-
1
-
-
84860741240
-
Engineering the third wave of biocatalysis
-
Bornscheuer U.T., Huisman G.W., Kazlauskas R.J., Lutz S., Moore J.C., Robins K. Engineering the third wave of biocatalysis. Nature 2012, 485:185-194.
-
(2012)
Nature
, vol.485
, pp. 185-194
-
-
Bornscheuer, U.T.1
Huisman, G.W.2
Kazlauskas, R.J.3
Lutz, S.4
Moore, J.C.5
Robins, K.6
-
2
-
-
84920869042
-
Recent advances in biocatalyst development in the pharmaceutical industry
-
Zhang M.M., Su X., Ang E.L., Zhao H. Recent advances in biocatalyst development in the pharmaceutical industry. Pharm Bioprocess 2013, 1:179-196.
-
(2013)
Pharm Bioprocess
, vol.1
, pp. 179-196
-
-
Zhang, M.M.1
Su, X.2
Ang, E.L.3
Zhao, H.4
-
3
-
-
84876304992
-
Directed evolution: past, present, and future
-
Cobb R.E., Chao R., Zhao H. Directed evolution: past, present, and future. AIChE J 2013, 59:1432-1440.
-
(2013)
AIChE J
, vol.59
, pp. 1432-1440
-
-
Cobb, R.E.1
Chao, R.2
Zhao, H.3
-
4
-
-
84877135608
-
Directed evolution as a powerful synthetic biology tool
-
Cobb R.E., Sun N., Zhao H. Directed evolution as a powerful synthetic biology tool. Methods 2013, 60:81-90.
-
(2013)
Methods
, vol.60
, pp. 81-90
-
-
Cobb, R.E.1
Sun, N.2
Zhao, H.3
-
5
-
-
84865279828
-
Directed evolution: an evolving and enabling synthetic biology tool
-
Cobb R.E., Si T., Zhao H. Directed evolution: an evolving and enabling synthetic biology tool. Curr Opin Chem Biol 2012, 16:285-291.
-
(2012)
Curr Opin Chem Biol
, vol.16
, pp. 285-291
-
-
Cobb, R.E.1
Si, T.2
Zhao, H.3
-
6
-
-
84878391705
-
Engineered thermostable fungal Cel6A and Cel7A cellobiohydrolases hydrolyze cellulose efficiently at elevated temperatures
-
Wu I., Arnold F.H. Engineered thermostable fungal Cel6A and Cel7A cellobiohydrolases hydrolyze cellulose efficiently at elevated temperatures. Biotechnol Bioeng 2013, 110:1874-1883.
-
(2013)
Biotechnol Bioeng
, vol.110
, pp. 1874-1883
-
-
Wu, I.1
Arnold, F.H.2
-
7
-
-
84868106496
-
Development of chimeric laccases by directed evolution
-
Pardo I., Vicente A.I., Mate D.M., Alcalde M., Camarero S. Development of chimeric laccases by directed evolution. Biotechnol Bioeng 2012, 109:2978-2986.
-
(2012)
Biotechnol Bioeng
, vol.109
, pp. 2978-2986
-
-
Pardo, I.1
Vicente, A.I.2
Mate, D.M.3
Alcalde, M.4
Camarero, S.5
-
8
-
-
84873080431
-
Improved thermostability of lipase B from Candida antarctica by directed evolution and display on yeast surface
-
Peng X.Q. Improved thermostability of lipase B from Candida antarctica by directed evolution and display on yeast surface. Appl Biochem Biotechnol 2013, 169:351-358.
-
(2013)
Appl Biochem Biotechnol
, vol.169
, pp. 351-358
-
-
Peng, X.Q.1
-
9
-
-
84862486755
-
Improving the thermostability of α-amylase by combinatorial coevolving-site saturation mutagenesis
-
Wang C., Huang R., He B., Du Q. Improving the thermostability of α-amylase by combinatorial coevolving-site saturation mutagenesis. BMC Bioinformatics 2012, 13:263.
-
(2012)
BMC Bioinformatics
, vol.13
, pp. 263
-
-
Wang, C.1
Huang, R.2
He, B.3
Du, Q.4
-
10
-
-
84890936547
-
Engineering protein thermostability using a generic activity-independent biophysical screen inside the cell
-
Asial I., Cheng Y.X., Engman H., Dollhopf M., Wu B., Nordlund P., Cornvik T. Engineering protein thermostability using a generic activity-independent biophysical screen inside the cell. Nat Commun 2013, 4:2901.
