TAK1 Negatively Regulates NF-κB and p38 MAP Kinase Activation in Gr-1 +CD11b + Neutrophils

Immunity

Volumn 36, Issue 1, 2012, Pages 43-54

  Alagbala Ajibade, Adebusola ^a,c   Wang, Qinfu ^a   Cui, Jun ^a,c   Zou, Jia ^a,c   Xia, Xiaojun ^a   Wang, Mingjun ^a,c   Tong, Yanzheng ^a,c   Hui, Wei ^a   Liu, Dou ^d   Su, Bing ^d   Wang, Helen Y ^a,b,c   Wang, Rong Fu ^a,b,c  

^a CENTER FOR CELL AND GENE THERAPY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; I KAPPA B KINASE; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; HOMEOSTASIS; IMMUNE RESPONSE; MOUSE; NEUTROPHIL; NONHUMAN; PHENOTYPE; PLASMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SEPTIC SHOCK; SIGNAL TRANSDUCTION; ERRATUM; ERROR;

ANIMALS; ANTIGENS, CD11B; APOPTOSIS; CELL PROLIFERATION; DOWN-REGULATION; GENE DELETION; MACROPHAGES; MAP KINASE KINASE KINASES; MICE; MICE, KNOCKOUT; MODELS, IMMUNOLOGICAL; NEUTROPHILS; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENOTYPE; RECEPTORS, CHEMOKINE; SIGNAL TRANSDUCTION;

EID: 84856301921     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2011.12.010     Document Type: Article

References (48)

