoro, L.6
Scaramuzzino, M.7
Terracciano, R.8
Savino, R.9
-
36
-
-
44949128833
-
The effect of azacitidine on interleukin-6 signaling and nuclear factor-kappaB activation and its in vitro and in vivo activity against multiple myeloma
-
Khong, T; Sharkey, J.; Spencer, A. The effect of azacitidine on interleukin-6 signaling and nuclear factor-kappaB activation and its in vitro and in vivo activity against multiple myeloma. Haematologica, 2008, 93, 860-869.
-
(2008)
Haematologica
, vol.93
, pp. 860-869
-
-
Khong, T.1
Sharkey, J.2
Spencer, A.3
-
37
-
-
0037179847
-
Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma
-
Pene, F; Claessens, Y.E.; Muller, O; Viguié, F.; Mayeux, P.; Dreyfus, F; Lacombe, C; Bouscary, D. Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma. Oncogene, 2002, 21, 6587-6597.
-
(2002)
Oncogene
, vol.21
, pp. 6587-6597
-
-
Pene, F.1
Claessens, Y.E.2
Muller, O.3
Viguié, F.4
Mayeux, P.5
Dreyfus, F.6
Lacombe, C.7
Bouscary, D.8
-
38
-
-
34548821574
-
MEK 1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism
-
Pei, X.Y; Dai, Y; Tenorio, S.; Lu, J.; Harada, H.; Dent, P.; Grant, S. MEK 1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism. Blood, 2007, 110, 2092-2101.
-
(2007)
Blood
, vol.110
, pp. 2092-2101
-
-
Pei, X.Y.1
Dai, Y.2
Tenorio, S.3
Lu, J.4
Harada, H.5
Dent, P.6
Grant, S.7
-
39
-
-
80053203115
-
The mammalian target of rapamycin pathway as a therapeutic target in multiple myeloma
-
Gera, J.; Lichtenstein, A. The mammalian target of rapamycin pathway as a therapeutic target in multiple myeloma. Leuk. Lymphoma, 2011, 52, 1857-1866.
-
(2011)
Leuk. Lymphoma
, vol.52
, pp. 1857-1866
-
-
Gera, J.1
Lichtenstein, A.2
-
40
-
-
84255197263
-
Defining the role of TORC 1/2 in multiple myeloma
-
Maiso, P.; Liu, Y; Morgan, B.; Kareem Azab, A.; Ren, P.; Martin, B.M.; Zhang, Y; Liu, Y; Sacco, A.; Ngo, H.; Azab F.; Quang, P.; Rodig, S.J.; Lin, C.P.; Roccaro, A.M.; Rommel, C; Ghobrial, I.M. Defining the role of TORC 1/2 in multiple myeloma. Blood, 2011, 118, 6860-6870.
-
(2011)
Blood
, vol.118
, pp. 6860-6870
-
-
Maiso, P.1
Liu, Y.2
Morgan, B.3
Kareem Azab, A.4
Ren, P.5
Martin, B.M.6
Zhang, Y.7
Liu, Y.8
Sacco, A.9
Ngo, H.10
Azab, F.11
Quang, P.12
Rodig, S.J.13
Lin, C.P.14
Roccaro, A.M.15
Rommel, C.16
Ghobrial, I.M.17
-
41
-
-
84868198690
-
Combined targeting of MEK/MAPK and PI3K/Akt signaling in multiple myeloma
-
Steinbrunn, T; Stühmer, T; Sayehli, C; Chatterjee, M.; Einsele, H.; Bargou, R.C. Combined targeting of MEK/MAPK and PI3K/Akt signaling in multiple myeloma. Br. J. Haematol, 2012, 159, 430-440.
-
(2012)
Br. J. Haematol
, vol.159
, pp. 430-440
-
-
Steinbrunn, T.1
Stühmer, T.2
Sayehli, C.3
Chatterjee, M.4
Einsele, H.5
Bargou, R.C.6
-
42
-
-
84865861715
-
Constitutive activation of p38 MAPK in tumor cells contributes to osteolytic bone lesions in multiple myeloma
-
Yang, J.; He, J.; Wang, J.; Cao, Y; Ling, J.; Qian, J.; Lu, Y; Li, H.; Zheng, Y; Lan, Y; Hong, S.; Matthews, J.; Starbruck, M.W.; Navone, N.M.; Orlowski, R.Z.; Lin, J.; Kwak, L.W.; Yi, Q. Constitutive activation of p38 MAPK in tumor cells contributes to osteolytic bone lesions in multiple myeloma. Leukemia, 2012, 26, 2114-2123.
-
(2012)
Leukemia
, vol.26
, pp. 2114-2123
-
-
Yang, J.1
He, J.2
Wang, J.3
Cao, Y.4
Ling, J.5
Qian, J.6
Lu, Y.7
Li, H.8
Zheng, Y.9
Lan, Y.10
Hong, S.11
Matthews, J.12
Starbruck, M.W.13
Navone, N.M.14
Orlowski, R.Z.15
Lin, J.16
Kwak, L.W.17
Yi, Q.18
-
43
-
-
84864883430
-
Optimal induction of myeloma cell death requires dual blockade of phosphoinositide 3-kinase and mTOR signaling and is determined by translocation subtype
-
Stengel, C; Cheung, C.W.; Quinn, J.; Yong, K.; Khwaja, A. Optimal induction of myeloma cell death requires dual blockade of phosphoinositide 3-kinase and mTOR signaling and is determined by translocation subtype. Leukemia, 2012, 26, 1761-1770.
-
(2012)
Leukemia
, vol.26
, pp. 1761-1770
-
-
Stengel, C.1
Cheung, C.W.2
Quinn, J.3
Yong, K.4
Khwaja, A.5
-
44
-
-
84863943384
-
Inhibition of cell cycle progression by dual phosphatidylinositol-3-kinase and mTOR blockade in cyclin D2 positive multiple myeloma bearing IgH translocations
-
Glassford, J.; Kassen, D.; Quinn, J.; Stengel, C; Kallinikou, K.; Khwaja, A.; Yong, K.L. Inhibition of cell cycle progression by dual phosphatidylinositol-3-kinase and mTOR blockade in cyclin D2 positive multiple myeloma bearing IgH translocations. Blood Cancer J., 2012, 2, e50.
-
(2012)
Blood Cancer J
, vol.2
-
-
Glassford, J.1
Kassen, D.2
Quinn, J.3
Stengel, C.4
Kallinikou, K.5
Khwaja, A.6
Yong, K.L.7
-
45
-
-
79951494668
-
Initial genome sequencing and analysis of multiple myeloma
-
Chapman, M.A.; Lawrence, M.S.; Keats, J.J.; Cibulskis, K.; Sougnez, C; Schinzel, A.C.; Harview, C.L.; Brunet, J.P; Ahmann, G.J.; Adli, M.; Anderson, K.C; Ardlie, K.G.; Auclair, D.; Baker, A.; Bergsagel, PL.; Bernstein, B.E.; Drier, Y; Fonseca, R.; Gabriel, S.B.; Hofmeister, C.C.; Jagannath, S.; Jakubowiak, A.J.; Krishnan, A.; Levy, J.; Liefeld, T; Lonial, S.; Mahan, S.; Mfuko, B.; Monti, S.; Perkins, L.M.; Onofrio, R.; Pugh, T.J.; Rajkumar, S.V.; Ramos, A.H.; Siegel, D.S; Sivachenko, A.; Stewart, A.K.; Trudel, S.; Vij, R.; Voet, D.; Winckler, W.; Zimmerman, T; Carpten, J.; Trent, J.; Hahn, W.C.; Garraway, L.A.; Meyerson, M.; Lander, E.S.; Getz, G.; Golub, T.R. Initial genome sequencing and analysis of multiple myeloma. Nature, 2011, 471, 467-472.
-
(2011)
Nature
, vol.471
, pp. 467-472
-
-
Chapman, M.A.1
Lawrence, M.S.2
Keats, J.J.3
Cibulskis, K.4
Sougnez, C.5
Schinzel, A.C.6
Harview, C.L.7
Brunet, J.P.8
Ahmann, G.J.9
Adli, M.10
Anderson, K.C.11
Ardlie, K.G.12
Auclair, D.13
Baker, A.14
Bergsagel, P.L.15
Bernstein, B.E.16
Drier, Y.17
Fonseca, R.18
Gabriel, S.B.19
Hofmeister, C.C.20
Jagannath, S.21
Jakubowiak, A.J.22
Krishnan, A.23
Levy, J.24
Liefeld, T.25
Lonial, S.26
Mahan, S.27
Mfuko, B.28
Monti, S.29
Perkins, L.M.30
Onofrio, R.31
Pugh, T.J.32
Rajkumar, S.V.33
Ramos, A.H.34
Siegel, D.S.35
Sivachenko, A.36
Stewart, A.K.37
Trudel, S.38
Vij, R.39
Voet, D.40
Winckler, W.41
Zimmerman, T.42
Carpten, J.43
Trent, J.44
Hahn, W.C.45
Garraway, L.A.46
Meyerson, M.47
Lander, E.S.48
Getz, G.49
Golub, T.R.50
more..
-
46
-
-
4444376712
-
Signaling to NF-κB
-
Hayden, MS.; Ghosh S. Signaling to NF-κB. Genes Dev, 2004, 15, 2195-2224.
-
(2004)
Genes Dev
, vol.15
, pp. 2195-2224
-
-
Hayden, M.S.1
Ghosh, S.2
-
47
-
-
33750466230
-
Introduction to NF-kappa B: Players, pathways, perspectives
-
Gilmore, TD. Introduction to NF-kappa B: players, pathways, perspectives. Oncogene, 2006, 25, 6680-6684.
-
(2006)
Oncogene
, vol.25
, pp. 6680-6684
-
-
Gilmore, T.D.1
-
48
-
-
0036234459
-
Missing pieces in the NF-κB puzzle
-
Ghosh, S.; Karin, M. Missing pieces in the NF-κB puzzle. Cell, 2002, 109(suppl.), S81-S96.
-
(2002)
Cell
, vol.109
, Issue.SUPPL.
-
-
Ghosh, S.1
Karin, M.2
-
49
-
-
38849199203
-
Shared principles in NF-kappaB signaling
-
Hayden, MS.; Ghosh, S. Shared principles in NF-kappaB signaling. Cell, 2008, 132, 344-362.
-
(2008)
Cell
, vol.132
, pp. 344-362
-
-
Hayden, M.S.1
Ghosh, S.2
-
50
-
-
0742324492
-
NF-kappaB/Rel-mediated regulation of apoptosis in hematologic malignancies and normal hematopoietic progenitors
-
Turco, MC; Romano, MF; Petrella, A.; Bisogni, R.; Tassone, P.; Venuta, S. NF-kappaB/Rel-mediated regulation of apoptosis in hematologic malignancies and normal hematopoietic progenitors. Leukemia, 2004, 18, 11-17.
-
(2004)
Leukemia
, vol.18
, pp. 11-17
-
-
Turco, M.C.1
Romano, M.F.2
Petrella, A.3
Bisogni, R.4
Tassone, P.5
Venuta, S.6
-
51
-
-
47149099552
-
NF-kappaB in the pathogenesis and treatment of multiple myeloma
-
Li, Z.W.; Chen, H.; Campbell, R.A.; Bonavida, B.; Berenson, J.R. NF-kappaB in the pathogenesis and treatment of multiple myeloma. Curr. Opin. Hematol, 2008, 15, 391-399.
-
(2008)
Curr. Opin. Hematol
, vol.15
, pp. 391-399
-
-
Li, Z.W.1
Chen, H.2
Campbell, R.A.3
Bonavida, B.4
Berenson, J.R.5
-
52
-
-
0028804551
-
Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses
-
Sha, W.C.; Liou, H.C.; Tuomanen, E.I.; Baltimore, D. Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses. Cell, 1995, 80, 321-330.
-
(1995)
Cell
, vol.80
, pp. 321-330
-
-
Sha, W.C.1
Liou, H.C.2
Tuomanen, E.I.3
Baltimore, D.4
-
53
-
-
0029150389
-
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
-
Köntgen, F.; Grumont, R.J.; Strasser, A.; Metcalf, D.; Li, R.; Tarlinton, D.; Gerondakis, S. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev., 1995, 9, 1965-1977.
-
(1995)
Genes Dev
, vol.9
, pp. 1965-1977
-
-
Köntgen, F.1
Grumont, R.J.2
Strasser, A.3
Metcalf, D.4
Li, R.5
Tarlinton, D.6
Gerondakis, S.7
-
54
-
-
0031964855
-
Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture
-
Franzoso, G.; Carlson, L.; Poljak, L.; Shores, EW.; Epstein, S.; Leonardi, A.; Grinberg, A.; Tran, T.; Scharton-Kersten, T.; Anver, M.; Love, P.; Brown, K.; Siebenlist, U. Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture. J. Exp. Med., 1998, 187, 147-159.
-
(1998)
J. Exp. Med
, vol.187
, pp. 147-159
-
-
Franzoso, G.1
Carlson, L.2
Poljak, L.3
Shores, E.W.4
Epstein, S.5
Leonardi, A.6
Grinberg, A.7
Tran, T.8
Scharton-Kersten, T.9
Anver, M.10
Love, P.11
Brown, K.12
Siebenlist, U.13
-
55
-
-
0032568792
-
Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation
-
Yamaoka, S.; Courtois, G.; Bessia, C; Whiteside, ST.; Weil, R.; Agou, F.; Kirk, H.E.; Kay, R.J.; Israël, A. Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation. Cell, 1998, 93, 1231-1240.
-
(1998)
Cell
, vol.93
, pp. 1231-1240
-
-
Yamaoka, S.1
Courtois, G.2
Bessia, C.3
Whiteside, S.T.4
Weil, R.5
Agou, F.6
Kirk, H.E.7
Kay, R.J.8
Israël, A.9
-
56
-
-
0032541657
-
IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex
-
Rothwarf, D.M.; Zandi, E.; Natoli, G.; Karin, M. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature, 1998, 395, 297-300.
-
(1998)
Nature
, vol.395
, pp. 297-300
-
-
Rothwarf, D.M.1
Zandi, E.2
Natoli, G.3
Karin, M.4
-
57
-
-
0032589935
-
IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex
-
Mercurio, F.; Murray B.W.; Shevchenko, A.; Bennett, B.L.; Young, D.B.; Li, J.W.; Pascual, G.; Motiwala, A.; Zhu, H.; Mann, M.; Manning, A.M. IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex. Mol. Cell. Biol, 1999, 19. 1526-1538.
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 1526-1538
-
-
Mercurio, F.1
Murray, B.W.2
Shevchenko, A.3
Bennett, B.L.4
Young, D.B.5
Li, J.W.6
Pascual, G.7
Motiwala, A.8
Zhu, H.9
Mann, M.10
Manning, A.M.11
-
58
-
-
0033106149
-
A ubiquitin ligase complex essential for the NF-κB, Wnt/Wingless, and Hedgehog signaling pathways
-
Maniatis, T. A ubiquitin ligase complex essential for the NF-κB, Wnt/Wingless, and Hedgehog signaling pathways. Genes Dev., 1999, 13, 505-510.
-
(1999)
Genes Dev
, vol.13
, pp. 505-510
-
-
Maniatis, T.1
-
59
-
-
0034084163
-
Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity
-
Karin, M.; Ben-Neriah, Y. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu. Rev. Immunol, 2000, 18, 621-663.
-
(2000)
Annu. Rev. Immunol
, vol.18
, pp. 621-663
-
-
Karin, M.1
Ben-Neriah, Y.2
-
60
-
-
24944489952
-
Stimulus specificity of gene expression programs determined by temporal control of IKK activity
-
Werner, S.L.; Barken, D.; Hoffmann, A. Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science, 2005, 309, 1857-1861.
-
(2005)
Science
, vol.309
, pp. 1857-1861
-
-
Werner, S.L.1
Barken, D.2
Hoffmann, A.3
-
61
-
-
24944554790
-
Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators
-
Park, J.M.; Greten, F.R.; Wong, A.; Westrick, R.J.; Arthur, J.S.; Otsu, K.; Hoffmann, A.; Montminy, M.; Karin, M. Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. Immunity, 2005, 23, 319-329.