-
(2013)
Nat Commun
, vol.4
, pp. 2901
-
-
Asial, I.1
Cheng, Y.X.2
Engman, H.3
Dollhopf, M.4
Wu, B.5
Nordlund, P.6
Cornvik, T.7
-
11
-
-
84892370944
-
Directed evolution of thermotolerant malic enzyme for improved malate production
-
Morimoto Y., Honda K., Ye X., Okano K., Ohtake H. Directed evolution of thermotolerant malic enzyme for improved malate production. J Biosci Bioeng 2014, 117:147-152.
-
(2014)
J Biosci Bioeng
, vol.117
, pp. 147-152
-
-
Morimoto, Y.1
Honda, K.2
Ye, X.3
Okano, K.4
Ohtake, H.5
-
12
-
-
84887930112
-
Engineered P450pyr monooxygenase for asymmetric epoxidation of alkenes with unique and high enantioselectivity
-
Li A., Liu J., Pham S.Q., Li Z. Engineered P450pyr monooxygenase for asymmetric epoxidation of alkenes with unique and high enantioselectivity. Chem Commun (Camb) 2013, 49:11572-11574.
-
(2013)
Chem Commun (Camb)
, vol.49
, pp. 11572-11574
-
-
Li, A.1
Liu, J.2
Pham, S.Q.3
Li, Z.4
-
13
-
-
84908497725
-
Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs
-
Venkataraman H., Verkade-Vreeker M.C., Capoferri L., Geerke D.P., Vermeulen N.P., Commandeur J.N. Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs. Bioorg Med Chem 2014.
-
(2014)
Bioorg Med Chem
-
-
Venkataraman, H.1
Verkade-Vreeker, M.C.2
Capoferri, L.3
Geerke, D.P.4
Vermeulen, N.P.5
Commandeur, J.N.6
-
14
-
-
84871371314
-
Hydroxylation of non-substituted polycyclic aromatic hydrocarbons by cytochrome P450 BM3 engineered by directed evolution
-
Sideri A., Goyal A., Di Nardo G., Tsotsou G.E., Gilardi G. Hydroxylation of non-substituted polycyclic aromatic hydrocarbons by cytochrome P450 BM3 engineered by directed evolution. J Inorg Biochem 2013, 120:1-7.
-
(2013)
J Inorg Biochem
, vol.120
, pp. 1-7
-
-
Sideri, A.1
Goyal, A.2
Di Nardo, G.3
Tsotsou, G.E.4
Gilardi, G.5
-
15
-
-
84899861423
-
Directed evolution of unspecific peroxygenase from Agrocybe aegerita
-
Molina-Espeja P., Garcia-Ruiz E., Gonzalez-Perez D., Ullrich R., Hofrichter M., Alcalde M. Directed evolution of unspecific peroxygenase from Agrocybe aegerita. Appl Environ Microbiol 2014, 80:3496-3507.
-
(2014)
Appl Environ Microbiol
, vol.80
, pp. 3496-3507
-
-
Molina-Espeja, P.1
Garcia-Ruiz, E.2
Gonzalez-Perez, D.3
Ullrich, R.4
Hofrichter, M.5
Alcalde, M.6
-
16
-
-
84857093916
-
Engineering platforms for directed evolution of Laccase from Pycnoporus cinnabarinus
-
Camarero S., Pardo I., Canas A.I., Molina P., Record E., Martinez A.T., Martinez M.J., Alcalde M. Engineering platforms for directed evolution of Laccase from Pycnoporus cinnabarinus. Appl Environ Microbiol 2012, 78:1370-1384.
-
(2012)
Appl Environ Microbiol
, vol.78
, pp. 1370-1384
-
-
Camarero, S.1
Pardo, I.2
Canas, A.I.3
Molina, P.4
Record, E.5
Martinez, A.T.6
Martinez, M.J.7
Alcalde, M.8
-
17
-
-
53549085133
-
Evolutionary history of a specialized P450 propane monooxygenase
-
Fasan R., Meharenna Y.T., Snow C.D., Poulos T.L., Arnold F.H. Evolutionary history of a specialized P450 propane monooxygenase. J Mol Biol 2008, 383:1069-1080.
