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Volumn 12, Issue 8, 2011, Pages 742-751

The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ORPHAN NUCLEAR RECEPTOR; REGULATOR PROTEIN; SMALL HETERODIMER PARTNER PROTEIN; SYNAPTOTAGMIN I; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

EID: 80052020185     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2064     Document Type: Review
Times cited : (169)

References (49)
  • 1
    • 0037180768 scopus 로고    scopus 로고
    • The immunopathogenesis of sepsis
    • DOI 10.1038/nature01326
    • Cohen, J. The immunopathogenesis of sepsis. Nature 420, 885-891 (2002). (Pubitemid 36019643)
    • (2002) Nature , vol.420 , Issue.6917 , pp. 885-891
    • Cohen, J.1
  • 2
    • 0037180812 scopus 로고    scopus 로고
    • Points of control in inflammation
    • DOI 10.1038/nature01320
    • Nathan, C. Points of control in inflammation. Nature 420, 846-852 (2002). (Pubitemid 36019637)
    • (2002) Nature , vol.420 , Issue.6917 , pp. 846-852
    • Nathan, C.1
  • 3
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • DOI 10.1038/90609
    • Akira, S., Takeda, K. & Kaisho, T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2, 675-680 (2001). (Pubitemid 32747155)
    • (2001) Nature Immunology , vol.2 , Issue.8 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 4
    • 20644450804 scopus 로고    scopus 로고
    • Negative regulation of toll-like receptor-mediated immune responses
    • DOI 10.1038/nri1630
    • Liew, F.Y., Xu, D., Brint, E.K. & O'Neill, L.-A. Negative regulation of toll-like receptor-mediated immune responses. Nat. Rev. Immunol. 5, 446-458 (2005). (Pubitemid 40835033)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.6 , pp. 446-458
    • Liew, F.Y.1    Xu, D.2    Brint, E.K.3    O'Neill, L.A.J.4
  • 5
    • 62649124147 scopus 로고    scopus 로고
    • Negative regulation of Toll-like receptor signaling pathway
    • Wang, J., Hu, Y., Deng, W.W. & Sun, B. Negative regulation of Toll-like receptor signaling pathway. Microbes Infect. 11, 321-327 (2009).
    • (2009) Microbes Infect , vol.11 , pp. 321-327
    • Wang, J.1    Hu, Y.2    Deng, W.W.3    Sun, B.4
  • 6
    • 0030001371 scopus 로고    scopus 로고
    • An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors
    • Seol, W., Choi, H.S. & Moore, D.D. An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science 272, 1336-1339 (1996). (Pubitemid 26199974)
    • (1996) Science , vol.272 , Issue.5266 , pp. 1336-1339
    • Seol, W.1    Choi, H.-S.2    Moore, D.D.3
  • 7
    • 34249793707 scopus 로고    scopus 로고
    • Structure and function of the atypical orphan nuclear receptor small heterodimer partner
    • DOI 10.1016/S0074-7696(07)61003-1, PII S0074769607610031, A Survey of Cell Biology
    • Lee, Y.S., Chanda, D., Sim, J., Park, Y.Y. & Choi, H.S. Structure and function of the atypical orphan nuclear receptor small heterodimer partner. Int. Rev. Cytol. 261, 117-158 (2007). (Pubitemid 46856618)
    • (2007) International Review of Cytology , vol.261 , pp. 117-158
    • Lee, Y.1    Chanda, D.2    Sim, J.3    Park, Y.4    Choi, H.5
  • 8
    • 27844509037 scopus 로고    scopus 로고