-
(2005)
Immunity
, vol.23
, pp. 319-329
-
-
Park, J.M.1
Greten, F.R.2
Wong, A.3
Westrick, R.J.4
Arthur, J.S.5
Otsu, K.6
Hoffmann, A.7
Montminy, M.8
Karin, M.9
-
62
-
-
24944586285
-
Achieving stability of lipopolysaccharide-induced NF-kappaB activation
-
Covert, M.W.; Leung, T.H.; Gaston, J.E.; Baltimore, D. Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science, 2005, 309, 1854-1857.
-
(2005)
Science
, vol.309
, pp. 1854-1857
-
-
Covert, M.W.1
Leung, T.H.2
Gaston, J.E.3
Baltimore, D.4
-
63
-
-
33750448661
-
Transcriptional regulation via the NF-kappaB signaling module
-
Hoffmann, A.; Natoli, G.; Ghosh, G. Transcriptional regulation via the NF-kappaB signaling module. Oncogene, 2006, 25, 6706-6716.
-
(2006)
Oncogene
, vol.25
, pp. 6706-6716
-
-
Hoffmann, A.1
Natoli, G.2
Ghosh, G.3
-
64
-
-
17944378526
-
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway
-
Senftleben, U.; Cao, Y; Xiao, G.; Greten, F.R.; Krähn G, Bonizzi, G.; Chen, Y; Hu, Y; Fong, A; Sun, S.C.; Karin, M. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science, 2001, 293, 1495-1499.
-
(2001)
Science
, vol.293
, pp. 1495-1499
-
-
Senftleben, U.1
Cao, Y.2
Xiao, G.3
Greten, F.R.4
Krähn, G.5
Bonizzi, G.6
Chen, Y.7
Hu, Y.8
Fong, A.9
Sun, S.C.10
Karin, M.11
-
65
-
-
9144275033
-
Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:P52 dimers
-
Bonizzi, G.; Bebien, M.; Otero, D.C.; Johnson-Vroom, K.E.; Cao, Y.; Vu, D.; Jegga, A.G.; Aronow, B.J; Ghosh, G.; Rickert, R.C.; Karin, M. Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. EMBO J., 2004, 23, 4202-4210.
-
(2004)
EMBO J
, vol.23
, pp. 4202-4210
-
-
Bonizzi, G.1
Bebien, M.2
Otero, D.C.3
Johnson-Vroom, K.E.4
Cao, Y.5
Vu, D.6
Jegga, A.G.7
Aronow, B.J.8
Ghosh, G.9
Rickert, R.C.10
Karin, M.11
-
66
-
-
2342464085
-
The two NF-kappaB activation pathways and their role in innate and adaptive immunity
-
Bonizzi, G.; Karin, M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol, 2004, 25, 280-288.
-
(2004)
Trends Immunol
, vol.25
, pp. 280-288
-
-
Bonizzi, G.1
Karin, M.2
-
67
-
-
0242298578
-
CK2 Is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV Response
-
Kato, T. Jr.; Delhase, M.; Hoffmann, A.; Karin, M. CK2 Is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV Response. Mol. Cell, 2003, 12, 829-839.
-
(2003)
Mol. Cell
, vol.12
, pp. 829-839
-
-
Kato Jr., T.1
Delhase, M.2
Hoffmann, A.3
Karin, M.4
-
68
-
-
0024541563
-
The human B lymphocyte and carcinoma antigen, CDw40, is a phosphoprotein involved in growth signal transduction
-
Paulie, S.; Rosen, A.; Ehlin-Henriksson, B.; Braesch-Andersen, S.; Jakobson, E.; Koho, H.; Perlmann, P. The human B lymphocyte and carcinoma antigen, CDw40, is a phosphoprotein involved in growth signal transduction. J. Immunol, 1989, 142, 590-595.
-
(1989)
J. Immunol
, vol.142
, pp. 590-595
-
-
Paulie, S.1
Rosen, A.2
Ehlin-Henriksson, B.3
Braesch-Andersen, S.4
Jakobson, E.5
Koho, H.6
Perlmann, P.7
-
69
-
-
0023108060
-
Augmentation of normal and malignant B-cell proliferation by monoclonal antibody to the B-cell-specific antigen BP50 (CDW40)
-
Ledbetter, J.A.; Shu, G.; Gallagher, M.; Clark, E.A. Augmentation of normal and malignant B-cell proliferation by monoclonal antibody to the B-cell-specific antigen BP50 (CDW40). J. Immunol, 1987, 138, 788-794.
-
(1987)
J. Immunol
, vol.138
, pp. 788-794
-
-
Ledbetter, J.A.1
Shu, G.2
Gallagher, M.3
Clark, E.A.4
-
70
-
-
0042591416
-
Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors
-
Nowak, A.K.; Robinson, B.W.; Lake, R.A. Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors. Cancer Res., 2003, 63, 4490-4496.
-
(2003)
Cancer Res
, vol.63
, pp. 4490-4496
-
-
Nowak, A.K.1
Robinson, B.W.2
Lake, R.A.3
-
71
-
-
0034124140
-
CD40 expressed on human melanoma cells mediates T-cell co-stimulation and tumor cell growth
-
Pirozzi, G.; Lombari, V.; Zanzi, D.; Ionna, F.; Lombardi, M.L.; Errico, S.; Ruggiero, G.; Manzo, C. CD40 expressed on human melanoma cells mediates T-cell co-stimulation and tumor cell growth. Int. Immunol., 2000, 12, 787-795.
-
(2000)
Int. Immunol
, vol.12
, pp. 787-795
-
-
Pirozzi, G.1
Lombari, V.2
Zanzi, D.3
Ionna, F.4
Lombardi, M.L.5
Errico, S.6
Ruggiero, G.7
Manzo, C.8
-
72
-
-
0036757072
-
CD40 activation as potential tool in malignant neoplasms
-
Ottaiano, A.; Pisano, C.; De Chiara, A.; Ascierto, P.A.; Botti, G.; Barletta, E.; Apice, G.; Gridelli, C.; Iaffaioli, V.R. CD40 activation as potential tool in malignant neoplasms. Tumori, 2002, 88, 361-366.
-
(2002)
Tumori
, vol.88
, pp. 361-366
-
-
Ottaiano, A.1
Pisano, C.2
de Chiara, A.3
Ascierto, P.A.4
Botti, G.5
Barletta, E.6
Apice, G.7
Gridelli, C.8
Iaffaioli, V.R.9
-
73
-
-
33645060195
-
Transfection and ligation of CD40 in human oral keratinocytes affect proliferation, adhesion and migration but not apoptosis in vitro
-
Villarroel Dorrego, M.; Whawell, S.A.; Speight, P.M.; Barrett, A.W. Transfection and ligation of CD40 in human oral keratinocytes affect proliferation, adhesion and migration but not apoptosis in vitro. Clin. Exp. Dermatol., 2006, 31, 266-271.
-
(2006)
Clin. Exp. Dermatol
, vol.31
, pp. 266-271
-
-
Villarroel Dorrego, M.1
Whawell, S.A.2
Speight, P.M.3
Barrett, A.W.4
-
74
-
-
34447637912
-
The key role of CD40 ligand in overcoming tumor-induced dendritic cell dysfunction
-
Pinzon-Charry, A.; Schmidt, C.W.; Lopez, J.A. The key role of CD40 ligand in overcoming tumor-induced dendritic cell dysfunction. Breast Cancer Res., 2006, 8, 402.
-
(2006)
Breast Cancer Res
, vol.8
, pp. 402
-
-
Pinzon-Charry, A.1
Schmidt, C.W.2
Lopez, J.A.3
-
75
-
-
16544387516
-
Erickson, LD. Determinations of B cell fate in immunity and autoimmunity
-
Noelle, RJ.; Erickson, LD. Determinations of B cell fate in immunity and autoimmunity. Curr. Dis. Autoimmun., 2005, 8, 1-24.
-
(2005)
Curr. Dis. Autoimmun
, vol.8
, pp. 1-24
-
-
Noelle, R.J.1
-
76
-
-
33749472033
-
Chemotherapeutic agents enhance AAV2-mediated gene transfer into breast cancer cells promoting CD40 ligand-based immunotherapy
-
Koppold, B.; Sauer, G.; Buening, H.; Hallek, M.; Kreienberg, R.; Deissler, H.; Kurzeder, C. Chemotherapeutic agents enhance AAV2-mediated gene transfer into breast cancer cells promoting CD40 ligand-based immunotherapy. J. Cancer Res. Clin. Oncol., 2006, 132, 787-794.
-
(2006)
J. Cancer Res. Clin. Oncol
, vol.132
, pp. 787-794
-
-
Koppold, B.1
Sauer, G.2
Buening, H.3
Hallek, M.4
Kreienberg, R.5
Deissler, H.6
Kurzeder, C.7
-
77
-
-
34248153303
-
Expression of CD40 and CD40L on tumor cells: The role of their interaction and new approach to immunotherapy
-
Bereznaya, N.M.; Chekhun, V.F. Expression of CD40 and CD40L on tumor cells: the role of their interaction and new approach to immunotherapy. Exp. Oncol., 2007, 29, 2-12.
-
(2007)
Exp. Oncol
, vol.29
, pp. 2-12
-
-
Bereznaya, N.M.1
Chekhun, V.F.2
-
78
-
-
0033561039
-
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
-
Lomaga, M.A.; Yeh, W.C.; Sarosi, I.; Duncan, G.S.; Furlonger, C.; Ho, A.; Morony, S.; Capparelli, C.; Van, G.; Kaufman, S.; van der Heiden, A.; Itie, A.; Wakeham, A.; Khoo, W.; Sasaki, T.; Cao, Z.; Penninger, J.M.; Paige, C.J.; Lacey, D.L.; Dunstan, C.R.; Boyle, W.J.; Goeddel D.V.; Mak T.W. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev., 1999, 13, 1015-1024.
-
(1999)
Genes Dev
, vol.13
, pp. 1015-1024
-
-
Lomaga, M.A.1
Yeh, W.C.2
Sarosi, I.3
Duncan, G.S.4
Furlonger, C.5
Ho, A.6
Morony, S.7
Capparelli, C.8
Van, G.9
Kaufman, S.10
van der Heiden, A.11
Itie, A.12
Wakeham, A.13
Khoo, W.14
Sasaki, T.15
Cao, Z.16
Penninger, J.M.17
Paige, C.J.18
Lacey, D.L.19
Dunstan, C.R.20
Boyle, W.J.21
Goeddel, D.V.22
Mak, T.W.23
more..
-
79
-
-
14544286868
-
TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs
-
Hauer, J.; Püschner, S.; Ramakrishnan, P.; Simon, U.; Bongers, M.; Federle, C.; Engelmann, H. TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs. Proc. Natl. Acad. Sci. U S A, 2005, 102, 2874-2879.
-
(2005)
Proc. Natl. Acad. Sci. U S A
, vol.102
, pp. 2874-2879
-
-
Hauer, J.1
Püschner, S.2
Ramakrishnan, P.3
Simon, U.4
Bongers, M.5
Federle, C.6
Engelmann, H.7
-
80
-
-
33750208645
-
Interference with nuclear factor kappa B and c-Jun NH2-terminal kinase signaling by TRAF6C small interfering RNA inhibits myeloma cell proliferation and enhances apoptosis
-
Chen, H.; Li, M.; Campbell, R.A.; Burkhardt, K.; Zhu, D.; Li, S.G.; Lee, H.J.; Wang, C.; Zeng, Z.; Gordon M.S.; Bonavida, B.; Berenson, J.R. Interference with nuclear factor kappa B and c-Jun NH2-terminal kinase signaling by TRAF6C small interfering RNA inhibits myeloma cell proliferation and enhances apoptosis. Oncogene, 2006, 25, 6520-6527.
-
(2006)
Oncogene
, vol.25
, pp. 6520-6527
-
-
Chen, H.1
Li, M.2
Campbell, R.A.3
Burkhardt, K.4
Zhu, D.5
Li, S.G.6
Lee, H.J.7
Wang, C.8
Zeng, Z.9
Gordon, M.S.10
Bonavida, B.11
Berenson, J.R.12
-
81
-
-
2942731516
-
Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation
-
Liao, G.; Zhang, M.; Harhaj, E.W.; Sun, S.C. Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation. J. Biol. Chem., 2004, 279, 26243-26250.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 26243-26250
-
-
Liao, G.1
Zhang, M.2
Harhaj, E.W.3
Sun, S.C.4
-
82
-
-
0035896422
-
Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice
-
Yin, L.; Wu, L.; Wesche, H.; Arthur, C.D.; White, J.M.; Goeddel, D.V.; Schreiber, R.D. Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice. Science, 2001, 291, 2162-2165.
-
(2001)
Science
, vol.291
, pp. 2162-2165
-
-
Yin, L.1
Wu, L.2
Wesche, H.3
Arthur, C.D.4
White, J.M.5
Goeddel, D.V.6
Schreiber, R.D.7
-
83
-
-
0036794398
-
BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells
-
Claudio, E.; Brown, K.; Park, S.; Wang, H.; Siebenlist, U. BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells. Nat. Immunol., 2002, 3, 958-965.
-
(2002)
Nat. Immunol
, vol.3
, pp. 958-965
-
-
Claudio, E.1
Brown, K.2
Park, S.3
Wang, H.4
Siebenlist, U.5
-
84
-
-
0037107399
-
CD40 regulates the processing of NF-kappaB2 p100 to p52
-
Coope, H.J.; Atkinson, P.G.; Huhse, B.; Belich, M.; Janzen, J.; Holman, M.J. CD40 regulates the processing of NF-kappaB2 p100 to p52. EMBO J., 2002, 21, 5375-5385.
-
(2002)
EMBO J
, vol.21
, pp. 5375-5385
-
-
Coope, H.J.1
Atkinson, P.G.2
Huhse, B.3
Belich, M.4
Janzen, J.5
Holman, M.J.6
-
85
-
-
5644302162
-
Receptor-specific signaling for both the alternative and the canonical NF-kappaB activation pathways by NF-kappaB-inducing kinase
-
Ramakrishnan, P.; Wang, W.; Wallach, D. Receptor-specific signaling for both the alternative and the canonical NF-kappaB activation pathways by NF-kappaB-inducing kinase. Immunity, 2004, 21, 477-489.
-
(2004)
Immunity
, vol.21
, pp. 477-489
-
-
Ramakrishnan, P.1
Wang, W.2
Wallach, D.3
-
86
-
-
0030611595
-
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK
-
Woronicz, J.D.; Gao, X.; Cao, Z.; Rothe, M.; Goeddel, D.V. IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science, 1997, 278, 866-869.
-
(1997)
Science
, vol.278
, pp. 866-869
-
-
Woronicz, J.D.1
Gao, X.2
Cao, Z.3
Rothe, M.4
Goeddel, D.V.5
-
87
-
-
0033621618
-
Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions
-
O'Mahony, A.; Lin, X.; Geleziunas, R.; Greene, W.C. Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions. Mol. Cell. Biol., 2000, 20, 1170-1178.
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 1170-1178
-
-
O'Mahony, A.1
Lin, X.2
Geleziunas, R.3
Greene, W.C.4
-
88
-
-
0042467554
-
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB
-
Brummelkamp, T.R.; Nijman, S.M.; Dirac, A.M.; Bernards, R. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. Nature 2003, 424, 797-801.
-
(2003)
Nature
, vol.424
, pp. 797-801
-
-
Brummelkamp, T.R.1
Nijman, S.M.2
Dirac, A.M.3
Bernards, R.4
-
89
-
-
0041967054
-
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination
-
Kovalenko, A.; Chable-Bessia, C.; Cantarella, G.; Israël, A.; Wallach, D.; Courtois, G. The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature, 2003, 424, 801-805.