-
(2008)
J Mol Biol
, vol.383
, pp. 1069-1080
-
-
Fasan, R.1
Meharenna, Y.T.2
Snow, C.D.3
Poulos, T.L.4
Arnold, F.H.5
-
18
-
-
84898968435
-
Tailoring d-amino acid oxidase from the pig kidney to R-stereoselective amine oxidase and its use in the deracemization of α-methylbenzylamine
-
Yasukawa K., Nakano S., Asano Y. Tailoring d-amino acid oxidase from the pig kidney to R-stereoselective amine oxidase and its use in the deracemization of α-methylbenzylamine. Angew Chem Int Ed Engl 2014, 53:4428-4431.
-
(2014)
Angew Chem Int Ed Engl
, vol.53
, pp. 4428-4431
-
-
Yasukawa, K.1
Nakano, S.2
Asano, Y.3
-
19
-
-
84896091292
-
An improved single cell ultrahigh throughput screening method based on in vitro compartmentalization
-
Ma F., Xie Y., Huang C., Feng Y., Yang G. An improved single cell ultrahigh throughput screening method based on in vitro compartmentalization. PLOS ONE 2014, 9:e89785.
-
(2014)
PLOS ONE
, vol.9
, pp. e89785
-
-
Ma, F.1
Xie, Y.2
Huang, C.3
Feng, Y.4
Yang, G.5
-
20
-
-
84906549486
-
Evolution of enzyme catalysts caged in biomimetic gel-shell beads
-
Fischlechner M., Schaerli Y., Mohamed M., Patil S., Abell C., Hollfelder F. Evolution of enzyme catalysts caged in biomimetic gel-shell beads. Nat Chem 2014, 6:791-796.
-
(2014)
Nat Chem
, vol.6
, pp. 791-796
-
-
Fischlechner, M.1
Schaerli, Y.2
Mohamed, M.3
Patil, S.4
Abell, C.5
Hollfelder, F.6
-
21
-
-
84876919552
-
P450 BM3 crystal structures reveal the role of the charged surface residue Lys/Arg184 in inversion of enantioselective styrene epoxidation
-
Shehzad A., Panneerselvam S., Linow M., Bocola M., Roccatano D., Mueller-Dieckmann J., Wilmanns M., Schwaneberg U. P450 BM3 crystal structures reveal the role of the charged surface residue Lys/Arg184 in inversion of enantioselective styrene epoxidation. Chem Commun (Camb) 2013, 49:4694-4696.
-
(2013)
Chem Commun (Camb)
, vol.49
, pp. 4694-4696
-
-
Shehzad, A.1
Panneerselvam, S.2
Linow, M.3
Bocola, M.4
Roccatano, D.5
Mueller-Dieckmann, J.6
Wilmanns, M.7
Schwaneberg, U.8
-
22
-
-
77954785506
-
Inverting the enantioselectivity of P450pyr monooxygenase by directed evolution
-
Tang W.L., Li Z., Zhao H. Inverting the enantioselectivity of P450pyr monooxygenase by directed evolution. Chem Commun (Camb) 2010, 46:5461-5463.
-
(2010)
Chem Commun (Camb)
, vol.46
, pp. 5461-5463
-
-
Tang, W.L.1
Li, Z.2
Zhao, H.3
-
23
-
-
78349313517
-
Beyond directed evolution - semi-rational protein engineering and design
-
Lutz S. Beyond directed evolution - semi-rational protein engineering and design. Curr Opin Biotechnol 2010, 21:734-743.
-
(2010)
Curr Opin Biotechnol
, vol.21
, pp. 734-743
-
-
Lutz, S.1
-
24
-
-
84887993076
-
Polishing the craft of genetic diversity creation in directed evolution
-
Tee K.L., Wong T.S. Polishing the craft of genetic diversity creation in directed evolution. Biotechnol Adv 2013, 31:1707-1721.
-
(2013)
Biotechnol Adv
, vol.31
, pp. 1707-1721
-
-
Tee, K.L.1
Wong, T.S.2
-
25
-
-
80052135332
-
Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution
-
Kille S., Zilly F.E., Acevedo J.P., Reetz M.T. Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution. Nat Chem 2011, 3:738-743.
