Enhancing the efficiency of directed evolution in focused enzyme libraries by the adaptive substituent reordering algorithm

Chemistry - A European Journal

Volumn 18, Issue 18, 2012, Pages 5646-5654

  Feng, Xiaojiang ^a   Sanchis, Joaquin ^b   Reetz, Manfred T ^b   Rabitz, Herschel ^a  

^a PRINCETON UNIVERSITY   (United States)

^b MAX PLANCK INSTITUT FÜR KOHLENFORSCHUNG   (Germany)

Author keywords

directed evolution; mutagenesis; optimization; protein engineering; structure activity relationships

Indexed keywords

ASPERGILLUS NIGER; DIRECTED EVOLUTION; ENANTIOSELECTIVE; ENZYME LIBRARIES; EPOXIDE HYDROLASES; EXPLICIT KNOWLEDGE; LABORATORY ERRORS; POTENTIAL PROTEINS; PROOF OF PRINCIPLES; PROTEIN ENGINEERING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP METHODS; SATURATION MUTAGENESIS; STRUCTURE ACTIVITY RELATIONSHIPS; STRUCTURE PROPERTY RELATIONSHIPS;

ASPERGILLUS; BIOCHEMICAL ENGINEERING; ENZYMES; GENETIC ENGINEERING; LIBRARIES; MUTAGENESIS; OPTIMIZATION;

ADAPTIVE ALGORITHMS;

EPOXIDE HYDROLASE;

ALGORITHM; AMINO ACID SEQUENCE; ARTICLE; ASPERGILLUS NIGER; CHEMICAL STRUCTURE; CHEMISTRY; DIRECTED MOLECULAR EVOLUTION; ENZYMOLOGY; GENETICS; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; MUTATION; PROTEIN ENGINEERING;

ALGORITHMS; AMINO ACID SEQUENCE; ASPERGILLUS NIGER; DIRECTED MOLECULAR EVOLUTION; EPOXIDE HYDROLASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN ENGINEERING;

EID: 84859882358     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201103811     Document Type: Article

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