-
1
-
-
0036212849
-
Innate immune recognition
-
Janeway CA Jr, Medzhitov R. Innate immune recognition. Annu Rev Immunol (2002) 20:197-216. doi: 10.1146/annurev.immunol.20.083001.084359
-
(2002)
Annu Rev Immunol
, vol.20
, pp. 197-216
-
-
Janeway, C.A.1
Medzhitov, R.2
-
2
-
-
32944464648
-
Pathogen recognition and innate immunity
-
Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell (2006) 124:783-801. doi:10.1016/j.cell.2006.02.015
-
(2006)
Cell
, vol.124
, pp. 783-801
-
-
Akira, S.1
Uematsu, S.2
Takeuchi, O.3
-
3
-
-
84899131835
-
The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling
-
Cai X, Chiu YH, Chen ZJ. The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling. Mol Cell (2014) 54:289-96. doi:10.1016/j.molcel.2014.03.040
-
(2014)
Mol Cell
, vol.54
, pp. 289-296
-
-
Cai, X.1
Chiu, Y.H.2
Chen, Z.J.3
-
4
-
-
79953890803
-
The structural biology of toll-like receptors
-
Botos I, Segal DM, Davies DR. The structural biology of toll-like receptors. Structure (2011) 19:447-59. doi:10.1016/j.str.2011.02.004
-
(2011)
Structure
, vol.19
, pp. 447-459
-
-
Botos, I.1
Segal, D.M.2
Davies, D.R.3
-
5
-
-
77951260924
-
The role of pattern-recognition receptors in innate immunity: update on toll-like receptors
-
Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on toll-like receptors. Nat Immunol (2010) 11:373-84. doi:10.1038/ni.1863
-
(2010)
Nat Immunol
, vol.11
, pp. 373-384
-
-
Kawai, T.1
Akira, S.2
-
6
-
-
84866735326
-
TLR7 and TLR9 in SLE: when sensing self goes wrong
-
Celhar T, Magalhaes R, Fairhurst AM. TLR7 and TLR9 in SLE: when sensing self goes wrong. Immunol Res (2012) 53:58-77. doi:10.1007/s12026-012-8270-1
-
(2012)
Immunol Res
, vol.53
, pp. 58-77
-
-
Celhar, T.1
Magalhaes, R.2
Fairhurst, A.M.3
-
7
-
-
84890382865
-
Identification of TLR10 as a key mediator of the inflammatory response to listeria monocytogenes in intestinal epithelial cells and macrophages
-
Regan T, Nally K, Carmody R, Houston A, Shanahan F, Macsharry J, et al. Identification of TLR10 as a key mediator of the inflammatory response to listeria monocytogenes in intestinal epithelial cells and macrophages. J Immunol (2013) 191:6084-92. doi:10.4049/jimmunol.1203245
-
(2013)
J Immunol
, vol.191
, pp. 6084-6092
-
-
Regan, T.1
Nally, K.2
Carmody, R.3
Houston, A.4
Shanahan, F.5
Macsharry, J.6
-
8
-
-
84896277732
-
Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection
-
Lee SM, Kok KH, Jaume M, Cheung TK, Yip TF, Lai JC, et al. Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection. Proc Natl Acad Sci USA (2014) 111:3793-8. doi:10.1073/pnas.1324266111
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 3793-3798
-
-
Lee, S.M.1
Kok, K.H.2
Jaume, M.3
Cheung, T.K.4
Yip, T.F.5
Lai, J.C.6
-
9
-
-
77949940198
-
Intracellular toll-like receptors
-
Blasius AL, Beutler B. Intracellular toll-like receptors. Immunity (2010) 32:305-15. doi:10.1016/j.immuni.2010.03.012
-
(2010)
Immunity
, vol.32
, pp. 305-315
-
-
Blasius, A.L.1
Beutler, B.2
-
10
-
-
34548699323
-
TLR3 deficiency in patients with herpes simplex encephalitis
-
Zhang SY, Jouanguy E, Ugolini S, Smahi A, Elain G, Romero P, et al. TLR3 deficiency in patients with herpes simplex encephalitis. Science (2007) 317:1522-7. doi:10.1126/science.1139522
-
(2007)
Science
, vol.317
, pp. 1522-1527
-
-
Zhang, S.Y.1
Jouanguy, E.2
Ugolini, S.3
Smahi, A.4
Elain, G.5
Romero, P.6
-
11
-
-
84864713870
-
Ultraviolet radiation damages self noncoding RNA and is detected by TLR3
-
Bernard JJ, Cowing-Zitron C, Nakatsuji T, Muehleisen B, Muto J, Borkowski AW, et al. Ultraviolet radiation damages self noncoding RNA and is detected by TLR3. Nat Med (2012) 18:1286-90. doi:10.1038/nm.2861
-
(2012)
Nat Med
, vol.18
, pp. 1286-1290
-
-
Bernard, J.J.1
Cowing-Zitron, C.2
Nakatsuji, T.3
Muehleisen, B.4
Muto, J.5
Borkowski, A.W.6
-
12
-
-
84897895944
-
Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome
-
Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, et al. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat Commun (2014) 5:3492. doi:10.1038/ncomms4492