    • Transcriptional corepression by SHP: Molecular mechanisms and physiological consequences
    • DOI 10.1016/j.tem.2005.10.005, PII S1043276005002365
    • Bavner, A., Sanyal, S., Gustafsson, J.A. & Treuter, E. Transcriptional corepression by SHP: molecular mechanisms and physiological consequences. Trends Endocrinol. Metab. 16, 478-488 (2005). (Pubitemid 41660864)
    • (2005) Trends in Endocrinology and Metabolism , vol.16 , Issue.10 , pp. 478-488
    • Bavner, A.1    Sanyal, S.2    Gustafsson, J.-A.3    Treuter, E.4
  • 9
    • 43449097571 scopus 로고    scopus 로고
    • Molecular basis of endocrine regulation by orphan nuclear receptor small heterodimer partner
    • DOI 10.1507/endocrj.K07E-103
    • Chanda, D., Park, J.H. & Choi, H.S. Molecular basis of endocrine regulation by orphan nuclear receptor Small Heterodimer Partner. Endocr. J. 55, 253-268 (2008). (Pubitemid 351670949)
    • (2008) Endocrine Journal , vol.55 , Issue.2 , pp. 253-268
    • Chanda, D.1    Park, J.-H.2    Choi, H.-S.3
  • 10
    • 47149095737 scopus 로고    scopus 로고
    • Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation
    • DOI 10.1002/hep.22342
    • Zhang, Y. et al. Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation. Hepatology 48, 289-298 (2008). (Pubitemid 351975553)
    • (2008) Hepatology , vol.48 , Issue.1 , pp. 289-298
    • Zhang, Y.1    Xu, P.2    Park, K.3    Choi, Y.4    Moore, D.D.5    Wang, L.6
  • 11
    • 23144449789 scopus 로고    scopus 로고
    • Ubiquitin signalling in the NF-kB pathway
    • Chen, Z.J. Ubiquitin signalling in the NF-kB pathway. Nat. Cell Biol. 7, 758-765 (2005).
    • (2005) Nat. Cell Biol. , vol.7 , pp. 758-765
    • Chen, Z.J.1
  • 14
    • 68049092912 scopus 로고    scopus 로고
    • RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway
    • Chiu, Y.H., Macmillan, J.B. & Chen, Z.J. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 138, 576-591 (2009).
    • (2009) Cell. , vol.138 , pp. 576-591
    • Chiu, Y.H.1    Macmillan, J.B.2    Chen, Z.J.3
  • 16
    • 0036221384 scopus 로고    scopus 로고
    • MAP kinases in the immune response
    • DOI 10.1146/annurev.immunol.20.091301.131133
    • Dong, C., Davis, R.J. & Flavell, R.A. MAP kinases in the immune response. Annu. Rev. Immunol. 20, 55-72 (2002). (Pubitemid 34293420)
    • (2002) Annual Review of Immunology , vol.20 , pp. 55-72
    • Dong, C.1    Davis, R.J.2    Flavell, R.A.3
  • 17
    • 39049183044 scopus 로고    scopus 로고
    • Regulation and function of IKK and IKK-related kinases
    • re13
    • Hacker, H. & Karin, M. Regulation and function of IKK and IKK-related kinases. Sci. STKE 2006, re13 (2006).
    • (2006) Sci. STKE 2006
    • Hacker, H.1    Karin, M.2
  • 18
    • 33645312379 scopus 로고    scopus 로고
    • Circuitry of nuclear factor ?B signaling
    • Hoffmann, A. & Baltimore, D. Circuitry of nuclear factor ?B signaling. Immunol. Rev. 210, 171-186 (2006).
    • (2006) Immunol. Rev. , vol.210 , pp. 171-186
    • Hoffmann, A.1    Baltimore, D.2
  • 19
    • 36049033394 scopus 로고    scopus 로고
    • Signaling to NF-kB by Toll-like receptors
    • Kawai, T. & Akira, S. Signaling to NF-kB by Toll-like receptors. Trends Mol. Med. 13, 460-469 (2007).