-
(2003)
Nature
, vol.424
, pp. 801-805
-
-
Kovalenko, A.1
Chable-Bessia, C.2
Cantarella, G.3
Israël, A.4
Wallach, D.5
Courtois, G.6
-
90
-
-
0346333095
-
The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor
-
Regamey, A.; Hohl, D.; Liu, J.W.; Roger, T.; Kogerman, P.; Toftgard, R.; Huber, M. The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor. J. Exp. Med., 2003, 198, 1959-1964.
-
(2003)
J. Exp. Med
, vol.198
, pp. 1959-1964
-
-
Regamey, A.1
Hohl, D.2
Liu, J.W.3
Roger, T.4
Kogerman, P.5
Toftgard, R.6
Huber, M.7
-
91
-
-
0042467558
-
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members
-
Trompouki, E.; Hatzivassiliou, E.; Tsichritzis, T.; Farmer, H.; Ashworth, A.; Mosialos, G. CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members. Nature, 2003, 424, 793-796.
-
(2003)
Nature
, vol.424
, pp. 793-796
-
-
Trompouki, E.1
Hatzivassiliou, E.2
Tsichritzis, T.3
Farmer, H.4
Ashworth, A.5
Mosialos, G.6
-
92
-
-
33646531810
-
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling
-
Massoumi, R.; Chmielarska, K.; Hennecke, K.; Pfeifer, A.; Fässler, R. Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell, 2006, 125, 665-677.
-
(2006)
Cell
, vol.125
, pp. 665-677
-
-
Massoumi, R.1
Chmielarska, K.2
Hennecke, K.3
Pfeifer, A.4
Fässler, R.5
-
93
-
-
0029595282
-
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
-
Rothe, M.; Pan, M.G.; Henzel, W.J.; Ayres, T.M.; Goeddel, D.V. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell, 1995, 83, 1243-1252.
-
(1995)
Cell
, vol.83
, pp. 1243-1252
-
-
Rothe, M.1
Pan, M.G.2
Henzel, W.J.3
Ayres, T.M.4
Goeddel, D.V.5
-
94
-
-
0037149542
-
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
-
Li, X.; Yang, Y.; Ashwell, J.D. TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature, 2002, 416, 345-347.
-
(2002)
Nature
, vol.416
, pp. 345-347
-
-
Li, X.1
Yang, Y.2
Ashwell, J.D.3
-
95
-
-
45449112944
-
Transcriptional regulation of autocrine IL-6 expression in multiple myeloma cells
-
Gerlo, S.; Haegeman, G.; Vanden Berghe, W. Transcriptional regulation of autocrine IL-6 expression in multiple myeloma cells. Cell Signal., 2008, 20, 1489-1496.
-
(2008)
Cell Signal
, vol.20
, pp. 1489-1496
-
-
Gerlo, S.1
Haegeman, G.2
Vanden Berghe, W.3
-
96
-
-
0030041147
-
Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B
-
Chauhan, D.; Uchiyama, H.; Akbarali, Y.; Urashima, M.; Yamamoto, K.; Libermann, TA.; Anderson, KC. Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B. Blood, 1996, 87, 1104-1112.
-
(1996)
Blood
, vol.87
, pp. 1104-1112
-
-
Chauhan, D.1
Uchiyama, H.2
Akbarali, Y.3
Urashima, M.4
Yamamoto, K.5
Libermann, T.A.6
Anderson, K.C.7
-
97
-
-
0028952405
-
Immunoreactive interleukin-6 and acute phase proteins as prognostic factors in multiple myeloma
-
Finnish Leukemia Group
-
Pelliniemi, T.T.; Irjala, K.; Mattila, K.; Pulkki, K.; Rajamäki, A.; Tienhaara, A.; Laakso, M.; Lahtinen, R. Immunoreactive interleukin-6 and acute phase proteins as prognostic factors in multiple myeloma. Finnish Leukemia Group. Blood, 1995, 85, 765-771.
-
(1995)
Blood
, vol.85
, pp. 765-771
-
-
Pelliniemi, T.T.1
Irjala, K.2
Mattila, K.3
Pulkki, K.4
Rajamäki, A.5
Tienhaara, A.6
Laakso, M.7
Lahtinen, R.8
-
98
-
-
0030057701
-
Soluble interleukin-6 receptor as a prognostic factor in multiple myeloma. Finnish Leukaemia Group
-
Pulkki, K.; Pelliniemi, T.T.; Rajamäki, A.; Tienhaara, A.; Laakso, M.; Lahtinen, R. Soluble interleukin-6 receptor as a prognostic factor in multiple myeloma. Finnish Leukaemia Group. Br. J. Haematol., 1996, 92, 370-374.
-
(1996)
Br. J. Haematol
, vol.92
, pp. 370-374
-
-
Pulkki, K.1
Pelliniemi, T.T.2
Rajamäki, A.3
Tienhaara, A.4
Laakso, M.5
Lahtinen, R.6
-
99
-
-
0028331014
-
Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice
-
Fattori, E.; Della Rocca, C.; Costa, P.; Giorgio, M.; Dente, B.; Pozzi, L.; Ciliberto, G. Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice. Blood 1994, 83, 2570-2579.
-
(1994)
Blood
, vol.83
, pp. 2570-2579
-
-
Fattori, E.1
della Rocca, C.2
Costa, P.3
Giorgio, M.4
Dente, B.5
Pozzi, L.6
Ciliberto, G.7
-
100
-
-
0025139463
-
Nf-Kappa B as inducible transcriptional activator of the granulocyte-macrophage colony-stimulating factor gene
-
Schreck, R.; Baeuerle, P.A. NF-kappa B as inducible transcriptional activator of the granulocyte-macrophage colony-stimulating factor gene. Mol. Cell. Biol., 1990, 10, 1281-1286.
-
(1990)
Mol. Cell. Biol
, vol.10
, pp. 1281-1286
-
-
Schreck, R.1
Baeuerle, P.A.2
-
101
-
-
0025633094
-
Granulocyte-macrophage colony-stimulating factor synergizes with interleukin-6 in supporting the proliferation of human myeloma cells
-
Zhang, X.G.; Bataille, R.; Jourdan, M.; Saeland, S.; Banchereau, J.; Mannoni, P.; Klein B. Granulocyte-macrophage colony-stimulating factor synergizes with interleukin-6 in supporting the proliferation of human myeloma cells. Blood, 1990, 76, 2599-2605.
-
(1990)
Blood
, vol.76
, pp. 2599-2605
-
-
Zhang, X.G.1
Bataille, R.2
Jourdan, M.3
Saeland, S.4
Banchereau, J.5
Mannoni, P.6
Klein, B.7
-
102
-
-
0031686759
-
Functional granulocyte/macrophage colony stimulating factor receptor is constitutively expressed on neoplastic plasma cells and mediates tumour cell longevity
-
Villunger, A.; Egle, A.; Kos, M.; Egle, D.; Tinhofer, I.; Henn, T.; Uberall, F.; Maly, K.; Greil, R. Functional granulocyte/macrophage colony stimulating factor receptor is constitutively expressed on neoplastic plasma cells and mediates tumour cell longevity. B r. J. Haematol., 1998, 102, 1069-1080.
-
(1998)
B r. J. Haematol
, vol.102
, pp. 1069-1080
-
-
Villunger, A.1
Egle, A.2
Kos, M.3
Egle, D.4
Tinhofer, I.5
Henn, T.6
Uberall, F.7
Maly, K.8
Greil, R.9
-
103
-
-
0027442070
-
Cytokine gene expression in human multiple myeloma
-
Portier, M.; Zhang, X.G.; Ursule, E.; Lees, D.; Jourdan, M.; Bataille, R.; Klein, B. Cytokine gene expression in human multiple myeloma. Br. J. Haematol., 1993, 85, 514-520.
-
(1993)
Br. J. Haematol
, vol.85
, pp. 514-520
-
-
Portier, M.1
Zhang, X.G.2
Ursule, E.3
Lees, D.4
Jourdan, M.5
Bataille, R.6
Klein, B.7
-
104
-
-
0942298590
-
Expression of BCMA, TACI, and BAFF-R in multiple myeloma: A mechanism for growth and survival
-
Novak, A.J.; Darce, J.R.; Arendt, B.K.; Harder, B.; Henderson, K.; Kindsvogel, W.; Gross J.A.; Greipp, P.R.; Jelinek, D.F. Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival. Blood, 2004, 103, 689-694.
-
(2004)
Blood
, vol.103
, pp. 689-694
-
-
Novak, A.J.1
Darce, J.R.2
Arendt, B.K.3
Harder, B.4
Henderson, K.5
Kindsvogel, W.6
Gross, J.A.7
Greipp, P.R.8
Jelinek, D.F.9
-
105
-
-
33746122751
-
Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment
-
Tai, YT.; Li, XF.; Breitkreutz, I.; Song, W.; Neri, P.; Catley, L.; Podar, K.; Hideshima, T.; Chauhan, D.; Raje, N.; Schlossman, R.; Richardson, P.; Munshi, N.C.; Anderson K.C. Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment. Cancer Res., 2006, 66, 6675-6682.
-
(2006)
Cancer Res
, vol.66
, pp. 6675-6682
-
-
Tai, Y.T.1
Li, X.F.2
Breitkreutz, I.3
Song, W.4
Neri, P.5
Catley, L.6
Podar, K.7
Hideshima, T.8
Chauhan, D.9
Raje, N.10
Schlossman, R.11
Richardson, P.12
Munshi, N.C.13
Anderson, K.C.14
-
106
-
-
33748614845
-
Chemokines in multiple myeloma
-
Aggarwal, R.; Ghobrial, IM.; Roodman, GD. Chemokines in multiple myeloma. Exp. Hematol., 2006, 34, 1289-1295.
-
(2006)
Exp. Hematol
, vol.34
, pp. 1289-1295
-
-
Aggarwal, R.1
Ghobrial, I.M.2
Roodman, G.D.3
-
107
-
-
58149185114
-
Vicious cycle between myeloma cell binding to bone marrow stromal cells via VLA-4-VCAM-1 adhesion and macrophage inflammatory protein-1alpha and MIP-1beta production
-
Abe, M.; Hiura, K.; Ozaki, S.; Kido, S.; Matsumoto, T. Vicious cycle between myeloma cell binding to bone marrow stromal cells via VLA-4-VCAM-1 adhesion and macrophage inflammatory protein-1alpha and MIP-1beta production. J. Bone Miner. Metab., 2009, 27, 16-23.
-
(2009)
J. Bone Miner. Metab
, vol.27
, pp. 16-23
-
-
Abe, M.1
Hiura, K.2
Ozaki, S.3
Kido, S.4
Matsumoto, T.5
-
108
-
-
0028899112
-
Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line
-
Lee, H.; Arsura, M.; Wu, M.; Duyao, M.; Buckler, A.J.; Sonenshein, G.E. Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line. J. Exp. Med., 1995, 181, 1169-1177.
-
(1995)
J. Exp. Med
, vol.181
, pp. 1169-1177
-
-
Lee, H.1
Arsura, M.2
Wu, M.3
Duyao, M.4
Buckler, A.J.5
Sonenshein, G.E.6
-
109
-
-
0032588186
-
NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1
-
Guttridge, D.C.; Albanese, C; Reuther, J.Y.; Pestell, R.G.; Baldwin, A.S. Jr. NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell. Biol, 1999, 19, 5785-5799.
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 5785-5799
-
-
Guttridge, D.C.1
Albanese, C.2
Reuther, J.Y.3
Pestell, R.G.4
Baldwin, A.S.5
-
110
-
-
0032588170
-
NF-kappaB function in growth control: Regulation of cyclin D1 expression and G0/G1-to-S-phase transition
-
Hinz, M.; Krappmann, D.; Eichten, A; Heder, A.; Scheidereit, C; Strauss, M. NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol. Cell. Biol, 1999, 19, 2690-2698.
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 2690-2698
-
-
Hinz, M.1
Krappmann, D.2
Eichten, A.3
Heder, A.4
Scheidereit, C.5
Strauss, M.6
-
111
-
-
0033520458
-
Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway
-
Joyce, D.; Bouzahzah, B.; Fu, M.; Albanese, C; D'Amico, M.; Steer, J.; Klein, J.U.; Lee, R.J.; Segall, J.E.; Westwick, J.K.; Der, C.J.; Pestell, R.G. Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway. J. Biol. Chem., 1999, 274, 25245-25249.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 25245-25249
-
-
Joyce, D.1
Bouzahzah, B.2
Fu, M.3
Albanese, C.4
D'Amico, M.5
Steer, J.6
Klein, J.U.7
Lee, R.J.8
Segall, J.E.9
Westwick, J.K.10
Der, C.J.11
Pestell, R.G.12
-
112
-
-
0034744949
-
NF-kappaB and cell-cycle regulation: The cyclin connection
-
Joyce, D.; Albanese, C; Steer, J; Fu, M.; Bouzahzah, B.; Pestell, R.G. NF-kappaB and cell-cycle regulation: the cyclin connection. Cytokine Growth Factor Rev., 2001, 12, 73-90.
-
(2001)
Cytokine Growth Factor Rev
, vol.12
, pp. 73-90
-
-
Joyce, D.1
Albanese, C.2
Steer, J.3
Fu, M.4
Bouzahzah, B.5
Pestell, R.G.6
-
113
-
-
16544395502
-
Osteoclast differentiation by RANKL requires NF-kappaB-mediated downregulation of cyclin-dependent kinase 6 (Cdk6)
-
Ogasawara, T.; Katagiri, M.; Yamamoto, A.; Hoshi, K.; Takato, T.; Nakamura, K.; Tanaka, S.; Okayama, H.; Kawaguchi, H. Osteoclast differentiation by RANKL requires NF-kappaB-mediated downregulation of cyclin-dependent kinase 6 (Cdk6). J. Bone Miner. Res., 2004, 19, 1128-1136.
-
(2004)
J. Bone Miner. Res
, vol.19
, pp. 1128-1136
-
-
Ogasawara, T.1
Katagiri, M.2
Yamamoto, A.3
Hoshi, K.4
Takato, T.5
Nakamura, K.6
Tanaka, S.7
Okayama, H.8
Kawaguchi, H.9
-
114
-
-
22044440425
-
Cyclin D dysregulation: An early and unifying pathogenic event in multiple myeloma
-
Bergsagel, PL.; Kuehl, W.M.; Zhan, F.; Sawyer, J.; Barlogie, B.; Shaughnessy, J. Jr. Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood, 2005, 106, 296-303.
-
(2005)
Blood
, vol.106
, pp. 296-303
-
-
Bergsagel, P.L.1
Kuehl, W.M.2
Zhan, F.3
Sawyer, J.4
Barlogie, B.5
Shaughnessy Jr., J.6
-
115
-
-
84864551707
-
1 arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4
-
Huang, X.; Di Liberto, M.; Jayabalan, D.; Liang, J.; Ely, S.; Bretz, J.; Shaffer A.L.; Louie, T.; Chen, I.; Randolph, S.; Hahn, W.C.; Staudt, L.M.; Niesvizky, R.; Moore, A.S.; Chen-Kiang, S. Prolonged early G1 arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4. Blood, 2012, 120, 1095-1106.
-
(2012)
Blood
, vol.120
, pp. 1095-1106
-
-
Huang, X.1
Di Liberto, M.2
Jayabalan, D.3
Liang, J.4
Ely, S.5
Bretz, J.6
Shaffer, A.L.7
Louie, T.8
Chen, I.9
Randolph, S.10
Hahn, W.C.11
Staudt, L.M.12
Niesvizky, R.13
Moore, A.S.14
Chen-Kiang, S.15
-
116
-
-
58149166787
-
Deletions of CDKN2C in multiple myeloma: Biological and clinical implications
-
Leone, P.E.; Walker, B.A.; Jenner, M.W.; Chiecchio, L.; Dagrada, G.; Protheroe, R.K.; Johnson, D.C.; Dickens, N.J.; Brito, J.L.; Else, M.; Gonzalez, D.; Ross, F.M.; Chen-Kiang, S.; Davies, F.E.; Morgan, G.J. Deletions of CDKN2C in multiple myeloma: biological and clinical implications. Clin. Cancer Res., 2008, 14, 6033-6041.
