Sequential Autophosphorylation Steps in the Interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling

Journal of Biological Chemistry

Volumn 279, Issue 7, 2004, Pages 5227-5236

  Kollewe, Christian ^a,c   Mackensen, Anne Christin ^a   Neumann, Detlef ^a   Knop, Johannes ^a,d   Cao, Ping ^b   Li, Shyun ^b   Wesche, Holger ^b   Martin, Michael U ^a,c  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b AMGEN INC   (United States)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

^d Tularik GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CONFORMATIONS; ENERGY TRANSFER; SIGNALING;

SEQUENTIAL AUTOPHOSPHORYLATION;

ENZYMES;

ADAPTOR PROTEIN; ALANINE; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; MYELOID DIFFERENTIATION FACTOR 88; PROLINE; PROTEIN KINASE; SERINE; THREONINE; TOLLIP PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; AUTOPHOSPHORYLATION; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DISSOCIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANTIGENS, DIFFERENTIATION; CARRIER PROTEINS; CELL LINE; CLONING, MOLECULAR; DIMERIZATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC VECTORS; HUMANS; IMMUNOBLOTTING; INTERLEUKIN-1; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MASS SPECTROMETRY; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN CONFORMATION; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, IMMUNOLOGIC; RECEPTORS, INTERLEUKIN-1; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THREONINE; TIME FACTORS; TRANSFECTION;

EID: 1242272100     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M309251200     Document Type: Article

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