-
(2011)
Nat Chem
, vol.3
, pp. 738-743
-
-
Kille, S.1
Zilly, F.E.2
Acevedo, J.P.3
Reetz, M.T.4
-
26
-
-
84861163924
-
Key residues for controlling enantioselectivity of Halohydrin dehalogenase from Arthrobacter sp. strain AD2, revealed by structure-guided directed evolution
-
Tang L., Zhu X., Zheng H., Jiang R., Majeric Elenkov M. Key residues for controlling enantioselectivity of Halohydrin dehalogenase from Arthrobacter sp. strain AD2, revealed by structure-guided directed evolution. Appl Environ Microbiol 2012, 78:2631-2637.
-
(2012)
Appl Environ Microbiol
, vol.78
, pp. 2631-2637
-
-
Tang, L.1
Zhu, X.2
Zheng, H.3
Jiang, R.4
Majeric Elenkov, M.5
-
27
-
-
84155174672
-
Directed evolution strategies for enantiocomplementary haloalkane dehalogenases: from chemical waste to enantiopure building blocks
-
van Leeuwen J.G., Wijma H.J., Floor R.J., van der Laan J.M., Janssen D.B. Directed evolution strategies for enantiocomplementary haloalkane dehalogenases: from chemical waste to enantiopure building blocks. Chembiochem 2012, 13:137-148.
-
(2012)
Chembiochem
, vol.13
, pp. 137-148
-
-
van Leeuwen, J.G.1
Wijma, H.J.2
Floor, R.J.3
van der Laan, J.M.4
Janssen, D.B.5
-
28
-
-
84879196613
-
Use of 'small but smart' libraries to enhance the enantioselectivity of an esterase from Bacillus stearothermophilus towards tetrahydrofuran-3-yl acetate
-
Nobili A., Gall M.G., Pavlidis I.V., Thompson M.L., Schmidt M., Bornscheuer U.T. Use of 'small but smart' libraries to enhance the enantioselectivity of an esterase from Bacillus stearothermophilus towards tetrahydrofuran-3-yl acetate. FEBS J 2013, 280:3084-3093.
-
(2013)
FEBS J
, vol.280
, pp. 3084-3093
-
-
Nobili, A.1
Gall, M.G.2
Pavlidis, I.V.3
Thompson, M.L.4
Schmidt, M.5
Bornscheuer, U.T.6
-
29
-
-
84887993706
-
Directed evolution by using iterative saturation mutagenesis based on multiresidue sites
-
Parra L.P., Agudo R., Reetz M.T. Directed evolution by using iterative saturation mutagenesis based on multiresidue sites. Chembiochem 2013, 14:2301-2309.
-
(2013)
Chembiochem
, vol.14
, pp. 2301-2309
-
-
Parra, L.P.1
Agudo, R.2
Reetz, M.T.3
-
30
-
-
84864621472
-
Protein engineering of stereoselective Baeyer-Villiger monooxygenases
-
Zhang Z.G., Parra L.P., Reetz M.T. Protein engineering of stereoselective Baeyer-Villiger monooxygenases. Chemistry 2012, 18:10160-10172.
-
(2012)
Chemistry
, vol.18
, pp. 10160-10172
-
-
Zhang, Z.G.1
Parra, L.P.2
Reetz, M.T.3
-
31
-
-
78149432825
-
Laboratory evolution of stereoselective enzymes: a prolific source of catalysts for asymmetric reactions
-
Reetz M.T. Laboratory evolution of stereoselective enzymes: a prolific source of catalysts for asymmetric reactions. Angew Chem Int Ed Engl 2011, 50:138-174.
-
(2011)
Angew Chem Int Ed Engl
, vol.50
, pp. 138-174
-
-
Reetz, M.T.1
-
32
-
-
84866723266
-
Obtaining optical purity for product diols in enzyme-catalyzed epoxide hydrolysis: contributions from changes in both enantio- and regioselectivity
-
Carlsson A.J., Bauer P., Ma H., Widersten M. Obtaining optical purity for product diols in enzyme-catalyzed epoxide hydrolysis: contributions from changes in both enantio- and regioselectivity. Biochemistry 2012, 51:7627-7637.
