Effect of melatonin on the expression of Nrf2 and NF-κB during cyclophosphamide-induced urinary bladder injury in rat

Journal of Pineal Research

Volumn 48, Issue 4, 2010, Pages 324-331

  Tripathi, D N ^a   Jena, G B ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Cyclophosphamide; Melatonin; NF B; Nrf2; Urotoxicity

Indexed keywords

CYCLOPHOSPHAMIDE; DNA; GLUTATHIONE; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MELATONIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRANSCRIPTION FACTOR NRF2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BLADDER INJURY; CELL DAMAGE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; HISTOPATHOLOGY; MALE; MOLECULAR MECHANICS; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; TREATMENT DURATION; TREATMENT OUTCOME; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; COMET ASSAY; CYCLOPHOSPHAMIDE; DNA DAMAGE; GENE EXPRESSION; HISTOCYTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MELATONIN; NF-E2-RELATED FACTOR 2; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; URINARY BLADDER DISEASES;

EID: 77950648335     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2010.00756.x     Document Type: Article

References (40)

1. Levine LA, Richie JP. Urological complications of cyclophosphamide. J Urol 1989 141 : 1063 1069.
2. Cox PJ. Cyclophosphamide cystitis - identification of acrolein as the causative agent. Biochem Pharmacol 1979 28 : 2045 2049.
3. Korkmaz A, Oter S, Sadir S et al. Peroxynitrite may be involved in bladder damage caused by cyclophosphamide in rats. J Urol 2005 173 : 1793 1796. (Pubitemid 40524834)
4. Oter S, Korkmaz A, Oztas E et al. Inducible nitric oxide synthase inhibition in cyclophosphamide induced hemorrhagic cystitis in rats. Urol Res 2004 32 : 185 189.
5. Zhou Q, Mrowietz U, Rostami-Yazdi M. Oxidative stress in the pathogenesis of psoriasis. Free Radic Biol Med 2009 47 : 891 905.
6. Yu X, Kensler T. Nrf2 as a target for cancer chemoprevention. Mutat Res 2005 591 : 93 102.
7. Surh YJ. NF-kappa B and Nrf2 as potential chemopreventive targets of some anti-inflammatory and antioxidative phytonutrients with anti-inflammatory and antioxidative activities. Asia Pac J Clin Nutr 2008 17 : 269 272.
8. Jin W, Wang H, Yan W et al. Disruption of Nrf2 enhances upregulation of nuclear factor-kappaB activity, proinflammatory cytokines, and intercellular adhesion molecule-1 in the brain after traumatic brain injury. Mediators Inflamm 2008 2008 : 725174.
9. Jung KH, Hong SW, Zheng HM et al. Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model. J Pineal Res 2009 47 : 173 183.
10. Tamura H, Takasaki A, Miwa I et al. Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate. J Pineal Res 2008 44 : 280 287.
11. Tengattini S, Reiter RJ, Tan DX et al. Cardiovascular diseases: protective effects of melatonin. J Pineal Res 2008 44 : 16 25.
12. Ganguly K, Swarnakar S. Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin. J Pineal Res 2009 47 : 43 55.
13. Lahiri S, Singh P, Singh S et al. Melatonin protects against experimental reflux esophagitis. J Pineal Res 2009 46 : 207 213.
14. Girgert R, Hanf V, Emons G et al. Membrane-bound melatonin receptor MT1 down-regulates estrogen responsive genes in breast cancer cells. J Pineal Res 2009 47 : 23 31.
15. Joo SS, Yoo YM. Melatonin induces apoptotic death in LNCaP cells via p38 and JNK pathways: therapeutic implications for prostate cancer. J Pineal Res 2009 47 : 8 14.
16. Hardeland R, Tan DX, Reiter RJ. Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines. J Pineal Res 2009 47 : 109 126.
17. Peyrot F, Ducrocq C. Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species. J Pineal Res 2008 45 : 235 246.
