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Volumn 50, Issue 3, 1996, Pages 299-318

Metabolic flux analysis of hybridoma cells in different culture media using mass balances

Author keywords

biosynthesis; hybridoma cells; mass balances; metabolic flux

Indexed keywords

AMINO ACIDS; AMMONIUM COMPOUNDS; ANIMAL CELL CULTURE; BIOSYNTHESIS; CALCULATIONS; CARBON DIOXIDE; ESTERS; GLUCOSE; HYDROGENATION; METABOLITES; OXIDATION; OXYGEN;

EID: 0030570128     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19960505)50:3<299::AID-BIT9>3.0.CO;2-B     Document Type: Article
Times cited : (217)

References (53)
  • 1
    • 0029256482 scopus 로고
    • Determination of the respiration quotient in mammalian cell culture in bicarbonate-buffered media
    • Bonarius, H. P. J., De Gooijer, C. D., Tramper, J., Schmid, G. 1995. Determination of the respiration quotient in mammalian cell culture in bicarbonate-buffered media. Biotechnol. Bioeng. 45: 524-535.
    • (1995) Biotechnol. Bioeng. , vol.45 , pp. 524-535
    • Bonarius, H.P.J.1    De Gooijer, C.D.2    Tramper, J.3    Schmid, G.4
  • 3
    • 0027169767 scopus 로고
    • A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples
    • Chomczynski, P. 1993. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques 15: 532-535.
    • (1993) Biotechniques , vol.15 , pp. 532-535
    • Chomczynski, P.1
  • 5
    • 0019755991 scopus 로고
    • Membrane cholesterol, tumorigenesis and the biochemical phenotype of neoplasia
    • Coleman, P. S., Lavietes, B. B. 1981. Membrane cholesterol, tumorigenesis and the biochemical phenotype of neoplasia. CRC Crit. Rev. Biochem. 11: 341-393.
    • (1981) CRC Crit. Rev. Biochem. , vol.11 , pp. 341-393
    • Coleman, P.S.1    Lavietes, B.B.2
  • 8
    • 0000069903 scopus 로고
    • New Perspectives on carbohydrate metabolism in tumor cells
    • R. Breitner (ed.), CRC Press, Boca Raton, FL
    • Eigenbrodt, E., Fister, P., Reinacher, M. 1985. New Perspectives on carbohydrate metabolism in tumor cells. pp. 141-169. In: R. Breitner (ed.), Regulation of carbohydrate metabolism, vol. 2. CRC Press, Boca Raton, FL.
    • (1985) Regulation of Carbohydrate Metabolism , vol.2 , pp. 141-169
    • Eigenbrodt, E.1    Fister, P.2    Reinacher, M.3
  • 9
    • 0027909873 scopus 로고
    • Utilization of glucose and amino acids in insect cultures: Quantifying the metabolic flows within primary pathways and medium development
    • Ferrance, J. P., Goel, A., Ataai, M. M. 1983. Utilization of glucose and amino acids in insect cultures: Quantifying the metabolic flows within primary pathways and medium development. Biotechnol. Bioeng. 42: 697-707.
    • (1983) Biotechnol. Bioeng. , vol.42 , pp. 697-707
    • Ferrance, J.P.1    Goel, A.2    Ataai, M.M.3
  • 10
    • 0027692808 scopus 로고
    • Glucose and glutamine metabolism of a murine B-lymphocyte hybridoma grown in batch culture
    • Fitzpatrick, L., Jenkins, H. A., Butler, M. 1993. Glucose and glutamine metabolism of a murine B-lymphocyte hybridoma grown in batch culture. Appl. Biochem. Biotechnol. 43: 93-116.
    • (1993) Appl. Biochem. Biotechnol. , vol.43 , pp. 93-116
    • Fitzpatrick, L.1    Jenkins, H.A.2    Butler, M.3
  • 12
    • 0024278869 scopus 로고
    • Mathematical descriptions of hybridoma culture kinetics: I. Initial metabolic rates
    • Glacken, M. W., Adema, E., Sinskey, A. J. 1988. Mathematical descriptions of hybridoma culture kinetics: I. Initial metabolic rates. Biotechnol. Bioeng. 32: 491-506.
    • (1988) Biotechnol. Bioeng. , vol.32 , pp. 491-506
    • Glacken, M.W.1    Adema, E.2    Sinskey, A.J.3
  • 13
    • 0026417325 scopus 로고
    • A kinetic analysis of hybridoma cell growth and metabolism in continuous suspension culture in serum-free medium