-
(2012)
Biochemistry
, vol.51
, pp. 7627-7637
-
-
Carlsson, A.J.1
Bauer, P.2
Ma, H.3
Widersten, M.4
-
33
-
-
84873346530
-
Laboratory evolution of enantiocomplementary Candida antarctica lipase B mutants with broad substrate scope
-
Wu Q., Soni P., Reetz M.T. Laboratory evolution of enantiocomplementary Candida antarctica lipase B mutants with broad substrate scope. J Am Chem Soc 2013, 135:1872-1881.
-
(2013)
J Am Chem Soc
, vol.135
, pp. 1872-1881
-
-
Wu, Q.1
Soni, P.2
Reetz, M.T.3
-
34
-
-
84873392200
-
Induced axial chirality in biocatalytic asymmetric ketone reduction
-
Agudo R., Roiban G.D., Reetz M.T. Induced axial chirality in biocatalytic asymmetric ketone reduction. J Am Chem Soc 2013, 135:1665-1668.
-
(2013)
J Am Chem Soc
, vol.135
, pp. 1665-1668
-
-
Agudo, R.1
Roiban, G.D.2
Reetz, M.T.3
-
36
-
-
84859949798
-
Evolving P450pyr hydroxylase for highly enantioselective hydroxylation at non-activated carbon atom
-
Pham S.Q., Pompidor G., Liu J., Li X.D., Li Z. Evolving P450pyr hydroxylase for highly enantioselective hydroxylation at non-activated carbon atom. Chem Commun (Camb) 2012, 48:4618-4620.
-
(2012)
Chem Commun (Camb)
, vol.48
, pp. 4618-4620
-
-
Pham, S.Q.1
Pompidor, G.2
Liu, J.3
Li, X.D.4
Li, Z.5
-
37
-
-
84896324602
-
Engineering of P450pyr hydroxylase for the highly regio- and enantioselective subterminal hydroxylation of alkanes
-
Yang Y., Liu J., Li Z. Engineering of P450pyr hydroxylase for the highly regio- and enantioselective subterminal hydroxylation of alkanes. Angew Chem Int Ed Engl 2014, 53:3120-3124.
-
(2014)
Angew Chem Int Ed Engl
, vol.53
, pp. 3120-3124
-
-
Yang, Y.1
Liu, J.2
Li, Z.3
-
38
-
-
84901396944
-
Engineering cytochrome P450 BM3 of Bacillus megaterium for terminal oxidation of palmitic acid
-
Bruhlmann F., Fourage L., Ullmann C., Haefliger O.P., Jeckelmann N., Dubois C., Wahler D. Engineering cytochrome P450 BM3 of Bacillus megaterium for terminal oxidation of palmitic acid. J Biotechnol 2014, 184C:17-26.
-
(2014)
J Biotechnol
, vol.184 C
, pp. 17-26
-
-
Bruhlmann, F.1
Fourage, L.2
Ullmann, C.3
Haefliger, O.P.4
Jeckelmann, N.5
Dubois, C.6
Wahler, D.7
-
39
-
-
84863466093
-
Achieving regio-selectivity and enantioselectivity of P450-catalyzed oxidative CH activation of small functionalized molecules by structure-guided directed evolution
-
Agudo R., Roiban G.D., Reetz M.T. Achieving regio-selectivity and enantioselectivity of P450-catalyzed oxidative CH activation of small functionalized molecules by structure-guided directed evolution. Chembiochem 2012, 13:1465-1473.
-
(2012)
Chembiochem
, vol.13
, pp. 1465-1473
-
-
Agudo, R.1
Roiban, G.D.2
Reetz, M.T.3
-
40
-
-
84905748792
-
Cytochrome P450 catalyzed oxidative hydroxylation of achiral organic compounds with simultaneous creation of two chirality centers in a single CH activation step
-
Roiban G.D., Agudo R., Reetz M.T. Cytochrome P450 catalyzed oxidative hydroxylation of achiral organic compounds with simultaneous creation of two chirality centers in a single CH activation step. Angew Chem Int Ed Engl 2014, 33:8803-8807.