-
(2014)
Nat Commun
, vol.5
, pp. 3492
-
-
Takemura, N.1
Kawasaki, T.2
Kunisawa, J.3
Sato, S.4
Lamichhane, A.5
Kobiyama, K.6
-
13
-
-
67349187318
-
Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells
-
Mancuso G, Gambuzza M, Midiri A, Biondo C, Papasergi S, Akira S, et al. Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells. Nat Immunol (2009) 10:587-94. doi:10.1038/ni.1733
-
(2009)
Nat Immunol
, vol.10
, pp. 587-594
-
-
Mancuso, G.1
Gambuzza, M.2
Midiri, A.3
Biondo, C.4
Papasergi, S.5
Akira, S.6
-
14
-
-
84890840281
-
RNA recognition by human TLR8 can lead to autoimmune inflammation
-
Guiducci C, Gong M, Cepika AM, Xu Z, Tripodo C, Bennett L, et al. RNA recognition by human TLR8 can lead to autoimmune inflammation. J Exp Med (2013) 210:2903-19. doi:10.1084/jem.20131044
-
(2013)
J Exp Med
, vol.210
, pp. 2903-2919
-
-
Guiducci, C.1
Gong, M.2
Cepika, A.M.3
Xu, Z.4
Tripodo, C.5
Bennett, L.6
-
15
-
-
84875425019
-
Structural reorganization of the toll-like receptor 8 dimer induced by agonistic ligands
-
Tanji H, Ohto U, Shibata T, Miyake K, Shimizu T. Structural reorganization of the toll-like receptor 8 dimer induced by agonistic ligands. Science (2013) 339:1426-9. doi:10.1126/science.1229159
-
(2013)
Science
, vol.339
, pp. 1426-1429
-
-
Tanji, H.1
Ohto, U.2
Shibata, T.3
Miyake, K.4
Shimizu, T.5
-
16
-
-
84866159316
-
Cutting edge: TLR13 is a receptor for bacterial RNA
-
Hidmark A, Paul A, Dalpke AH. Cutting edge: TLR13 is a receptor for bacterial RNA. J Immunol (2012) 189:2717-21. doi:10.4049/jimmunol.1200898
-
(2012)
J Immunol
, vol.189
, pp. 2717-2721
-
-
Hidmark, A.1
Paul, A.2
Dalpke, A.H.3
-
17
-
-
84877579519
-
Sequence specific detection of bacterial 23S ribosomal RNA by TLR13
-
Li XD, Chen ZJ. Sequence specific detection of bacterial 23S ribosomal RNA by TLR13. eLife (2012) 1:e00102. doi:10.7554/eLife.00102
-
(2012)
eLife
, vol.1
-
-
Li, X.D.1
Chen, Z.J.2
-
18
-
-
84865571191
-
TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification
-
Oldenburg M, Kruger A, Ferstl R, Kaufmann A, Nees G, Sigmund A, et al. TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification. Science (2012) 337:1111-5. doi:10.1126/science.1220363
-
(2012)
Science
, vol.337
, pp. 1111-1115
-
-
Oldenburg, M.1
Kruger, A.2
Ferstl, R.3
Kaufmann, A.4
Nees, G.5
Sigmund, A.6
-
19
-
-
79953020324
-
A novel toll-like receptor that recognizes vesicular stomatitis virus
-
Shi Z, Cai Z, Sanchez A, Zhang T, Wen S, Wang J, et al. A novel toll-like receptor that recognizes vesicular stomatitis virus. J Biol Chem (2011) 286:4517-24. doi:10.1074/jbc.M110.159590
-
(2011)
J Biol Chem
, vol.286
, pp. 4517-4524
-
-
Shi, Z.1
Cai, Z.2
Sanchez, A.3
Zhang, T.4
Wen, S.5
Wang, J.6
-
20
-
-
74049121298
-
Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9
-
Coban C, Igari Y, Yagi M, Reimer T, Koyama S, Aoshi T, et al. Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9. Cell Host Microbe (2010) 7:50-61. doi:10.1016/j.chom.2009.12.003
-
(2010)
Cell Host Microbe
, vol.7
, pp. 50-61
-
-
Coban, C.1
Igari, Y.2
Yagi, M.3
Reimer, T.4
Koyama, S.5
Aoshi, T.6
-
21
-
-
84868028801
-
A mouse model of Salmonella typhi infection
-
Mathur R, Oh H, Zhang D, Park SG, Seo J, Koblansky A, et al. A mouse model of Salmonella typhi infection. Cell (2012) 151:590-602. doi:10.1016/j.cell.2012.08.042
-
(2012)
Cell
, vol.151
, pp. 590-602
-
-
Mathur, R.1
Oh, H.2
Zhang, D.3
Park, S.G.4
Seo, J.5
Koblansky, A.6
-
22
-
-
20644433342
-
TLR11 activation of dendritic cells by a protozoan profilin-like protein
-
Yarovinsky F, Zhang D, Andersen JF, Bannenberg GL, Serhan CN, Hayden MS, et al. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science (2005) 308:1626-9. doi:10.1126/science.1109893
-
(2005)
Science
, vol.308
, pp. 1626-1629
-
-
Yarovinsky, F.1
Zhang, D.2
Andersen, J.F.3
Bannenberg, G.L.4
Serhan, C.N.5
Hayden, M.S.6
-
23
-
-
84872761427
-
Recognition of profilin by toll-like receptor 12 is critical for host resistance to Toxoplasma gondii
