Laboratory evolution of enantiocomplementary Candida antarctica lipase B mutants with broad substrate scope

Journal of the American Chemical Society

Volumn 135, Issue 5, 2013, Pages 1872-1881

  Wu, Qi ^a,b   Soni, Pankaj ^b,c   Reetz, Manfred T ^b,d  

^a ZHEJIANG UNIVERSITY   (China)

^b MAX PLANCK INSTITUT FÜR KOHLENFORSCHUNG   (Germany)

^c INSTITUTE OF MICROBIAL TECHNOLOGY   (India)

^d PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CANDIDA ANTARCTICA LIPASE B; CHIRAL ESTERS; CHIRAL SECONDARY ALCOHOLS; DESYM-METRIZATION; DIRECTED EVOLUTION; FINE CHEMICALS; HYDROLYTIC KINETIC RESOLUTION; HYDROLYTIC REACTIONS; KINETIC RESOLUTION; MOLECULAR DYNAMICS SIMULATIONS; MUTAGENESIS EXPERIMENT; POINT MUTATIONS; RACEMIC SECONDARY ALCOHOLS; SATURATION MUTAGENESIS; WILD TYPES;

CARBOXYLIC ACIDS; ENZYMES; ESTERIFICATION; ESTERS; EXPERIMENTS; ISOMERS; MOLECULAR DYNAMICS; MUTAGENESIS; STEREOSELECTIVITY;

KINETICS;

ALCOHOL; CANDIDA ANTARCTICA LIPASE B; CARBOXYLIC ACID; ESTER DERIVATIVE; LIPASE B; UNCLASSIFIED DRUG;

ARTICLE; BIOCATALYST; CHIRALITY; ESTERIFICATION; MOLECULAR DYNAMICS; MUTAGENESIS; NONHUMAN; POINT MUTATION; PROTEIN HYDROLYSIS; RACEMIC MIXTURE; STEREOCHEMISTRY; WILD TYPE;

ALCOHOLS; BIOCATALYSIS; CARBOXYLIC ACIDS; ESTERS; FUNGAL PROTEINS; HYDROLYSIS; KINETICS; LABORATORIES; LIPASE; MODELS, MOLECULAR; MUTATION; STEREOISOMERISM;

EID: 84873346530     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja310455t     Document Type: Article

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