-
1
-
-
0032127279
-
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
-
Adachi, O., T. Kawai, K. Takeda, M. Matsumoto, H. Tsutsui, M. Sakagami, K. Nakanishi, and S. Akira. 1998. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9:143-150.
-
(1998)
Immunity
, vol.9
, pp. 143-150
-
-
Adachi, O.1
Kawai, T.2
Takeda, K.3
Matsumoto, M.4
Tsutsui, H.5
Sakagami, M.6
Nakanishi, K.7
Akira, S.8
-
2
-
-
0030615201
-
Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases
-
Barnes, P. J., and M. Karin. 1997. Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336:1066-1071.
-
(1997)
N. Engl. J. Med.
, vol.336
, pp. 1066-1071
-
-
Barnes, P.J.1
Karin, M.2
-
3
-
-
0033776154
-
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
-
Burns, K., J. Clatworthy, L. Martin, F. Martinon, C. Plumpton, B. Maschera, A. Lewis, K. Ray, J. Tschopp, and F. Volpe. 2000. Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat. Cell Biol. 2:346-351.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 346-351
-
-
Burns, K.1
Clatworthy, J.2
Martin, L.3
Martinon, F.4
Plumpton, C.5
Maschera, B.6
Lewis, A.7
Ray, K.8
Tschopp, J.9
Volpe, F.10
-
4
-
-
0029865142
-
IRAK: A kinase associated with the interleukin-1 receptor
-
Cao, Z., W. J. Henzel, and X. Gao. 1996. IRAK: a kinase associated with the interleukin-1 receptor. Science 271:1128-1131.
-
(1996)
Science
, vol.271
, pp. 1128-1131
-
-
Cao, Z.1
Henzel, W.J.2
Gao, X.3
-
5
-
-
0029761275
-
TRAF6 is a signal transducer for interleukin-1
-
Cao, Z., J. Xiang, M. Takeuchi, T. Kurama, and D. V. Goeddel. 1996. TRAF6 is a signal transducer for interleukin-1. Nature 383:443-446.
-
(1996)
Nature
, vol.383
, pp. 443-446
-
-
Cao, Z.1
Xiang, J.2
Takeuchi, M.3
Kurama, T.4
Goeddel, D.V.5
-
6
-
-
0034644474
-
Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
-
Deng, L., C. Wang, E. Spencer, L. Yang, A. Braun, J. You, C. Slaughter, C. Pickart, and Z. J. Chen. 2000. Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103:351-361.
-
(2000)
Cell
, vol.103
, pp. 351-361
-
-
Deng, L.1
Wang, C.2
Spencer, E.3
Yang, L.4
Braun, A.5
You, J.6
Slaughter, C.7
Pickart, C.8
Chen, Z.J.9
-
7
-
-
0029979369
-
Biologic basis for interleukin-1 in disease
-
Dinarello, C. A. 1996. Biologic basis for interleukin-1 in disease. Blood 87:2095-2147.
-
(1996)
Blood
, vol.87
, pp. 2095-2147
-
-
Dinarello, C.A.1
-
8
-
-
0029009910
-
Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex
-
Greenfeder, S. A., P. Nunes, L. Kwee, M. Labow, R. A. Chizzonite, and G. Ju. 1995. Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex. J. Biol. Chem. 270:13757-13765.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 13757-13765
-
-
Greenfeder, S.A.1
Nunes, P.2
Kwee, L.3
Labow, M.4
Chizzonite, R.A.5
Ju, G.6
-
9
-
-
0030662372
-
Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein
-
Huang, J., X. Gao, S. Li, and Z. Cao. 1997. Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Proc. Natl. Acad. Sci. USA 94:12829-12832.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 12829-12832
-
-
Huang, J.1
Gao, X.2
Li, S.3
Cao, Z.4
-
10
-
-
0031013038
-
A critical role for interleukin-1 receptor accessory protein in interleukin-1 signaling
-
Korherr, C., R. Hofmeister, H. Wesche, and W. Falk. 1997. A critical role for interleukin-1 receptor accessory protein in interleukin-1 signaling. Eur. J. Immunol. 27:262-267.
-
(1997)
Eur. J. Immunol.
