메뉴 건너뛰기




Volumn 11, Issue 6, 2013, Pages 621-640

Potassium channels in peripheral pain pathways: Expression, function and therapeutic potential

Author keywords

Dorsal root ganglion; KATP channel; K+ channel; M channel; Nociception; Pain; Two pore K+ channel

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ACRYLAMIDE; ADAMANTANE DERIVATIVE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ANALGESIC AGENT; ANTHRANILIC ACID DERIVATIVE; AUTOANTIBODY; BENZIMIDAZOLE; CALCITONIN GENE RELATED PEPTIDE; CALCIUM ACTIVATED POTASSIUM CHANNEL; DENDROTOXIN; DIAZOXIDE; FAMPRIDINE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.1; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; POTASSIUM CHANNEL; POTASSIUM CHANNEL KCNQ5; POTASSIUM CHANNEL KV1.1; POTASSIUM CHANNEL KV1.2; PYRAZOLO[1,5 A]PYRIMIDINE DERIVATIVE; PYRIDINE DERIVATIVE; SHAB POTASSIUM CHANNEL; SHAKER POTASSIUM CHANNEL; SHAL POTASSIUM CHANNEL; SHAW POTASSIUM CHANNEL; TETRYLAMMONIUM; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; UNINDEXED DRUG; VANILLOID RECEPTOR 1;

EID: 84913549379     PISSN: 1570159X     EISSN: 18756190     Source Type: Journal    
DOI: 10.2174/1570159X113119990042     Document Type: Article
Times cited : (99)

References (220)
  • 2
    • 77955239085 scopus 로고    scopus 로고
    • Ion channels as novel therapeutic targets in the treatment of pain
    • Mathie, A. Ion channels as novel therapeutic targets in the treatment of pain. J. Pharm. Pharmacol., 2010, 62, 1089-1095.
    • (2010) J. Pharm. Pharmacol. , vol.62 , pp. 1089-1095
    • Mathie, A.1
  • 6
    • 33745428781 scopus 로고    scopus 로고
    • The NK1-receptor antagonist TKA731 in painful diabetic neuropathy: A randomised, controlled trial
    • Sindrup, S.H.; Graf, A.; Sfikas, N. The NK1-receptor antagonist TKA731 in painful diabetic neuropathy: a randomised, controlled trial. Eur. J. Pain, 2006, 10, 567-571.
    • (2006) Eur. J. Pain , vol.10 , pp. 567-571
    • Sindrup, S.H.1    Graf, A.2    Sfikas, N.3
  • 7
    • 23044442325 scopus 로고    scopus 로고
    • Distinct membrane effects of spinal nerve ligation on injured and adjacent dorsal root ganglion neurons in rats
    • Sapunar, D.; Ljubkovic, M.; Lirk, P.; McCallum, J.B.; Hogan, Q.H. Distinct membrane effects of spinal nerve ligation on injured and adjacent dorsal root ganglion neurons in rats. Anesthesiology, 2005, 103, 360-376.
    • (2005) Anesthesiology , vol.103 , pp. 360-376
    • Sapunar, D.1    Ljubkovic, M.2    Lirk, P.3    McCallum, J.B.4    Hogan, Q.H.5
  • 8
    • 84856920657 scopus 로고    scopus 로고
    • M channel enhancers and physiological M channel block
    • Linley, J.E.; Pettinger, L.; Huang, D.; Gamper, N. M channel enhancers and physiological M channel block. J. Physiol., 2012, 590, 793-807.
    • (2012) J. Physiol. , vol.590 , pp. 793-807
    • Linley, J.E.1    Pettinger, L.2    Huang, D.3    Gamper, N.4
  • 11
    • 51049108643 scopus 로고    scopus 로고
    • - cotransport and intracellular chloride regulation in rat primary sensory neurons: Thermodynamic and kinetic aspects
    • - cotransport and intracellular chloride regulation in rat primary sensory neurons: thermodynamic and kinetic aspects. J. Neurophysiol., 2008, 100, 169-184.
    • (2008) J. Neurophysiol. , vol.100 , pp. 169-184
    • Rocha-Gonzalez, H.I.1    Mao, S.2    Alvarez-Leefmans, F.J.3
  • 13
    • 36148971268 scopus 로고    scopus 로고
    • Differential maturation of chloride homeostasis in primary afferent neurons of the somatosensory system
    • Gilbert, D.; Franjic-Wurtz, C.; Funk, K.; Gensch, T.; Frings, S.; Mohrlen, F. Differential maturation of chloride homeostasis in primary afferent neurons of the somatosensory system. Int. J. Dev. Neurosci., 2007, 25, 479-489.
    • (2007) Int. J. Dev. Neurosci. , vol.25 , pp. 479-489
    • Gilbert, D.1    Franjic-Wurtz, C.2    Funk, K.3    Gensch, T.4    Frings, S.5    Mohrlen, F.6
  • 14
    • 51049094672 scopus 로고    scopus 로고
    • Modulation of chloride homeostasis by inflammatory mediators in dorsal root ganglion neurons
    • Funk, K.; Woitecki, A.; Franjic-Wurtz, C.; Gensch, T.; Mohrlen, F.; Frings, S. Modulation of chloride homeostasis by inflammatory mediators in dorsal root ganglion neurons. Mol. Pain., 2008, 4, 32.
    • (2008) Mol. Pain. , vol.4 , pp. 32
    • Funk, K.1    Woitecki, A.2    Franjic-Wurtz, C.3    Gensch, T.4    Mohrlen, F.5    Frings, S.6
  • 16
    • 77950921542 scopus 로고    scopus 로고
    • Understanding inflammatory pain: Ion channels contributing to acute and chronic nociception
    • Linley, J.E.; Rose, K.; Ooi, L.; Gamper, N. Understanding inflammatory pain: ion channels contributing to acute and chronic nociception. Pflugers Arch., 2010, 459, 657-669.
    • (2010) Pflugers Arch , vol.459 , pp. 657-669
    • Linley, J.E.1    Rose, K.2    Ooi, L.3    Gamper, N.4
  • 17
  • 18
    • 0020572727 scopus 로고
    • Potassium channels moderate ectopic excitability of nerve-end neuromas in rats
    • Devor, M. Potassium channels moderate ectopic excitability of nerve-end neuromas in rats. Neurosci. Lett., 1983, 40, 181-186.
    • (1983) Neurosci. Lett. , vol.40 , pp. 181-186
    • Devor, M.1
  • 19
    • 0022002166 scopus 로고
    • Effects of potassium channel-blocking agents on spontaneous discharges from neuromas in rats
    • Burchiel, K.J.; Russell, L.C. Effects of potassium channel-blocking agents on spontaneous discharges from neuromas in rats. J. Neurosurg., 1985, 63, 246-249.
