Screening soy hydrolysates for the production of a recombinant therapeutic protein in commercial cell line by combined approach of near-infrared spectroscopy and chemometrics

Applied Microbiology and Biotechnology

Volumn 97, Issue 6, 2013, Pages 2653-2660

  Li, Guiyang ^a   Wen, Zai Qing ^a  

^a AMGEN INC   (United States)

Author keywords

Chemometrics; Commercial cell line; Harvest titer; Near infrared spectroscopy; Soy hydrolysates; Therapeutic protein

Indexed keywords

CELL LINES; CHEMOMETRICS; HARVEST TITER; SOY HYDROLYSATES; THERAPEUTIC PROTEIN;

BOTTLES; INFRARED DEVICES; MANUFACTURE; MODELS; PROBES; RECOMBINANT PROTEINS;

CELL CULTURE;

PHOSPHOPROTEIN; RECOMBINANT PROTEIN; SOY HYDROLYSATE; UNCLASSIFIED DRUG;

PROTEIN; RECOMBINATION; REFLECTANCE; SAMPLING; SOYBEAN; SPECTROSCOPY;

ANIMAL CELL; ARTICLE; CELL LINE; CHEMOMETRICS; CULTURE MEDIUM; ENZYME ACTIVITY; FIBER OPTICS; HYDROLYSIS; NEAR INFRARED SPECTROSCOPY; NONHUMAN; PREDICTIVE VALUE;

BIOLOGICAL AGENTS; CELL LINE; CULTURE MEDIA; MASS SCREENING; PLANT CELLS; PLANTS, GENETICALLY MODIFIED; RECOMBINANT PROTEINS; SPECTROSCOPY, NEAR-INFRARED; TECHNOLOGY, PHARMACEUTICAL;

BOTTLES; FORESTRY; HARVESTING; INFRARED DETECTORS; PROTEINS; TISSUE CULTURE;

EID: 84878863603     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-013-4694-3     Document Type: Article

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