, vol.27
, pp. 262-267
-
-
Korherr, C.1
Hofmeister, R.2
Wesche, H.3
Falk, W.4
-
11
-
-
0037117543
-
IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase
-
Li, S., A. Strelow, E. J. Fontana, and H. Wesche. 2002. IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc. Natl. Acad. Sci. USA 99:5567-5572.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 5567-5572
-
-
Li, S.1
Strelow, A.2
Fontana, E.J.3
Wesche, H.4
-
12
-
-
0033002994
-
Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase
-
Li, X., M. Commane, C. Burns, K. Vithalani, Z. Cao, and G. R. Stark. 1999. Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase. Mol. Cell. Biol. 19:4643-4652.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 4643-4652
-
-
Li, X.1
Commane, M.2
Burns, C.3
Vithalani, K.4
Cao, Z.5
Stark, G.R.6
-
13
-
-
0035836638
-
IL-1-induced NF-κB and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptorassociated kinase (IRAK)
-
Li, X., M. Commane, Z. Jiang, and G. R. Stark. 2001. IL-1-induced NF-κB and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptorassociated kinase (IRAK). Proc. Natl. Acad. Sci. USA 98:4461-4465.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 4461-4465
-
-
Li, X.1
Commane, M.2
Jiang, Z.3
Stark, G.R.4
-
14
-
-
0033561039
-
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
-
Lomaga, M. A., W. C. Yeh, I. Sarosi, G. S. Duncan, C. Furlonger, A. Ho, S. Morony, C. Capparelli, G. Van, S. Kaufman, A. van der Heider, A. Itie, A. Wakeham, W. Khoo, T. Sasaki, Z. Cao, J. M. Penninger, C. J. Paige, D. L. Lacey, C. R. Dunstan, W. J. Boyle, D. V. Goeddel, and T. W. Mak. 1999. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 13:1015-1024.
-
(1999)
Genes Dev.
, vol.13
, pp. 1015-1024
-
-
Lomaga, M.A.1
Yeh, W.C.2
Sarosi, I.3
Duncan, G.S.4
Furlonger, C.5
Ho, A.6
Morony, S.7
Capparelli, C.8
Van, G.9
Kaufman, S.10
Van der Heider, A.11
Itie, A.12
Wakeham, A.13
Khoo, W.14
Sasaki, T.15
Cao, Z.16
Penninger, J.M.17
Paige, C.J.18
Lacey, D.L.19
Dunstan, C.R.20
Boyle, W.J.21
Goeddel, D.V.22
Mak, T.W.23
more..
-
15
-
-
0025290213
-
Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6
-
Lord, K. A., B. Hoffman-Liebermann, and D. A. Liebermann. 1990. Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6. Oncogene 5:1095-1097.
-
(1990)
Oncogene
, vol.5
, pp. 1095-1097
-
-
Lord, K.A.1
Hoffman-Liebermann, B.2
Liebermann, D.A.3
-
16
-
-
0035809310
-
Essential role of nuclear factor (NF)-κB-inducing kinase and inhibitor of κB (IκB) kinase alpha in NF-κB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I
-
Matsushima, A., T. Kaisho, P. D. Rennert, H. Nakano, K. Kurosawa, D. Uchida, K. Takeda, S. Akira, and M. Matsumoto. 2001. Essential role of nuclear factor (NF)-κB-inducing kinase and inhibitor of κB (IκB) kinase alpha in NF-κB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I. J. Exp. Med. 193:631-636.
-
(2001)
J. Exp. Med.
, vol.193
, pp. 631-636
-
-
Matsushima, A.1
Kaisho, T.2
Rennert, P.D.3
Nakano, H.4
Kurosawa, K.5
Uchida, D.6
Takeda, K.7
Akira, S.8
Matsumoto, M.9
-
17
-
-
0030685825
-
IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation
-
Mercurio, F., H. Zhu, B. W. Murray, A. Shevchenko, B. L. Bennett, J. Li, D. B. Young, M. Barbosa, M. Mann, A. Manning, and A. Rao. 1997. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 278:860-866.
-
(1997)
Science
, vol.278
, pp. 860-866
-
-
Mercurio, F.1
Zhu, H.2
Murray, B.W.3
Shevchenko, A.4
Bennett, B.L.5
Li, J.6
Young, D.B.7
Barbosa, M.8
Mann, M.9
Manning, A.10
Rao, A.11
-
18
-
-
0033580466
-
The kinase TAK1 can activate the NIK-I κB as well as the MAP kinase cascade in the IL-1 signalling pathway
-
Ninomiya-Tsuji, J., K. Kishimoto, A. Hiyama, J. Inoue, Z. Cao, and K. Matsumoto. 1999. The kinase TAK1 can activate the NIK-I κB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 398:252-256.
