Melatonin inhibits IL1β-induced MMP9 expression and activity in human umbilical vein endothelial cells by suppressing NF-κB activation

Journal of Endocrinology

Volumn 214, Issue 2, 2012, Pages 145-153

  Qin, Weiwei ^a   Lu, Wenbao ^a   Li, Hongwei ^a   Yuan, Xiaochen ^a   Li, Bingwei ^a   Zhang, Qiuju ^a   Xiu, Ruijuan ^a  

^a Chinese Academy of Medical Sciences   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; FLUORESCEIN SODIUM; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MELATONIN; OCCLUDIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ARTICLE; CELL NUCLEUS; CELL PROTECTION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME REGULATION; GENE EXPRESSION REGULATION; HORMONE ACTION; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MEMBRANE PERMEABILITY; MONOLAYER CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION;

CELLS, CULTURED; DOWN-REGULATION; DRUG COMBINATIONS; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERLEUKIN-1BETA; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MELATONIN; MICROSCOPY, FLUORESCENCE; NF-KAPPA B; TISSUE INHIBITOR OF METALLOPROTEINASES;

EID: 84866303931     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-12-0147     Document Type: Article

References (57)

1. Abbott NJ, Patabendige AA, Dolman DE, Yusof SR and Begley DJ 2010 Structure and function of the blood-brain barrier. Neurobiological Disorders 37 13-25.
2. Alexander JS and Elrod JW 2002 Extracellular matrix, junctional integrity and matrix metalloproteinase interactions in endothelial permeability regulation. Journal of Anatomy 200 561-574.
3. Bauer AT, Burgers HF, Rabie T and Marti HH 2010 Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement. Journal of Cerebral Blood Flow and Metabolism 30 837-848.
4. Bazzoni G and Dejana E 2004 Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiological Reviews 84 869-901.
5. Beyer CE, Steketee JD and Saphier D 1998 Antioxidant properties of melatonin-an emerging mystery. Biochemical Pharmacology 56 1265-1272.
6. Birkedal-HansenH, MooreWG, BoddenMK, Windsor LJ, Birkedal-HansenB, DeCarlo A and Engler JA 1993 Matrix metalloproteinases: a review. Critical Reviews in Oral Biology and Medicine 4 197-250.
7. Chahbouni M, Escames G, Venegas C, Sevilla B, Garcia JA, Lopez LC, Munoz-Hoyos A, Molina-Carballo A and Acuna-Castroviejo D 2010 Melatonin treatment normalizes plasma pro-inflammatory cytokines and nitrosative/oxidative stress in patients suffering from Duchenne muscular dystrophy. Journal of Pineal Research 48 282-289.
8. Chuang JI, Mohan N, Meltz ML and Reiter RJ 1996 Effect of melatonin on NF-kappa-B DNA-binding activity in the rat spleen. Cell Biology International 20 687-692.
9. DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E and Karin M 1997 A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 388 548-554.
10. Esposito E, Genovese T, Caminiti R, Bramanti P, Meli R and Cuzzocrea S 2008a Melatonin regulates matrix metalloproteinases after traumatic experimental spinal cord injury. Journal of Pineal Research 45 149-156.
11. Esposito E, Mazzon E, Riccardi L, Caminiti R, Meli R and Cuzzocrea S 2008b Matrix metalloproteinase-9 and metalloproteinase-2 activity and expression is reduced by melatonin during experimental colitis. Journal of Pineal Research 45 166-173.
12. Esteve PO, Chicoine E, Robledo O, Aoudjit F, Descoteaux A, Potworowski EF and St-Pierre Y 2002 Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B. Journal of Biological Chemistry 277 35150-35155.
13. Gao M, Zhang JH, Zhou FX, Xie CH, Han G, Fang SQ and Zhou YF 2012 Angelica sinensis suppresses human lung adenocarcinoma A549 cell metastasis by regulating MMPs/TIMPs and TGF-beta1. Oncology Reports 27 585-593.
14. Gitto E, Pellegrino S, Gitto P, Barberi I and Reiter RJ 2009 Oxidative stress of the newborn in the pre- and postnatal period and the clinical utility of melatonin. Journal of Pineal Research 46 128-139.
15. Han YP, Tuan TL, Wu H, Hughes M and Garner WL 2001 TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP. Journal of Cell Science 114 131-139.
16. Jaffe EA, Nachman RL, Becker CG and Minick CR 1973 Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. Journal of Clinical Investigation 52 2745-2756.
17. Jones NA, Boswell-Smith V, Lever R and Page CP 2005 The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vitro. Pulmonary Pharmacology and Therapeutics 18 93-101.