-
(2008)
Clin. Cancer Res
, vol.14
, pp. 6033-6041
-
-
Leone, P.E.1
Walker, B.A.2
Jenner, M.W.3
Chiecchio, L.4
Dagrada, G.5
Protheroe, R.K.6
Johnson, D.C.7
Dickens, N.J.8
Brito, J.L.9
Else, M.10
Gonzalez, D.11
Ross, F.M.12
Chen-Kiang, S.13
Davies, F.E.14
Morgan, G.J.15
-
117
-
-
29244477228
-
Mutually exclusive cyclin-dependent kinase 4/cyclin D1 and cyclin-dependent kinase 6/cyclin D2 pairing inactivates retinoblastoma protein and promotes cell cycle dysregulation in multiple myeloma
-
Ely, S.; Di Liberto, M.; Niesvizky, R.; Baughn, L.B.; Cho, H.J.; Hatada, E.N.; Knowles, D.M.; Lane, J.; Chen-Kiang, S. Mutually exclusive cyclin-dependent kinase 4/cyclin D1 and cyclin-dependent kinase 6/cyclin D2 pairing inactivates retinoblastoma protein and promotes cell cycle dysregulation in multiple myeloma. Cancer Res., 2005 65,11345-11353.
-
(2005)
Cancer Res
, vol.65
, pp. 11345-11353
-
-
Ely, S.1
Di Liberto, M.2
Niesvizky, R.3
Baughn, L.B.4
Cho, H.J.5
Hatada, E.N.6
Knowles, D.M.7
Lane, J.8
Chen-Kiang, S.9
-
118
-
-
0033529416
-
NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes
-
Lee, H.H.; Dadgostar, H.; Cheng, Q.; Shu, J.; Cheng, G. NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. Proc. Natl. Acad. Sci. U S A, 1999, 96, 9136-9141.
-
(1999)
Proc. Natl. Acad. Sci. U S A
, vol.96
, pp. 9136-9141
-
-
Lee, H.H.1
Dadgostar, H.2
Cheng, Q.3
Shu, J.4
Cheng, G.5
-
119
-
-
0032490670
-
Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis
-
Stehlik, C; de Martin, R.; Kumabashiri, I.; Schmid, J.A.; Binder, B.R.; Lipp, J. Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis. J. Exp. Med, 1998, 188, 211-216.
-
(1998)
J. Exp. Med
, vol.188
, pp. 211-216
-
-
Stehlik, C.1
de Martin, R.2
Kumabashiri, I.3
Schmid, J.A.4
Binder, B.R.5
Lipp, J.6
-
120
-
-
0032531994
-
Lipopolysaccharide induces the antiapoptotic molecules, A1 and A20, in microvascular endothelial cells
-
Hu, X.; Yee, E.; Harlan, J.M.; Wong, F.; Karsan, A. Lipopolysaccharide induces the antiapoptotic molecules, A1 and A20, in microvascular endothelial cells. Blood, 1998, 92, 2759-2765.
-
(1998)
Blood
, vol.92
, pp. 2759-2765
-
-
Hu, X.1
Yee, E.2
Harlan, J.M.3
Wong, F.4
Karsan, A.5
-
121
-
-
0032508414
-
NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
-
Wang, C.Y; Mayo, M.W.; Korneluk, R.G.; Goeddel, D.V.; Baldwin, A.S. Jr. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science, 1998, 281, 1680-1683.
-
(1998)
Science
, vol.281
, pp. 1680-1683
-
-
Wang, C.Y.1
Mayo, M.W.2
Korneluk, R.G.3
Goeddel, D.V.4
Baldwin Jr., A.S.5
-
122
-
-
1842425016
-
Nuclear factor-kappaB modulation as a therapeutic approach in hematologic malignancies
-
Panwalkar, A.; Verstovsek, S.; Giles, F. Nuclear factor-kappaB modulation as a therapeutic approach in hematologic malignancies. Cancer, 2004, 100, 1578-1589.
-
(2004)
Cancer
, vol.100
, pp. 1578-1589
-
-
Panwalkar, A.1
Verstovsek, S.2
Giles, F.3
-
123
-
-
43249117703
-
NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A
-
Benayoun, B.; Baghdiguian, S.; Lajmanovich, A.; Bartoli, M.; Daniele, N.; Gicquel, E.; Bourg, N.; Raynaud, F.; Pasquier, M.A.; Suel, L.; Lochmuller, H.; Lefranc, G.; Richard, I. NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A. FASEB J., 2008, 22, 1521-1529.
-
(2008)
FASEB J
, vol.22
, pp. 1521-1529
-
-
Benayoun, B.1
Baghdiguian, S.2
Lajmanovich, A.3
Bartoli, M.4
Daniele, N.5
Gicquel, E.6
Bourg, N.7
Raynaud, F.8
Pasquier, M.A.9
Suel, L.10
Lochmuller, H.11
Lefranc, G.12
Richard, I.13
-
124
-
-
13244252299
-
Novel NF-kappaB inhibitor DHMEQ selectively targets constitutive NF-kappaB activity and induces apoptosis of multiple myeloma cells in vitro and in vivo
-
Watanabe, M.; Dewan, M.Z.; Okamura, T.; Sasaki, M.; Itoh, K.; Higashihara, M.; Mizoguchi, H.; Honda, M.; Sata, T.; Watanabe, T.; Yamamoto, N.; Umezawa, K.; Horie, R. A novel NF-kappaB inhibitor DHMEQ selectively targets constitutive NF-kappaB activity and induces apoptosis of multiple myeloma cells in vitro and in vivo. Int. J. Cancer, 2005, 114, 32-38.
-
(2005)
Int. J. Cancer
, vol.114
, pp. 32-38
-
-
Watanabe, M.1
Dewan, M.Z.2
Okamura, T.3
Sasaki, M.4
Itoh, K.5
Higashihara, M.6
Mizoguchi, H.7
Honda, M.8
Sata, T.9
Watanabe, T.10
Yamamoto, N.11
Umezawa, K.12
Horie, R.A.13
-
125
-
-
33750589355
-
IAP family protein expression correlates with poor outcome of multiple myeloma patients in association with chemotherapy-induced overexpression of multidrug resistance genes
-
Nakagawa, Y.; Abe, S.; Kurata, M.; Hasegawa, M.; Yamamoto, K.; Inoue, M.; Takemura, T.; Suzuki, K.; Kitagawa, M. IAP family protein expression correlates with poor outcome of multiple myeloma patients in association with chemotherapy-induced overexpression of multidrug resistance genes. Am. J. Hematol., 2006, 81, 824-831.
-
(2006)
Am. J. Hematol
, vol.81
, pp. 824-831
-
-
Nakagawa, Y.1
Abe, S.2
Kurata, M.3
Hasegawa, M.4
Yamamoto, K.5
Inoue, M.6
Takemura, T.7
Suzuki, K.8
Kitagawa, M.9
-
126
-
-
84862815471
-
Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancer
-
Wen, X.; Lin, Z.Q.; Liu, B.; Wei, Y.Q. Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancer. Cell Prolif., 2012, 45, 217-224.
-
(2012)
Cell Prolif
, vol.45
, pp. 217-224
-
-
Wen, X.1
Lin, Z.Q.2
Liu, B.3
Wei, Y.Q.4
-
127
-
-
80052337651
-
TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms
-
Rauert, H.; Stühmer, T.; Bargou, R.; Wajant, H.; Siegmund, D. TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms. Cell. Death Dis., 2011, 2, e194.
-
(2011)
Cell. Death Dis
, vol.2
-
-
Rauert, H.1
Stühmer, T.2
Bargou, R.3
Wajant, H.4
Siegmund, D.5
-
128
-
-
0037207872
-
Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein
-
Akiyama, M.; Hideshima, T.; Hayashi, T.; Tai, Y.T.; Mitsiades, C.S.; Mitsiades, N.; Chauhan, D.; Richardson, P.; Munshi, N.C.; Anderson, K.C. Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein. Cancer Res., 2003, 63, 18-21.
-
(2003)
Cancer Res
, vol.63
, pp. 18-21
-
-
Akiyama, M.1
Hideshima, T.2
Hayashi, T.3
Tai, Y.T.4
Mitsiades, C.S.5
Mitsiades, N.6
Chauhan, D.7
Richardson, P.8
Munshi, N.C.9
Anderson, K.C.10
-
129
-
-
47549118123
-
Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo
-
Shammas, M.A.; Koley, H.; Bertheau, R.C.; Neri, P.; Fulciniti, M.; Tassone, P.; Blotta, S.; Protopopov, A.; Mitsiades, C.; Batchu, R.B.; Anderson, K.C.; Chin, A.; Gryaznov, S.; Munshi, N.C. Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo. Leukemia, 2008, 22, 1410-1418.
-
(2008)
Leukemia
, vol.22
, pp. 1410-1418
-
-
Shammas, M.A.1
Koley, H.2
Bertheau, R.C.3
Neri, P.4
Fulciniti, M.5
Tassone, P.6
Blotta, S.7
Protopopov, A.8
Mitsiades, C.9
Batchu, R.B.10
Anderson, K.C.11
Chin, A.12
Gryaznov, S.13
Munshi, N.C.14
-
130
-
-
84871035566
-
Expression profile of telomere-associated genes in multiple myeloma
-
de la Guardia, R.D.; Catalina, P.; Panero, J.; Elosua, C.; Pulgarin, A.; López, M.B.; Ayllón, V.; Ligero, G.; Slavutsky, I.; Leone, P.E. Expression profile of telomere-associated genes in multiple myeloma. J. Cell. Mol. Med., 2012, 16, 3009-3021.
-
(2012)
J. Cell. Mol. Med
, vol.16
, pp. 3009-3021
-
-
de la Guardia, R.D.1
Catalina, P.2
Panero, J.3
Elosua, C.4
Pulgarin, A.5
López, M.B.6
Ayllón, V.7
Ligero, G.8
Slavutsky, I.9
Leone, P.E.10
-
131
-
-
0037442674
-
VEGF expression in human macrophages is NF-kappaB-dependent: Studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2
-
Kiriakidis, S.; Andreakos, E.; Monaco, C.; Foxwell, B.; Feldmann, M.; Paleolog, E. VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2. J. Cell. Sci., 2003, 116, 665-674.
-
(2003)
J. Cell. Sci
, vol.116
, pp. 665-674
-
-
Kiriakidis, S.1
Andreakos, E.2
Monaco, C.3
Foxwell, B.4
Feldmann, M.5
Paleolog, E.6
-
132
-
-
26844516068
-
Schaffner, W. NF-kappaB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells
-
Cramer, M.; Nagy, I.; Murphy, B.J.; Gassmann, M.; Hottiger, M.O.; Georgiev, O.; Schaffner, W. NF-kappaB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells. Biol. Chem., 2005, 386, 865-872.
-
(2005)
Biol. Chem
, vol.386
, pp. 865-872
-
-
Cramer, M.1
Nagy, I.2
Murphy, B.J.3
Gassmann, M.4
Hottiger, M.O.5
Georgiev, O.6
-
133
-
-
28844501340
-
The role of nuclear factor kappaB on angiogenesis regulation through monocyte chemotactic protein-1 in myeloma
-
Stifter S. The role of nuclear factor kappaB on angiogenesis regulation through monocyte chemotactic protein-1 in myeloma. Med. Hypotheses, 2006, 66, 384-386.
-
(2006)
Med. Hypotheses
, vol.66
, pp. 384-386
-
-
Stifter, S.1
-
134
-
-
10144233477
-
Expression of adhesion molecules on myeloma cells
-
Tatsumi, T.; Shimazaki, C.; Goto, H.; Araki, S.; Sudo, Y.; Yamagata, N.; Ashihara, E.; Inaba, T.; Fujita, N.; Nakagawa, M. Expression of adhesion molecules on myeloma cells. Jpn. J. Cancer Res., 1996, 87, 837-842.
-
(1996)
Jpn. J. Cancer Res
, vol.87
, pp. 837-842
-
-
Tatsumi, T.1
Shimazaki, C.2
Goto, H.3
Araki, S.4
Sudo, Y.5
Yamagata, N.6
Ashihara, E.7
Inaba, T.8
Fujita, N.9
Nakagawa, M.10
-
135
-
-
0034981119
-
VLA-4-dependent myeloma cell adhesion
-
Sanz-Rodríguez, F.; Teixidó, J. VLA-4-dependent myeloma cell adhesion. Leuk. Lymphoma, 2001, 41, 239-245.
-
(2001)
Leuk. Lymphoma
, vol.41
, pp. 239-245
-
-
Sanz-Rodríguez, F.1
Teixidó, J.2
-
136
-
-
0032508674
-
Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: An absolute requirement for transcription factor NF-kappa B
-
Bond, M.; Fabunmi, R.P.; Baker, A.H.; Newby, A.C. Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-kappa B. FEBS Lett., 1998, 435, 29-34.
-
(1998)
FEBS Lett
, vol.435
, pp. 29-34
-
-
Bond, M.1
Fabunmi, R.P.2
Baker, A.H.3
Newby, A.C.4
-
137
-
-
0031596140
-
Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts
-
Vincenti, M.P.; Coon, C.I.; Brinckerhoff, C.E. Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts. Arthritis Rheum., 1998, 41, 1987-1994.
-
(1998)
Arthritis Rheum
, vol.41
, pp. 1987-1994
-
-
Vincenti, M.P.1
Coon, C.I.2
Brinckerhoff, C.E.3
-
138
-
-
39449098165
-
Interactions of myeloma cells with osteoclasts promote tumour expansion and bone degradation through activation of a complex signalling network and upregulation of cathepsin K, matrix metalloproteinases (MMPs) and urokinase plasminogen activator (uPA)
-
Hecht, M.; von Metzler, I.; Sack, K.; Kaiser, M.; Sezer, O. Interactions of myeloma cells with osteoclasts promote tumour expansion and bone degradation through activation of a complex signalling network and upregulation of cathepsin K, matrix metalloproteinases (MMPs) and urokinase plasminogen activator (uPA). Exp. Cell Res., 2008, 314, 1082-1093.
-
(2008)
Exp. Cell Res
, vol.314
, pp. 1082-1093
-
-
Hecht, M.1
von Metzler, I.2
Sack, K.3
Kaiser, M.4
Sezer, O.5
-
139
-
-
0038780897
-
Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities
-
Delaissé, J.M.; Andersen, T.L.; Engsig, M.T.; Henriksen, K.; Troen, T.; Blavier, L. Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities. Microsc. Res. Tech., 2003, 61, 504-513.
-
(2003)
Microsc. Res. Tech
, vol.61
, pp. 504-513
-
-
Delaissé, J.M.1
Andersen, T.L.2
Engsig, M.T.3
Henriksen, K.4
Troen, T.5
Blavier, L.6
-
140
-
-
18544367201
-
NF-kappa B as a therapeutic target in multiple myeloma
-
Hideshima, T.; Chauhan, D.; Richardson, P.; Mitsiades, C.; Mitsiades, N.; Hayashi, T.; Munshi, N.; Dang, L.; Castro, A.; Palombella, V.; Adams, J.; Anderson, K.C. NF-kappa B as a therapeutic target in multiple myeloma. J. Biol. Chem., 2002, 277, 16639-16647.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 16639-16647
-
-
Hideshima, T.1
Chauhan, D.2
Richardson, P.3
Mitsiades, C.4
Mitsiades, N.5
Hayashi, T.6
Munshi, N.7
Dang, L.8
Castro, A.9
Palombella, V.10
Adams, J.11
Anderson, K.C.12
-
141
-
-
0036624741
-
Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: Therapeutic applications
-
Mitsiades, N.; Mitsiades, CS.; Poulaki, V.; Chauhan, D.; Richardson, PG.; Hideshima, T.; Munshi, N.; Treon, S.P.; Anderson, K.C. Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications. Blood, 2002, 99, 4079-4086.
-
(2002)
Blood
, vol.99
, pp. 4079-4086
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
Chauhan, D.4
Richardson, P.G.5
Hideshima, T.6
Munshi, N.7
Treon, S.P.8
Anderson, K.C.9
-
142
-
-
0037097595
-
Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: Therapeutic implications
-
Mitsiades, N.; Mitsiades, C.S.; Poulaki, V.; Chauhan, D.; Richardson, P.G.; Hideshima, T.; Munshi, N.C.; Treon, S.P.; Anderson, K.C. Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications. Blood, 2002, 99, 4525-4530.
