Metabolic flux rearrangement in the amino acid metabolism reduces ammonia stress in the α 1-antitrypsin producing human AGE1.HN cell line

Metabolic Engineering

Volumn 14, Issue 2, 2012, Pages 128-137

  Priesnitz, Christian ^a   Niklas, Jens ^a   Rose, Thomas ^b   Sandig, Volker ^b   Heinzle, Elmar ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b PROBIOGEN AG   (Germany)

Author keywords

AAT deficiency; Biopharmaceutical; Mammalian cell; Metabolic flux analysis; Nitrogen metabolism; Therapeutic protein

Indexed keywords

AAT DEFICIENCY; BIOPHARMACEUTICAL; MAMMALIAN CELL; METABOLIC FLUX ANALYSIS; NITROGEN METABOLISM; THERAPEUTIC PROTEIN;

AMINO ACIDS; AMMONIA; CELL CULTURE; ENZYME ACTIVITY; METABOLITES; NITROGEN; PHYSIOLOGY; UREA;

METABOLISM;

ALANINE; ALPHA 1 ANTITRYPSIN; AMINOTRANSFERASE; AMMONIA; GLUTAMATE DEHYDROGENASE; NITROGEN; SERINE;

AMINO ACID METABOLISM; ARTICLE; CELL FUNCTION; CELL GROWTH; CELL LINE; CELL STRESS; CONTROLLED STUDY; ENERGY METABOLISM; GLYCOLYSIS; HUMAN; HUMAN CELL; METABOLIC BALANCE; METABOLIC REGULATION; NERVE CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT;

ALPHA 1-ANTITRYPSIN; AMINO ACIDS; AMMONIA; CELL LINE; ENERGY METABOLISM; HUMANS; STRESS, PHYSIOLOGICAL; TRANSAMINASES;

MAMMALIA;

EID: 84857993340     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2012.01.001     Document Type: Article

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