    • (2007) Trends Mol. Med. , vol.13 , pp. 460-469
    • Kawai, T.1    Akira, S.2
  • 20
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • DOI 10.1016/j.cell.2006.02.015, PII S0092867406001905
    • Akira, S., Uematsu, S. & Takeuchi, O. Pathogen recognition and innate immunity. Cell 124, 783-801 (2006). (Pubitemid 43261452)
    • (2006) Cell , vol.124 , Issue.4 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 21
    • 0036212849 scopus 로고    scopus 로고
    • Innate immune recognition
    • DOI 10.1146/annurev.immunol.20.083001.084359
    • Janeway, C.A. Jr. & Medzhitov, R. Innate immune recognition. Annu. Rev. Immunol. 20, 197-216 (2002). (Pubitemid 34293424)
    • (2002) Annual Review of Immunology , vol.20 , pp. 197-216
    • Janeway Jr., C.A.1    Medzhitov, R.2
  • 22
    • 46249124976 scopus 로고    scopus 로고
    • Deubiquitylation and regulation of the immune response
    • Sun, S.C. Deubiquitylation and regulation of the immune response. Nat. Rev. Immunol. 8, 501-511 (2008).
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 501-511
    • Sun, S.C.1
  • 23
    • 0034644474 scopus 로고    scopus 로고
    • Activation of the I?B kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
    • Deng, L. et al. Activation of the I?B kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103, 351-361 (2000).
    • (2000) Cell. , vol.103 , pp. 351-361
    • Deng, L.1
  • 24
    • 76549089547 scopus 로고    scopus 로고
    • Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: Synergistic effects of Ca2+ and AMP
    • Fogarty, S. et al. Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP. Biochem. J. 426, 109-118 (2010).
    • (2010) Biochem. J. , vol.426 , pp. 109-118
    • Fogarty, S.1
  • 25
    • 15044358594 scopus 로고    scopus 로고
    • New roles for the LKB1?AMPK pathway
    • Hardie, D.G. New roles for the LKB1?AMPK pathway. Curr. Opin. Cell Biol. 17, 167-173 (2005).
    • (2005) Curr. Opin. Cell Biol. , vol.17 , pp. 167-173
    • Hardie, D.G.1
  • 26
    • 70350399521 scopus 로고    scopus 로고
    • Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes
    • Chanda, D. et al. Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes. J. Biol. Chem. 284, 28510-28521 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 28510-28521
    • Chanda, D.1
  • 27
    • 40749116561 scopus 로고    scopus 로고
    • Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP
    • Kim, Y.D. et al. Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP. Diabetes 57, 306-314 (2008).
    • (2008) Diabetes , vol.57 , pp. 306-314
    • Kim, Y.D.1
  • 28
    • 0032741542 scopus 로고    scopus 로고
    • Negative regulation of macrophage activation in response to IFN-γ and lipopolysaccharide by the STK RON receptor tyrosine kinase
    • Liu, Q.P., Fruit, K., Ward, J. & Correll, P.H. Negative regulation of macrophage activation in response to IFN-γ and lipopolysaccharide by the STK/RON receptor tyrosine kinase. J. Immunol. 163, 6606-6613 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 6606-6613
    • Liu, Q.P.1    Fruit, K.2    Ward, J.3    Correll, P.H.4
  • 29
    • 0033637121 scopus 로고    scopus 로고
    • A regulatory cascade of the nuclear receptors FXR SHP-1 and LRH-1 represses bile acid biosynthesis
    • Goodwin, B. et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol. Cell 6, 517-526 (2000).
    • (2000) Mol. Cell. , vol.6 , pp. 517-526
    • Goodwin, B.1
  • 30
    • 67650088002 scopus 로고    scopus 로고
    • Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner SHP
    • Lam, I.P., Lee, L.T., Choi, H.S., Alpini, G. & Chow, B.K. Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP). Am. J. Physiol. Gastrointest. Liver Physiol. 297, G90-G97 (2009).