18. Kessenbrock K, Plaks V andWerb Z 2010 Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141 52-67.
19. Li YY, McTiernan CF and Feldman AM 1999 Proinflammatory cytokines regulate tissue inhibitors of metalloproteinases and disintegrin metalloproteinase in cardiac cells. Cardiovascular Research 42 162-172.
20. Li Z, Nickkholgh A, Yi X, Bruns H, Gross ML, Hoffmann K, Mohr E, Zorn M, Buchler MW and Schemmer P 2009 Melatonin protects kidney grafts from ischemia/reperfusion injury through inhibition of NF-kB and apoptosis after experimental kidney transplantation. Journal of Pineal Research 46 365-372.
21. Liang KC, Lee CW, Lin WN, Lin CC, Wu CB, Luo SF and Yang CM 2007 Interleukin-1beta induces MMP-9 expression via p42/p44 MAPK, p38 MAPK, JNK, and nuclear factor-kappaB signaling pathways in human tracheal smooth muscle cells. Journal of Cellular Physiology 211 759-770.
22. Mackay AR, Ballin M, Pelina MD, Farina AR, Nason AM, Hartzler JL and Thorgeirsson UP 1992 Effect of phorbol ester and cytokines on matrix metalloproteinase and tissue inhibitor of metalloproteinase expression in tumor and normal cell lines. Invasion and Metastasis 12 168-184.
23. Mishra A, Paul S and Swarnakar S 2011 Downregulation of matrix metalloproteinase-9 by melatonin during prevention of alcohol-induced liver injury in mice. Biochimie 93 854-866.
24. Morgan PJ, Hastings MH, Thompson M, Barrett P, Lawson W and Davidson G 1991 Intracellular signalling in the ovine pars tuberalis: an investigation using aluminium fluoride and melatonin. Journal of Molecular Endocrinology 7 137-144.
25. Mori K, Shibanuma M and Nose K 2004 Invasive potential induced under long-term oxidative stress in mammary epithelial cells. Cancer Research 64 7464-7472.
26. Mostafa Mtairag E, Chollet-Martin S, Oudghiri M, Laquay N, Jacob MP, Michel JB and Feldman LJ 2001 Effects of interleukin-10 on monocyte/ endothelial cell adhesion and MMP-9/TIMP-1 secretion. Cardiovascular Research 49 882-890.
27. Mountain DJ, Singh M, Menon B and Singh K 2007 Interleukin-1beta increases expression and activity of matrix metalloproteinase-2 in cardiac microvascular endothelial cells: role of PKCalpha/beta1 and MAPKs. American Journal of Physiology. Cell Physiology 292 C867-C875.
28. Murphy G, Nguyen Q, Cockett MI, Atkinson SJ, Allan JA, Knight CG, Willenbrock F and Docherty AJ 1994 Assessment of the role of the fibronectin-like domain of gelatinase A by analysis of a deletion mutant. Journal of Biological Chemistry 269 6632-6636.
29. Nakagawa S, Deli MA, Kawaguchi H, Shimizudani T, Shimono T, Kittel A, Tanaka K and Niwa M 2009 A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes. Neurochemistry International 54 253-263.
30. Navaratna D, McGuire PG, Menicucci G and Das A 2007 Proteolytic degradation of VE-cadherin alters the blood-retinal barrier in diabetes. Diabetes 56 2380-2387.
31. Paradies G, Petrosillo G, Paradies V, Reiter RJ and Ruggiero FM 2010 Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease. Journal of Pineal Research 48 297-310.
32. Paul S, Sharma AV, Mahapatra PD, Bhattacharya P, Reiter RJ and Swarnakar S 2008 Role of melatonin in regulating matrix metalloproteinase-9 via tissue inhibitors of metalloproteinase-1 during protection against endometriosis. Journal of Pineal Research 44 439-449.
33. Pratheeshkumar P and Kuttan G 2011 Vernolide-A inhibits radiation-induced hypoxia-mediated tumor angiogenesis by regulating HIF-1alpha, MMP-2, MMP-9, and VEGF. Journal of Environmental Pathology, Toxicology and Oncology 30 139-151.
34. Pustovrh MC, Jawerbaum A, Capobianco E, White V, Martinez N, Lopez-Costa JJ and Gonzalez E 2005 Oxidative stress promotes the increase of matrix metalloproteinases-2 and -9 activities in the feto-placental unit of diabetic rats. Free Radical Research 39 1285-1293.
35. Rajagopalan S, Meng XP, Ramasamy S, Harrison DG and Galis ZS 1996 Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. Journal of Clinical Investigation 98 2572-2579.
36. Ramos-Fernandez M, Bellolio MF and Stead LG 2010 Matrix metalloproteinase-9 as a marker for acute ischemic stroke: a systematic review. Journal of Stroke and Cerebrovascular Diseases 20 47-54.
37. Rangasamy S, Srinivasan R, Maestas J, McGuire PG and Das A 2011 A potential role for angiopoietin 2 in the regulation of the blood-retinal barrier in diabetic retinopathy. Investigative Ophthalmology and Visual Science 52 3784-3791.