    • (1985) J. Neurosurg. , vol.63 , pp. 246-249
    • Burchiel, K.J.1    Russell, L.C.2
  • 20
    • 84867509174 scopus 로고    scopus 로고
    • Chronic pain as a manifestation of potassium channel-complex autoimmunity
    • Klein, C.J.; Lennon, V.A.; Aston, P.A.; McKeon, A.; Pittock, S.J. Chronic pain as a manifestation of potassium channel-complex autoimmunity. Neurology, 2012, 79, 1136-1144.
    • (2012) Neurology , vol.79 , pp. 1136-1144
    • Klein, C.J.1    Lennon, V.A.2    Aston, P.A.3    McKeon, A.4    Pittock, S.J.5
  • 22
    • 0019787440 scopus 로고
    • Ionic currents in the somatic membrane of rat dorsal root ganglion neurons-III. Potassium currents
    • Kostyuk, P.G.; Veselovsky, N.S.; Fedulova, S.A.; Tsyndrenko, A.Y. Ionic currents in the somatic membrane of rat dorsal root ganglion neurons-III. Potassium currents. Neuroscience, 1981, 6, 2439-2444.
    • (1981) Neuroscience , vol.6 , pp. 2439-2444
    • Kostyuk, P.G.1    Veselovsky, N.S.2    Fedulova, S.A.3    Tsyndrenko, A.Y.4
  • 23
    • 0023552463 scopus 로고
    • Mast cell degranulating peptide and dendrotoxin selectively inhibit a fast-activating potassium current and bind to common neuronal proteins
    • Stansfeld, C.E.; Marsh, S.J.; Parcej, D.N.; Dolly, J.O.; Brown, D.A. Mast cell degranulating peptide and dendrotoxin selectively inhibit a fast-activating potassium current and bind to common neuronal proteins. Neuroscience, 1987, 23, 893-902.
    • (1987) Neuroscience , vol.23 , pp. 893-902
    • Stansfeld, C.E.1    Marsh, S.J.2    Parcej, D.N.3    Dolly, J.O.4    Brown, D.A.5
  • 24
    • 0025951655 scopus 로고
    • Kinetics and voltage dependence of A-type currents on neonatal rat sensory neurons
    • McFarlane, S.; Cooper, E. Kinetics and voltage dependence of A-type currents on neonatal rat sensory neurons. J. Neurophysiol., 1991, 66, 1380-1391.
    • (1991) J. Neurophysiol. , vol.66 , pp. 1380-1391
    • McFarlane, S.1    Cooper, E.2
  • 28
    • 1642564113 scopus 로고    scopus 로고
    • Altered expression of potassium channel subunit mRNA and alpha-dendrotoxin sensitivity of potassium currents in rat dorsal root ganglion neurons after axotomy
    • Yang, E.K.; Takimoto, K.; Hayashi, Y.; de Groat, W.C.; Yoshimura, N. Altered expression of potassium channel subunit mRNA and alpha-dendrotoxin sensitivity of potassium currents in rat dorsal root ganglion neurons after axotomy. Neuroscience, 2004, 123, 867-874.
    • (2004) Neuroscience , vol.123 , pp. 867-874
    • Yang, E.K.1    Takimoto, K.2    Hayashi, Y.3    De Groat, W.C.4    Yoshimura, N.5
  • 29
    • 0027501342 scopus 로고
    • Characterization of potassium currents in adult rat sensory neurons and modulation by opioids and cyclic AMP
    • Akins, P.T.; McCleskey, E.W. Characterization of potassium currents in adult rat sensory neurons and modulation by opioids and cyclic AMP. Neuroscience, 1993, 56, 759-769.
    • (1993) Neuroscience , vol.56 , pp. 759-769
    • Akins, P.T.1    McCleskey, E.W.2
  • 30
    • 0031945498 scopus 로고    scopus 로고
    • Morphologically identified cutaneous afferent DRG neurons express three different potassium currents in varying proportions
    • Everill, B.; Rizzo, M.A.; Kocsis, J.D. Morphologically identified cutaneous afferent DRG neurons express three different potassium currents in varying proportions. J. Neurophysiol., 1998, 79, 1814-1824.
    • (1998) J. Neurophysiol. , vol.79 , pp. 1814-1824
    • Everill, B.1    Rizzo, M.A.2    Kocsis, J.D.3
  • 32
    • 0037200772 scopus 로고    scopus 로고
    • Downregulation of voltage-gated potassium channel alpha gene expression in dorsal root ganglia following chronic constriction injury of the rat sciatic nerve
    • Kim, D.S.; Choi, J.O.; Rim, H.D.; Cho, H.J. Downregulation of voltage-gated potassium channel alpha gene expression in dorsal root ganglia following chronic constriction injury of the rat sciatic nerve. Brain Res. Mol. Brain Res., 2002, 105, 146-152.
    • (2002) Brain Res. Mol. Brain Res. , vol.105 , pp. 146-152
    • Kim, D.S.1    Choi, J.O.2    Rim, H.D.3    Cho, H.J.4
  • 33
    • 19344369407 scopus 로고    scopus 로고
    • + currents influence firing properties of isolectin B4-positive but not isolectin B4-negative primary sensory neurons
    • + currents influence firing properties of isolectin B4-positive but not isolectin B4-negative primary sensory neurons. J. Neurophysiol., 2005, 93, 3401-3409.
    • (2005) J. Neurophysiol. , vol.93 , pp. 3401-3409
    • Vydyanathan, A.1    Wu, Z.Z.2    Chen, S.R.3    Pan, H.L.4
  • 36
    • 84870233117 scopus 로고    scopus 로고
    • Sensory Neuron Downregulation of the Kv9.1 Potassium Channel Subunit Mediates Neuropathic Pain following Nerve Injury
    • Tsantoulas, C.; Zhu, L.; Shaifta, Y.; Grist, J.; Ward, J.P.; Raouf, R.; Michael, G.J.; McMahon, S.B. Sensory Neuron Downregulation of the Kv9.1 Potassium Channel Subunit Mediates Neuropathic Pain following Nerve Injury. J. Neurosci., 2012, 32, 17502-17513.
    • (2012) J. Neurosci. , vol.32 , pp. 17502-17513
    • Tsantoulas, C.1    Zhu, L.2    Shaifta, Y.3    Grist, J.4    Ward, J.P.5    Raouf, R.6    Michael, G.J.7    McMahon, S.B.8
  • 37
    • 77956269591 scopus 로고    scopus 로고
    • Going native: Voltage-gated potassium channels controlling neuronal excitability
    • Johnston, J.; Forsythe, I.D.; Kopp-Scheinpflug, C. Going native: voltage-gated potassium channels controlling neuronal excitability. J. Physiol., 2010, 588, 3187-3200.
    • (2010) J. Physiol. , vol.588 , pp. 3187-3200
    • Johnston, J.1    Forsythe, I.D.2    Kopp-Scheinpflug, C.3
  • 38
    • 34548641073 scopus 로고    scopus 로고
    • Reduced expression of A-type potassium channels in primary sensory neurons induces mechanical hypersensitivity
    • Chien, L.Y.; Cheng, J.K.; Chu, D.; Cheng, C.F.; Tsaur, M.L. Reduced expression of A-type potassium channels in primary sensory neurons induces mechanical hypersensitivity. J. Neurosci., 2007, 27, 9855-9865.