    • (2009) Am. J. Physiol. Gastrointest Liver Physiol. , vol.297
    • Lam, I.P.1    Lee, L.T.2    Choi, H.S.3    Alpini, G.4    Chow, B.K.5
  • 31
    • 36849033963 scopus 로고    scopus 로고
    • TAM receptors are pleiotropic inhibitors of the innate immune response
    • DOI 10.1016/j.cell.2007.10.034, PII S0092867407013529
    • Rothlin, C.V., Ghosh, S., Zuniga, E.I., Oldstone, M.B. & Lemke, G. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131, 1124-1136 (2007). (Pubitemid 350235020)
    • (2007) Cell , vol.131 , Issue.6 , pp. 1124-1136
    • Rothlin, C.V.1    Ghosh, S.2    Zuniga, E.I.3    Oldstone, M.B.A.4    Lemke, G.5
  • 32
    • 77749330820 scopus 로고    scopus 로고
    • Nuclear receptor SHP a death receptor that targets mitochondria induces apoptosis and inhibits tumor growth
    • Zhang, Y. et al. Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Mol. Cell. Biol. 30, 1341-1356 (2010).
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 1341-1356
    • Zhang, Y.1
  • 33
    • 31344463886 scopus 로고    scopus 로고
    • Association of β-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling
    • DOI 10.1038/ni1294, PII N1294
    • Wang, Y. et al. Association of β-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 7, 139-147 (2006). (Pubitemid 43135879)
    • (2006) Nature Immunology , vol.7 , Issue.2 , pp. 139-147
    • Wang, Y.1    Tang, Y.2    Teng, L.3    Wu, Y.4    Zhao, X.5    Pei, G.6
  • 34
    • 65249104853 scopus 로고    scopus 로고
    • Bile acid signaling pathways increase stability of small heterodimer partner SHP by inhibiting ubiquitin-proteasomal degradation
    • Miao, J. et al. Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation. Genes Dev. 23, 986-996 (2009).
    • (2009) Genes Dev. , vol.23 , pp. 986-996
    • Miao, J.1
  • 35
    • 36849061190 scopus 로고    scopus 로고
    • Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders
    • DOI 10.1016/j.diabet.2007.10.004, PII S1262363607002005
    • Viollet, B. et al. Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders. Diabetes Metab. 33, 395-402 (2007). (Pubitemid 350218220)
    • (2007) Diabetes and Metabolism , vol.33 , Issue.6 , pp. 395-402
    • Viollet, B.1    Mounier, R.2    Leclerc, J.3    Yazigi, A.4    Foretz, M.5    Andreelli, F.6
  • 36
    • 58849115949 scopus 로고    scopus 로고
    • Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
    • Sag, D., Carling, D., Stout, R.D. & Suttles, J. Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J. Immunol. 181, 8633-8641 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 8633-8641
    • Sag, D.1    Carling, D.2    Stout, R.D.3    Suttles, J.4
  • 37
    • 52649141738 scopus 로고    scopus 로고
    • Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury
    • Zhao, X. et al. Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 295, L497-L504 (2008).
    • (2008) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.295
    • Zhao, X.1
  • 38
    • 2142640818 scopus 로고    scopus 로고
    • 5-Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide- induced TNF-α production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages
    • DOI 10.1016/j.bbrc.2004.04.035, PII S0006291X04007600
    • Jhun, B.S. et al. 5-Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages. Biochem. Biophys. Res. Commun. 318, 372-380 (2004). (Pubitemid 38553790)
    • (2004) Biochemical and Biophysical Research Communications , vol.318 , Issue.2 , pp. 372-380
    • Jhun, B.S.1    Jin, Q.2    Oh, Y.T.3    Kim, S.S.4    Kong, Y.5    Cho, Y.H.6    Ha, J.7    Baik, H.H.8    Kang, I.9
  • 39
    • 0025938869 scopus 로고
    • Characterization of the DNF15S2 locus on human chromosome 3: Identification of a gene coding for four kringle domains with homology to hepatocyte growth factor
    • Han, S., Stuart, L.A. & Degen, S.-J. Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor. Biochemistry 30, 9768-9780 (1991).