-
Koblansky AA, Jankovic D, Oh H, Hieny S, Sungnak W, Mathur R, et al. Recognition of profilin by toll-like receptor 12 is critical for host resistance to Toxoplasma gondii. Immunity (2013) 38:119-30. doi:10.1016/j.immuni.2012.09.016
-
(2013)
Immunity
, vol.38
, pp. 119-130
-
-
Koblansky, A.A.1
Jankovic, D.2
Oh, H.3
Hieny, S.4
Sungnak, W.5
Mathur, R.6
-
24
-
-
84872596639
-
Combined action of nucleic acid-sensing toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice
-
Andrade WA, Souza Mdo C, Ramos-Martinez E, Nagpal K, Dutra MS, Melo MB, et al. Combined action of nucleic acid-sensing toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice. Cell Host Microbe (2013) 13:42-53. doi:10.1016/j.chom.2012.12.003
-
(2013)
Cell Host Microbe
, vol.13
, pp. 42-53
-
-
Andrade, W.A.1
Souza Mdo, C.2
Ramos-Martinez, E.3
Nagpal, K.4
Dutra, M.S.5
Melo, M.B.6
-
25
-
-
84880923978
-
Newly described pattern recognition receptors team up against intracellular pathogens
-
Broz P, Monack DM. Newly described pattern recognition receptors team up against intracellular pathogens. Nat Rev Immunol (2013) 13:551-65. doi:10.1038/nri3479
-
(2013)
Nat Rev Immunol
, vol.13
, pp. 551-565
-
-
Broz, P.1
Monack, D.M.2
-
26
-
-
31344466165
-
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via toll-like receptors 3, 7 and 9
-
Tabeta K, Hoebe K, Janssen EM, Du X, Georgel P, Crozat K, et al. The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via toll-like receptors 3, 7 and 9. Nat Immunol (2006) 7:156-64. doi:10.1038/ni1297
-
(2006)
Nat Immunol
, vol.7
, pp. 156-164
-
-
Tabeta, K.1
Hoebe, K.2
Janssen, E.M.3
Du, X.4
Georgel, P.5
Crozat, K.6
-
27
-
-
40749098665
-
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes
-
Kim YM, Brinkmann MM, Paquet ME, Ploegh HL. UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature (2008) 452:234-8. doi:10.1038/nature06726
-
(2008)
Nature
, vol.452
, pp. 234-238
-
-
Kim, Y.M.1
Brinkmann, M.M.2
Paquet, M.E.3
Ploegh, H.L.4
-
28
-
-
77956689533
-
Bifurcation of toll-like receptor 9 signaling by adaptor protein 3
-
Sasai M, Linehan MM, Iwasaki A. Bifurcation of toll-like receptor 9 signaling by adaptor protein 3. Science (2010) 329:1530-4. doi:10.1126/science.1187029
-
(2010)
Science
, vol.329
, pp. 1530-1534
-
-
Sasai, M.1
Linehan, M.M.2
Iwasaki, A.3
-
29
-
-
84881559292
-
UNC93B1 mediates differential trafficking of endosomal TLRs
-
Lee BL, Moon JE, Shu JH, Yuan L, Newman ZR, Schekman R, et al. UNC93B1 mediates differential trafficking of endosomal TLRs. eLife (2013) 2:e00291.
-
(2013)
eLife
, vol.2
-
-
Lee, B.L.1
Moon, J.E.2
Shu, J.H.3
Yuan, L.4
Newman, Z.R.5
Schekman, R.6
-
30
-
-
67449136127
-
Unc93B1 biases toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing
-
Fukui R, Saitoh S, Matsumoto F, Kozuka-Hata H, Oyama M, Tabeta K, et al. Unc93B1 biases toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing. J Exp Med (2009) 206:1339-50. doi:10.1084/jem.20082316
-
(2009)
J Exp Med
, vol.206
, pp. 1339-1350
-
-
Fukui, R.1
Saitoh, S.2
Matsumoto, F.3
Kozuka-Hata, H.4
Oyama, M.5
Tabeta, K.6
-
31
-
-
36549072863
-
A protein associated with toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses
-
Takahashi K, Shibata T, Akashi-Takamura S, Kiyokawa T, Wakabayashi Y, Tanimura N, et al. A protein associated with toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses. J Exp Med (2007) 204:2963-76. doi:10.1084/jem.20071132
-
(2007)
J Exp Med
, vol.204
, pp. 2963-2976
-
-
Takahashi, K.1
Shibata, T.2
Akashi-Takamura, S.3
Kiyokawa, T.4
Wakabayashi, Y.5
Tanimura, N.6
-
32
-
-
33847260278
-
Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages
-
Yang Y, Liu B, Dai J, Srivastava PK, Zammit DJ, Lefrancois L, et al. Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages. Immunity (2007) 26:215-26. doi:10.1016/j.immuni.2006.12.005
-
(2007)
Immunity
, vol.26
, pp. 215-226
-
-
Yang, Y.1
Liu, B.2
Dai, J.3
Srivastava, P.K.4
Zammit, D.J.5
Lefrancois, L.6
-
33
-
-