    • (2007) J. Neurosci. , vol.27 , pp. 9855-9865
    • Chien, L.Y.1    Cheng, J.K.2    Chu, D.3    Cheng, C.F.4    Tsaur, M.L.5
  • 39
    • 79959398966 scopus 로고    scopus 로고
    • Kv4 Channels Underlie the Subthreshold-Operating A-type K-current in Nociceptive Dorsal Root Ganglion Neurons
    • Phuket, T.R.; Covarrubias, M. Kv4 Channels Underlie the Subthreshold-Operating A-type K-current in Nociceptive Dorsal Root Ganglion Neurons. Front. Mol. Neurosci., 2009, 2, 3.
    • (2009) Front. Mol. Neurosci. , vol.2 , pp. 3
    • Phuket, T.R.1    Covarrubias, M.2
  • 40
    • 84865586604 scopus 로고    scopus 로고
    • Distinct cellular distributions of Kv4 pore-forming and auxiliary subunits in rat dorsal root ganglion neurons
    • Matsuyoshi, H.; Takimoto, K.; Yunoki, T.; Erickson, V.L.; Tyagi, P.; Hirao, Y.; Wanaka, A.; Yoshimura, N. Distinct cellular distributions of Kv4 pore-forming and auxiliary subunits in rat dorsal root ganglion neurons. Life Sci., 2012, 91, 258-263.
    • (2012) Life Sci , vol.91 , pp. 258-263
    • Matsuyoshi, H.1    Takimoto, K.2    Yunoki, T.3    Erickson, V.L.4    Tyagi, P.5    Hirao, Y.6    Wanaka, A.7    Yoshimura, N.8
  • 41
    • 79959660840 scopus 로고    scopus 로고
    • KCNQ5 channels control resting properties and release probability of a synapse
    • Huang, H.; Trussell, L.O. KCNQ5 channels control resting properties and release probability of a synapse. Nat. Neurosci., 2011, 14, 840-847.
    • (2011) Nat. Neurosci. , vol.14 , pp. 840-847
    • Huang, H.1    Trussell, L.O.2
  • 42
    • 27644518764 scopus 로고    scopus 로고
    • Pathways modulating neural KCNQ/M (Kv7) potassium channels
    • Delmas, P.; Brown, D.A. Pathways modulating neural KCNQ/M (Kv7) potassium channels. Nat. Rev. Neurosci., 2005, 6, 850-862.
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 850-862
    • Delmas, P.1    Brown, D.A.2
  • 43
    • 77950960751 scopus 로고    scopus 로고
    • Regulation of Neuronal Ion Channels by G-Protein-Coupled Receptors in Sympathetic Neurons
    • Gribkoff, V.K., Kaczmarek, L.K., Hoboken, New Jersey, Wiley
    • Shapiro, M.S., Gamper, N. Regulation of Neuronal Ion Channels by G-Protein-Coupled Receptors in Sympathetic Neurons. In: Gribkoff, V.K., Kaczmarek, L.K. Ed, Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels. Hoboken, New Jersey, Wiley. 2009, 291-316.
    • (2009) Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels , pp. 291-316
    • Shapiro, M.S.1    Gamper, N.2
  • 45
    • 79953064829 scopus 로고    scopus 로고
    • Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury
    • Rose, K.; Ooi, L.; Dalle, C.; Robertson, B.; Wood, I.C.; Gamper, N. Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury. Pain, 2011, 152, 742-754.
    • (2011) Pain , vol.152 , pp. 742-754
    • Rose, K.1    Ooi, L.2    Dalle, C.3    Robertson, B.4    Wood, I.C.5    Gamper, N.6
  • 46
    • 84859486595 scopus 로고    scopus 로고
    • Kv7.5 is the primary Kv7 subunit expressed in C-fibers
    • King, C.H.; Scherer, S.S. Kv7.5 is the primary Kv7 subunit expressed in C-fibers. J. Comp. Neurol., 2012, 520, 1940-1950.
    • (2012) J. Comp. Neurol. , vol.520 , pp. 1940-1950
    • King, C.H.1    Scherer, S.S.2
  • 47
    • 84874520584 scopus 로고    scopus 로고
    • Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model
    • Zheng, Q.; Fang, D.; Liu, M.; Cai, J.; Wan, Y.; Han, J.S.; Xing, G.G. Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model. Pain, 2013, 154, 434-448.
    • (2013) Pain , vol.154 , pp. 434-448
    • Zheng, Q.1    Fang, D.2    Liu, M.3    Cai, J.4    Wan, Y.5    Han, J.S.6    Xing, G.G.7
  • 50
    • 80051580059 scopus 로고    scopus 로고
    • Accumulation of Kv7.2 channels in putative ectopic transduction zones of mice nerve-end neuromas
    • Roza, C.; Castillejo, S.; Lopez-Garcia, J.A. Accumulation of Kv7.2 channels in putative ectopic transduction zones of mice nerve-end neuromas. Mol. Pain, 2011, 7, 58.
    • (2011) Mol. Pain , vol.7 , pp. 58
    • Roza, C.1    Castillejo, S.2    Lopez-Garcia, J.A.3
  • 51
    • 33748175036 scopus 로고    scopus 로고
    • Retigabine-induced population primary afferent hyperpolarisation in vitro
    • Rivera-Arconada, I.; Lopez-Garcia, J.A. Retigabine-induced population primary afferent hyperpolarisation in vitro. Neuropharmacology, 2006, 51, 756-763.
    • (2006) Neuropharmacology , vol.51 , pp. 756-763
    • Rivera-Arconada, I.1    Lopez-Garcia, J.A.2
  • 52
    • 56149103900 scopus 로고    scopus 로고
    • Inhibition of M current in sensory neurons by exogenous proteases: A signaling pathway mediating inflammatory nociception
    • Linley, J.E.; Rose, K.; Patil, M.; Robertson, B.; Akopian, A.N.; Gamper, N. Inhibition of M current in sensory neurons by exogenous proteases: a signaling pathway mediating inflammatory nociception. J. Neurosci., 2008, 28, 11240-11249.
    • (2008) J. Neurosci. , vol.28 , pp. 11240-11249
    • Linley, J.E.1    Rose, K.2    Patil, M.3    Robertson, B.4    Akopian, A.N.5    Gamper, N.6
  • 53
    • 0037462422 scopus 로고    scopus 로고
    • The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain
    • Blackburn-Munro, G.; Jensen, B.S. The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain. Eur. J. Pharmacol., 2003, 460, 109-116.
    • (2003) Eur. J. Pharmacol. , vol.460 , pp. 109-116
    • Blackburn-Munro, G.1    Jensen, B.S.2
  • 54
    • 33846675852 scopus 로고    scopus 로고
    • Kv7.2-7.5 voltage-gated potassium channel (KCNQ2-5) opener, retigabine, reduces capsaicin-induced visceral pain in mice
    • Hirano, K.; Kuratani, K.; Fujiyoshi, M.; Tashiro, N.; Hayashi, E.; Kinoshita, M. Kv7.2-7.5 voltage-gated potassium channel (KCNQ2-5) opener, retigabine, reduces capsaicin-induced visceral pain in mice. Neurosci. Lett., 2007, 413, 159-162.
