Optimizing amino acid composition of CHO cell culture media for a fusion protein production

Process Biochemistry

Volumn 46, Issue 7, 2011, Pages 1423-1429

  Xing, Zizhuo ^a   Kenty, Brian ^a   Koyrakh, Inna ^b   Borys, Michael ^a   Pan, Shih Hsie ^a   Li, Zheng Jian ^a  

^a BRISTOL MYERS SQUIBB COMPANY   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Medium optimization; Metabolic flux analysis; Nutrient demands; Productivity improvement; Toxic metabolites

Indexed keywords

MEDIUM OPTIMIZATION; METABOLIC FLUX ANALYSIS; NUTRIENT DEMANDS; PRODUCTIVITY IMPROVEMENT; TOXIC METABOLITES;

BATCH CELL CULTURE; CARBOXYLIC ACIDS; MANUFACTURE; METABOLISM; OPTIMIZATION; PRODUCTIVITY; PROTEINS;

AMINO ACIDS;

EID: 79957858590     PISSN: 13595113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.procbio.2011.03.014     Document Type: Article

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