38. Redondo-Munoz J, Escobar-Diaz E, Samaniego R, Terol MJ, Garcia-Marco JA and Garcia-Pardo A 2006 MMP-9 in B-cell chronic lymphocytic leukemia is up-regulated by alpha4beta1 integrin or CXCR4 engagement via distinct signaling pathways, localizes to podosomes, and is involved in cell invasion and migration. Blood 108 3143-3151.
39. Reyes R, Guo M, Swann K, Shetgeri SU, Sprague SM, Jimenez DF, Barone CM and Ding Y 2009 Role of tumor necrosis factor-alpha and matrix metalloproteinase-9 in blood-brain barrier disruption after peripheral thermal injury in rats. Journal of Neurosurgery 110 1218-1226.
40. Rosenberg GA 2009 Matrix metalloproteinases and their multiple roles in neurodegenerative diseases. Lancet Neurology 8 205-216.
41. Shen Q, Lee ES, Pitts RL, Wu MH and Yuan SY 2010 Tissue inhibitor of metalloproteinase-2 regulates matrix metalloproteinase-2-mediated endothelial barrier dysfunction and breast cancer cell transmigration through lung microvascular endothelial cells. Molecular Cancer Research 8 939-951.
42. Shipley JM, Doyle GA, Fliszar CJ, Ye Q-Z, Johnson LL, Shapiro SD, Welgus HG and Senior RM 1996 The structural basis for the elastolytic activity of the 92-kDa and 72-kDa gelatinases. Role of the fibronectin type II-like repeats. Journal of Biological Chemistry 271 4335-4341.
43. Siwik DA, Chang DL and Colucci WS 2000 Interleukin-1beta and tumor necrosis factor-alpha decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro. Circulation Research 86 1259-1265.
44. Sulik A and Chyczewski L 2008 Immunohistochemical analysis of MMP-9, MMP-2 and TIMP-1, TIMP-2 expression in the central nervous system following infection with viral and bacterial meningitis. Folia Histochemica et Cytobiologica 46 437-442.
45. Swarnakar S, Mishra A, Ganguly K and Sharma AV 2007 Matrix metalloproteinase-9 activity and expression is reduced by melatonin during prevention of ethanol-induced gastric ulcer in mice. Journal of Pineal Research 43 56-64.
46. Swarnakar S, Paul S, Singh LP and Reiter RJ 2011 Matrix metalloproteinases in health and disease: regulation by melatonin. Journal of Pineal Research 50 8-20.
47. Tai SH, Chen HY, Lee EJ, Chen TY, Lin HW, Hung YC, Huang SY, Chen YH, Lee WT andWu TS 2010 Melatonin inhibits postischemic matrix metalloproteinase-9 (MMP-9) activation via dual modulation of plasminogen/plasmin system and endogenous MMP inhibitor in mice subjected to transient focal cerebral ischemia. Journal of Pineal Research 49 332-341.
48. Takada Y and Aggarwal BB 2003 Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9. Journal of Immunology 171 3278-3286.
49. Tan DX, Manchester LC, Sanchez-Barcelo E, Mediavilla MD and Reiter RJ 2010 Significance of high levels of endogenous melatonin in mammalian cerebrospinal fluid and in the central nervous system. Current Neuropharmacology 8 162-167.
50. Thanabalasundaram G, Pieper C, Lischper M and Galla HJ 2010 Regulation of the blood-brain barrier integrity by pericytes via matrix metalloproteinases mediated activation of vascular endothelial growth factor in vitro. Brain Research 1347 1-10.
51. Toth M and Fridman R 2001 Assessment of gelatinases (MMP-2 and MMP-9 by gelatin zymography. Methods in Molecular Medicine 57 163-174.
52. Visse R and Nagase H 2003 Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circulation Research 92 827-839.
53. Wachtel M, Frei K, Ehler E, Fontana A, Winterhalter K and Gloor SM 1999 Occludin proteolysis and increased permeability in endothelial cells through tyrosine phosphatase inhibition. Journal of Cell Science 112 (PART 23) 4347-4356.
54. Williams LM 1989 Melatonin-binding sites in the rat brain and pituitary mapped by in-vitro autoradiography. Journal of Molecular Endocrinology 3 71-75.
55. Xie Z, Singh M & Singh K 2004 Differential regulation of matrix metalloproteinase-2 and -9 expression and activity in adult rat cardiac fibroblasts in response to interleukin-1beta. Journal of Biological Chemistry 279 39513-39519.
56. Yuan X, Li B, Li H & Xiu R 2011 Melatonin inhibits IL-1beta-induced monolayer permeability of human umbilical vein endothelial cells via Rac activation. Journal of Pineal Research 51 220-225.
57. Zhang D, Samani AA & Brodt P 2003 The role of the IGF-I receptor in the regulation of matrix metalloproteinases, tumor invasion and metastasis. Hormone and Metabolic Research 35 802-808.