    • (2007) Neurosci. Lett. , vol.413 , pp. 159-162
    • Hirano, K.1    Kuratani, K.2    Fujiyoshi, M.3    Tashiro, N.4    Hayashi, E.5    Kinoshita, M.6
  • 55
  • 56
    • 50549100189 scopus 로고    scopus 로고
    • Retigabine, the specific KCNQ channel opener, blocks ectopic discharges in axotomized sensory fibres
    • Roza, C.; Lopez-Garcia, J.A. Retigabine, the specific KCNQ channel opener, blocks ectopic discharges in axotomized sensory fibres. Pain, 2008, 138, 537-545.
    • (2008) Pain , vol.138 , pp. 537-545
    • Roza, C.1    Lopez-Garcia, J.A.2
  • 57
    • 38849088576 scopus 로고    scopus 로고
    • The KCNQ/M-current modulates arterial baroreceptor function at the sensory terminal in rats
    • Wladyka, C.L.; Feng, B.; Glazebrook, P.A.; Schild, J.H.; Kunze, D.L. The KCNQ/M-current modulates arterial baroreceptor function at the sensory terminal in rats. J. Physiol., 2008, 586, 795-802.
    • (2008) J. Physiol. , vol.586 , pp. 795-802
    • Wladyka, C.L.1    Feng, B.2    Glazebrook, P.A.3    Schild, J.H.4    Kunze, D.L.5
  • 58
    • 84857303814 scopus 로고    scopus 로고
    • A Role for K2P Channels in the Operation of Somatosensory Nociceptors
    • Plant, L.D. A Role for K2P Channels in the Operation of Somatosensory Nociceptors. Front. Mol. Neurosci., 2012, 5, 21.
    • (2012) Front. Mol. Neurosci. , vol.5 , pp. 21
    • Plant, L.D.1
  • 59
    • 0035816558 scopus 로고    scopus 로고
    • Block of Kcnk3 by protons. Evidence that 2-P-domain potassium channel subunits function as homodimers
    • Lopes, C.M.; Zilberberg, N.; Goldstein, S.A. Block of Kcnk3 by protons. Evidence that 2-P-domain potassium channel subunits function as homodimers. J. Biol. Chem., 2001, 276, 24449-24452.
    • (2001) J. Biol. Chem. , vol.276 , pp. 24449-24452
    • Lopes, C.M.1    Zilberberg, N.2    Goldstein, S.A.3
  • 60
    • 67649923704 scopus 로고    scopus 로고
    • A structural model for K2P potassium channels based on 23 pairs of interacting sites and continuum electrostatics
    • Kollewe, A.; Lau, A.Y.; Sullivan, A.; Roux, B.; Goldstein, S.A. A structural model for K2P potassium channels based on 23 pairs of interacting sites and continuum electrostatics. J. Gen. Physiol., 2009, 134, 53-68.
    • (2009) J. Gen. Physiol. , vol.134 , pp. 53-68
    • Kollewe, A.1    Lau, A.Y.2    Sullivan, A.3    Roux, B.4    Goldstein, S.A.5
  • 61
    • 33947360830 scopus 로고    scopus 로고
    • The neuronal background K2P channels: Focus on TREK-1
    • Honore, E. The neuronal background K2P channels: focus on TREK-1. Nat. Rev. Neurosci., 2007, 8, 251-261.
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 251-261
    • Honore, E.1
  • 62
    • 76949125485 scopus 로고
    • The components of membrane conductance in the giant axon of Loligo
    • Hodgkin, A.L.; Huxley, A.F. The components of membrane conductance in the giant axon of Loligo. J. Physiol., 1952, 116, 473-496.
    • (1952) J. Physiol. , vol.116 , pp. 473-496
    • Hodgkin, A.L.1    Huxley, A.F.2
  • 63
    • 0035478067 scopus 로고    scopus 로고
    • Cns distribution of members of the two-pore-domain (KCNK) potassium channel family
    • Talley, E.M.; Solorzano, G.; Lei, Q.; Kim, D.; Bayliss, D.A. Cns distribution of members of the two-pore-domain (KCNK) potassium channel family. J. Neurosci., 2001, 21, 7491-7505.
    • (2001) J. Neurosci. , vol.21 , pp. 7491-7505
    • Talley, E.M.1    Solorzano, G.2    Lei, Q.3    Kim, D.4    Bayliss, D.A.5
  • 64
    • 84857125385 scopus 로고    scopus 로고
    • + channel mRNAs in dorsal root ganglia: Relation to inflammation and spontaneous pain behaviour
    • + channel mRNAs in dorsal root ganglia: relation to inflammation and spontaneous pain behaviour. Mol. Cell. Neurosci., 2012, 49, 375-386.
    • (2012) Mol. Cell. Neurosci. , vol.49 , pp. 375-386
    • Marsh, B.1    Acosta, C.2    Djouhri, L.3    Lawson, S.N.4
  • 65
    • 33745686085 scopus 로고    scopus 로고
    • + channels in dorsal root ganglion neurons
    • + channels in dorsal root ganglion neurons. Am. J. Physiol. Cell.Physiol., 2006, 291, C138-146.
    • (2006) Am. J. Physiol. Cell.Physiol. , vol.291 , pp. C138-C146
    • Kang, D.1    Kim, D.2
  • 67
    • 0033578649 scopus 로고    scopus 로고
    • Mechano-or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel
    • Maingret, F.; Patel, A.J.; Lesage, F.; Lazdunski, M.; Honore, E. Mechano-or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel. J. Biol. Chem., 1999, 274, 26691-26696.
    • (1999) J. Biol. Chem. , vol.274 , pp. 26691-26696
    • Maingret, F.1    Patel, A.J.2    Lesage, F.3    Lazdunski, M.4    Honore, E.5
  • 70
    • 0034596067 scopus 로고    scopus 로고
    • Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3
    • Lopes, C.M.; Gallagher, P.G.; Buck, M.E.; Butler, M.H.; Goldstein, S.A. Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3. J. Biol. Chem., 2000, 275, 16969-16978.
    • (2000) J. Biol. Chem. , vol.275 , pp. 16969-16978
    • Lopes, C.M.1    Gallagher, P.G.2    Buck, M.E.3    Butler, M.H.4    Goldstein, S.A.5
  • 72
    • 74949143771 scopus 로고    scopus 로고
    • Inwardly rectifying potassium channels: Their structure, function, and physiological roles
    • Hibino, H.; Inanobe, A.; Furutani, K.; Murakami, S.; Findlay, I.; Kurachi, Y. Inwardly rectifying potassium channels: their structure, function, and physiological roles. Physiol. Rev., 2010, 90, 291-366.