56349114913
-
Proteolytic cleavage in an endolysosomal compartment is required for activation of toll-like receptor 9
-
Park B, Brinkmann MM, Spooner E, Lee CC, Kim YM, Ploegh HL. Proteolytic cleavage in an endolysosomal compartment is required for activation of toll-like receptor 9. Nat Immunol (2008) 9:1407-14. doi:10.1038/ni.1669
-
(2008)
Nat Immunol
, vol.9
, pp. 1407-1414
-
-
Park, B.1
Brinkmann, M.M.2
Spooner, E.3
Lee, C.C.4
Kim, Y.M.5
Ploegh, H.L.6
-
34
-
-
79955743119
-
Nucleic acid recognition by toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase
-
Ewald SE, Engel A, Lee J, Wang M, Bogyo M, Barton GM. Nucleic acid recognition by toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase. J Exp Med (2011) 208:643-51. doi:10.1084/jem.20100682
-
(2011)
J Exp Med
, vol.208
, pp. 643-651
-
-
Ewald, S.E.1
Engel, A.2
Lee, J.3
Wang, M.4
Bogyo, M.5
Barton, G.M.6
-
35
-
-
84861861142
-
Cleavage of toll-like receptor 3 by cathepsins B and H is essential for signaling
-
Garcia-Cattaneo A, Gobert FX, Muller M, Toscano F, Flores M, Lescure A, et al. Cleavage of toll-like receptor 3 by cathepsins B and H is essential for signaling. Proc Natl Acad Sci USA (2012) 109:9053-8. doi:10.1073/pnas.1115091109
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 9053-9058
-
-
Garcia-Cattaneo, A.1
Gobert, F.X.2
Muller, M.3
Toscano, F.4
Flores, M.5
Lescure, A.6
-
36
-
-
67649232601
-
Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation
-
Peter ME, Kubarenko AV, Weber AN, Dalpke AH. Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation. J Immunol (2009) 182:7690-7. doi:10.4049/jimmunol.0900819
-
(2009)
J Immunol
, vol.182
, pp. 7690-7697
-
-
Peter, M.E.1
Kubarenko, A.V.2
Weber, A.N.3
Dalpke, A.H.4
-
37
-
-
84887504831
-
An essential role for the N-terminal fragment of toll-like receptor 9 in DNA sensing
-
Onji M, Kanno A, Saitoh S, Fukui R, Motoi Y, Shibata T, et al. An essential role for the N-terminal fragment of toll-like receptor 9 in DNA sensing. Nat Commun (2013) 4:1949. doi:10.1038/ncomms2949
-
(2013)
Nat Commun
, vol.4
, pp. 1949
-
-
Onji, M.1
Kanno, A.2
Saitoh, S.3
Fukui, R.4
Motoi, Y.5
Shibata, T.6
-
38
-
-
33646908228
-
Phosphoinositide-mediated adaptor recruitment controls toll-like receptor signaling
-
Kagan JC, Medzhitov R. Phosphoinositide-mediated adaptor recruitment controls toll-like receptor signaling. Cell (2006) 125:943-55. doi:10.1016/j.cell.2006.03.047
-
(2006)
Cell
, vol.125
, pp. 943-955
-
-
Kagan, J.C.1
Medzhitov, R.2
-
39
-
-
84894203179
-
A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction
-
Bonham KS, Orzalli MH, Hayashi K, Wolf AI, Glanemann C, Weninger W, et al. A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction. Cell (2014) 156:705-16. doi:10.1016/j.cell.2014.01.019
-
(2014)
Cell
, vol.156
, pp. 705-716
-
-
Bonham, K.S.1
Orzalli, M.H.2
Hayashi, K.3
Wolf, A.I.4
Glanemann, C.5
Weninger, W.6
-
40
-
-
84859564599
-
Bruton's tyrosine kinase phosphorylates toll-like receptor 3 to initiate antiviral response
-
Lee KG, Xu S, Kang ZH, Huo J, Huang M, Liu D, et al. Bruton's tyrosine kinase phosphorylates toll-like receptor 3 to initiate antiviral response. Proc Natl Acad Sci USA (2012) 109:5791-6. doi:10.1073/pnas.1119238109
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 5791-5796
-
-
Lee, K.G.1
Xu, S.2
Kang, Z.H.3
Huo, J.4
Huang, M.5
Liu, D.6
-
41
-
-
84864120697
-
Epidermal growth factor receptor is essential for toll-like receptor 3 signaling
-
Yamashita M, Chattopadhyay S, Fensterl V, Saikia P, Wetzel JL, Sen GC. Epidermal growth factor receptor is essential for toll-like receptor 3 signaling. Sci Signal (2012) 5:ra50. doi:10.1126/scisignal.2002581
-
(2012)
Sci Signal
, vol.5
, pp. ra50
-
-
Yamashita, M.1
Chattopadhyay, S.2
Fensterl, V.3
Saikia, P.4
Wetzel, J.L.5
Sen, G.C.6
-
42
-
-
77953714711
-
Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling
-
Lin SC, Lo YC, Wu H. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature (2010) 465:885-90. doi:10.1038/nature09121