-
(2002)
Blood
, vol.99
, pp. 4525-4530
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
Chauhan, D.4
Richardson, P.G.5
Hideshima, T.6
Munshi, N.C.7
Treon, S.P.8
Anderson, K.C.9
-
143
-
-
79955822004
-
Richardson, PG. Future directions of next-generation novel therapies, combination approaches, and the development of personalized medicine in myeloma
-
Mitsiades, C.S.; Davies, F.E.; Laubach, J.P.; Joshua, D.; San Miguel, J.; Anderson, K.C; Richardson, PG. Future directions of next-generation novel therapies, combination approaches, and the development of personalized medicine in myeloma. J. Clin. Oncol, 2011, 29, 1916-1923.
-
(2011)
J. Clin. Oncol
, vol.29
, pp. 1916-1923
-
-
Mitsiades, C.S.1
Davies, F.E.2
Laubach, J.P.3
Joshua, D.4
San Miguel, J.5
Anderson, K.C.6
-
144
-
-
80051691845
-
In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells
-
Chauhan, D.; Tian, Z.; Zhou, B.; Kuhn, D.; Orlowski, R.; Raje, N.; Richardson, P.; Anderson, K.C. In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells. Clin. Cancer Res., 2011, 17, 5311-5321.
-
(2011)
Clin. Cancer Res
, vol.17
, pp. 5311-5321
-
-
Chauhan, D.1
Tian, Z.2
Zhou, B.3
Kuhn, D.4
Orlowski, R.5
Raje, N.6
Richardson, P.7
Anderson, K.C.8
-
145
-
-
78649707335
-
Lenalidomide mode of action" linking bench and clinical findings
-
Davies, F.; Baz, R. Lenalidomide mode of action" linking bench and clinical findings. Blood Rev, 2010, 24 (Suppl.1), S13-S19.
-
(2010)
Blood Rev
, vol.24
, Issue.SUPPL. 1
-
-
Davies, F.1
Baz, R.2
-
146
-
-
78649715070
-
Lenalidomide: An update on evidence from clinical trials
-
Dimopoulos, M.A.; Terpos, E. Lenalidomide: an update on evidence from clinical trials. Blood Rev, 2010, 24 (Suppl.1), S21-S26.
-
(2010)
Blood Rev
, vol.24
, Issue.SUPPL. 1
-
-
Dimopoulos, M.A.1
Terpos, E.2
-
147
-
-
78649714233
-
Future drug developments in multiple myeloma: An overview of novel lenalidomide-based combination therapies
-
Morgan, G. Future drug developments in multiple myeloma: an overview of novel lenalidomide-based combination therapies. Blood Rev, 2010, 24 (Suppl.1), S27-S32.
-
(2010)
Blood Rev
, vol.24
, Issue.SUPPL. 1
-
-
Morgan, G.1
-
148
-
-
79951509269
-
Management of older patients with multiple myeloma
-
Gay, F.; Palumbo, A. Management of older patients with multiple myeloma. Blood Rev, 2011, 25, 65-73.
-
(2011)
Blood Rev
, vol.25
, pp. 65-73
-
-
Gay, F.1
Palumbo, A.2
-
149
-
-
1642278407
-
Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells
-
Dai, Y.; Pei, X.Y.; Rahmani, M.; Conrad, D.H.; Dent, P.; Grant, S. Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells. Blood, 2004, 103, 2761-2770.
-
(2004)
Blood
, vol.103
, pp. 2761-2770
-
-
Dai, Y.1
Pei, X.Y.2
Rahmani, M.3
Conrad, D.H.4
Dent, P.5
Grant, S.6
-
150
-
-
33750283069
-
MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo
-
Hideshima, T.; Neri, P.; Tassone, P.; Yasui, H.; Ishitsuka, K.; Raje, N.; Chauhan, D.; Podar, K.; Mitsiades, C; Dang, L.; Munshi, N.; Richardson, P.; Schenkein, D.; Anderson, K.C. MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo. Clin. Cancer Res., 2006, 12, 5887-5894.
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 5887-5894
-
-
Hideshima, T.1
Neri, P.2
Tassone, P.3
Yasui, H.4
Ishitsuka, K.5
Raje, N.6
Chauhan, D.7
Podar, K.8
Mitsiades, C.9
Dang, L.10
Munshi, N.11
Richardson, P.12
Schenkein, D.13
Anderson, K.C.14
-
151
-
-
35948980027
-
Canonical nuclear factor kappaB pathway inhibition blocks myeloma cell growth and induces apoptosis in strong synergy with TRAIL
-
Romagnoli, M.; Desplanques, G.; Maïga, S.; Legouill, S.; Dreano, M.; Bataille, R.; Barillé-Nion, S. Canonical nuclear factor kappaB pathway inhibition blocks myeloma cell growth and induces apoptosis in strong synergy with TRAIL. Clin. Cancer Res., 2007, 13, 6010-6018.
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 6010-6018
-
-
Romagnoli, M.1
Desplanques, G.2
Maïga, S.3
Legouill, S.4
Dreano, M.5
Bataille, R.6
Barillé-Nion, S.7
-
152
-
-
34250855679
-
Targeting NF-kappaB pathway with an IKK2 inhibitor induces inhibition of multiple myeloma cell growth
-
Jourdan, M.; Moreaux, J.; Vos, JD.; Hose, D.; Mahtouk, K.; Abouladze, M.; Robert, N.; Baudard, M.; Rème, T.; Romanelli, A.; Goldschmidt, H.; Rossi, J.F.; Dreano, M.; Klein, B. Targeting NF-kappaB pathway with an IKK2 inhibitor induces inhibition of multiple myeloma cell growth. Br. J. Haematol, 2007, 138, 160-168.
-
(2007)
Br. J. Haematol
, vol.138
, pp. 160-168
-
-
Jourdan, M.1
Moreaux, J.2
Vos, J.D.3
Hose, D.4
Mahtouk, K.5
Abouladze, M.6
Robert, N.7
Baudard, M.8
Rème, T.9
Romanelli, A.10
Goldschmidt, H.11
Rossi, J.F.12
Dreano, M.13
Klein, B.14
-
153
-
-
54049149951
-
Simultaneous inhibition of the constitutively activated nuclear factor kappaB and of the interleukin-6 pathways is necessary and sufficient to completely overcome apoptosis resistance of human U266 myeloma cells
-
Malara, N.; Focà, D.; Casadonte, F.; Sesto, MF.; Macrina, L.; Santoro, L.; Scaramuzzino, M.; Terracciano, R.; Savino, R. Simultaneous inhibition of the constitutively activated nuclear factor kappaB and of the interleukin-6 pathways is necessary and sufficient to completely overcome apoptosis resistance of human U266 myeloma cells. Cell Cycle, 2008, 7, 3235-3245.
-
(2008)
Cell Cycle
, vol.7
, pp. 3235-3245
-
-
Malara, N.1
Focà, D.2
Casadonte, F.3
Sesto, M.F.4
Macrina, L.5
Santoro, L.6
Scaramuzzino, M.7
Terracciano, R.8
Savino, R.9
-
154
-
-
84862672118
-
Biologic impact of proteasome inhibition in multiple myeloma cells-from the aspects of preclinical studies
-
Hideshima, T; Anderson, K.C. Biologic impact of proteasome inhibition in multiple myeloma cells-from the aspects of preclinical studies. Semin. Hematol, 2012, 49, 223-227.
-
(2012)
Semin. Hematol
, vol.49
, pp. 223-227
-
-
Hideshima, T.1
Anderson, K.C.2
-
155
-
-
84862696482
-
Bortezomib combination therapy in multiple myeloma
-
Kapoor, P.; Ramakrishnan, V.; Rajkumar, S.V. Bortezomib combination therapy in multiple myeloma. Semin. Hematol, 2012, 49, 228-242.
-
(2012)
Semin. Hematol
, vol.49
, pp. 228-242
-
-
Kapoor, P.1
Ramakrishnan, V.2
Rajkumar, S.V.3
-
156
-
-
52449135431
-
Bortezomib-resistant nuclear factor-KB activity in myeloma cells
-
Markovina, S.; Callander, N.S.; O'Connor S.L., Kim J.; Werndli, J.E.; Raschko, M.; Leith, C.P.; Kahl, B.S.; Kim, K.; Miyamoto, S. Bortezomib-resistant nuclear factor-KB activity in myeloma cells. Mol. Cancer Res., 2008, 6, 1356-1364.
-
(2008)
Mol. Cancer Res
, vol.6
, pp. 1356-1364
-
-
Markovina, S.1
Callander, N.S.2
O'Connor, S.L.3
Kim, J.4
Werndli, J.E.5
Raschko, M.6
Leith, C.P.7
Kahl, B.S.8
Kim, K.9
Miyamoto, S.10
-
157
-
-
77954194855
-
Bone marrow stromal cells from multiple myeloma paytients uniquely induce bortezomib resistant NF-κB activity in myeloma cells
-
Markovina, S.; Callander, N.S.; O'Connor, S.L.; Xu, G.; Shi, Y; Leith, C.P; Kim, K.; Trivedi, P.; Kim, J.; Hematti, P.; Miyamoto, S. Bone marrow stromal cells from multiple myeloma paytients uniquely induce bortezomib resistant NF-κB activity in myeloma cells. Mol. Cancer, 2010, 9, 176.
-
(2010)
Mol. Cancer
, vol.9
, pp. 176
-
-
Markovina, S.1
Callander, N.S.2
O'Connor, S.L.3
Xu, G.4
Shi, Y.5
Leith, C.P.6
Kim, K.7
Trivedi, P.8
Kim, J.9
Hematti, P.10
Miyamoto, S.11
-
158
-
-
84855204408
-
Bortezomib resistance in a myeloma cell line is associated to PSMp5 overexpression and polyploidy
-
Balsas, P.; Galán-Malo, P.; Marzo, I.; Naval, J. Bortezomib resistance in a myeloma cell line is associated to PSMp5 overexpression and polyploidy. Leuk. Res. 2012, 363, 212-218.
-
(2012)
Leuk. Res
, vol.363
, pp. 212-218
-
-
Balsas, P.1
Galán-Malo, P.2
Marzo, I.3
Naval, J.4
-
159
-
-
79957539428
-
Tanespimycin and bortezomib combination treatment in patients with relapsed or relapsed and refractory multiple myeloma: Results of a phase 1/2 study
-
Richardson, P.G.; Chanan-Khan, A.A.; Lonial, S.; Krishnan, A.Y; Carroll, M.P; Alsina, M.; Albitar, M.; Berman, D.; Messina, M.; Anderson, K.C. Tanespimycin and bortezomib combination treatment in patients with relapsed or relapsed and refractory multiple myeloma: results of a phase 1/2 study. Br. J. Haematol, 2011, 153, 729-740.
-
(2011)
Br. J. Haematol
, vol.153
, pp. 729-740
-
-
Richardson, P.G.1
Chanan-Khan, A.A.2
Lonial, S.3
Krishnan, A.Y.4
Carroll, M.P.5
Alsina, M.6
Albitar, M.7
Berman, D.8
Messina, M.9
Anderson, K.C.10
-
160
-
-
34447116376
-
Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome
-
Demo, S.D.; Kirk, C.J.; Aujay, M.A.; Buchholz, T.J.; Dajee, M.; Ho, M.N.; Jiang, J.; Laidig, G.J.; Lewis, E.R.; Parlati, F.; Shenk, K.D.; Smyth, M.S.; Sun, CM.; Vallone, M.K.; Woo, T.M.; Molineaux, C.J.; Bennett, M.K. Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome. Cancer Res., 2007, 67, 6383-6391.
-
(2007)
Cancer Res
, vol.67
, pp. 6383-6391
-
-
Demo, S.D.1
Kirk, C.J.2
Aujay, M.A.3
Buchholz, T.J.4
Dajee, M.5
Ho, M.N.6
Jiang, J.7
Laidig, G.J.8
Lewis, E.R.9
Parlati, F.10
Shenk, K.D.11
Smyth, M.S.12
Sun, C.M.13
Vallone, M.K.14
Woo, T.M.15
Molineaux, C.J.16
Bennett, M.K.17
-
161
-
-
84865552564
-
An open-label, single-arm, phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma who have been previously treated with bortezomib
-
Vij, R.; Siegel, D.S.; Jagannath, S.; Jakubowiak, A.J.; Stewart, A.K.; McDonagh, K.; Bahlis, N.; Belch, A.; Kunkel, L.A.; Wear, S.; Wong, A.F.; Wang, M. An open-label, single-arm, phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma who have been previously treated with bortezomib. Br. J. Haematol, 2012, 158, 739-748.
-
(2012)
Br. J. Haematol
, vol.158
, pp. 739-748
-
-
Vij, R.1
Siegel, D.S.2
Jagannath, S.3
Jakubowiak, A.J.4
Stewart, A.K.5
McDonagh, K.6
Bahlis, N.7
Belch, A.8
Kunkel, L.A.9
Wear, S.10
Wong, A.F.11
Wang, M.12
-
162
-
-
84868614577
-
Design and rationale of FOCUS (PX-171-011): A randomized, open-label, phase 3 study of carfilzomib versus best supportive care regimen in patients with relapsed and refractory multiple myeloma (R/R MM)
-
Hajek, R.; Bryce, R.; Ro, S.; Klencke, B.; Ludwig, H. Design and rationale of FOCUS (PX-171-011): A randomized, open-label, phase 3 study of carfilzomib versus best supportive care regimen in patients with relapsed and refractory multiple myeloma (R/R MM). BMC Cancer., 2012, 12, 415.
-
(2012)
BMC Cancer
, vol.12
, pp. 415
-
-
Hajek, R.1
Bryce, R.2
Ro, S.3
Klencke, B.4
Ludwig, H.5
-
163
-
-
65549136174
-
-
Fuchs, O.; Provaznikova, D.; Marinov, I.; Kuzelova, K.; Spicka, I. Antiproliferative and proapoptotic effects of proteasome inhibitors and their combination with histone deacetylase inhibitors on leukemia cells. Cardiovasc. Hematol Disord. Drug Targets., 2009, 9, 62-77.
-
(2009)
Antiproliferative and Proapoptotic Effects of Proteasome Inhibitors and Their Combination With Histone Deacetylase Inhibitors On Leukemia Cells.Cardiovasc
, vol.9
, pp. 62-77
-
-
Fuchs, O.1
Provaznikova, D.2
Marinov, I.3
Kuzelova, K.4
Spicka, I.5
-
164
-
-
84866715502
-
Role of carfilzomib in the treatment of multiple myeloma
-
Khan, R.Z.; Badros, A. Role of carfilzomib in the treatment of multiple myeloma. Expert. Rev. Hematol, 2012, 5, 361-372.
-
(2012)
Expert. Rev. Hematol
, vol.5
, pp. 361-372
-
-
Khan, R.Z.1
Badros, A.2
-
165
-
-
84865333050
-
A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma
-
Jakubowiak, A.J.; Dytfeld, D.; Griffith, K.A.; Lebovic, D.; Vesole, D.H.; Jagannath, S.; Al-Zoubi, A.; Anderson, T.; Nordgren, B.; Detweiler-Short, K.; Stockerl-Goldstein, K.; Ahmed, A.; Jobkar, T.; Durecki, D.E.; McDonnell, K.; Mietzel, M.; Couriel, D.; Kaminski, M.; Vij, R. A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma. Blood, 2012, 120, 1801-1809.