-
(2014)
Angew Chem Int Ed Engl
, vol.33
, pp. 8803-8807
-
-
Roiban, G.D.1
Agudo, R.2
Reetz, M.T.3
-
41
-
-
84882286824
-
Regioselective o-hydroxylation of monosubstituted benzenes by P450 BM3
-
Dennig A., Lulsdorf N., Liu H., Schwaneberg U. Regioselective o-hydroxylation of monosubstituted benzenes by P450 BM3. Angew Chem Int Ed Engl 2013, 52:8459-8462.
-
(2013)
Angew Chem Int Ed Engl
, vol.52
, pp. 8459-8462
-
-
Dennig, A.1
Lulsdorf, N.2
Liu, H.3
Schwaneberg, U.4
-
42
-
-
84872495336
-
Olefin cyclopropanation via carbene transfer catalyzed by engineered cytochrome P450 enzymes
-
Coelho P.S., Brustad E.M., Kannan A., Arnold F.H. Olefin cyclopropanation via carbene transfer catalyzed by engineered cytochrome P450 enzymes. Science 2013, 339:307-310.
-
(2013)
Science
, vol.339
, pp. 307-310
-
-
Coelho, P.S.1
Brustad, E.M.2
Kannan, A.3
Arnold, F.H.4
-
43
-
-
84891459977
-
Cytochrome P450-catalyzed insertion of carbenoids into NH bonds
-
Wang Z.J., Peck N.E., Renata H., Arnold F.H. Cytochrome P450-catalyzed insertion of carbenoids into NH bonds. Chem Sci 2014, 5:598-601.
-
(2014)
Chem Sci
, vol.5
, pp. 598-601
-
-
Wang, Z.J.1
Peck, N.E.2
Renata, H.3
Arnold, F.H.4
-
44
-
-
84896520980
-
Expanding P450 catalytic reaction space through evolution and engineering
-
McIntosh J.A., Farwell C.C., Arnold F.H. Expanding P450 catalytic reaction space through evolution and engineering. Curr Opin Chem Biol 2014, 19:126-134.
-
(2014)
Curr Opin Chem Biol
, vol.19
, pp. 126-134
-
-
McIntosh, J.A.1
Farwell, C.C.2
Arnold, F.H.3
-
45
-
-
84880921220
-
A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo
-
Coelho P.S., Wang Z.J., Ener M.E., Baril S.A., Kannan A., Arnold F.H., Brustad E.M. A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo. Nat Chem Biol 2013, 9:485-487.
-
(2013)
Nat Chem Biol
, vol.9
, pp. 485-487
-
-
Coelho, P.S.1
Wang, Z.J.2
Ener, M.E.3
Baril, S.A.4
Kannan, A.5
Arnold, F.H.6
Brustad, E.M.7
-
46
-
-
84903168457
-
Improved cyclopropanation activity of histidine-ligated cytochrome P450 enables the enantioselective formal synthesis of levomilnacipran
-
Wang Z.J., Renata H., Peck N.E., Farwell C.C., Coelho P.S., Arnold F.H. Improved cyclopropanation activity of histidine-ligated cytochrome P450 enables the enantioselective formal synthesis of levomilnacipran. Angew Chem Int Ed Engl 2014, 53:6810-6813.
-
(2014)
Angew Chem Int Ed Engl
, vol.53
, pp. 6810-6813
-
-
Wang, Z.J.1
Renata, H.2
Peck, N.E.3
Farwell, C.C.4
Coelho, P.S.5
Arnold, F.H.6
-
47
-
-
84907157378
-
P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions
-
Renata H., Wang Z.J., Kitto R.Z., Arnold F.H. P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions. Catal Sci Technol 2014.
-
(2014)
Catal Sci Technol
-
-
Renata, H.1
Wang, Z.J.2
Kitto, R.Z.3
Arnold, F.H.4
-
48
-
-
84893822655
-
P450-catalyzed intramolecular CH amination with arylsulfonyl azide substrates
-
Singh R., Bordeaux M., Fasan R. P450-catalyzed intramolecular CH amination with arylsulfonyl azide substrates. ACS Catal 2014, 4:546-552.
-
(2014)
ACS Catal
, vol.4
, pp. 546-552
-
-
Singh, R.1
Bordeaux, M.2
Fasan, R.3
-
49
-
-
84883040115
-
Enantioselective intramolecular CH amination catalyzed by engineered cytochrome P450 enzymes in vitro and in vivo
-
McIntosh J.A., Coelho P.S., Farwell C.C., Wang Z.J., Lewis J.C., Brown T.R., Arnold F.H. Enantioselective intramolecular CH amination catalyzed by engineered cytochrome P450 enzymes in vitro and in vivo. Angew Chem Int Ed Engl 2013, 52:9309-9312.