-
(2010)
Nature
, vol.465
, pp. 885-890
-
-
Lin, S.C.1
Lo, Y.C.2
Wu, H.3
-
43
-
-
1242272100
-
Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling
-
Kollewe C, Mackensen AC, Neumann D, Knop J, Cao P, Li S, et al. Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling. J Biol Chem (2004) 279:5227-36. doi:10.1074/jbc.M309251200
-
(2004)
J Biol Chem
, vol.279
, pp. 5227-5236
-
-
Kollewe, C.1
Mackensen, A.C.2
Neumann, D.3
Knop, J.4
Cao, P.5
Li, S.6
-
44
-
-
0036788753
-
Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol
-
Jiang Z, Ninomiya-Tsuji J, Qian Y, Matsumoto K, Li X. Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. Mol Cell Biol (2002) 22:7158-67. doi:10.1128/MCB.22.20.7158-7167.2002
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7158-7167
-
-
Jiang, Z.1
Ninomiya-Tsuji, J.2
Qian, Y.3
Matsumoto, K.4
Li, X.5
-
45
-
-
84863338304
-
Ubiquitination in signaling to and activation of IKK
-
Chen ZJ. Ubiquitination in signaling to and activation of IKK. Immunol Rev (2012) 246:95-106. doi:10.1111/j.1600-065X.2012.01108.x
-
(2012)
Immunol Rev
, vol.246
, pp. 95-106
-
-
Chen, Z.J.1
-
46
-
-
84880847105
-
Cell type-specific function of TAK1 in innate immune signaling
-
Ajibade AA, Wang HY, Wang RF. Cell type-specific function of TAK1 in innate immune signaling. Trends Immunol (2013) 34:307-16. doi:10.1016/j.it.2013.03.007
-
(2013)
Trends Immunol
, vol.34
, pp. 307-316
-
-
Ajibade, A.A.1
Wang, H.Y.2
Wang, R.F.3
-
47
-
-
84856301921
-
TAK1 negatively regulates NF-kappaB and p38 MAP kinase activation in Gr-1+CD11b+ neutrophils
-
Ajibade AA, Wang Q, Cui J, Zou J, Xia X, Wang M, et al. TAK1 negatively regulates NF-kappaB and p38 MAP kinase activation in Gr-1+CD11b+ neutrophils. Immunity (2012) 36:43-54. doi:10.1016/j.immuni.2011.12.010
-
(2012)
Immunity
, vol.36
, pp. 43-54
-
-
Ajibade, A.A.1
Wang, Q.2
Cui, J.3
Zou, J.4
Xia, X.5
Wang, M.6
-
48
-
-
27744577296
-
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
-
Shim JH, Xiao C, Paschal AE, Bailey ST, Rao P, Hayden MS, et al. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev (2005) 19:2668-81. doi:10.1101/gad.1360605
-
(2005)
Genes Dev
, vol.19
, pp. 2668-2681
-
-
Shim, J.H.1
Xiao, C.2
Paschal, A.E.3
Bailey, S.T.4
Rao, P.5
Hayden, M.S.6
-
49
-
-
84875996333
-
Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs
-
Ori D, Kato H, Sanjo H, Tartey S, Mino T, Akira S, et al. Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs. J Immunol (2013) 190:4037-45. doi:10.4049/jimmunol.1300173
-
(2013)
J Immunol
, vol.190
, pp. 4037-4045
-
-
Ori, D.1
Kato, H.2
Sanjo, H.3
Tartey, S.4
Mino, T.5
Akira, S.6
-
50
-
-
78049250350
-
Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands
-
West XZ, Malinin NL, Merkulova AA, Tischenko M, Kerr BA, Borden EC, et al. Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature (2010) 467:972-6. doi:10.1038/nature09421
-
(2010)
Nature
, vol.467
, pp. 972-996
-
-
West, X.Z.1
Malinin, N.L.2
Merkulova, A.A.3
Tischenko, M.4
Kerr, B.A.5
Borden, E.C.6
-
51
-
-
84655176306
-
The role of ubiquitylation in immune defence and pathogen evasion
-
Jiang X, Chen ZJ. The role of ubiquitylation in immune defence and pathogen evasion. Nat Rev Immunol (2012) 12:35-48. doi:10.1038/nri3111
-
(2012)
Nat Rev Immunol
, vol.12
, pp. 35-48
-
-
Jiang, X.1
Chen, Z.J.2
-
52
-
-
70349472923
-
Peli1 facilitates TRIF-dependent toll-like receptor signaling and proinflammatory cytokine production
-
Chang M, Jin W, Sun SC. Peli1 facilitates TRIF-dependent toll-like receptor signaling and proinflammatory cytokine production. Nat Immunol (2009) 10:1089-95. doi:10.1038/ni.1777
-
(2009)
Nat Immunol
, vol.10
, pp. 1089-1095
-
-
Chang, M.1
Jin, W.2
Sun, S.C.3
-
53
-
-
84882384477
-
The second messenger phosphatidylinositol-5-phosphate facilitates antiviral innate immune signaling
-
Kawasaki T, Takemura N, Standley DM, Akira S, Kawai T. The second messenger phosphatidylinositol-5-phosphate facilitates antiviral innate immune signaling. Cell Host Microbe (2013) 14:148-58. doi:10.1016/j.chom.2013.07.011
