Intracellular metabolic flux analysis of CHO cells supplemented with wheat hydrolysates for improved mAb production and cell-growth

Journal of Chemical Technology and Biotechnology

Volumn 90, Issue 2, 2015, Pages 291-302

  Lee, Hae Woo ^e   Christie, Andrew ^b   Starkey, Jason A ^c   Read, Erik K ^d   Yoon, Seongkyu ^a  

^a University of Massachusetts   (United States)

^b SAFC Biosciences ^*  (United States)

^c PFIZER INC   (United States)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^e Daegu Gyeongbuk Medical Innovation Foundation   (South Korea)

Author keywords

CHO cell culture; Flux balance analysis; Metabolic flux analysis; Raw materials; Wheat hydrolysates

Indexed keywords

AMINO ACIDS; ANTIBODIES; CELL CULTURE; CELL GROWTH; CELLS; CYTOLOGY; GROWTH KINETICS; MONOCLONAL ANTIBODIES; MULTIVARIANT ANALYSIS; PHYSIOLOGY; PROTEINS; RAW MATERIALS;

CHINESE HAMSTER OVARY CELLS; CHO CELL CULTURES; COMPOSITIONAL VARIABILITY; FLUX BALANCE ANALYSIS; METABOLIC FLUX ANALYSIS; MONOCLONAL ANTIBODY PRODUCTION; MULTIVARIATE DATA ANALYSIS; WHEAT HYDROLYSATES;

METABOLISM;

GLYCINE; MONOCLONAL ANTIBODY; SERINE;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; CELL CULTURE; CELL GROWTH; CELL METABOLISM; CHO CELL LINE; CITRIC ACID CYCLE; METABOLIC FLUX ANALYSIS; NONHUMAN; WHEAT;

CRICETULUS GRISEUS; TRITICUM AESTIVUM;

EID: 84920879773     PISSN: 02682575     EISSN: 10974660     Source Type: Journal    
DOI: 10.1002/jctb.4523     Document Type: Article

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