    • (1991) Biochemistry , vol.30 , pp. 9768-9780
    • Han, S.1    Stuart, L.A.2    Degen, S.-J.3
  • 40
    • 0027248125 scopus 로고
    • Hepatocyte-specific expression of the mouse hepatocyte growth factor-like protein
    • DOI 10.1016/0270-9139(93)90024-H
    • Bezerra, J.A., Witte, D.P., Aronow, B.J. & Degen, S.J. Hepatocyte-specific expression of the mouse hepatocyte growth factor-like protein. Hepatology 18, 394-399 (1993). (Pubitemid 23225112)
    • (1993) Hepatology , vol.18 , Issue.2 , pp. 394-399
    • Bezerra, J.A.1    Witte, D.P.2    Aronow, B.J.3    Degen, S.J.F.4
  • 41
    • 0030056374 scopus 로고    scopus 로고
    • Proteolytic cleavage and activation of pro-macrophage-stimulating protein by resident peritoneal macrophage membrane proteases
    • Wang, M.H., Skeel, A. & Leonard, E.J. Proteolytic cleavage and activation of pro-macrophage-stimulating protein by resident peritoneal macrophage membrane proteases. J. Clin. Invest. 97, 720-727 (1996). (Pubitemid 26057091)
    • (1996) Journal of Clinical Investigation , vol.97 , Issue.3 , pp. 720-727
    • Wang, M.-H.1    Skeel, A.2    Leonard, E.J.3
  • 42
    • 0032211131 scopus 로고    scopus 로고
    • Activation of the RON receptor tyrosine kinase inhibits inducible nitric oxide synthase (iNOS) expression by murine peritoneal exudate macrophages: Phosphatidylinositol-3 kinase is required for RON-mediated inhibition of iNOS expression
    • Chen, Y.Q., Fisher, J.H. & Wang, M.H. Activation of the RON receptor tyrosine kinase inhibits inducible nitric oxide synthase (iNOS) expression by murine peritoneal exudate macrophages: phosphatidylinositol-3 kinase is required for RON-mediated inhibition of iNOS expression. J. Immunol. 161, 4950-4959 (1998). (Pubitemid 28492076)
    • (1998) Journal of Immunology , vol.161 , Issue.9 , pp. 4950-4959
    • Chen, Y.-Q.1    Fisher, J.H.2    Wang, M.-H.3
  • 43
    • 78650671081 scopus 로고    scopus 로고
    • Inhibition of TLR4-Induced I?B kinase activity by the RON receptor tyrosine kinase and its ligand macrophage-stimulating protein
    • Ray, M. et al. Inhibition of TLR4-Induced I?B kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein. J. Immunol. 185, 7309-7316 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 7309-7316
    • Ray, M.1
  • 45
    • 0041324898 scopus 로고    scopus 로고
    • The interplay between the glucocorticoid receptor and nuclear factor-κB or activator protein-1: Molecular mechanisms for gene repression
    • DOI 10.1210/er.2002-0006
    • De Bosscher, K., Vanden Berghe, W. & Haegeman, G. The interplay between the glucocorticoid receptor and nuclear factor-?B or activator protein-1: molecular mechanisms for gene repression. Endocr. Rev. 24, 488-522 (2003). (Pubitemid 37059110)
    • (2003) Endocrine Reviews , vol.24 , Issue.4 , pp. 488-522
    • De Bosscher, K.1    Vanden Berghe, W.2    Haegeman, G.3
  • 48
    • 33947380590 scopus 로고    scopus 로고
    • Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock
    • Yang, C.S. et al. Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock. J. Exp. Med. 204, 583-594 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 583-594
    • Yang, C.S.1
  • 49
    • 77954519851 scopus 로고    scopus 로고
    • Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury
    • Schingnitz, U. et al. Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury. J. Immunol. 184, 5271-5279 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 5271-5279
    • Schingnitz, U.1


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