-
(2013)
Cell Host Microbe
, vol.14
, pp. 148-158
-
-
Kawasaki, T.1
Takemura, N.2
Standley, D.M.3
Akira, S.4
Kawai, T.5
-
54
-
-
67649229630
-
The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon
-
Wang C, Chen T, Zhang J, Yang M, Li N, Xu X, et al. The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon. Nat Immunol (2009) 10:744-52. doi:10.1038/ni.1742
-
(2009)
Nat Immunol
, vol.10
, pp. 744-752
-
-
Wang, C.1
Chen, T.2
Zhang, J.3
Yang, M.4
Li, N.5
Xu, X.6
-
55
-
-
79954997147
-
Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk
-
Liu X, Zhan Z, Li D, Xu L, Ma F, Zhang P, et al. Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol (2011) 12:416-24. doi:10.1038/ni.2015
-
(2011)
Nat Immunol
, vol.12
, pp. 416-424
-
-
Liu, X.1
Zhan, Z.2
Li, D.3
Xu, L.4
Ma, F.5
Zhang, P.6
-
56
-
-
33645963170
-
Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells
-
Shinohara ML, Lu L, Bu J, Werneck MB, Kobayashi KS, Glimcher LH, et al. Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol (2006) 7:498-506. doi:10.1038/ni1327
-
(2006)
Nat Immunol
, vol.7
, pp. 498-506
-
-
Shinohara, M.L.1
Lu, L.2
Bu, J.3
Werneck, M.B.4
Kobayashi, K.S.5
Glimcher, L.H.6
-
57
-
-
42449096400
-
Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells
-
Gotoh K, Tanaka Y, Nishikimi A, Inayoshi A, Enjoji M, Takayanagi R, et al. Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells. Blood (2008) 111:2973-6. doi:10.1182/blood-2007-09-112169
-
(2008)
Blood
, vol.111
, pp. 2973-2976
-
-
Gotoh, K.1
Tanaka, Y.2
Nishikimi, A.3
Inayoshi, A.4
Enjoji, M.5
Takayanagi, R.6
-
58
-
-
79952762131
-
Antiviral protein viperin promotes toll-like receptor 7- and toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells
-
Saitoh T, Satoh T, Yamamoto N, Uematsu S, Takeuchi O, Kawai T, et al. Antiviral protein viperin promotes toll-like receptor 7- and toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. Immunity (2011) 34:352-63. doi:10.1016/j.immuni.2011.03.010
-
(2011)
Immunity
, vol.34
, pp. 352-363
-
-
Saitoh, T.1
Satoh, T.2
Yamamoto, N.3
Uematsu, S.4
Takeuchi, O.5
Kawai, T.6
-
59
-
-
17144404177
-
IRF-7 is the master regulator of type-I interferon-dependent immune responses
-
Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature (2005) 434:772-7. doi:10.1038/nature03464
-
(2005)
Nature
, vol.434
, pp. 772-777
-
-
Honda, K.1
Yanai, H.2
Negishi, H.3
Asagiri, M.4
Sato, M.5
Mizutani, T.6
-
60
-
-
84870861513
-
Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes
-
Henault J, Martinez J, Riggs JM, Tian J, Mehta P, Clarke L, et al. Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes. Immunity (2012) 37:986-97. doi:10.1016/j.immuni.2012.09.014
-
(2012)
Immunity
, vol.37
, pp. 986-997
-
-
Henault, J.1
Martinez, J.2
Riggs, J.M.3
Tian, J.4
Mehta, P.5
Clarke, L.6
-
61
-
-
33750064259
-
Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in toll-like receptor-dependent gene induction program
-
Negishi H, Fujita Y, Yanai H, Sakaguchi S, Ouyang X, Shinohara M, et al. Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in toll-like receptor-dependent gene induction program. Proc Natl Acad Sci USA (2006) 103:15136-41. doi:10.1073/pnas.0607181103
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 15136-15141
-
-
Negishi, H.1
Fujita, Y.2
Yanai, H.3
Sakaguchi, S.4
Ouyang, X.5
Shinohara, M.6
-
62
-
-
15044345461
-
Integral role of IRF-5 in the gene induction programme activated by toll-like receptors
-
Takaoka A, Yanai H, Kondo S, Duncan G, Negishi H, Mizutani T, et al. Integral role of IRF-5 in the gene induction programme activated by toll-like receptors. Nature (2005) 434:243-9. doi:10.1038/nature03308
-
(2005)
Nature
, vol.434
, pp. 243-249
-
-
Takaoka, A.1
Yanai, H.2
Kondo, S.3
Duncan, G.4
Negishi, H.5
Mizutani, T.6
-
63
-
-
2442689141
-
Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells
-
Tsujimura H, Tamura T, Kong HJ, Nishiyama A, Ishii KJ, Klinman DM, et al. Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells. J Immunol (2004) 172:6820-7. doi:10.4049/jimmunol.172.11.6820