1. Adhikari A., Xu M., Chen Z.J. Ubiquitin-mediated activation of TAK1 and IKK. Oncogene 2007, 26:3214-3226.
2. Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006, 124:783-801.
3. Allen I.C., Moore C.B., Schneider M., Lei Y., Davis B.K., Scull M.A., Gris D., Roney K.E., Zimmermann A.G., Bowzard J.B., et al. NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways. Immunity 2011, 34:854-865.
4. Asehnoune K., Strassheim D., Mitra S., Kim J.Y., Abraham E. Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. J.Immunol. 2004, 172:2522-2529.
5. Bettermann K., Vucur M., Haybaeck J., Koppe C., Janssen J., Heymann F., Weber A., Weiskirchen R., Liedtke C., Gassler N., et al. TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer. Cancer Cell 2010, 17:481-496.
6. Bhoj V.G., Chen Z.J. Ubiquitylation in innate and adaptive immunity. Nature 2009, 458:430-437.
7. Cohen M.M. The new bone biology: pathologic, molecular, and clinical correlates. Am. J. Med. Genet. A. 2006, 140:2646-2706.
8. Cui J., Zhu L., Xia X., Wang H.Y., Legras X., Hong J., Ji J., Shen P., Zheng S., Chen Z.J., Wang R.F. NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell 2010, 141:483-496.
9. Engel F.B., Schebesta M., Duong M.T., Lu G., Ren S., Madwed J.B., Jiang H., Wang Y., Keating M.T. p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes Dev. 2005, 19:1175-1187.
10. Ge B., Gram H., Di Padova F., Huang B., New L., Ulevitch R.J., Luo Y., Han J. MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science 2002, 295:1291-1294.
11. Geissmann F., Manz M.G., Jung S., Sieweke M.H., Merad M., Ley K. Development of monocytes, macrophages, and dendritic cells. Science 2010, 327:656-661.
12. Greten F.R., Arkan M.C., Bollrath J., Hsu L.C., Goode J., Miething C., Göktuna S.I., Neuenhahn M., Fierer J., Paxian S., et al. NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell 2007, 130:918-931.
13. Han J., Ulevitch R.J. Limiting inflammatory responses during activation of innate immunity. Nat. Immunol. 2005, 6:1198-1205.
14. Hayden M.S., Ghosh S. Shared principles in NF-kappaB signaling. Cell 2008, 132:344-362.
15. Honda K., Taniguchi T. IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat. Rev. Immunol. 2006, 6:644-658.
16. Huang Q., Yang J., Lin Y., Walker C., Cheng J., Liu Z.G., Su B. Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3. Nat. Immunol. 2004, 5:98-103.
17. Inokuchi S., Aoyama T., Miura K., Osterreicher C.H., Kodama Y., Miyai K., Akira S., Brenner D.A., Seki E. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc. Natl. Acad. Sci. USA 2010, 107:844-849.
18. Ito K., Hirao A., Arai F., Takubo K., Matsuoka S., Miyamoto K., Ohmura M., Naka K., Hosokawa K., Ikeda Y., Suda T. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat. Med. 2006, 12:446-451.
19. Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., Cua D.J., Littman D.R. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006, 126:1121-1133.
20. Janeway C.A., Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002, 20:197-216.
21. Kajino-Sakamoto R., Inagaki M., Lippert E., Akira S., Robine S., Matsumoto K., Jobin C., Ninomiya-Tsuji J. Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J.Immunol. 2008, 181:1143-1152.
22. Kang Y.J., Seit-Nebi A., Davis R.J., Han J. Multiple activation mechanisms of p38alpha mitogen-activated protein kinase. J.Biol. Chem. 2006, 281:26225-26234.
23. Kang Y.J., Chen J., Otsuka M., Mols J., Ren S., Wang Y., Han J. Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation. J.Immunol. 2008, 180:5075-5082.
24. Kantari C., Pederzoli-Ribeil M., Witko-Sarsat V. The role of neutrophils and monocytes in innate immunity. Contrib. Microbiol. 2008, 15:118-146.
25. Kato H., Sato S., Yoneyama M., Yamamoto M., Uematsu S., Matsui K., Tsujimura T., Takeda K., Fujita T., Takeuchi O., Akira S. Cell type-specific involvement of RIG-I in antiviral response. Immunity 2005, 23:19-28.
26. Kato H., Takeuchi O., Sato S., Yoneyama M., Yamamoto M., Matsui K., Uematsu S., Jung A., Kawai T., Ishii K.J., et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006, 441:101-105.
27. Kawai T., Akira S. Signaling to NF-kappaB by Toll-like receptors. Trends Mol. Med. 2007, 13:460-469.
28. Kulisz A., Chen N., Chandel N.S., Shao Z., Schumacker P.T. Mitochondrial ROS initiate phosphorylation of p38 MAP kinase during hypoxia in cardiomyocytes. Am. J. Physiol. Lung Cell. Mol. Physiol. 2002, 282:L1324-L1329.
29. Lam C.R., Tan M.J., Tan S.H., Tang M.B., Cheung P.C., Tan N.S. TAK1 regulates SCF expression to modulate PKBα activity that protects keratinocytes from ROS-induced apoptosis. Cell Death Differ. 2011, 18:1120-1129.
30. Liu H.H., Xie M., Schneider M.D., Chen Z.J. Essential role of TAK1 in thymocyte development and activation. Proc. Natl. Acad. Sci. USA 2006, 103:11677-11682.
31. Marigo I., Dolcetti L., Serafini P., Zanovello P., Bronte V. Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells. Immunol. Rev. 2008, 222:162-179.
32. Matsushita K., Takeuchi O., Standley D.M., Kumagai Y., Kawagoe T., Miyake T., Satoh T., Kato H., Tsujimura T., Nakamura H., Akira S. Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature 2009, 458:1185-1190.
33. Matsuzawa A., Saegusa K., Noguchi T., Sadamitsu C., Nishitoh H., Nagai S., Koyasu S., Matsumoto K., Takeda K., Ichijo H. ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nat. Immunol. 2005, 6:587-592.
34. Miyahara Y., Odunsi K., Chen W., Peng G., Matsuzaki J., Wang R.F. Generation and regulation of human CD4+ IL-17-producing Tcells in ovarian cancer. Proc. Natl. Acad. Sci. USA 2008, 105:15505-15510.
35. Ninomiya-Tsuji J., Kishimoto K., Hiyama A., Inoue J., Cao Z., Matsumoto K. The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 1999, 398:252-256.
36. Omori E., Matsumoto K., Sanjo H., Sato S., Akira S., Smart R.C., Ninomiya-Tsuji J. TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis. J.Biol. Chem. 2006, 281:19610-19617.
37. Sato S., Sanjo H., Takeda K., Ninomiya-Tsuji J., Yamamoto M., Kawai T., Matsumoto K., Takeuchi O., Akira S. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat. Immunol. 2005, 6:1087-1095.
38. Sato S., Sanjo H., Tsujimura T., Ninomiya-Tsuji J., Yamamoto M., Kawai T., Takeuchi O., Akira S. TAK1 is indispensable for development of Tcells and prevention of colitis by the generation of regulatory Tcells. Int. Immunol. 2006, 18:1405-1411.
39. Schroder K., Tschopp J. The inflammasomes. Cell 2010, 140:821-832.
40. Schuman J., Chen Y., Podd A., Yu M., Liu H.H., Wen R., Chen Z.J., Wang D. A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation. Blood 2009, 113:4566-4574.
41. Shim J.H., Xiao C., Paschal A.E., Bailey S.T., Rao P., Hayden M.S., Lee K.Y., Bussey C., Steckel M., Tanaka N., et al. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways invivo. Genes Dev. 2005, 19:2668-2681.
42. Su B. Linking stress to immunity?. Nat. Immunol. 2005, 6:541-542.
43. Tang M., Wei X., Guo Y., Breslin P., Zhang S., Zhang S., Wei W., Xia Z., Diaz M., Akira S., Zhang J. TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice. J.Exp. Med. 2008, 205:1611-1619.
44. Wan Y.Y., Chi H., Xie M., Schneider M.D., Flavell R.A. The kinase TAK1 integrates antigen and cytokine receptor signaling for Tcell development, survival and function. Nat. Immunol. 2006, 7:851-858.
45. Wang C., Deng L., Hong M., Akkaraju G.R., Inoue J., Chen Z.J. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 2001, 412:346-351.
46. Wang H.Y., Lee D.A., Peng G., Guo Z., Li Y., Kiniwa Y., Shevach E.M., Wang R.F. Tumor-specific human CD4+ regulatory Tcells and their ligands: implications for immunotherapy. Immunity 2004, 20:107-118.
47. Wertz I.E., O'Rourke K.M., Zhou H., Eby M., Aravind L., Seshagiri S., Wu P., Wiesmann C., Baker R., Boone D.L., et al. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 2004, 430:694-699.
48. Xia X., Cui J., Wang H.Y., Zhu L., Matsueda S., Wang Q., Yang X., Hong J., Songyang Z., Chen Z.J., Wang R.F. NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK. Immunity 2011, 34:843-853.