Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

Nature Immunology

Volumn 11, Issue 8, 2010, Pages 734-742

  Han, Chaofeng ^a   Jin, Jing ^b   Xu, Sheng ^a   Liu, Haibo ^a   Li, Nan ^a   Cao, Xuetao ^a,b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CBL B PROTEIN; CBL PROTEIN; CD11B ANTIGEN; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE SYK; PROTEIN TYROSINE KINASE; RAP PROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ESCHERICHIA COLI; GENE ACTIVATION; GENE CONTROL; HUMAN; HUMAN CELL; INFLAMMATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SEPSIS; SEPTIC SHOCK;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; ANTIGENS, CD11B; ENZYME ACTIVATION; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IMMUNITY, INNATE; INFLAMMATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROPHAGES; MICE; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-CBL; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TOLL-LIKE RECEPTORS;

EID: 77954946392     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1908     Document Type: Article

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