-
(2013)
Angew Chem Int Ed Engl
, vol.52
, pp. 9309-9312
-
-
McIntosh, J.A.1
Coelho, P.S.2
Farwell, C.C.3
Wang, Z.J.4
Lewis, J.C.5
Brown, T.R.6
Arnold, F.H.7
-
50
-
-
84904466057
-
Catalytic efficiency of designed catalytic proteins
-
Korendovych I.V., DeGrado W.F. Catalytic efficiency of designed catalytic proteins. Curr Opin Struct Biol 2014, 27C:113-121.
-
(2014)
Curr Opin Struct Biol
, vol.27 C
, pp. 113-121
-
-
Korendovych, I.V.1
DeGrado, W.F.2
-
51
-
-
43449098518
-
Kemp elimination catalysts by computational enzyme design
-
Rothlisberger D., et al. Kemp elimination catalysts by computational enzyme design. Nature 2008, 453:190-195.
-
(2008)
Nature
, vol.453
, pp. 190-195
-
-
Rothlisberger, D.1
-
52
-
-
79955570791
-
Design of a switchable eliminase
-
Korendovych I.V., Kulp D.W., Wu Y., Cheng H., Roder H., DeGrado W.F. Design of a switchable eliminase. Proc Natl Acad Sci U S A 2011, 108:6823-6827.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 6823-6827
-
-
Korendovych, I.V.1
Kulp, D.W.2
Wu, Y.3
Cheng, H.4
Roder, H.5
DeGrado, W.F.6
-
53
-
-
84888034901
-
Precision is essential for efficient catalysis in an evolved Kemp eliminase
-
Blomberg R., Kries H., Pinkas D.M., Mittl P.R., Grutter M.G., Privett H.K., Mayo S.L., Hilvert D. Precision is essential for efficient catalysis in an evolved Kemp eliminase. Nature 2013, 503:418-421.
-
(2013)
Nature
, vol.503
, pp. 418-421
-
-
Blomberg, R.1
Kries, H.2
Pinkas, D.M.3
Mittl, P.R.4
Grutter, M.G.5
Privett, H.K.6
Mayo, S.L.7
Hilvert, D.8
-
54
-
-
77954811495
-
Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction
-
Siegel J.B., et al. Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction. Science 2010, 329:309-313.
-
(2010)
Science
, vol.329
, pp. 309-313
-
-
Siegel, J.B.1
-
55
-
-
84865518513
-
Artificial metalloenzymes as catalysts in stereoselective Diels-Alder reactions
-
Reetz M.T. Artificial metalloenzymes as catalysts in stereoselective Diels-Alder reactions. Chem Rec 2012, 12:391-406.
-
(2012)
Chem Rec
, vol.12
, pp. 391-406
-
-
Reetz, M.T.1
-
56
-
-
84901855811
-
Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase
-
Preiswerk N., Beck T., Schulz J.D., Milovnik P., Mayer C., Siegel J.B., Baker D., Hilvert D. Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase. Proc Natl Acad Sci U S A 2014, 111:8013-8018.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 8013-8018
-
-
Preiswerk, N.1
Beck, T.2
Schulz, J.D.3
Milovnik, P.4
Mayer, C.5
Siegel, J.B.6
Baker, D.7
Hilvert, D.8
-
57
-
-
79958708794
-
Assessing directed evolution methods for the generation of biosynthetic enzymes with potential in drug biosynthesis
-
Nannemann D.P., Birmingham W.R., Scism R.A., Bachmann B.O. Assessing directed evolution methods for the generation of biosynthetic enzymes with potential in drug biosynthesis. Future Med Chem 2011, 3:809-819.
-
(2011)
Future Med Chem
, vol.3
, pp. 809-819
-
-
Nannemann, D.P.1
Birmingham, W.R.2
Scism, R.A.3
Bachmann, B.O.4
-
58
-
-
84904790042
-
GeneGenie: optimized oligomer design for directed evolution
-
Swainston N., Currin A., Day P.J., Kell D.B. GeneGenie: optimized oligomer design for directed evolution. Nucleic Acids Res 2014, 42:W395-W400.