-
(2004)
J Immunol
, vol.172
, pp. 6820-6827
-
-
Tsujimura, H.1
Tamura, T.2
Kong, H.J.3
Nishiyama, A.4
Ishii, K.J.5
Klinman, D.M.6
-
64
-
-
34548035397
-
The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8
-
Tailor P, Tamura T, Kong HJ, Kubota T, Kubota M, Borghi P, et al. The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8. Immunity (2007) 27:228-39. doi:10.1016/j.immuni.2007.06.009
-
(2007)
Immunity
, vol.27
, pp. 228-239
-
-
Tailor, P.1
Tamura, T.2
Kong, H.J.3
Kubota, T.4
Kubota, M.5
Borghi, P.6
-
65
-
-
81055129630
-
CD14 controls the LPS-induced endocytosis of toll-like receptor 4
-
Zanoni I, Ostuni R, Marek LR, Barresi S, Barbalat R, Barton GM, et al. CD14 controls the LPS-induced endocytosis of toll-like receptor 4. Cell (2011) 147:868-80. doi:10.1016/j.cell.2011.09.051
-
(2011)
Cell
, vol.147
, pp. 868-880
-
-
Zanoni, I.1
Ostuni, R.2
Marek, L.R.3
Barresi, S.4
Barbalat, R.5
Barton, G.M.6
-
66
-
-
78649434143
-
CD14 is a coreceptor of toll-like receptors 7 and 9
-
Baumann CL, Aspalter IM, Sharif O, Pichlmair A, Bluml S, Grebien F, et al. CD14 is a coreceptor of toll-like receptors 7 and 9. J Exp Med (2010) 207:2689-701. doi:10.1084/jem.20101111
-
(2010)
J Exp Med
, vol.207
, pp. 2689-2701
-
-
Baumann, C.L.1
Aspalter, I.M.2
Sharif, O.3
Pichlmair, A.4
Bluml, S.5
Grebien, F.6
-
67
-
-
75649087741
-
CD36 ligands promote sterile inflammation through assembly of a toll-like receptor 4 and 6 heterodimer
-
Stewart CR, Stuart LM, Wilkinson K, Van Gils JM, Deng J, Halle A, et al. CD36 ligands promote sterile inflammation through assembly of a toll-like receptor 4 and 6 heterodimer. Nat Immunol (2010) 11:155-61. doi:10.1038/ni.1836
-
(2010)
Nat Immunol
, vol.11
, pp. 155-161
-
-
Stewart, C.R.1
Stuart, L.M.2
Wilkinson, K.3
Van Gils, J.M.4
Deng, J.5
Halle, A.6
-
68
-
-
84880777411
-
CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
-
Sheedy FJ, Grebe A, Rayner KJ, Kalantari P, Ramkhelawon B, Carpenter SB, et al. CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat Immunol (2013) 14:812-20. doi:10.1038/ni.2639
-
(2013)
Nat Immunol
, vol.14
, pp. 812-820
-
-
Sheedy, F.J.1
Grebe, A.2
Rayner, K.J.3
Kalantari, P.4
Ramkhelawon, B.5
Carpenter, S.B.6
-
69
-
-
67349092199
-
TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway
-
Palsson-McDermott EM, Doyle SL, Mcgettrick AF, Hardy M, Husebye H, Banahan K, et al. TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway. Nat Immunol (2009) 10:579-86. doi:10.1038/ni.1727
-
(2009)
Nat Immunol
, vol.10
, pp. 579-586
-
-
Palsson-McDermott, E.M.1
Doyle, S.L.2
Mcgettrick, A.F.3
Hardy, M.4
Husebye, H.5
Banahan, K.6
-
70
-
-
77954946392
-
Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b
-
Han C, Jin J, Xu S, Liu H, Li N, Cao X. Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Nat Immunol (2010) 11:734-42. doi:10.1038/ni.1908
-
(2010)
Nat Immunol
, vol.11
, pp. 734-742
-
-
Han, C.1
Jin, J.2
Xu, S.3
Liu, H.4
Li, N.5
Cao, X.6
-
71
-
-
36448943427
-
DUBA: a deubiquitinase that regulates type I interferon production
-
Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O'rourke KM, et al. DUBA: a deubiquitinase that regulates type I interferon production. Science (2007) 318:1628-32. doi:10.1126/science.1145918
-
(2007)
Science
, vol.318
, pp. 1628-1632
-
-
Kayagaki, N.1
Phung, Q.2
Chan, S.3
Chaudhari, R.4
Quan, C.5
O'rourke, K.M.6
-
72
-
-
81355150892
-
Direct, noncatalytic mechanism of IKK inhibition by A20
-
Skaug B, Chen J, Du F, He J, Ma A, Chen ZJ. Direct, noncatalytic mechanism of IKK inhibition by A20. Mol Cell (2011) 44:559-71. doi:10.1016/j.molcel.2011.09.015
-
(2011)
Mol Cell
, vol.44
, pp. 559-571
-
-
Skaug, B.1
Chen, J.2
Du, F.3
He, J.4
Ma, A.5
Chen, Z.J.6
-
73
-
-
80052020185
-
The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by toll-like receptors
-
Yuk JM, Shin DM, Lee HM, Kim JJ, Kim SW, Jin HS, et al. The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by toll-like receptors. Nat Immunol (2011) 12:742-51. doi:10.1038/ni.2064