-
(2012)
Blood
, vol.120
, pp. 1801-1809
-
-
Jakubowiak, A.J.1
Dytfeld, D.2
Griffith, K.A.3
Lebovic, D.4
Vesole, D.H.5
Jagannath, S.6
Al-Zoubi, A.7
Anderson, T.8
Nordgren, B.9
Detweiler-Short, K.10
Stockerl-Goldstein, K.11
Ahmed, A.12
Jobkar, T.13
Durecki, D.E.14
McDonnell, K.15
Mietzel, M.16
Couriel, D.17
Kaminski, M.18
Vij, R.19
-
166
-
-
65649139708
-
Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047)
-
Zhou, H.J.; Aujay, M.A.; Bennett, M.K.; Dajee, M.; Demo, S.D.; Fang, Y.; Ho, M.N.; Jiang, J.; Kirk, C.J.; Laidig, G.J.; Lewis, E.R.; Lu, Y.; Muchamuel, T.; Parlati, F; Ring, E.; Shenk, K.D.; Shields, J.; Shwonek, P.J.; Stanton, T.; Sun, CM.; Sylvain, C; Woo T.M.; Yang, J. Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047). J. Med. Chem., 2009, 52, 3028-3038.
-
(2009)
J. Med. Chem
, vol.52
, pp. 3028-3038
-
-
Zhou, H.J.1
Aujay, M.A.2
Bennett, M.K.3
Dajee, M.4
Demo, S.D.5
Fang, Y.6
Ho, M.N.7
Jiang, J.8
Kirk, C.J.9
Laidig, G.J.10
Lewis, E.R.11
Lu, Y.12
Muchamuel, T.13
Parlati, F.14
Ring, E.15
Shenk, K.D.16
Shields, J.17
Shwonek, P.J.18
Stanton, T.19
Sun, C.M.20
Sylvain, C.21
Woo, T.M.22
Yang, J.23
more..
-
167
-
-
76649142741
-
The novel, proteasome-independent NF-kappaB inhibitor V1810 induces apoptosis and cell cycle arrest in multiple myeloma and overcomes NF-kappaB-mediated drug resistance
-
Meinel, F.G.; Mandl-Weber, S.; Baumann, P.; Leban, J.; Schmidmaier, R. The novel, proteasome-independent NF-kappaB inhibitor V1810 induces apoptosis and cell cycle arrest in multiple myeloma and overcomes NF-kappaB-mediated drug resistance. Mol Cancer Ther, 2010, 9, 300-310.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 300-310
-
-
Meinel, F.G.1
Mandl-Weber, S.2
Baumann, P.3
Leban, J.4
Schmidmaier, R.5
-
168
-
-
84865736407
-
Dual Inhibition of Canonical and Noncanonical NF-κB Pathways Demonstrates Significant Antitumor Activities in Multiple Myeloma
-
Fabre, C; Mimura, N.; Bobb, K.; Kong, S.Y; Gorgun, G.; Cirstea, D.; Hu, Y; Minami, J.; Ohguchi, H.; Zhang, J.; Meshulam, J.; Carrasco, R.D.; Tai, Y.T.; Richardson, P.G.; Hideshima, T.; Anderson, K.C. Dual Inhibition of Canonical and Noncanonical NF-κB Pathways Demonstrates Significant Antitumor Activities in Multiple Myeloma. Clin. Cancer Res., 2012, 18, 4669-4681.
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 4669-4681
-
-
Fabre, C.1
Mimura, N.2
Bobb, K.3
Kong, S.Y.4
Gorgun, G.5
Cirstea, D.6
Hu, Y.7
Minami, J.8
Ohguchi, H.9
Zhang, J.10
Meshulam, J.11
Carrasco, R.D.12
Tai, Y.T.13
Richardson, P.G.14
Hideshima, T.15
Anderson, K.C.16
-
169
-
-
84860744403
-
Continuous lenalidomide treatment for newly diagnosed multiple myeloma
-
MM-015 Investigators
-
Palumbo, A.; Hajek, R.; Delforge, M.; Kropff, M.; Petrucci, M.T.; Catalano, J.; Gisslinger, H.; Wiktor-Jedrzejczak, W.; Zodelava, M.; Weisel, K.; Cascavilla, N.; Iosava, G; Cavo, M.; Kloczko, J.; Bladé, J.; Beksac, M.; Spicka, I.; Plesner, T.; Radke, J.; Langer, C; Ben Yehuda, D.; Corso, A.; Herbein, L.; Yu, Z.; Mei, J.; Jacques, C; Dimopoulos, M.A.; MM-015 Investigators. Continuous lenalidomide treatment for newly diagnosed multiple myeloma. N. Engl. J. Med., 2012, 366, 1759-1769.
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 1759-1769
-
-
Palumbo, A.1
Hajek, R.2
Delforge, M.3
Kropff, M.4
Petrucci, M.T.5
Catalano, J.6
Gisslinger, H.7
Wiktor-Jedrzejczak, W.8
Zodelava, M.9
Weisel, K.10
Cascavilla, N.11
Iosava, G.12
Cavo, M.13
Kloczko, J.14
Bladé, J.15
Beksac, M.16
Spicka, I.17
Plesner, T.18
Radke, J.19
Langer, C.20
Ben Yehuda, D.21
Corso, A.22
Herbein, L.23
Yu, Z.24
Mei, J.25
Jacques, C.26
Dimopoulos, M.A.27
more..
-
170
-
-
84860741191
-
Lenalidomide after stem-cell transplantation for multiple myeloma
-
McCarthy, PL.; Owzar, K.; Hofmeister, C.C.; Hurd, D.D.; Hassoun, H.; Richardson, P.G.; Giralt, S.; Stadtmauer, E.A.; Weisdorf, D.J.; Vij, R.; Moreb, J.S.; Callander, N.S.; Van Besien, K.; Gentile, T.; Isola, L.; Maziarz, R.T.; Gabriel, D.A.; Bashey, A.; Landau, H.; Martin, T.; Qazilbash, M.H.; Levitan, D.; McClune, B.; Schlossman, R.; Hars, V; Postiglione, J.; Jiang, C; Bennett, E.; Barry, S.; Bressler, L.; Kelly, M.; Seiler, M.; Rosenbaum, C; Hari, P.; Pasquini, M.C.; Horowitz, M.M.; Shea, T.C.; Devine, S.M.; Anderson, K.C; Linker, C. Lenalidomide after stem-cell transplantation for multiple myeloma. N. Engl. J. Med., 2012, 366, 1770-1781.
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 1770-1781
-
-
McCarthy, P.L.1
Owzar, K.2
Hofmeister, C.C.3
Hurd, D.D.4
Hassoun, H.5
Richardson, P.G.6
Giralt, S.7
Stadtmauer, E.A.8
Weisdorf, D.J.9
Vij, R.10
Moreb, J.S.11
Callander, N.S.12
van Besien, K.13
Gentile, T.14
Isola, L.15
Maziarz, R.T.16
Gabriel, D.A.17
Bashey, A.18
Landau, H.19
Martin, T.20
Qazilbash, M.H.21
Levitan, D.22
McClune, B.23
Schlossman, R.24
Hars, V.25
Postiglione, J.26
Jiang, C.27
Bennett, E.28
Barry, S.29
Bressler, L.30
Kelly, M.31
Seiler, M.32
Rosenbaum, C.33
Hari, P.34
Pasquini, M.C.35
Horowitz, M.M.36
Shea, T.C.37
Devine, S.M.38
Anderson, K.C.39
Linker, C.40
more..
-
171
-
-
84860709392
-
Lenalidomide maintenance after stem-cell transplantation for multiple myeloma
-
Attal, M.; Lauwers-Cances, V; Marit, G.; Caillot, D.; Moreau, P.; Facon, T.; Stoppa, A.M.; Hulin, C; Benboubker, L.; Garderet, L.; Decaux, O.; Leyvraz, S.; Vekemans, M.C.; Voillat, L.; Michallet, M.; Pegourie, B.; Dumontet, C.; Roussel, M.; Leleu, X.; Mathiot, C.; Payen, C.; Avet-Loiseau, H.; Harousseau, J.L.; IFM Investigators. Lenalidomide maintenance after stem-cell transplantation for multiple myeloma. N. Engl. J. Med., 2012, 366, 1782-1791.
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 1782-1791
-
-
Attal, M.1
Lauwers-Cances, V.2
Marit, G.3
Caillot, D.4
Moreau, P.5
Facon, T.6
Stoppa, A.M.7
Hulin, C.8
Benboubker, L.9
Garderet, L.10
Decaux, O.11
Leyvraz, S.12
Vekemans, M.C.13
Voillat, L.14
Michallet, M.15
Pegourie, B.16
Dumontet, C.17
Roussel, M.18
Leleu, X.19
Mathiot, C.20
Payen, C.21
Avet-Loiseau, H.22
Harousseau, J.L.23
Investigators, I.F.M.24
more..
-
172
-
-
84865190788
-
Mechanism of immunomodulatory drugs in multiple myeloma
-
Sedlarikova, L.; Kubiczkova, L.; Sevcikova, S.; Hajek, R. Mechanism of immunomodulatory drugs in multiple myeloma. Leuk. Res., 2012, 36, 1218-1224.
-
(2012)
Leuk. Res
, vol.36
, pp. 1218-1224
-
-
Sedlarikova, L.1
Kubiczkova, L.2
Sevcikova, S.3
Hajek, R.4
-
173
-
-
84876724199
-
Molecular mechanism of action of the immune-modulatory drugs, thalidomide, lenalidomide and pomalidomide in multiple myeloma
-
(doi:10.3109/10428194.2012.728597)
-
Zhu, Y.X.; Kortuem, K.M.; Stewart, A.K. Molecular mechanism of action of the immune-modulatory drugs, thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leuk. Lymphoma, 2012, (doi:10.3109/10428194.2012.728597)
-
(2012)
Leuk. Lymphoma
-
-
Zhu, Y.X.1
Kortuem, K.M.2
Stewart, A.K.3
-
174
-
-
0035933772
-
Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity
-
Keifer, J.A.; Guttridge, D.C.; Ashburner, B.P.; Baldwin, A.S. Jr.; Keifer, J.A.; Guttridge, D.C.; Ashburner, B.P.; Baldwin, A.S. Jr. Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity. J. Biol. Chem., 2001, 276, 22382-22387.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 22382-22387
-
-
Keifer, J.A.1
Guttridge, D.C.2
Ashburner, B.P.3
Baldwin Jr., A.S.4
Keifer, J.A.5
Guttridge, D.C.6
Ashburner, B.P.7
Baldwin Jr., A.S.8
-
175
-
-
79953300083
-
Lenalidomide restrains motility and overangiogenic potential of bone marrow endothelial cells in patients with active multiple myeloma
-
De Luisi, A.; Ferrucci, A.; Coluccia, A.M.; Ria, R.; Moschetta, M.; de Luca, E.; Pieroni, L.; Maffia, M.; Urbani, A.; Di Pietro, G.; Guarini, A.; Ranieri, G.; Ditonno, P.; Berardi, S.; Caivano, A.; Basile, A.; Cascavilla, N.; Capalbo, S.; Quarta, G.; Dammacco, F.; Ribatti, D.; Vacca, A. Lenalidomide restrains motility and overangiogenic potential of bone marrow endothelial cells in patients with active multiple myeloma. Clin. Cancer Res., 2011, 17, 1935-1946.
-
(2011)
Clin. Cancer Res
, vol.17
, pp. 1935-1946
-
-
de Luisi, A.1
Ferrucci, A.2
Coluccia, A.M.3
Ria, R.4
Moschetta, M.5
de Luca, E.6
Pieroni, L.7
Maffia, M.8
Urbani, A.9
Di Pietro, G.10
Guarini, A.11
Ranieri, G.12
Ditonno, P.13
Berardi, S.14
Caivano, A.15
Basile, A.16
Cascavilla, N.17
Capalbo, S.18
Quarta, G.19
Dammacco, F.20
Ribatti, D.21
Vacca, A.22
more..
-
176
-
-
77949350034
-
Identification of a primary target of thalidomide teratogenicity
-
Ito, T.; Ando, H.; Suzuki, T.; Ogura, T.; Hotta, K.; Imamura, Y.; Yamaguchi, Y.; Handa, H. Identification of a primary target of thalidomide teratogenicity. Science, 2010, 327, 1345-1350.
-
(2010)
Science
, vol.327
, pp. 1345-1350
-
-
Ito, T.1
Ando, H.2
Suzuki, T.3
Ogura, T.4
Hotta, K.5
Imamura, Y.6
Yamaguchi, Y.7
Handa, H.8
-
177
-
-
79960220394
-
Lenalidomide downregulates the cell survival factor, interferon regulatory factor-4, providing a potential mechanistic link for predicting response
-
Lopez-Girona, A.; Heintel, D.; Zhang, L.H.; Mendy, D.; Gaidarova, S.; Brady, H.; Bartlett, J.B.; Schafer, P.H.; Schreder, M.; Bolomsky, A.; Hilgarth, B.; Zojer, N.; Gisslinger, H.; Ludwig, H.; Daniel, T.; Jäger, U.; Chopra, R. Lenalidomide downregulates the cell survival factor, interferon regulatory factor-4, providing a potential mechanistic link for predicting response. Br. J. Haematol., 2011, 154, 325-336.
-
(2011)
Br. J. Haematol
, vol.154
, pp. 325-336
-
-
Lopez-Girona, A.1
Heintel, D.2
Zhang, L.H.3
Mendy, D.4
Gaidarova, S.5
Brady, H.6
Bartlett, J.B.7
Schafer, P.H.8
Schreder, M.9
Bolomsky, A.10
Hilgarth, B.11
Zojer, N.12
Gisslinger, H.13
Ludwig, H.14
Daniel, T.15
Jäger, U.16
Chopra, R.17
-
178
-
-
80855156719
-
Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide
-
Zhu, Y.X.; Braggio, E.; Shi, C.X.; Bruins, L.A.; Schmidt, J.E.; Van Wier, S.; Chang, X.B.; Bjorklund, C.C.; Fonseca, R.; Bergsagel, P.L.; Orlowski, R.Z.; Stewart, A.K. Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide. Blood, 2011, 118, 4771-4779.
-
(2011)
Blood
, vol.118
, pp. 4771-4779
-
-
Zhu, Y.X.1
Braggio, E.2
Shi, C.X.3
Bruins, L.A.4
Schmidt, J.E.5
Van Wier, S.6
Chang, X.B.7
Bjorklund, C.C.8
Fonseca, R.9
Bergsagel, P.L.10
Orlowski, R.Z.11
Stewart, A.K.12
-
179
-
-
84869082150
-
Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide
-
A.; Mendy D.; Ito, T.; Miller K, Gandhi, A.K.; Kang J, Karasawa, S.; Carmel G.; Jackson P, Abbasian M, Mahmoudi, A.; Cathers, B.; Rychak, E.; Gaidarova, S.; Chen, R.; Schafer, P.H.; Handa, H.; Daniel, T.O.; Evans, J.F.; Chopra, R. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia, 2012, 26, 2326-2335.
-
(2012)
Leukemia
, vol.26
, pp. 2326-2335
-
-
-
180
-
-
8444220061
-
Triptolide inhibits transcription factor NF-kappaB and induces apoptosis of multiple myeloma cells
-
YinJun, L.; Jie, J.; YunGui, W. Triptolide inhibits transcription factor NF-kappaB and induces apoptosis of multiple myeloma cells. Leuk. Res., 2005, 29, 99-105.
-
(2005)
Leuk. Res
, vol.29
, pp. 99-105
-
-
Yinjun, L.1
Jie, J.2
Yungui, W.3
-
181
-
-
33646355210
-
Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide
-
Wang, X.; Matta R.; Shen, G.; Nelin, L.D.; Pei, D.; Liu, Y. Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide. J. Mol. Med., 2006, 84, 405-415.
-
(2006)
J. Mol. Med
, vol.84
, pp. 405-415
-
-
Wang, X.1
Matta, R.2
Shen, G.3
Nelin, L.D.4
Pei, D.5
Liu, Y.6
-
182
-
-
33845868505
-
The roles of endogenous reactive oxygen species and nitric oxide in triptolide-induced apoptotic cell death in macrophages
-
Bao, X.; Cui, J.; Wu, Y.; Han, X.; Gao, C.; Hua, Z.; Shen, P. The roles of endogenous reactive oxygen species and nitric oxide in triptolide-induced apoptotic cell death in macrophages. J. Mol. Med., 2007, 85, 85-98.