-
(1999)
Nature
, vol.398
, pp. 252-256
-
-
Ninomiya-Tsuji, J.1
Kishimoto, K.2
Hiyama, A.3
Inoue, J.4
Cao, Z.5
Matsumoto, K.6
-
19
-
-
0028930858
-
Towards an understanding of the signal transduction pathways for interleukin 1
-
O'Neill, L. A. 1995. Towards an understanding of the signal transduction pathways for interleukin 1. Biochim. Biophys. Acta 1266:31-44.
-
(1995)
Biochim. Biophys. Acta
, vol.1266
, pp. 31-44
-
-
O'Neill, L.A.1
-
20
-
-
0031049333
-
Molecular mechanisms underlying the actions of the pro-inflammatory cytokine interleukin 1
-
O'Neill, L. A. 1997. Molecular mechanisms underlying the actions of the pro-inflammatory cytokine interleukin 1. R. Irish Acad. Medal Lect. Biochem. Soc. Trans. 25:295-302.
-
(1997)
R. Irish Acad. Medal Lect. Biochem. Soc. Trans.
, vol.25
, pp. 295-302
-
-
O'Neill, L.A.1
-
21
-
-
0035834672
-
IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NF-κB
-
Qian, Y., M. Commane, J. Ninomiya-Tsuji, K. Matsumoto, and X. Li. 2001. IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NF-κB. J. Biol. Chem. 276:41661-41667.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 41661-41667
-
-
Qian, Y.1
Commane, M.2
Ninomiya-Tsuji, J.3
Matsumoto, K.4
Li, X.5
-
22
-
-
0031586174
-
Identification and characterization of an IκB kinase
-
Regnier, C. H., H. Y. Song, X. Gao, D. V. Goeddel, Z. Cao, and M. Rothe. 1997. Identification and characterization of an IκB kinase. Cell 90:373-383.
-
(1997)
Cell
, vol.90
, pp. 373-383
-
-
Regnier, C.H.1
Song, H.Y.2
Gao, X.3
Goeddel, D.V.4
Cao, Z.5
Rothe, M.6
-
23
-
-
0028168798
-
Three NF-κB binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression
-
Schindler, U., and V. R. Baichwal. 1994. Three NF-κB binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression. Mol. Cell. Biol. 14:5820-5831.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 5820-5831
-
-
Schindler, U.1
Baichwal, V.R.2
-
24
-
-
0037129212
-
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
-
Suzuki, N., S. Suzuki, G. S. Duncan, D. G. Millar, T. Wada, C. Mirtsos, H. Takada, A. Wakeham, A. Itie, S. Li, J. M. Penninger, H. Wesche, P. S. Ohashi, T. W. Mak, and W. C. Yeh. 2002. Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature 416:750-756.
-
(2002)
Nature
, vol.416
, pp. 750-756
-
-
Suzuki, N.1
Suzuki, S.2
Duncan, G.S.3
Millar, D.G.4
Wada, T.5
Mirtsos, C.6
Takada, H.7
Wakeham, A.8
Itie, A.9
Li, S.10
Penninger, J.M.11
Wesche, H.12
Ohashi, P.S.13
Mak, T.W.14
Yeh, W.C.15
-
25
-
-
0033634977
-
TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway
-
Takaesu, G., S. Kishida, A. Hiyama, K. Yamaguchi, H. Shibuya, K. Irie, J. Ninomiya-Tsuji, and K. Matsumoto. 2000. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol. Cell 5:649-658.
-
(2000)
Mol. Cell
, vol.5
, pp. 649-658
-
-
Takaesu, G.1
Kishida, S.2
Hiyama, A.3
Yamaguchi, K.4
Shibuya, H.5
Irie, K.6
Ninomiya-Tsuji, J.7
Matsumoto, K.8
-
26
-
-
0035099717
-
Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway
-
Takaesu, G., J. Ninomiya-Tsuji, S. Kishida, X. Li, G. R. Stark, and K. Matsumoto. 2001. Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway. Mol. Cell. Biol. 21:2475-2484.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 2475-2484
-
-
Takaesu, G.1
Ninomiya-Tsuji, J.2
Kishida, S.3
Li, X.4
Stark, G.R.5
Matsumoto, K.6
-
27
-
-
0035913278
-
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
-
Wang, C., L. Deng, M. Hong, G. R. Akkaraju, J. Inoue, and Z. J. Chen. 2001. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412:346-351.