-
(2011)
Nat Immunol
, vol.12
, pp. 742-751
-
-
Yuk, J.M.1
Shin, D.M.2
Lee, H.M.3
Kim, J.J.4
Kim, S.W.5
Jin, H.S.6
-
74
-
-
84865298775
-
Dissecting negative regulation of toll-like receptor signaling
-
Kondo T, Kawai T, Akira S. Dissecting negative regulation of toll-like receptor signaling. Trends Immunol (2012) 33:449-58. doi:10.1016/j.it.2012.05.002
-
(2012)
Trends Immunol
, vol.33
, pp. 449-458
-
-
Kondo, T.1
Kawai, T.2
Akira, S.3
-
75
-
-
40949163764
-
TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation
-
Shi M, Deng W, Bi E, Mao K, Ji Y, Lin G, et al. TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation. Nat Immunol (2008) 9:369-77. doi:10.1038/ni1577
-
(2008)
Nat Immunol
, vol.9
, pp. 369-377
-
-
Shi, M.1
Deng, W.2
Bi, E.3
Mao, K.4
Ji, Y.5
Lin, G.6
-
76
-
-
33744499683
-
Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1
-
Saitoh T, Tun-Kyi A, Ryo A, Yamamoto M, Finn G, Fujita T, et al. Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1. Nat Immunol (2006) 7:598-605. doi:10.1038/ni1347
-
(2006)
Nat Immunol
, vol.7
, pp. 598-605
-
-
Saitoh, T.1
Tun-Kyi, A.2
Ryo, A.3
Yamamoto, M.4
Finn, G.5
Fujita, T.6
-
77
-
-
81055129618
-
Systematic discovery of TLR signaling components delineates viral-sensing circuits
-
Chevrier N, Mertins P, Artyomov MN, Shalek AK, Iannacone M, Ciaccio MF, et al. Systematic discovery of TLR signaling components delineates viral-sensing circuits. Cell (2011) 147:853-67. doi:10.1016/j.cell.2011.10.022
-
(2011)
Cell
, vol.147
, pp. 853-867
-
-
Chevrier, N.1
Mertins, P.2
Artyomov, M.N.3
Shalek, A.K.4
Iannacone, M.5
Ciaccio, M.F.6
-
78
-
-
67349167059
-
Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay
-
Matsushita K, Takeuchi O, Standley DM, Kumagai Y, Kawagoe T, Miyake T, et al. Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature (2009) 458:1185-90. doi:10.1038/nature07924
-
(2009)
Nature
, vol.458
, pp. 1185-1190
-
-
Matsushita, K.1
Takeuchi, O.2
Standley, D.M.3
Kumagai, Y.4
Kawagoe, T.5
Miyake, T.6
-
79
-
-
79956300649
-
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
-
Kawai T, Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity (2011) 34:637-50. doi:10.1016/j.immuni.2011.05.006
-
(2011)
Immunity
, vol.34
, pp. 637-650
-
-
Kawai, T.1
Akira, S.2
-
80
-
-
57849159061
-
Toll-like receptors and cancer
-
Rakoff-Nahoum S, Medzhitov R. Toll-like receptors and cancer. Nat Rev Cancer (2009) 9:57-63. doi:10.1038/nrc2541
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 57-63
-
-
Rakoff-Nahoum, S.1
Medzhitov, R.2
-
81
-
-
79551686422
-
Oncogenically active MYD88 mutations in human lymphoma
-
Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, et al. Oncogenically active MYD88 mutations in human lymphoma. Nature (2011) 470:115-9. doi:10.1038/nature09671
-
(2011)
Nature
, vol.470
, pp. 115-119
-
-
Ngo, V.N.1
Young, R.M.2
Schmitz, R.3
Jhavar, S.4
Xiao, W.5
Lim, K.H.6
-
82
-
-
66649127621
-
Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma
-
Compagno M, Lim WK, Grunn A, Nandula SV, Brahmachary M, Shen Q, et al. Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Nature (2009) 459:717-21. doi:10.1038/nature07968
-
(2009)
Nature
, vol.459
, pp. 717-721
-
-
Compagno, M.1
Lim, W.K.2
Grunn, A.3
Nandula, S.V.4
Brahmachary, M.5
Shen, Q.6
-
83
-
-
66649112854
-
Frequent inactivation of A20 in B-cell lymphomas
-
Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, et al. Frequent inactivation of A20 in B-cell lymphomas. Nature (2009) 459:712-6. doi:10.1038/nature07969
-
(2009)
Nature
, vol.459
, pp. 712-776
-
-
Kato, M.1
Sanada, M.2
Kato, I.3
Sato, Y.4
Takita, J.5
Takeuchi, K.6
-
84
-
-
70449091786
-
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
-
Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature (2009) 462:108-12. doi:10.1038/nature08460
-
(2009)
Nature
, vol.462
, pp. 108-112
-
-
Barbie, D.A.1
Tamayo, P.2
Boehm, J.S.3
Kim, S.Y.4
Moody, S.E.5
Dunn, I.F.6
|