    • (2010) Physiol. Rev. , vol.90 , pp. 291-366
    • Hibino, H.1    Inanobe, A.2    Furutani, K.3    Murakami, S.4    Findlay, I.5    Kurachi, Y.6
  • 75
    • 79958278870 scopus 로고    scopus 로고
    • Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability of DRG neurons from rats
    • Du, X.; Wang, C.; Zhang, H. Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability of DRG neurons from rats. Mol. Pain., 2011, 7, 35.
    • (2011) Mol. Pain. , vol.7 , pp. 35
    • Du, X.1    Wang, C.2    Zhang, H.3
  • 77
    • 0032533717 scopus 로고    scopus 로고
    • + channels in small neurones of rat dorsal root ganglion studied in a thin slice preparation
    • + channels in small neurones of rat dorsal root ganglion studied in a thin slice preparation. J. Physiol., 1998, 513, 55-69.
    • (1998) J. Physiol. , vol.513 , pp. 55-69
    • Scholz, A.1    Gruss, M.2    Vogel, W.3
  • 79
  • 80
    • 65549152473 scopus 로고    scopus 로고
    • NAD+ activates KNa channels in dorsal root ganglion neurons
    • Tamsett, T.J.; Picchione, K.E.; Bhattacharjee, A. NAD+ activates KNa channels in dorsal root ganglion neurons. J. Neurosci., 2009, 29, 5127-5134.
    • (2009) J. Neurosci. , vol.29 , pp. 5127-5134
    • Tamsett, T.J.1    Picchione, K.E.2    Bhattacharjee, A.3
  • 81
    • 49249135312 scopus 로고    scopus 로고
    • Na channels are required for the depolarizing afterpotential of acutely isolated, medium diameter rat dorsal root ganglion neurons
    • Na channels are required for the depolarizing afterpotential of acutely isolated, medium diameter rat dorsal root ganglion neurons. Acta Pharmacol. Sin., 2008, 29, 899-905.
    • (2008) Acta Pharmacol. Sin. , vol.29 , pp. 899-905
    • Gao, S.B.1    Wu, Y.2    Lu, C.X.3    Guo, Z.H.4    Li, C.H.5    Ding, J.P.6
  • 82
    • 67650659853 scopus 로고    scopus 로고
    • CAMP-dependent kinase does not modulate the Slack sodium-activated potassium channel
    • Nuwer, M.O.; Picchione, K.E.; Bhattacharjee, A. cAMP-dependent kinase does not modulate the Slack sodium-activated potassium channel. Neuropharmacology, 2009, 57, 219-226.
    • (2009) Neuropharmacology , vol.57 , pp. 219-226
    • Nuwer, M.O.1    Picchione, K.E.2    Bhattacharjee, A.3
  • 84
    • 33749061243 scopus 로고    scopus 로고
    • Mechanisms of neuropathic pain
    • Campbell, J.N.; Meyer, R.A. Mechanisms of neuropathic pain. Neuron, 2006, 52, 77-92.
    • (2006) Neuron , vol.52 , pp. 77-92
    • Campbell, J.N.1    Meyer, R.A.2
  • 85
    • 70349481938 scopus 로고    scopus 로고
    • Treatment of neuropathic pain: An overview of recent guidelines
    • O'Connor, A.B.; Dworkin, R.H. Treatment of neuropathic pain: an overview of recent guidelines. Am. J. Med., 2009, 122, S22-32.
    • (2009) Am. J. Med. , vol.122 , pp. S22-S32
    • O'connor, A.B.1    Dworkin, R.H.2
  • 86
    • 30844438395 scopus 로고    scopus 로고
    • McMahon, S.B., Koltzenburg, M. Ed, Wall and Melzack's Textbook of Pain, Elsevier Churchill Livingstone
    • Devor, M. Response of nerves to Injury in relation to neuropathic pain. In: McMahon, S.B., Koltzenburg, M. Ed, Wall and Melzack's Textbook of Pain, Elsevier Churchill Livingstone. 2006, 905-927.
    • (2006) Response of Nerves to Injury in Relation to Neuropathic Pain , pp. 905-927
    • Devor, M.1
  • 88
    • 0018127665 scopus 로고
    • Ongoing activity in severed nerves: Source and variation with time
    • Govrin-Lippmann, R.; Devor, M. Ongoing activity in severed nerves: source and variation with time. Brain Res., 1978, 159, 406-410.
    • (1978) Brain Res , vol.159 , pp. 406-410
    • Govrin-Lippmann, R.1    Devor, M.2
  • 89
    • 0021015545 scopus 로고
    • Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats
    • Wall, P.D.; Devor, M. Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats. Pain, 1983, 17, 321-339.
    • (1983) Pain , vol.17 , pp. 321-339
    • Wall, P.D.1    Devor, M.2
  • 90
    • 0030971318 scopus 로고    scopus 로고
    • Spike-evoked suppression and burst patterning in dorsal root ganglion neurons of the rat
    • Amir, R.; Devor, M. Spike-evoked suppression and burst patterning in dorsal root ganglion neurons of the rat. J. Physiol., 1997, 501, 183-196.
    • (1997) J. Physiol. , vol.501 , pp. 183-196
    • Amir, R.1    Devor, M.2
  • 91
    • 0034175686 scopus 로고    scopus 로고
    • Tactile allodynia in the absence of C-fiber activation: Altered firing properties of DRG neurons following spinal nerve injury
    • Liu, C.N.; Wall, P.D.; Ben-Dor, E.; Michaelis, M.; Amir, R.; Devor, M. Tactile allodynia in the absence of C-fiber activation: altered firing properties of DRG neurons following spinal nerve injury. Pain, 2000, 85, 503-521.
    • (2000) Pain , vol.85 , pp. 503-521
    • Liu, C.N.1    Wall, P.D.2    Ben-Dor, E.3    Michaelis, M.4    Amir, R.5    Devor, M.6
  • 92
    • 0001316768 scopus 로고    scopus 로고
    • Inflammatory Models of Pain and Hyperalgesia
    • Ren, K.; Dubner, R. Inflammatory Models of Pain and Hyperalgesia. Ilar J., 1999, 40, 111-118.
    • (1999) Ilar J , vol.40 , pp. 111-118
    • Ren, K.1    Dubner, R.2
  • 93
    • 10544244579 scopus 로고    scopus 로고
    • Sympathetic sprouting in the dorsal root ganglia of the injured peripheral nerve in a rat neuropathic pain model
    • Chung, K.; Lee, B.H.; Yoon, Y.W.; Chung, J.M. Sympathetic sprouting in the dorsal root ganglia of the injured peripheral nerve in a rat neuropathic pain model. J. Comp. Neurol., 1996, 376, 241-252.
    • (1996) J. Comp. Neurol. , vol.376 , pp. 241-252
    • Chung, K.1    Lee, B.H.2    Yoon, Y.W.3    Chung, J.M.4
  • 94
    • 0027263155 scopus 로고
    • Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia
    • McLachlan, E.M.; Janig, W.; Devor, M.; Michaelis, M. Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia. Nature, 1993, 363, 543-546.