-
(2007)
J. Mol. Med
, vol.85
, pp. 85-98
-
-
Bao, X.1
Cui, J.2
Wu, Y.3
Han, X.4
Gao, C.5
Hua, Z.6
Shen, P.7
-
183
-
-
65449174330
-
Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with anti-myeloma activity in vitro and in vivo
-
Tiedemann, R.E.; Schmidt, J.; Keats, J.J.; Shi, CX.; Zhu, Y.X.; Palmer, S.E.; Mao, X.; Schimmer, A.D.; Stewart, A.K. Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with anti-myeloma activity in vitro and in vivo. Blood, 2009, 113, 4027-4037.
-
(2009)
Blood
, vol.113
, pp. 4027-4037
-
-
Tiedemann, R.E.1
Schmidt, J.2
Keats, J.J.3
Shi, C.X.4
Zhu, Y.X.5
Palmer, S.E.6
Mao, X.7
Schimmer, A.D.8
Stewart, A.K.9
-
184
-
-
81155148175
-
High resolution meling analysis for detection of BRAF exon 15 mutations in hairy cell leukaemia and other lymphoid malignancies
-
Boyd, E.M.; Bench, A.J.; van't Veer M.B, Wright, P.; Bloxham, D.M.; Follows, G.A. Scott, M.A. High resolution meling analysis for detection of BRAF exon 15 mutations in hairy cell leukaemia and other lymphoid malignancies. Br. J. Haematol., 2011, 155, 609-612.
-
(2011)
Br. J. Haematol
, vol.155
, pp. 609-612
-
-
Boyd, E.M.1
Bench, A.J.2
van't Veer, M.B.3
Wright, P.4
Bloxham, D.M.5
Follows, G.A.6
Scott, M.A.7
-
185
-
-
79960027865
-
BRAF targeted therapy changes the treatment paradigm in melanoma
-
Ribas, A.; Flaherty, K.T. BRAF targeted therapy changes the treatment paradigm in melanoma. Nat. Rev. Clin. Oncol., 2011, 8, 426-433.
-
(2011)
Nat. Rev. Clin. Oncol
, vol.8
, pp. 426-433
-
-
Ribas, A.1
Flaherty, K.T.2
-
186
-
-
67349203626
-
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
-
van Haaften, G.; Dalgliesh, G.L.; Davies, H.; Chen, L.; Bignell, G.; Greenman, C.; Edkins, S.; Hardy, C.; O'Meara, S.; Teague, J.; Butler, A.; Hinton, J.; Latimer, C.; Andrews, J.; Barthorpe, S.; Beare, D.; Buck, G.; Campbell, P.J.; Cole, J.; Forbes, S.; Jia, M.; Jones, D.; Kok, C.Y.; Leroy, C; Lin, M.L.; McBride, D.J.; Maddison, M.; Maquire, S.; McLay, K.; Menzies, A.; Mironenko, T.; Mulderrig, L.; Mudie, L.; Pleasance, E.; Shepherd, R.; Smith, R.; Stebbings, L.; Stephens, P.; Tang, G.; Tarpey, P.S.; Turner, R.; Turrell, K.; Varian, J.; West, S.; Widaa, S.; Wray, P.; Collins, V.P; Ichimura, K.; Law, S.; Wong, J.; Yuen, S.T.; Leung, S.Y.; Tonon, G.; DePinho, R.A.; Tai, Y.T.; Anderson, K.C.; Kahnoski, R.J.; Massie, A.; Khoo, S.K.; The, B.T.; Stratton, M.R.; Futreal, PA. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat. Genet., 2009, 41, 521-523.
-
(2009)
Nat. Genet
, vol.41
, pp. 521-523
-
-
van Haaften, G.1
Dalgliesh, G.L.2
Davies, H.3
Chen, L.4
Bignell, G.5
Greenman, C.6
Edkins, S.7
Hardy, C.8
O'Meara, S.9
Teague, J.10
Butler, A.11
Hinton, J.12
Latimer, C.13
Andrews, J.14
Barthorpe, S.15
Beare, D.16
Buck, G.17
Campbell, P.J.18
Cole, J.19
Forbes, S.20
Jia, M.21
Jones, D.22
Kok, C.Y.23
Leroy, C.24
Lin, M.L.25
McBride, D.J.26
Maddison, M.27
Maquire, S.28
McLay, K.29
Menzies, A.30
Mironenko, T.31
Mulderrig, L.32
Mudie, L.33
Pleasance, E.34
Shepherd, R.35
Smith, R.36
Stebbings, L.37
Stephens, P.38
Tang, G.39
Tarpey, P.S.40
Turner, R.41
Turrell, K.42
Varian, J.43
West, S.44
Widaa, S.45
Wray, P.46
Collins, V.P.47
Ichimura, K.48
Law, S.49
Wong, J.50
Yuen, S.T.51
Leung, S.Y.52
Tonon, G.53
Depinho, R.A.54
Tai, Y.T.55
Anderson, K.C.56
Kahnoski, R.J.57
Massie, A.58
Khoo, S.K.59
The, B.T.60
Stratton, M.R.61
Futreal, P.A.62
more..
-
187
-
-
76449105686
-
The potential role of epigenetic therapy in multiple myeloma
-
Smith, E.M.; Boyd, K.; Davies, F.E. The potential role of epigenetic therapy in multiple myeloma. Br. J. Haematol, 2010, 148, 702-713.
-
(2010)
Br. J. Haematol
, vol.148
, pp. 702-713
-
-
Smith, E.M.1
Boyd, K.2
Davies, F.E.3
-
188
-
-
80955123699
-
Effects of epigenetic-based anti-cancer drugs in leukaemia and multiple myeloma cells
-
Jugová, A.; Sustácková, G.; Legartová, S.; Stixová, L.; Kozubek, S.; Bártová, E. Effects of epigenetic-based anti-cancer drugs in leukaemia and multiple myeloma cells. Cell. Biol. Int., 2011, 35, 1195-1203.
-
(2011)
Cell. Biol. Int
, vol.35
, pp. 1195-1203
-
-
Jugová, A.1
Sustácková, G.2
Legartová, S.3
Stixová, L.4
Kozubek, S.5
Bártová, E.6
-
189
-
-
78650992102
-
Phase 2 trial of the histone deacetylase inhibitor romidepsin for the treatment of refractory multiple myeloma
-
Niesvizky, R.; Ely, S.; Mark, T.; Aggarwal, S.; Gabrilove, J.L.; Wright, J.J.; Chen-Kiang, S.; Sparano, J.A. Phase 2 trial of the histone deacetylase inhibitor romidepsin for the treatment of refractory multiple myeloma. Cancer, 2011, 117, 336-342.
-
(2011)
Cancer
, vol.117
, pp. 336-342
-
-
Niesvizky, R.1
Ely, S.2
Mark, T.3
Aggarwal, S.4
Gabrilove, J.L.5
Wright, J.J.6
Chen-Kiang, S.7
Sparano, J.A.8
-
190
-
-
39149102515
-
Genome-wide transcriptional response to 5-aza-2'-deoxycytidine and trichostatin a in multiple myeloma cells
-
Heller, G.; Schmidt, W.M.; Ziegler, B.; Holzer, S.; Müllauer, L.; Bilban, M.; Zielinski, C.C.; Drach, J.; Zöchbauer-Müller, S. Genome-wide transcriptional response to 5-aza-2'-deoxycytidine and trichostatin a in multiple myeloma cells. Cancer Res., 2008, 68, 44-54.
-
(2008)
Cancer Res
, vol.68
, pp. 44-54
-
-
Heller, G.1
Schmidt, W.M.2
Ziegler, B.3
Holzer, S.4
Müllauer, L.5
Bilban, M.6
Zielinski, C.C.7
Drach, J.8
Zöchbauer-Müller, S.9
-
191
-
-
81155148158
-
Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells
-
Chauhan, D.; Bandi, M.; Singh, A.V.; Ray, A.; Raje, N.; Richardson, P.; Anderson, K.C. Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells. Br. J. Haematol, 2011, 155, 588-598.
-
(2011)
Br. J. Haematol
, vol.155
, pp. 588-598
-
-
Chauhan, D.1
Bandi, M.2
Singh, A.V.3
Ray, A.4
Raje, N.5
Richardson, P.6
Anderson, K.C.7
-
192
-
-
84875216520
-
MMSET stimulates myeloma cell growth through microRNA-mediated modulation of c-MYC
-
(doi 10.1038/leu.2012.269)
-
Min, D.J.; Ezponda, T; Kim, M.; Will, CM.; Martinez-Garcia, E.; Popovic, R.; Basrur, V.; Elenitoba-Johnson, K.S.; Licht, J.D. MMSET stimulates myeloma cell growth through microRNA-mediated modulation of c-MYC. Leukemia, 2012, (doi 10.1038/leu.2012.269).
-
(2012)
Leukemia
-
-
Min, D.J.1
Ezponda, T.2
Kim, M.3
Will, C.M.4
Martinez-Garcia, E.5
Popovic, R.6
Basrur, V.7
Elenitoba-Johnson, K.S.8
Licht, J.D.9
-
193
-
-
78650978001
-
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells
-
Martinez-Garcia, E.; Popovic, R.; Min, D.J.; Sweet, S.M.; Thomas, P.M.; Zamdborg, L.; Heffner, A.; Will, C; Lamy, L.; Staudt, L.M.; Levens, D.L.; Kelleher, N.L.; Licht, J.D. The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. Blood, 2011, 117, 211-220.
-
(2011)
Blood
, vol.117
, pp. 211-220
-
-
Martinez-Garcia, E.1
Popovic, R.2
Min, D.J.3
Sweet, S.M.4
Thomas, P.M.5
Zamdborg, L.6
Heffner, A.7
Will, C.8
Lamy, L.9
Staudt, L.M.10
Levens, D.L.11
Kelleher, N.L.12
Licht, J.D.13
-
194
-
-
33748451151
-
Anticancer activities of histone deacetylase inhibitors
-
Bolden, J.E.; Peart, M.J.; Johnstone, R.W. Anticancer activities of histone deacetylase inhibitors. Nat. Rev. Drug Discov., 2006, 5, 769-784.
-
(2006)
Nat. Rev. Drug Discov
, vol.5
, pp. 769-784
-
-
Bolden, J.E.1
Peart, M.J.2
Johnstone, R.W.3
-
195
-
-
39749103428
-
Phase I trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) in patients with advanced multiple myeloma
-
Richardson, P.; Mitsiades, C; Colson, K.; Reilly, E.; McBride, L.; Chiao, J.; Sun, L.; Ricker, J.; Rizvi, S.; Oerth, C; Atkins, B.; Fearen, I.; Anderson, K.; Siegel, D. Phase I trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) in patients with advanced multiple myeloma. Leuk. Lymphoma, 2008, 49, 502-507.
-
(2008)
Leuk. Lymphoma
, vol.49
, pp. 502-507
-
-
Richardson, P.1
Mitsiades, C.2
Colson, K.3
Reilly, E.4
McBride, L.5
Chiao, J.6
Sun, L.7
Ricker, J.8
Rizvi, S.9
Oerth, C.10
Atkins, B.11
Fearen, I.12
Anderson, K.13
Siegel, D.14
-
196
-
-
67650995912
-
Antimyeloma activity of the orally bioavailable dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235
-
McMillin, D.W.; Ooi, M.; Delmore, J.; Negri, J.; Hayden, P.; Mitsiades, N.; Jakubikova, J.; Maira, S.M.; Garcia-Echeverria, C; Schlossman, R.; Munshi, N.C.; Richardson, P.G.; Anderson, K.C; Mitsiades, C.S. Antimyeloma activity of the orally bioavailable dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235. Cancer Res., 2009, 69, 5835-5842.
-
(2009)
Cancer Res
, vol.69
, pp. 5835-5842
-
-
McMillin, D.W.1
Ooi, M.2
Delmore, J.3
Negri, J.4
Hayden, P.5
Mitsiades, N.6
Jakubikova, J.7
Maira, S.M.8
Garcia-Echeverria, C.9
Schlossman, R.10
Munshi, N.C.11
Richardson, P.G.12
Anderson, K.C.13
Mitsiades, C.S.14
-
197
-
-
58149481284
-
The novel orally bioavailable inhibitor of phosphoinositol-3-kinase and mammalian target of rapamycin, NVP-BEZ235, inhibits growth and proliferation in multiple myeloma
-
Baumann, P.; Mandl-Weber, S.; Oduncu, F.; Schmidmaier, R. The novel orally bioavailable inhibitor of phosphoinositol-3-kinase and mammalian target of rapamycin, NVP-BEZ235, inhibits growth and proliferation in multiple myeloma. Exp. Cell Res., 2009, 315, 485-497.
-
(2009)
Exp. Cell Res
, vol.315
, pp. 485-497
-
-
Baumann, P.1
Mandl-Weber, S.2
Oduncu, F.3
Schmidmaier, R.4
-
198
-
-
82555166037
-
Simultaneous targeting of PI3K and mTOR with NVP-BGT226 is highly effective in multiple myeloma
-
Baumann, P.; Schneider, L.; Mandl-Weber, S.; Oduncu, F.; Schmidmaier, R. Simultaneous targeting of PI3K and mTOR with NVP-BGT226 is highly effective in multiple myeloma. Anticancer Drugs, 2012, 23, 131-138.
-
(2012)
Anticancer Drugs
, vol.23
, pp. 131-138
-
-
Baumann, P.1
Schneider, L.2
Mandl-Weber, S.3
Oduncu, F.4
Schmidmaier, R.5
-
199
-
-
34248591612
-
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
-
Roberts, P.J.; Der, C.J. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene, 2007, 26, 3291-3310.
-
(2007)
Oncogene
, vol.26
, pp. 3291-3310
-
-
Roberts, P.J.1
Der, C.J.2
-
200
-
-
57849129292
-
Clinical and biological significance of RAS mutations in multiple myeloma
-
Chng, W.J.; Gonzalez-Paz, N.; Price-Troska, T; Jacobus, S.; Rajkumar, S.V.; Oken, M.M.; Kyle, R.A.; Henderson, K.J.; Van Wier, S.; Greipp, P.; Van Ness, B.; Fonseca, R. Clinical and biological significance of RAS mutations in multiple myeloma. Leukemia, 2008, 22, 2280-2284.
-
(2008)
Leukemia
, vol.22
, pp. 2280-2284
-
-
Chng, W.J.1
Gonzalez-Paz, N.2
Price-Troska, T.3
Jacobus, S.4
Rajkumar, S.V.5
Oken, M.M.6
Kyle, R.A.7
Henderson, K.J.8
van Wier, S.9
Greipp, P.10
van Ness, B.11
Fonseca, R.12
-
201
-
-
0034284027
-
Targeting the Ras signaling pathway: A rational, mechanism-based treatment for hematological malignancies?
-
Reuter, C.W.M.; Morgan, M.A.; Bergmann, L. Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematological malignancies? Blood, 2000, 96, 1655-1669.
-
(2000)
Blood
, vol.96
, pp. 1655-1669
-
-
Reuter, C.W.M.1
Morgan, M.A.2
Bergmann, L.3
-
202
-
-
11144358447
-
Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma
-
Alsina, M.; Fonseca, R.; Wilson, E.F.; Belle, A.N.; Gerbino, E.; Price-Troska, T.; Overton, R.M.; Ahmann, G.; Bruzek, L.M.; Adjei, A.A.; Kaufmann, S.H.; Wright, J.J.; Sullivan, D.; Djulbegovic, B.; Cantor, A.B.; Greipp, P.R.; Dalton, W.S.; Sebti, S.M. Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma. Blood, 2004, 103, 3271-3277.