-
(2014)
Nucleic Acids Res
, vol.42
, pp. W395-W400
-
-
Swainston, N.1
Currin, A.2
Day, P.J.3
Kell, D.B.4
-
59
-
-
84906822583
-
SpeedyGenes: an improved gene synthesis method for the efficient production of error-corrected, synthetic protein libraries for directed evolution
-
Currin A., Swainston N., Day P.J., Kell D.B. SpeedyGenes: an improved gene synthesis method for the efficient production of error-corrected, synthetic protein libraries for directed evolution. Protein Eng Des Sel 2014, 9:273-280.
-
(2014)
Protein Eng Des Sel
, vol.9
, pp. 273-280
-
-
Currin, A.1
Swainston, N.2
Day, P.J.3
Kell, D.B.4
-
60
-
-
84855916144
-
Towards quantitative computer-aided studies of enzymatic enantioselectivity: the case of Candida antarctica lipase A
-
Frushicheva M.P., Warshel A. Towards quantitative computer-aided studies of enzymatic enantioselectivity: the case of Candida antarctica lipase A. Chembiochem 2012, 13:215-223.
-
(2012)
Chembiochem
, vol.13
, pp. 215-223
-
-
Frushicheva, M.P.1
Warshel, A.2
-
61
-
-
84892918142
-
Computationally designed libraries for rapid enzyme stabilization
-
Wijma H.J., Floor R.J., Jekel P.A., Baker D., Marrink S.J., Janssen D.B. Computationally designed libraries for rapid enzyme stabilization. Protein Eng Des Sel 2014, 27:49-58.
-
(2014)
Protein Eng Des Sel
, vol.27
, pp. 49-58
-
-
Wijma, H.J.1
Floor, R.J.2
Jekel, P.A.3
Baker, D.4
Marrink, S.J.5
Janssen, D.B.6
-
62
-
-
84863337761
-
Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes
-
Chen M.M., Snow C.D., Vizcarra C.L., Mayo S.L., Arnold F.H. Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes. Protein Eng Des Sel 2012, 25:171-178.
-
(2012)
Protein Eng Des Sel
, vol.25
, pp. 171-178
-
-
Chen, M.M.1
Snow, C.D.2
Vizcarra, C.L.3
Mayo, S.L.4
Arnold, F.H.5
-
63
-
-
84859882358
-
Enhancing the efficiency of directed evolution in focused enzyme libraries by the adaptive substituent reordering algorithm
-
Feng X., Sanchis J., Reetz M.T., Rabitz H. Enhancing the efficiency of directed evolution in focused enzyme libraries by the adaptive substituent reordering algorithm. Chemistry 2012, 18:5646-5654.
-
(2012)
Chemistry
, vol.18
, pp. 5646-5654
-
-
Feng, X.1
Sanchis, J.2
Reetz, M.T.3
Rabitz, H.4
-
64
-
-
84876464573
-
Quantum chemistry as a tool in asymmetric biocatalysis: limonene epoxide hydrolase test case
-
Lind M.E.S., Himo F. Quantum chemistry as a tool in asymmetric biocatalysis: limonene epoxide hydrolase test case. Angew Chem Int Ed 2013, 52:4563-4567.
-
(2013)
Angew Chem Int Ed
, vol.52
, pp. 4563-4567
-
-
Lind, M.E.S.1
Himo, F.2
-
65
-
-
84872552315
-
Navigating the protein fitness landscape with Gaussian processes
-
Romero P.A., Krause A., Arnold F.H. Navigating the protein fitness landscape with Gaussian processes. Proc Natl Acad Sci U S A 2013, 110:193-201.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 193-201
-
-
Romero, P.A.1
Krause, A.2
Arnold, F.H.3
-
66
-
-
84911915299
-
Directed evolution of stereoselective enzymes based on genetic selection as opposed to screening systems
-
Acevedo-Rocha C.G., Agudo R., Reetz M.T. Directed evolution of stereoselective enzymes based on genetic selection as opposed to screening systems. J Biotechnol 2014, 10.1016/j.jbiotec.2014.04.009.
-
(2014)
J Biotechnol
-
-
Acevedo-Rocha, C.G.1
Agudo, R.2
Reetz, M.T.3
|