Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 15, 2012, Pages 5791-5796

  Lee, Koon Guan ^a   Xu, Shengli ^a   Kang, Zi Han ^a   Huo, Jianxin ^a   Huang, Mei ^b   Liu, Dingxiang ^b   Takeuchi, Osamu ^c   Akira, Shizuo ^c   Lam, Kong Peng ^a  

^a AGENCY FOR SCIENCE   (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Innate immunity; Pattern recognition receptors; Signal transduction

Indexed keywords

BETA INTERFERON; BRUTON TYROSINE KINASE; I KAPPA B; INTERFERON REGULATORY FACTOR 3; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; TOLL LIKE RECEPTOR 3;

ANIMAL EXPERIMENT; ARTICLE; CYTOKINE PRODUCTION; DENGUE VIRUS; ENZYME ACTIVATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; ANTIVIRAL AGENTS; CYTOKINES; DENGUE VIRUS; ENZYME ACTIVATION; GTPASE-ACTIVATING PROTEINS; HEK293 CELLS; HUMANS; INTERFERON-BETA; MACROPHAGE ACTIVATION; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; TOLL-LIKE RECEPTOR 3; TRANSCRIPTION FACTORS; VIRUS REPLICATION;

DENGUE VIRUS; MUS;

EID: 84859564599     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1119238109     Document Type: Article

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