-
(2004)
Blood
, vol.103
, pp. 3271-3277
-
-
Alsina, M.1
Fonseca, R.2
Wilson, E.F.3
Belle, A.N.4
Gerbino, E.5
Price-Troska, T.6
Overton, R.M.7
Ahmann, G.8
Bruzek, L.M.9
Adjei, A.A.10
Kaufmann, S.H.11
Wright, J.J.12
Sullivan, D.13
Djulbegovic, B.14
Cantor, A.B.15
Greipp, P.R.16
Dalton, W.S.17
Sebti, S.M.18
-
203
-
-
78650041246
-
Tipifarnib sensitizes cells to proteasome inhibition by blocking degradation of bortezomib-induced aggresomes
-
David, E.; Kaufman, J.L.; Flowers, C.R.; Schafer-Hales, K.; Torre, C.; Chen, J.; Marcus, A.I.; Sun, S.Y.; Boise, L.H.; Lonial, S. Tipifarnib sensitizes cells to proteasome inhibition by blocking degradation of bortezomib-induced aggresomes. Blood, 2010, 116, 5285-5288.
-
(2010)
Blood
, vol.116
, pp. 5285-5288
-
-
David, E.1
Kaufman, J.L.2
Flowers, C.R.3
Schafer-Hales, K.4
Torre, C.5
Chen, J.6
Marcus, A.I.7
Sun, S.Y.8
Boise, L.H.9
Lonial, S.10
-
204
-
-
77649193345
-
Sorafenib, a dual Raf kinase/vascular endothelial growth factor receptor inhibitor has significant anti-myeloma activity and synergizes with common anti-myeloma drugs
-
Ramakrishnan, V.; Timm, M.; Haug, J.L.; Kimlinger, T.K.; Wellik, L.E.; Witzig, T.E.; Rajkumar, S.V.; Adjei, A.A.; Kumar, S. Sorafenib, a dual Raf kinase/vascular endothelial growth factor receptor inhibitor has significant anti-myeloma activity and synergizes with common anti-myeloma drugs. Oncogene, 2010, 29, 1190-1202.
-
(2010)
Oncogene
, vol.29
, pp. 1190-1202
-
-
Ramakrishnan, V.1
Timm, M.2
Haug, J.L.3
Kimlinger, T.K.4
Wellik, L.E.5
Witzig, T.E.6
Rajkumar, S.V.7
Adjei, A.A.8
Kumar, S.9
-
205
-
-
84867517513
-
Sorafenib has potent anti-tumor activity in multiple myeloma in vitro, ex vivo and in vivo, in the 5T33MM mouse model
-
Kharaziha, P.; De Raeve, H.; Fristedt, C.; Li, Q.; Gruber, A.; Johnsson, P.; Kokaraki, G.; Panzar, M.; Laane, E.; Osterborg, A.; Zhivotovsky, B.; Jernberg-Wiklund, H.; Grander, D.; Celsing, F.; Bjorkholm, M.; Vanderkerken, K.; Panaretakis, T. Sorafenib has potent anti-tumor activity in multiple myeloma in vitro, ex vivo and in vivo, in the 5T33MM mouse model. Cancer Res. 2012, 72, 5348-5362.
-
(2012)
Cancer Res
, vol.72
, pp. 5348-5362
-
-
Kharaziha, P.1
de Raeve, H.2
Fristedt, C.3
Li, Q.4
Gruber, A.5
Johnsson, P.6
Kokaraki, G.7
Panzar, M.8
Laane, E.9
Osterborg, A.10
Zhivotovsky, B.11
Jernberg-Wiklund, H.12
Grander, D.13
Celsing, F.14
Bjorkholm, M.15
Vanderkerken, K.16
Panaretakis, T.17
-
206
-
-
28844500739
-
The combination of the farnesyl transferase inhibitor lonafarnib and the proteasome inhibitor bortezomib induces synergistic apoptosis in human myeloma cells that is associated with down-regulation of p-AKT
-
David, E.; Sun, S.Y.; Waller, E.K.; Chen, J.; Khuri, F.R.; Lonial, S. The combination of the farnesyl transferase inhibitor lonafarnib and the proteasome inhibitor bortezomib induces synergistic apoptosis in human myeloma cells that is associated with down-regulation of p-AKT. Blood, 2005, 106, 4322-4329.
-
(2005)
Blood
, vol.106
, pp. 4322-4329
-
-
David, E.1
Sun, S.Y.2
Waller, E.K.3
Chen, J.4
Khuri, F.R.5
Lonial, S.6
-
207
-
-
23044478114
-
Atiprimod blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells
-
Amit-Vazina, M.; Shishodia, S.; Harris, D.; Van, Q.; Wang, M.; Weber, D.; Alexanian, R.; Talpaz, M.; Aggarwal, B.B.; Estrov, Z. Atiprimod blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells. Br. J. Cancer, 2005, 93, 70-80.
-
(2005)
Br. J. Cancer
, vol.93
, pp. 70-80
-
-
Amit-Vazina, M.1
Shishodia, S.2
Harris, D.3
Van, Q.4
Wang, M.5
Weber, D.6
Alexanian, R.7
Talpaz, M.8
Aggarwal, B.B.9
Estrov, Z.10
-
208
-
-
77956471258
-
TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells
-
Ramakrishnan, V.; Kimlinger, T.; Haug, J.; Timm, M.; Wellik, L.; Halling, T.; Pardanani, A.; Tefferi, A.; Rajkumar, S.V.; Kumar, S. TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells. Am. J. Hematol., 2010, 85, 675-686.
-
(2010)
Am. J. Hematol
, vol.85
, pp. 675-686
-
-
Ramakrishnan, V.1
Kimlinger, T.2
Haug, J.3
Timm, M.4
Wellik, L.5
Halling, T.6
Pardanani, A.7
Tefferi, A.8
Rajkumar, S.V.9
Kumar, S.10
-
209
-
-
84860630975
-
Targeting the interleukin-6/Jak/Stat pathway in human malignancies
-
Sansone, P.; Bromberg, J. Targeting the interleukin-6/Jak/Stat pathway in human malignancies. J. Clin. Oncol., 2012, 30, 1005-1014.
-
(2012)
J. Clin. Oncol
, vol.30
, pp. 1005-1014
-
-
Sansone, P.1
Bromberg, J.2
-
210
-
-
0344076348
-
Combination chemotherapy versus melphalan plus prednisone as treatment for multiple myeloma: An overview of 6,633 patients from 27 randomized trials: Myeloma TrialistśCollaborative Group
-
Myeloma TrialistśCollaborative Group
-
Myeloma TrialistśCollaborative Group: Combination chemotherapy versus melphalan plus prednisone as treatment for multiple myeloma: An overview of 6,633 patients from 27 randomized trials: Myeloma TrialistśCollaborative Group. J. Clin. Oncol., 1998, 16, 3832-3842.
-
(1998)
J. Clin. Oncol
, vol.16
, pp. 3832-3842
-
-
-
211
-
-
0030887695
-
Standard therapy versus autologous transplantation in multiple myeloma
-
Attal, M.; Harousseau, J.L. Standard therapy versus autologous transplantation in multiple myeloma. Hematol. Oncol. Clin. North Am., 1997, 11, 133-146.
-
(1997)
Hematol. Oncol. Clin. North Am
, vol.11
, pp. 133-146
-
-
Attal, M.1
Harousseau, J.L.2
-
212
-
-
76249096571
-
How I treat multiple myeloma in younger patients
-
Stewart, A.K.; Richardson, P.G.; San-Miguel, J.F. How I treat multiple myeloma in younger patients. Blood, 2009, 114, 5436-5443.
-
(2009)
Blood
, vol.114
, pp. 5436-5443
-
-
Stewart, A.K.1
Richardson, P.G.2
San-Miguel, J.F.3
-
213
-
-
84863576232
-
GIMEMA (Gruppo Italiano Malattie Ematologiche dell'Adulto) Italian Myeloma Network. Bortezomib-thalidomide-dexamethasone is superior to thalidomide-dexamethasone as consolidation therapy after autologous hematopoietic stem cell transplantation in patients with newly diagnosed multiple myeloma
-
Cavo, M.; Pantani, L.; Petrucci, M.T.; Patriarca, F.; Zamagni, E.; Donnarumma, D.; Crippa, C.; Boccadoro, M.; Perrone, G.; Falcone, A.; Nozzoli, C.; Zambello, R.; Masini, L.; Furlan, A.; Brioli, A.; Derudas, D.; Ballanti, S.; Dessanti, M.L.; De Stefano, V.; Carella, A.M.; Marcatti, M.; Nozza, A.; Ferrara, F.; Callea, V.; Califano, C.; Pezzi, A.; Baraldi, A.; Grasso, M.; Musto, P.; Palumbo, A.; GIMEMA (Gruppo Italiano Malattie Ematologiche dell'Adulto) Italian Myeloma Network. Bortezomib-thalidomide-dexamethasone is superior to thalidomide-dexamethasone as consolidation therapy after autologous hematopoietic stem cell transplantation in patients with newly diagnosed multiple myeloma. Blood, 2012, 120, 9-19.
-
(2012)
Blood
, vol.120
, pp. 9-19
-
-
Cavo, M.1
Pantani, L.2
Petrucci, M.T.3
Patriarca, F.4
Zamagni, E.5
Donnarumma, D.6
Crippa, C.7
Boccadoro, M.8
Perrone, G.9
Falcone, A.10
Nozzoli, C.11
Zambello, R.12
Masini, L.13
Furlan, A.14
Brioli, A.15
Derudas, D.16
Ballanti, S.17
Dessanti, M.L.18
de Stefano, V.19
Carella, A.M.20
Marcatti, M.21
Nozza, A.22
Ferrara, F.23
Callea, V.24
Califano, C.25
Pezzi, A.26
Baraldi, A.27
Grasso, M.28
Musto, P.29
Palumbo, A.30
more..
-
214
-
-
84864069892
-
The era of combination therapy in myeloma
-
Lonial, S.; Kaufman, J.L. The era of combination therapy in myeloma. J. Clin. Oncol., 2012, 30, 2434-2436.
-
(2012)
J. Clin. Oncol
, vol.30
, pp. 2434-2436
-
-
Lonial, S.1
Kaufman, J.L.2
-
215
-
-
84864055971
-
Superiority of the triple combination of bortezomib-thalidomide-dexamethasone over the dual combination of thalidomide-dexamethasone in patients with multiple myeloma progressing or relapsing after autologous transplantation: The MMVAR/IFM 2005-04 Randomized Phase III Trial from the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation
-
Garderet, L.; Iacobelli, S.; Moreau, P.; Dib, M.; Lafon, I.; Niederwieser, D.; Masszi, T.; Fontan, J.; Michallet, M.; Gratwohl, A.; Milone, G.; Doyen, C.; Pegourie, B.; Hajek, R.; Casassus, P.; Kolb, B.; Chaleteix, C.; Hertenstein, B.; Onida, F.; Ludwig, H.; Ketterer, N.; Koenecke, C.; van Os, M.; Mohty, M.; Cakana, A.; Gorin, N.C.; de Witte, T.; Harousseau, J.L.; Morris, C.; Gahrton, G. Superiority of the triple combination of bortezomib-thalidomide-dexamethasone over the dual combination of thalidomide-dexamethasone in patients with multiple myeloma progressing or relapsing after autologous transplantation: the MMVAR/IFM 2005-04 Randomized Phase III Trial from the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. J. Clin. Oncol., 2012, 30, 2475-2482.
-
(2012)
J. Clin. Oncol
, vol.30
, pp. 2475-2482
-
-
Garderet, L.1
Iacobelli, S.2
Moreau, P.3
Dib, M.4
Lafon, I.5
Niederwieser, D.6
Masszi, T.7
Fontan, J.8
Michallet, M.9
Gratwohl, A.10
Milone, G.11
Doyen, C.12
Pegourie, B.13
Hajek, R.14
Casassus, P.15
Kolb, B.16
Chaleteix, C.17
Hertenstein, B.18
Onida, F.19
Ludwig, H.20
Ketterer, N.21
Koenecke, C.22
van Os, M.23
Mohty, M.24
Cakana, A.25
Gorin, N.C.26
de Witte, T.27
Harousseau, J.L.28
Morris, C.29
Gahrton, G.30
more..
-
216
-
-
84867317687
-
Carfilzomib in multiple myeloma: Gold, silver or bronze?
-
Reece, D.E. Carfilzomib in multiple myeloma: gold, silver or bronze? Blood, 2012, 120, 2776-2777.
-
(2012)
Blood
, vol.120
, pp. 2776-2777
-
-
Reece, D.E.1
-
217
-
-
84867295563
-
A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma
-
Siegel, D.S.; Martin, T.; Wang, M.; Vij, R.; Jakubowiak, A.J.; Lonial, S.; Trudel, S.; Kukreti, V.; Bahlis, N.; Alsina, M.; Chanan-Khan, A.; Buadi, F.; Reu, F.J.; Somio, G.; Zonder, J.; Song, K.; Stewart, A.K.; Stadtmauer, E.; Kunkel, L.; Wear, S.; Wong, A.F.; Orlowski, R.Z., Jaganath, S. A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma. Blood, 2012, 120, 2817-2825.
-
(2012)
Blood
, vol.120
, pp. 2817-2825
-
-
Siegel, D.S.1
Martin, T.2
Wang, M.3
Vij, R.4
Jakubowiak, A.J.5
Lonial, S.6
Trudel, S.7
Kukreti, V.8
Bahlis, N.9
Alsina, M.10
Chanan-Khan, A.11
Buadi, F.12
Reu, F.J.13
Somio, G.14
Zonder, J.15
Song, K.16
Stewart, A.K.17
Stadtmauer, E.18
Kunkel, L.19
Wear, S.20
Wong, A.F.21
Orlowski, R.Z.22
Jaganath, S.23
more..
-
219
-
-
78649645749
-
RITA inhibits multiple myeloma cell growth through induction of p53-mediated caspase-dependent apoptosis and synergistically enhances nutlin-induced cytotoxic responses
-
Saha, M.N.; Jiang, H.; Mukai, A.; Chang, H. RITA inhibits multiple myeloma cell growth through induction of p53-mediated caspase-dependent apoptosis and synergistically enhances nutlin-induced cytotoxic responses. Mol. Cancer Ther., 2010, 9, 3041-3051.
-
(2010)
Mol. Cancer Ther
, vol.9
, pp. 3041-3051
-
-
Saha, M.N.1
Jiang, H.2
Mukai, A.3
Chang, H.4
-
220
-
-
77957936826
-
Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development
-
Pichiorri, F.; Suh, S.S.; Rocci, A.; De Luca, L.; Taccioli, C.; Santhanam, R.; Zhou, W.; Benson, D.M. Jr.; Hofmainster, C.; Alder, H.; Garofalo, M.; Di Leva, G.; Volinia, S.; Lin, H.J.; Perrotti, D.; Kuehl, M.; Aqeilan, R.I.; Palumbo, A.; Croce, C.M. Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development. Cancer Cell, 2010, 18, 367-381.
-
(2010)
Cancer Cell
, vol.18
, pp. 367-381
-
-
Pichiorri, F.1
Suh, S.S.2
Rocci, A.3
de Luca, L.4
Taccioli, C.5
Santhanam, R.6
Zhou, W.7
Benson Jr., D.M.8
Hofmainster, C.9
Alder, H.10
Garofalo, M.11
Di Leva, G.12
Volinia, S.13
Lin, H.J.14
Perrotti, D.15
Kuehl, M.16
Aqeilan, R.I.17
Palumbo, A.18
Croce, C.M.19
-
221
-
-
80755153537
-
MicroRNA signatures characterize multiple myeloma patients
-
Corthals, S.L.; Sun, S.M.; Kuiper, R.; de Knegt, Y.; Broyl, A.; van der Holt, B.; Beverloo, H.B.; Peeters, J.K.; El Jarari, L.; Lokhorst, H.M.; Zweegman, S.; Jongen-Lavrencic, M.; Sonneveld, P. MicroRNA signatures characterize multiple myeloma patients. Leukemia, 2011, 25, 1784-1789.
-
(2011)
Leukemia
, vol.25
, pp. 1784-1789
-
-
Corthals, S.L.1
Sun, S.M.2
Kuiper, R.3
de Knegt, Y.4
Broyl, A.5
van der Holt, B.6
Beverloo, H.B.7
Peeters, J.K.8
El-Jarari, L.9
Lokhorst, H.M.10
Zweegman, S.11
Jongen-Lavrencic, M.12
Sonneveld, P.13
|