18. Topal T, Oztas Y, Korkmaz A et al. Melatonin ameliorates bladder damage induced by cyclophosphamide in rats. J Pineal Res 2005 38 : 272 277. (Pubitemid 41475439)
19. Abraham P, Rabi S, Selvakumar D. Protective effect of aminoguanidine against oxidative stress and bladder injury in cyclophosphamide-induced hemorrhagic cystitis in rat. Cell Biochem Funct 2009 27 : 56 62.
20. Arafa HM. Uroprotective effects of curcumin in cyclophosphamide-induced haemorrhagic cystitis paradigm. Basic Clin Pharmacol Toxicol 2009 104 : 393 399.
21. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979 95 : 351 358.
22. Moron MS, Depierre JW, Mannervik B. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta 1979 582 : 67 78. (Pubitemid 9065588)
23. Lowry OH, Rosebrough NJ, Farr AL et al. Protein measurement with the Folin phenol reagent. J Biol Chem 1951 193 : 265 275.
24. Singh NP, McCoy MT, Tice RR et al. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988 175 : 184 191.
25. Tripathi DN, Jena GB. Intervention of astaxanthin against cyclophosphamide-induced oxidative stress and DNA damage: a study in mice. Chem Biol Interact 2009 180 : 398 406.
26. Collins AR, Duthie SJ, Dobson VL. Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA. Carcinogenesis 1993 14 : 1733 1735.
27. Lee JS, Surh YJ. Nrf2 as a novel molecular target for chemoprevention. Cancer Lett 2005 224 : 171 184.
28. Kiuchi H, Takao T, Yamamoto K et al. Sesquiterpene lactone parthenolide ameliorates bladder inflammation and bladder overactivity in cyclophosphamide induced rat cystitis model by inhibiting nuclear factor-kappaB phosphorylation. J Urol 2009 181 : 2339 2348.
29. Surh YJ, Na HK. NF-kappaB and Nrf2 as prime molecular targets for chemoprevention and cytoprotection with anti-inflammatory and antioxidant phytochemicals. Genes Nutr 2008 2 : 313 317.
30. Leon J, Acuna-Castroviejo D, Escames G et al. Melatonin mitigates mitochondrial malfunction. J Pineal Res 2005 38 : 1 9.
31. Reiter RJ, Paredes SD, Korkmaz A et al. Melatonin combats molecular terrorism at the mitochondrial level. Interdisc Toxicol 2008 1 : 137 149.
32. Tan DX, Chen LD, Poeggeler B et al. Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocrine J 1993 1 : 57 60.
33. Gilad E, Cuzzocrea S, Zingarelli B et al. Melatonin is a scavenger of peroxynitrite. Life Sci 1997 60 : PL169 PL174.
34. Lopez-Burillo S, Tan DX, Rodriguez-Gallego V et al. Melatonin and its derivatives cyclic 3-hydroxymelatonin, N1-acetyl-N2-formyl-5-methoxykynuramine and 6-methoxymelatonin reduce oxidative DNA damage induced by Fenton reagents. J Pineal Res 2003 34 : 178 184.
35. Manda K, Ueno M, Anzai K. Space radiation-induced inhibition of neurogenesis in the hippocampal dentate gyrus and memory impairment in mice: ameliorative potential of the melatonin metabolite, AFMK. J Pineal Res 2008 45 : 430 438.
36. Zupancic D, Jezernik K, Vidmar G. Effect of melatonin on apoptosis, proliferation and differentiation of urothelial cells after cyclophosphamide treatment. J Pineal Res 2008 44 : 299 306.
37. Jia L, Liu Z, Sun L et al. Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. Invest Ophthalmol Vis Sci 2007 48 : 339 348.
38. Chuang JI, Natarajan M, Meltz ML et al. Effect of melatonin on NF-kappa-B DNA-binding activity in the rat spleen. Cell Biol Int 1996 20 : 687 692.
39. Natarajan M, Sadeghi K, Reiter RJ et al. The neurohormone melatonin inhibits cytokine, mitogen and ionizing radiation induced NF-kappa B. Biochem Mol Biol Int 1995 37 : 1063 1070.
40. Lavrovsky Y, Schwartzman ML, Levere RD et al. Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene. Proc Natl Acad Sci USA 1994 91 : 5987 5991.