    • (1993) Nature , vol.363 , pp. 543-546
    • McLachlan, E.M.1    Janig, W.2    Devor, M.3    Michaelis, M.4
  • 96
    • 0032783674 scopus 로고    scopus 로고
    • Reduction in potassium currents in identified cutaneous afferent dorsal root ganglion neurons after axotomy
    • Everill, B.; Kocsis, J.D. Reduction in potassium currents in identified cutaneous afferent dorsal root ganglion neurons after axotomy. J. Neurophysiol., 1999, 82, 700-708.
    • (1999) J. Neurophysiol. , vol.82 , pp. 700-708
    • Everill, B.1    Kocsis, J.D.2
  • 97
    • 0035124717 scopus 로고    scopus 로고
    • + channel currents of rat dorsal root ganglion neurons
    • + channel currents of rat dorsal root ganglion neurons. J. Neurophysiol., 2001, 85, 644-658.
    • (2001) J. Neurophysiol. , vol.85 , pp. 644-658
    • Abdulla, F.A.1    Smith, P.A.2
  • 100
  • 101
    • 84873395152 scopus 로고    scopus 로고
    • Specification of Skeletal Muscle Differentiation by Repressor Element-1 Silencing Transcription Factor (REST)-Regulated Kv7.4 Potassium Channels
    • Iannotti, F.A.; Barrese, V.; Formisano, L.; Miceli, F.; Taglialatela, M. Specification of Skeletal Muscle Differentiation by Repressor Element-1 Silencing Transcription Factor (REST)-Regulated Kv7.4 Potassium Channels. Mol. Biol. Cell., 2012, 24 (3), 274-84.
    • (2012) Mol. Biol. Cell. , vol.24 , Issue.3 , pp. 274-284
    • Iannotti, F.A.1    Barrese, V.2    Formisano, L.3    Miceli, F.4    Taglialatela, M.5
  • 102
    • 77950632304 scopus 로고    scopus 로고
    • Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain
    • Uchida, H.; Ma, L.; Ueda, H. Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain. J. Neurosci., 2010, 30, 4806-4814.
    • (2010) J. Neurosci. , vol.30 , pp. 4806-4814
    • Uchida, H.1    Ma, L.2    Ueda, H.3
  • 103
    • 34250767817 scopus 로고    scopus 로고
    • Chromatin crosstalk in development and disease: Lessons from REST
    • Ooi, L.; Wood, I.C. Chromatin crosstalk in development and disease: lessons from REST. Nat. Rev. Genet., 2007, 8, 544-554.
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 544-554
    • Ooi, L.1    Wood, I.C.2
  • 104
    • 84871377149 scopus 로고    scopus 로고
    • + channels by AKAP79/150-mediated NFAT actions
    • + channels by AKAP79/150-mediated NFAT actions. Neuron, 2012, 76, 1133-1146.
    • (2012) Neuron , vol.76 , pp. 1133-1146
    • Zhang, J.1    Shapiro, M.S.2
  • 105
    • 84875464198 scopus 로고    scopus 로고
    • Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain
    • Cai, Y.Q.; Chen, S.R.; Pan, H.L. Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain. J. Pharmacol. Exp. Ther., 2013, 345, 161-168.
    • (2013) J. Pharmacol. Exp. Ther. , vol.345 , pp. 161-168
    • Cai, Y.Q.1    Chen, S.R.2    Pan, H.L.3
  • 106
    • 74449093596 scopus 로고    scopus 로고
    • Neuron-restrictive silencer factor causes epigenetic silencing of Kv4.3 gene after peripheral nerve injury
    • Uchida, H.; Sasaki, K.; Ma, L.; Ueda, H. Neuron-restrictive silencer factor causes epigenetic silencing of Kv4.3 gene after peripheral nerve injury. Neuroscience, 2010, 166, 1-4.
    • (2010) Neuroscience , vol.166 , pp. 1-4
    • Uchida, H.1    Sasaki, K.2    Ma, L.3    Ueda, H.4
  • 107
    • 77955143610 scopus 로고    scopus 로고
    • + channel activity in primary sensory neurons in painful diabetic neuropathy: Role of brain-derived neurotrophic factor
    • + channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor. J. Neurochem., 2010, 114, 1460-1475.
    • (2010) J. Neurochem. , vol.114 , pp. 1460-1475
    • Cao, X.H.1    Byun, H.S.2    Chen, S.R.3    Cai, Y.Q.4    Pan, H.L.5
  • 108
    • 68349148357 scopus 로고    scopus 로고
    • Voltage-gated potassium channels in IB4-positive colonic sensory neurons mediate visceral hypersensitivity in the rat
    • Qian, A.H.; Liu, X.Q.; Yao, W.Y.; Wang, H.Y.; Sun, J.; Zhou, L.; Yuan, Y.Z. Voltage-gated potassium channels in IB4-positive colonic sensory neurons mediate visceral hypersensitivity in the rat. Am. J. Gastroenterol, 2009, 104, 2014-2027.
    • (2009) Am. J. Gastroenterol , vol.104 , pp. 2014-2027
    • Qian, A.H.1    Liu, X.Q.2    Yao, W.Y.3    Wang, H.Y.4    Sun, J.5    Zhou, L.6    Yuan, Y.Z.7
  • 109
    • 0032958131 scopus 로고    scopus 로고
    • Changes in expression of voltage-gated potassium channels in dorsal root ganglion neurons following axotomy
    • Ishikawa, K.; Tanaka, M.; Black, J.A.; Waxman, S.G. Changes in expression of voltage-gated potassium channels in dorsal root ganglion neurons following axotomy. Muscle Nerve, 1999, 22, 502-507.
    • (1999) Muscle Nerve , vol.22 , pp. 502-507
    • Ishikawa, K.1    Tanaka, M.2    Black, J.A.3    Waxman, S.G.4
  • 110
    • 0026767449 scopus 로고
    • Onset of a painful peripheral neuropathy in rat: A partial and differential deafferentation and spontaneous discharge in A beta and A delta primary afferent neurons
    • Kajander, K.C.; Bennett, G.J. Onset of a painful peripheral neuropathy in rat: a partial and differential deafferentation and spontaneous discharge in A beta and A delta primary afferent neurons. J. Neurophysiol., 1992, 68, 734-744.
    • (1992) J. Neurophysiol. , vol.68 , pp. 734-744
    • Kajander, K.C.1    Bennett, G.J.2
  • 112
    • 84859763493 scopus 로고    scopus 로고
    • Electrically silent Kv subunits: Their molecular and functional characteristics
    • Bocksteins, E.; Snyders, D.J. Electrically silent Kv subunits: their molecular and functional characteristics. Physiology (Bethesda), 2012, 27, 73-84.
