Precision is essential for efficient catalysis in an evolved Kemp eliminase

Nature

Volumn 503, Issue 7476, 2013, Pages 418-421

  Blomberg, Rebecca ^a,e   Kries, Hajo ^a   Pinkas, Daniel M ^a   Mittl, Peer R E ^b   Grütter, Markus G ^b   Privett, Heidi K ^c,e,f   Mayo, Stephen L ^d   Hilvert, Donald ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c California Institute of Technology   (United States)

^d California Institute of Technology   (United States)

^e Analysis and Perception Department   (Switzerland)

^f Protabit LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CARBON; ENZYME; FUNCTIONAL GROUP; KEMP ELIMINASE; TRIOSEPHOSPHATE ISOMERASE; UNCLASSIFIED DRUG;

ANTIBODY; CATALYSIS; CATALYST; COMPUTER SIMULATION; CONCEPTUAL FRAMEWORK; ENZYME ACTIVITY; PRECISION;

ACCELERATION; ACCURACY; ARTICLE; CATALYSIS; CATALYST; CHEMICAL REACTION; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVITY; HYDROGEN BOND; LIGAND BINDING; MOLECULAR RECOGNITION; NEGATIVE FEEDBACK; PRIORITY JOURNAL; PROTON TRANSPORT; QUANTUM MECHANICS; RACEMIZATION; STATIC ELECTRICITY; THERMOSTABILITY;

EID: 84888034901     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12623     Document Type: Article

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