    • Hiller, A. G., Aeschlimann, A. D., Clark, D. S., Blanch, H. W. 1991. A kinetic analysis of hybridoma cell growth and metabolism in continuous suspension culture in serum-free medium. Biotechnol. Bioeng. 38: 733-741.
    • (1991) Biotechnol. Bioeng. , vol.38 , pp. 733-741
    • Hiller, A.G.1    Aeschlimann, A.D.2    Clark, D.S.3    Blanch, H.W.4
  • 16
    • 0026560877 scopus 로고
    • Characterization of glutamine metabolism in two related murine hybridomas
    • Jenkins, H. A., Butler, M., Dickson, A. J. 1992. Characterization of glutamine metabolism in two related murine hybridomas. J. Biotechnol. 23: 167-182.
    • (1992) J. Biotechnol. , vol.23 , pp. 167-182
    • Jenkins, H.A.1    Butler, M.2    Dickson, A.J.3
  • 17
    • 0029278153 scopus 로고
    • Metabolic flux distributions in Penicillium chrysogenum during fedbatch cultivations
    • Jorgensen, H., Nielsen, J., Villadsen, J., Mollgaard, H. 1995. Metabolic flux distributions in Penicillium chrysogenum during fedbatch cultivations. Biotechnol. Bioeng. 46: 117-131.
    • (1995) Biotechnol. Bioeng. , vol.46 , pp. 117-131
    • Jorgensen, H.1    Nielsen, J.2    Villadsen, J.3    Mollgaard, H.4
  • 18
    • 0000311344 scopus 로고
    • 14C for the evaluation of the pathways of glucose metabolism
    • 14C for the evaluation of the pathways of glucose metabolism. J. Biol. Chem. 238: 517-523.
    • (1963) J. Biol. Chem. , vol.238 , pp. 517-523
    • Katz, J.1    Wood, H.G.2
  • 19
    • 84912602888 scopus 로고
    • Animal and plant cells and cell parts: Chemical composition
    • P. L. Altman and D. S. Dittmer (eds.), FASEB, Bethesda, Maryland
    • Kirkman, W. R., Allfrey, V. G. 1972. Animal and plant cells and cell parts: Chemical composition. pp. 387-392. In: P. L. Altman and D. S. Dittmer (eds.), Biology data book. 2nd edition, vol. 1. FASEB, Bethesda, Maryland.
    • (1972) Biology Data Book. 2nd Edition , vol.1 , pp. 387-392
    • Kirkman, W.R.1    Allfrey, V.G.2
  • 20
    • 0019457724 scopus 로고
    • Amino acids and glucose utilization by different metabolic pathways in ascites-tumour cells
    • Lazo, P. A. 1981. Amino acids and glucose utilization by different metabolic pathways in ascites-tumour cells. Eur. J. Biochem. 117: 19-25.
    • (1981) Eur. J. Biochem. , vol.117 , pp. 19-25
    • Lazo, P.A.1
  • 21
    • 0027033716 scopus 로고
    • Physiology of myeloma cells grown in glucose-limited chemostat cultures
    • Levering, P. R., Van Heijst, J. A. M., Sünnen, C. M. G. 1992. Physiology of myeloma cells grown in glucose-limited chemostat cultures. Cytotechnology 9: 125-130.
    • (1992) Cytotechnology , vol.9 , pp. 125-130
    • Levering, P.R.1    Van Heijst, J.A.M.2    Sünnen, C.M.G.3
  • 23
    • 0016552503 scopus 로고
    • The measurement of glycogen in tissues by amyloglucosidase after the destruction of preexisting glucose
    • Lust, W. P., Passoneau, J. V., Crites, S. K. 1975. The measurement of glycogen in tissues by amyloglucosidase after the destruction of preexisting glucose. Anal. Biochem. 68: 328-331.
    • (1975) Anal. Biochem. , vol.68 , pp. 328-331
    • Lust, W.P.1    Passoneau, J.V.2    Crites, S.K.3
  • 24
    • 0028484019 scopus 로고
    • Examination of primary metabolic pathways in a murine hybridoma with carbon-13 nuclear magnetic resonance spectroscopy
    • Mancuso, A., Sharfstein, S. T., Tucker, S. N., Clark, D. S., Blanch, H. W. 1994. Examination of primary metabolic pathways in a murine hybridoma with carbon-13 nuclear magnetic resonance spectroscopy. Biotechnol. Bioeng. 44: 563-585.
    • (1994) Biotechnol. Bioeng. , vol.44 , pp. 563-585
    • Mancuso, A.1    Sharfstein, S.T.2    Tucker, S.N.3    Clark, D.S.4    Blanch, H.W.5
  • 25
    • 0027551630 scopus 로고
    • Effect of dilution rate on growth, productivity, cell cycle and size, and shear stress sensitivity of hybridoma cells in continuous culture