    • (2012) Physiology (Bethesda) , vol.27 , pp. 73-84
    • Bocksteins, E.1    Snyders, D.J.2
  • 113
    • 0033837994 scopus 로고    scopus 로고
    • Modification of delayed rectifier potassium currents by the Kv9.1 potassium channel subunit
    • Richardson, F.C.; Kaczmarek, L.K. Modification of delayed rectifier potassium currents by the Kv9.1 potassium channel subunit. Hear. Res., 2000, 147, 21-30.
    • (2000) Hear. Res. , vol.147 , pp. 21-30
    • Richardson, F.C.1    Kaczmarek, L.K.2
  • 114
    • 30044449982 scopus 로고    scopus 로고
    • Resolution of inflammation: The beginning programs the end
    • Serhan, C.N.; Savill, J. Resolution of inflammation: the beginning programs the end. Nat. Immunol., 2005, 6, 1191-1197.
    • (2005) Nat. Immunol. , vol.6 , pp. 1191-1197
    • Serhan, C.N.1    Savill, J.2
  • 115
    • 33846257261 scopus 로고    scopus 로고
    • Chronic inflammation: Importance of NOD2 and NALP3 in interleukin-1beta generation
    • Ferrero-Miliani, L.; Nielsen, O.H.; Andersen, P.S.; Girardin, S.E. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation. Clin. Exp. Immunol., 2007, 147, 227-235.
    • (2007) Clin. Exp. Immunol. , vol.147 , pp. 227-235
    • Ferrero-Miliani, L.1    Nielsen, O.H.2    Andersen, P.S.3    Girardin, S.E.4
  • 116
    • 84964169519 scopus 로고
    • The chemistry of pain production
    • Keele, C.A. The chemistry of pain production. Proc. R. Soc. Med., 1967, 60, 419-422.
    • (1967) Proc. R. Soc. Med. , vol.60 , pp. 419-422
    • Keele, C.A.1
  • 117
    • 33646039121 scopus 로고    scopus 로고
    • McMahon, S.B., Koltzenburg, M. Ed, Wall and Melzack's textbook of pain. Edinburgh, Elsevier Churchill Livingstone
    • McMahon, S.B., Bennet, D.L.H., Bevan, S. Inflammatory mediators and modulators. In: McMahon, S.B., Koltzenburg, M. Ed, Wall and Melzack's textbook of pain. Edinburgh, Elsevier Churchill Livingstone. 2006, 49-72.
    • (2006) Inflammatory Mediators and Modulators , pp. 49-72
    • McMahon, S.B.1    Bennet, D.L.H.2    Bevan, S.3
  • 118
    • 84867705860 scopus 로고    scopus 로고
    • Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors
    • Petho, G.; Reeh, P.W. Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors. Physiol. Rev., 2012, 92, 1699-1775.
    • (2012) Physiol. Rev. , vol.92 , pp. 1699-1775
    • Petho, G.1    Reeh, P.W.2
  • 119
    • 70449587066 scopus 로고    scopus 로고
    • TRPV1 and TRPA1 mediate peripheral nitric oxide-induced nociception in mice
    • Miyamoto, T.; Dubin, A.E.; Petrus, M.J.; Patapoutian, A. TRPV1 and TRPA1 mediate peripheral nitric oxide-induced nociception in mice. PLoS One, 2009, 4, e7596.
    • (2009) Plos One , vol.4
    • Miyamoto, T.1    Dubin, A.E.2    Petrus, M.J.3    Patapoutian, A.4
  • 121
    • 33847104189 scopus 로고    scopus 로고
    • Inflammatory mediators modulating the transient receptor potential vanilloid 1 receptor: Therapeutic targets to treat inflammatory and neuropathic pain
    • Ma, W.; Quirion, R. Inflammatory mediators modulating the transient receptor potential vanilloid 1 receptor: therapeutic targets to treat inflammatory and neuropathic pain. Expert Opin. Ther. Targets, 2007, 11, 307-320.
    • (2007) Expert Opin. Ther. Targets , vol.11 , pp. 307-320
    • Ma, W.1    Quirion, R.2
  • 122
    • 84856269228 scopus 로고    scopus 로고
    • The thermo-TRP ion channel family: Properties and therapeutic implications
    • Vay, L.; Gu, C.; McNaughton, P.A. The thermo-TRP ion channel family: properties and therapeutic implications. Br. J. Pharmacol., 2012, 165, 787-801.
    • (2012) Br. J. Pharmacol. , vol.165 , pp. 787-801
    • Vay, L.1    Gu, C.2    McNaughton, P.A.3
  • 123
    • 69249228607 scopus 로고    scopus 로고
    • ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons
    • Hattori, T.; Chen, J.; Harding, A.M.; Price, M.P.; Lu, Y.; Abboud, F.M.; Benson, C.J. ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons. Circ. Res., 2009, 105, 279-286.
    • (2009) Circ. Res. , vol.105 , pp. 279-286
    • Hattori, T.1    Chen, J.2    Harding, A.M.3    Price, M.P.4    Lu, Y.5    Abboud, F.M.6    Benson, C.J.7
  • 127
    • 1542498425 scopus 로고    scopus 로고
    • Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons
    • Dai, Y.; Fukuoka, T.; Wang, H.; Yamanaka, H.; Obata, K.; Tokunaga, A.; Noguchi, K. Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons. Pain, 2004, 108, 258-266.
    • (2004) Pain , vol.108 , pp. 258-266
    • Dai, Y.1    Fukuoka, T.2    Wang, H.3    Yamanaka, H.4    Obata, K.5    Tokunaga, A.6    Noguchi, K.7
  • 128
    • 58149173964 scopus 로고    scopus 로고
    • Peripheral mechanisms underlying the essential role of P2X3,2/3 receptors in the development of inflammatory hyperalgesia
    • Oliveira, M.C.; Pelegrini-da-Silva, A.; Tambeli, C.H.; Parada, C.A. Peripheral mechanisms underlying the essential role of P2X3,2/3 receptors in the development of inflammatory hyperalgesia. Pain, 2009, 141, 127-134.
    • (2009) Pain , vol.141 , pp. 127-134
    • Oliveira, M.C.1    Pelegrini-Da-Silva, A.2    Tambeli, C.H.3    Parada, C.A.4
  • 129
    • 0032945690 scopus 로고    scopus 로고
    • The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat
    • Hamilton, S.G.; Wade, A.; McMahon, S.B. The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat. Br. J. Pharmacol., 1999, 126, 326-332.
    • (1999) Br. J. Pharmacol. , vol.126 , pp. 326-332
    • Hamilton, S.G.1    Wade, A.2    McMahon, S.B.3
  • 130
    • 0034256565 scopus 로고    scopus 로고
    • Mechanical allodynia caused by intraplantar injection of P2X receptor agonist in rats: Involvement of heteromeric P2X2/3 receptor signaling in capsaicin-insensitive primary afferent neurons
    • Tsuda, M.; Koizumi, S.; Kita, A.; Shigemoto, Y.; Ueno, S.; Inoue, K. Mechanical allodynia caused by intraplantar injection of P2X receptor agonist in rats: involvement of heteromeric P2X2/3 receptor signaling in capsaicin-insensitive primary afferent neurons. J. Neurosci., 2000, 20, RC90.
