Enantioselective intramolecular C-H amination catalyzed by engineered cytochrome P450 enzymes in vitro and in vivo

Angewandte Chemie - International Edition

Volumn 52, Issue 35, 2013, Pages 9309-9312

  McIntosh, John A ^a   Coelho, Pedro S ^a   Farwell, Christopher C ^a   Wang, Z Jane ^a   Lewis, Jared C ^a,b   Brown, Tristan R ^a   Arnold, Frances H ^a  

^a California Institute of Technology   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

C H activation; cytochromes; enzyme catalysis; protein engineering; synthetic biology

Indexed keywords

C-H ACTIVATION; CYTOCHROME P450 BM3; CYTOCHROME P450 ENZYMES; ENZYME CATALYSIS; NITROGEN ACTIVATION; OXYGEN ACTIVATIONS; PROTEIN ENGINEERING; SYNTHETIC BIOLOGY;

ACTIVATION ANALYSIS; AMINATION; CATALYSIS; NITROGEN; PROTEINS;

ENZYMES;

BETA SULTAM; BETA-SULTAM; CYTOCHROME; CYTOCHROME P450; SULFONAMIDE;

AMINATION; ARTICLE; BIOCATALYSIS; C H ACTIVATION; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME CATALYSIS; METABOLISM; PROTEIN ENGINEERING; STEREOISOMERISM; SYNTHETIC BIOLOGY;

C H ACTIVATION; CYTOCHROMES; ENZYME CATALYSIS; PROTEIN ENGINEERING; SYNTHETIC BIOLOGY;

AMINATION; BIOCATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; MOLECULAR STRUCTURE; PROTEIN ENGINEERING; STEREOISOMERISM; SULFONAMIDES;

EID: 84883040115     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201304401     Document Type: Article

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