    • Martens, D. E., De Gooijer, C. D., Van der Velden-de Groot, C. A. M., Beuvery, C. E., Tramper, J. 1993. Effect of dilution rate on growth, productivity, cell cycle and size, and shear stress sensitivity of hybridoma cells in continuous culture. Biotechnol. Bioeng. 41: 421-439.
    • (1993) Biotechnol. Bioeng. , vol.41 , pp. 421-439
    • Martens, D.E.1    De Gooijer, C.D.2    Van Der Velden-de Groot, C.A.M.3    Beuvery, C.E.4    Tramper, J.5
  • 26
    • 0023483203 scopus 로고
    • Effects of dissolved oxygen concentration on hybridoma growth and metabolism in continuous culture
    • Miller, W. M., Wilke, C. R., Blanch, H. W. 1987. Effects of dissolved oxygen concentration on hybridoma growth and metabolism in continuous culture. J. Cell. Phys. 132: 524-533.
    • (1987) J. Cell. Phys. , vol.132 , pp. 524-533
    • Miller, W.M.1    Wilke, C.R.2    Blanch, H.W.3
  • 27
    • 84996094699 scopus 로고
    • Transient responses of hybridoma cells to nutrient additions in continuous culture
    • Miller, W. M., Wilke, C. R., Blanch, H. W. 1989. Transient responses of hybridoma cells to nutrient additions in continuous culture. Biotechnol. Bioeng. 33: 477-499.
    • (1989) Biotechnol. Bioeng. , vol.33 , pp. 477-499
    • Miller, W.M.1    Wilke, C.R.2    Blanch, H.W.3
  • 29
    • 0026223316 scopus 로고
    • Linear relations in microbial reaction systems: A general overview of their origin, form, use
    • Noorman, H. J., Heijnen, J. J., Luyben, Ch. A. M. 1991. Linear relations in microbial reaction systems: A general overview of their origin, form, use. Biotechnol. Bioeng. 38: 603-618.
    • (1991) Biotechnol. Bioeng. , vol.38 , pp. 603-618
    • Noorman, H.J.1    Heijnen, J.J.2    Luyben, Ch.A.M.3
  • 30
    • 0026147822 scopus 로고
    • Effect of medium osmolarity on hybridoma growth, metabolism, and antibody production
    • Ozturk, S. S., Palsson, B. O. 1991. Effect of medium osmolarity on hybridoma growth, metabolism, and antibody production. Biotechnol. Bioeng. 37: 989-993.
    • (1991) Biotechnol. Bioeng. , vol.37 , pp. 989-993
    • Ozturk, S.S.1    Palsson, B.O.2
  • 31
    • 0026816686 scopus 로고
    • Effects of ammonia and lactate on hybridoma growth, metabolism and antibody production
    • Ozturk, S. S., Riley, M. R., Palsson, B. O. 1992. Effects of ammonia and lactate on hybridoma growth, metabolism and antibody production. Biotechnol. Bioeng. 39: 418-431.
    • (1992) Biotechnol. Bioeng. , vol.39 , pp. 418-431
    • Ozturk, S.S.1    Riley, M.R.2    Palsson, B.O.3
  • 32
    • 0021918026 scopus 로고
    • Equations and calculations of product yields and preferred pathways for Butanediol and mixed-acid fermentations
    • Papoutsakis, E. T., Meyer, C. L. 1985. Equations and calculations of product yields and preferred pathways for Butanediol and mixed-acid fermentations. Biotechnol. Bioeng. 27: 50-66.
    • (1985) Biotechnol. Bioeng. , vol.27 , pp. 50-66
    • Papoutsakis, E.T.1    Meyer, C.L.2
  • 35
    • 0027507949 scopus 로고
    • High-level production of recombinant immunoglobulins in mammalian cells
    • Reff, E. R. 1993. High-level production of recombinant immunoglobulins in mammalian cells. Curr. Opin. Biotechnol. 4: 573-576.
    • (1993) Curr. Opin. Biotechnol. , vol.4 , pp. 573-576
    • Reff, E.R.1
  • 37
    • 0026254425 scopus 로고
    • Estimation of dissolved carbon dioxide concentrations in aerobic fermentations
    • Royce, P. N., Thornhill, N. F. 1991. Estimation of dissolved carbon dioxide concentrations in aerobic fermentations. AIChE. J. 37: 1680-1686.
    • (1991) AIChE. J. , vol.37 , pp. 1680-1686
    • Royce, P.N.1    Thornhill, N.F.2
  • 38
    • 0343130364 scopus 로고
    • Nitrogen metabolism of amino acids
    • D. M. Greenberg (ed.), Academic, New York
    • Satlach, H. J., Fabien, L. A. 1969. Nitrogen metabolism of amino acids. pp. 1-79. In: D. M. Greenberg (ed.), Metabolic pathways, vol. 3. Academic, New York.
