Age-related decline in melatonin and Its MT1 receptor are associated with decreased sensitivity to melatonin and enhanced mammary tumor growth

Current Aging Science

Volumn 6, Issue 1, 2013, Pages 125-133

  Hill, Steven M ^a   Cheng, Chi ^a   Yuan, Lin ^a   Mao, Lulu ^a   Jockers, Rolf ^b   Dauchy, Bob ^a   Blask, David E ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INSTITUT COCHIN   (France)

Author keywords

Aging; Breast cancer; Circadian rhythms; Light at night; Mammary tumor; Melatonin; MT1 receptor; Pineal gland; Tumor growth

Indexed keywords

CELL NUCLEUS RECEPTOR; MELATONIN; MELATONIN 1 RECEPTOR;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; BREAST TUMOR; CANCER INCIDENCE; CONTROLLED STUDY; FEMALE; NONHUMAN; PINEAL BODY; PRIORITY JOURNAL; RAT; TUMOR GROWTH;

AGING; ANIMALS; BREAST NEOPLASMS; FEMALE; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MELATONIN; MICE; PINEAL GLAND; RATS; RECEPTOR, MELATONIN, MT1; RECEPTORS, CYTOPLASMIC AND NUCLEAR; UTERUS;

EID: 84882736324     PISSN: 18746098     EISSN: 18746128     Source Type: Journal    
DOI: 10.2174/1874609811306010016     Document Type: Article

References (25)

1. Mangus K. Trends in Cancer Incidence: Causes and Practicle Implications, Washington, D.C. Hemisphrere, 1982.
2. Balducci L. Epidemiology of cancer and aging. J Oncol Manag 2005; 14: 47-50.
3. Newell GR, Spitz MR, Sider JG. Cancer and age. Semin Oncol 1989; 16: 3-9.
4. Waldhauser F, Dietzel M. Daily and annual rhythms in human melatonin secretion; role in puberty control. Ann NY Acad Sci 1985; 453: 205-14.
5. Cassone VM. The pineal gland influences rat circadian rhythms in constant light. J Biol Rhythms 1992; 7: 27-35.
6. Iguchi H, Kato K, Ibayashi H. Age-dependent reduction in serum melatonin concentrations in healthy human subjects. J Clin Endocrinol Metab 1982; 55: 27-35.
7. Schernhammer ES, Laden F, Speizer FE, et al. Rotating night shifts and risk of breast cancer in women participating in the nurse's health study. J Natl Cancer Inst 2001; 93:1563-8.
8. Dauchy RT, Blask DE, Sauer LA, Brainard GC, Grause JA. Dim light during darkness stimulates tumor progression by enhancing tumor fatty acid uptake and metabolism. Cancer Lett 1999; 144: 131-6.
9. Molis TM, Spriggs LS, Jupiter Y, Hill SM. Melatonin modulation of estrogen-regulated proteins, growth factors, and proto-oncogenes in human breast cancer. J Pineal Res 1995; 18: 93-103.
10. Hill SM, Kiefer T, Teplinzky S, Eck K, Spriggs LL, Ram PT. Melatonin Modulation of the Estrogen Response Pathway in Breast Cancer. In: The Pineal Gland and Cancer Editors, Bartsch C, Bartsch H, Blask DE. Cardinali D, Hrushesky W, Mecke D. Springer-Verlag: Heidelberg, 2000.
11. Ram PT, Kiefer T, Sliverman M, Song Y, Brown GM, Hill SM. Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors. Mol Cell Endocrinol 1998; 141: 53-64.
12. Dai J, Ram P, Yuan L, Spriggs LL, Hill SM. Transcriptional repression of RORalpha activity in human breast cancer cells by melatonin. Mol Cell Endocrinol 2001; 176: 111-20.
13. Kiefer TL, Lai L, Burow ME, Hill SM. Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor transcriptional activity by melatonin is mediated via the Gαi2 protein. J. Pineal Res 2005; 38: 231-9.
14. Blask DE, Sauer LA, Dauchy RT, Holowachuk EW, Ruhoff MS, Kopff HS. Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin-receptormediated signal transduction events. Cancer Res 1999; 59: 4693-701.
15. Skene DJ, Vivien-Roels B, Sparks DL, et al. Daily variantin in the concentration of melatonin in the human pineal gland: effects of age and Alzheimer's disease. Brain Res. 1990; 528:170-4.
16. Lai L, Yuan L, Chen Q, et al. The G-alpha(i) and G-alpha(q) proteins mediate the effects of melatonin on steroid/thyroid hormone receptor transcriptional activity and breast cancer cell proliferation. J Pineal Res 2008; 45: 476-88.
17. del Río B, García Pedrero JM, Martínez-Campa C, Zuazua P, Lazo PS, Ramos S. Melatonin, An endogenous specific inhibitor of estrogen receptor alpha viacalmodulin J Biol Chem 2004; 279: 38294-302.
18. Pang SF, Tsang CW, Hong GX, Yip PC, Tang PL, Brown GM. Fluctuation of blood melatonin concentrations with age: result of changes in pineal melatonin secretion, body growth, and aging. J Pineal Res 1990; 8:179-92.
19. Vaughan MK, Vaughan GM, Reiter RJ, Blask DE. Influence of melatonin, constant light, or blinding on reproductive system of gerbils (Meriones unguiculatus). Experentia 1976; 32: 1341-2.
20. Blask DE, Pellitier DB, Hill SM, Massa J. Pineal melatonin inhibition of tumor promotion in the N-nitroso-N-methylurea model of mammary carcinogenesis: Potential involvement of the antiestrogenic mechanisms in vivo. J Cancer Res Clin Oncol 1991; 117: 526-34.
21. Yuan L, Collins AR, Dai J, Dubocovich ML, Hill SM. MT1 melatonin receptor over expression enhances the growth suppressive effect of melatonin in human breast cancer cells. Mol Cell Endocrinol 2002; 192: 147-156.
22. Teplitzky SR, Kiefer TL, Cheng Q, Blask DE, Hill SM. Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis retinoic acid. Cancer Lett 2001; 168: 155-63.
23. Melancon K, Cheng Q, Kiefer TL, Teplitzky SR, Hill SM. Regression of NMU-induced mammary tumors with the combination of melatonin and 9-cis retinoic acid. Cancer Lett 2005; 227: 39-48.
24. Sanchez-Hidalgo M, Guerrero Montavez JM, Carrascosa-Salmoral MD, Naranjo-Gutierrez MD, Lardone PJ, de la Lastra Romero CA. Decreased MT1 and MT2 melatonin receptor expression in extrapineal tissues of the rat during physiological aging. J Pineal Res 2009; 46: 29-35.
25. Zeitzer JM, Duffy JF, Lockley SW, Dijk DJ, Czeisler CA. Plasma melatonin rhythms in young and older humans during sleep, sleep deprivation, and wake. Sleep 2007; 30: 1437-43.