-
(2001)
Nature
, vol.412
, pp. 346-351
-
-
Wang, C.1
Deng, L.2
Hong, M.3
Akkaraju, G.R.4
Inoue, J.5
Chen, Z.J.6
-
28
-
-
0031423761
-
MyD88: An adapter that recruits IRAK to the IL-1 receptor complex
-
Wesche, H., W. J. Henzel, W. Shillinglaw, S. Li, and Z. Cao. 1997. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7:837-847.
-
(1997)
Immunity
, vol.7
, pp. 837-847
-
-
Wesche, H.1
Henzel, W.J.2
Shillinglaw, W.3
Li, S.4
Cao, Z.5
-
29
-
-
0030611595
-
IκB kinase-beta: NF-κB activation and complex formation with IκB kinase-α and NIK
-
Woronicz, J. D., X. Gao, Z. Cao, M. Rothe, and D. V. Goeddel. 1997. IκB kinase-beta: NF-κB activation and complex formation with IκB kinase-α and NIK. Science 278:866-869.
-
(1997)
Science
, vol.278
, pp. 866-869
-
-
Woronicz, J.D.1
Gao, X.2
Cao, Z.3
Rothe, M.4
Goeddel, D.V.5
-
30
-
-
0034745420
-
NF-κB-inducing kinase regulates the processing of NF-κB2 p100
-
Xiao, G., E. W. Harhaj, and S. C. Sun. 2001. NF-κB-inducing kinase regulates the processing of NF-κB2 p100. Mol. Cell 7:401-409.
-
(2001)
Mol. Cell
, vol.7
, pp. 401-409
-
-
Xiao, G.1
Harhaj, E.W.2
Sun, S.C.3
-
31
-
-
0030868909
-
The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation
-
Yamin, T. T., and D. K. Miller. 1997. The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation. J. Biol. Chem. 272:21540-21547.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 21540-21547
-
-
Yamin, T.T.1
Miller, D.K.2
-
32
-
-
0034922161
-
The essential role of MEKK3 in TNF-induced NF-κB activation
-
Yang, J., Y. Lin, Z. Guo, J. Cheng, J. Huang, L. Deng, W. Liao, Z. Chen, Z. Liu, and B. Su. 2001. The essential role of MEKK3 in TNF-induced NF-κB activation. Nat. Immunol. 2:620-624.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 620-624
-
-
Yang, J.1
Lin, Y.2
Guo, Z.3
Cheng, J.4
Huang, J.5
Deng, L.6
Liao, W.7
Chen, Z.8
Liu, Z.9
Su, B.10
-
33
-
-
0035896422
-
Defective lymphotoxin-β receptor-induced NF-κB transcriptional activity in NIK-deficient mice
-
Yin, L., L. Wu, H. Wesche, C. D. Arthur, J. M. White, D. V. Goeddel, and R. D. Schreiber. 2001. Defective lymphotoxin-β receptor-induced NF-κB transcriptional activity in NIK-deficient mice. Science 291:2162-2165.
-
(2001)
Science
, vol.291
, pp. 2162-2165
-
-
Yin, L.1
Wu, L.2
Wesche, H.3
Arthur, C.D.4
White, J.M.5
Goeddel, D.V.6
Schreiber, R.D.7
-
34
-
-
0034691062
-
MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-κB activation
-
Yujiri, T., M. Ware, C. Widmann, R. Oyer, D. Russell, E. Chan, Y. Zaitsu, P. Clarke, K. Tyler, Y. Oka, G. R. Fanger, P. Henson, and G. L. Johnson. 2000. MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-κB activation. Proc. Natl. Acad. Sci. USA 97:7272-7277.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 7272-7277
-
-
Yujiri, T.1
Ware, M.2
Widmann, C.3
Oyer, R.4
Russell, D.5
Chan, E.6
Zaitsu, Y.7
Clarke, P.8
Tyler, K.9
Oka, Y.10
Fanger, G.R.11
Henson, P.12
Johnson, G.L.13
-
35
-
-
0030613551
-
The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation
-
Zandi, E., D. M. Rothwarf, M. Delhase, M. Hayakawa, and M. Karin. 1997. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell 91: 243-252.
-
(1997)
Cell
, vol.91
, pp. 243-252
-
-
Zandi, E.1
Rothwarf, D.M.2
Delhase, M.3
Hayakawa, M.4
Karin, M.5
|