    • (1969) Metabolic Pathways , vol.3 , pp. 1-79
    • Satlach, H.J.1    Fabien, L.A.2
  • 39
    • 0026516223 scopus 로고
    • Network analysis of intermediary metabolism using linear optimization. I. Development of mathematical formalism
    • Savinell, J. M., Palsson, B. O. 1992. Network analysis of intermediary metabolism using linear optimization. I. Development of mathematical formalism. J. Theor. Biol. 154: 421-454.
    • (1992) J. Theor. Biol. , vol.154 , pp. 421-454
    • Savinell, J.M.1    Palsson, B.O.2
  • 40
    • 0026566666 scopus 로고
    • Optimal selection of metabolic fluxes for in vivo measurement. II. Application to Escherichia coli and hybridoma cell metabolism
    • Savinell, J. M., Palsson, B. O. 1992. Optimal selection of metabolic fluxes for in vivo measurement. II. Application to Escherichia coli and hybridoma cell metabolism. J. Theor. Biol. 155: 215-242.
    • (1992) J. Theor. Biol. , vol.155 , pp. 215-242
    • Savinell, J.M.1    Palsson, B.O.2
  • 41
    • 0027033717 scopus 로고
    • Monitoring hybridoma metabolism in continuous suspension culture at the intracellular level
    • Schmid, G., Keller, T. 1992. Monitoring hybridoma metabolism in continuous suspension culture at the intracellular level. Cytotechnology 9: 217-229.
    • (1992) Cytotechnology , vol.9 , pp. 217-229
    • Schmid, G.1    Keller, T.2
  • 42
  • 43
    • 0025048134 scopus 로고
    • Citric acid cycle redux
    • Srere, P. A. 1990. Citric acid cycle redux. Trends Biochem. Sci. 10: 411-412.
    • (1990) Trends Biochem. Sci. , vol.10 , pp. 411-412
    • Srere, P.A.1
  • 46
    • 0030051960 scopus 로고    scopus 로고
    • Effect of Vutreoscilla hemoglobin dosage on microaerobic Escherichia coli carbon and energy metabolism
    • Tsai, P. S , Hatzimanikatis V., Bailey, J. 1996. Effect of Vutreoscilla hemoglobin dosage on microaerobic Escherichia coli carbon and energy metabolism. Biotechnol. Bioeng. 49: 139-150.
    • (1996) Biotechnol. Bioeng. , vol.49 , pp. 139-150
    • Tsai, P.S.1    Hatzimanikatis, V.2    Bailey, J.3
  • 47
    • 0027572102 scopus 로고
    • Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction
    • Vallino, J. J., Stephanopoulos, G. 1993. Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction. Biotechnol. Bioeng. 41: 633-646.
    • (1993) Biotechnol. Bioeng. , vol.41 , pp. 633-646
    • Vallino, J.J.1    Stephanopoulos, G.2
  • 49
    • 0028108519 scopus 로고
    • Metabolic flux balancing: Basic concepts, scientific and practical use
    • Varma, A., Palsson, B. O. 1994. Metabolic flux balancing: Basic concepts, scientific and practical use. Bio/Technology 12: 994-998.
    • (1994) Bio/Technology , vol.12 , pp. 994-998
    • Varma, A.1    Palsson, B.O.2
  • 50
    • 0020812944 scopus 로고
    • Application of macroscopic balances to the identification of gross measurement errors
    • Wang, N. S., Stephanopoulos, G. 1983. Application of macroscopic balances to the identification of gross measurement errors. Biotechnol. Bioeng. 25: 2177-2208.
    • (1983) Biotechnol. Bioeng. , vol.25 , pp. 2177-2208
    • Wang, N.S.1    Stephanopoulos, G.2
  • 51
    • 0028693147 scopus 로고
    • Applications of improved stoichiometric model in medium design and fed-batch cultivation of animal cells in bioreactor
    • Xie, L., Wang, D. I. C. 1994. Applications of improved stoichiometric model in medium design and fed-batch cultivation of animal cells in bioreactor. Cytotechnology 15: 17-29.
    • (1994) Cytotechnology , vol.15 , pp. 17-29
    • Xie, L.1    Wang, D.I.C.2
  • 52
    • 0004122938 scopus 로고
    • Addison-Wesley, New York
    • Zubay, G. 1983. Biochemistry. Addison-Wesley, New York.
    • (1983) Biochemistry
    • Zubay, G.1


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