    • (2000) J. Neurosci. , vol.20 , pp. RC90
    • Tsuda, M.1    Koizumi, S.2    Kita, A.3    Shigemoto, Y.4    Ueno, S.5    Inoue, K.6
  • 131
    • 0035878949 scopus 로고    scopus 로고
    • Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin
    • Hamilton, S.G.; McMahon, S.B.; Lewin, G.R. Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin. J. Physiol., 2001, 534, 437-445.
    • (2001) J. Physiol. , vol.534 , pp. 437-445
    • Hamilton, S.G.1    McMahon, S.B.2    Lewin, G.R.3
  • 133
    • 40849083674 scopus 로고    scopus 로고
    • Inflammatory mediators increase Nav1.9 current and excitability in nociceptors through a coincident detection mechanism
    • Maingret, F.; Coste, B.; Padilla, F.; Clerc, N.; Crest, M.; Korogod, S.M.; Delmas, P. Inflammatory mediators increase Nav1.9 current and excitability in nociceptors through a coincident detection mechanism. J. Gen. Physiol., 2008, 131, 211-225.
    • (2008) J. Gen. Physiol. , vol.131 , pp. 211-225
    • Maingret, F.1    Coste, B.2    Padilla, F.3    Clerc, N.4    Crest, M.5    Korogod, S.M.6    Delmas, P.7
  • 135
    • 30644463076 scopus 로고    scopus 로고
    • Gereau, R.W.t. Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-alpha
    • Jin, X.; Gereau, R.W.t. Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-alpha. J. Neurosci., 2006, 26, 246-255.
    • (2006) J. Neurosci. , vol.26 , pp. 246-255
    • Jin, X.1
  • 136
    • 68349111767 scopus 로고    scopus 로고
    • v1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons
    • v1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons. Mol. Pain, 2009, 5, 33.
    • (2009) Mol. Pain , vol.5 , pp. 33
    • Cang, C.L.1    Zhang, H.2    Zhang, Y.Q.3    Zhao, Z.Q.4
  • 137
    • 1542510699 scopus 로고    scopus 로고
    • v1.8 peripheral nerve sodium channels by protein kinase A and protein kinase C
    • v1.8 peripheral nerve sodium channels by protein kinase A and protein kinase C. J. Neurophysiol., 2004, 91, 1556-1569.
    • (2004) J. Neurophysiol. , vol.91 , pp. 1556-1569
    • Vijayaragavan, K.1    Boutjdir, M.2    Chahine, M.3
  • 138
    • 0018886033 scopus 로고
    • + current in a vertebrate neurone
    • + current in a vertebrate neurone. Nature, 1980, 283, 673-676.
    • (1980) Nature , vol.283 , pp. 673-676
    • Brown, D.A.1    Adams, P.R.2
  • 140
    • 45549107093 scopus 로고    scopus 로고
    • Regulation of neural KCNQ channels: Signalling pathways, structural motifs and functional implications
    • Hernandez, C.C.; Zaika, O.; Tolstykh, G.P.; Shapiro, M.S. Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications. J. Physiol., 2008, 586, 1811-1821.
    • (2008) J. Physiol. , vol.586 , pp. 1811-1821
    • Hernandez, C.C.1    Zaika, O.2    Tolstykh, G.P.3    Shapiro, M.S.4
  • 141
    • 84874230625 scopus 로고    scopus 로고
    • Phosphoinositide sensitivity of ion channels, a functional perspective
    • Gamper, N.; Rohacs, T. Phosphoinositide sensitivity of ion channels, a functional perspective. Subcell. Biochem., 2012, 59, 289-333.
    • (2012) Subcell. Biochem. , vol.59 , pp. 289-333
    • Gamper, N.1    Rohacs, T.2
  • 142
    • 0036683972 scopus 로고    scopus 로고
    • Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis
    • Suh, B.; Hille, B. Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis. Neuron, 2002, 35, 507-520.
    • (2002) Neuron , vol.35 , pp. 507-520
    • Suh, B.1    Hille, B.2
  • 144
  • 146
    • 0038502077 scopus 로고    scopus 로고
    • Calmodulin mediates Ca2+-dependent modulation of M-type K+ channels
    • Gamper, N.; Shapiro, M.S. Calmodulin mediates Ca2+-dependent modulation of M-type K+ channels. J. Gen. Physiol., 2003, 122, 17-31.
    • (2003) J. Gen. Physiol. , vol.122 , pp. 17-31
    • Gamper, N.1    Shapiro, M.S.2
  • 147
    • 0030047777 scopus 로고    scopus 로고
    • Intracellular calcium directly inhibits potassium M channels in excised membrane patches from rat sympathetic neurons
    • Selyanko, A.A.; Brown, D.A. Intracellular calcium directly inhibits potassium M channels in excised membrane patches from rat sympathetic neurons. Neuron, 1996, 16, 151-162.
    • (1996) Neuron , vol.16 , pp. 151-162
    • Selyanko, A.A.1    Brown, D.A.2
  • 150
    • 79956330530 scopus 로고    scopus 로고
    • AKAP79/150 signal complexes in G-protein modulation of neuronal ion channels
    • Zhang, J.; Bal, M.; Bierbower, S.; Zaika, O.; Shapiro, M.S. AKAP79/150 signal complexes in G-protein modulation of neuronal ion channels. J. Neurosci., 2011, 31, 7199-7211.
    • (2011) J. Neurosci. , vol.31 , pp. 7199-7211
    • Zhang, J.1    Bal, M.2    Bierbower, S.3    Zaika, O.4    Shapiro, M.S.5
  • 152
    • 0029658171 scopus 로고    scopus 로고
    • G proteins of the Gq family couple the H2 histamine receptor to phospholipase C
    • Kuhn, B.; Schmid, A.; Harteneck, C.; Gudermann, T.; Schultz, G. G proteins of the Gq family couple the H2 histamine receptor to phospholipase C. Mol. Endocrinol., 1996, 10, 1697-1707.
    • (1996) Mol. Endocrinol. , vol.10 , pp. 1697-1707
    • Kuhn, B.1    Schmid, A.2    Harteneck, C.3    Gudermann, T.4    Schultz, G.5
  • 153
    • 33646011568 scopus 로고    scopus 로고
    • Characterization of proteinase-activated receptor 2 signalling and expression in rat hippocampal neurons and astrocytes
    • Bushell, T.J.; Plevin, R.; Cobb, S.; Irving, A.J. Characterization of proteinase-activated receptor 2 signalling and expression in rat hippocampal neurons and astrocytes. Neuropharmacology, 2006, 50, 714-725.
    • (2006) Neuropharmacology , vol.50 , pp. 714-725
    • Bushell, T.J.1    Plevin, R.2    Cobb, S.3    Irving, A.J.4
  • 154
    • 0030047930 scopus 로고    scopus 로고
    • Functional and molecular aspects of renal prostaglandin receptors
    • Breyer, M.D.; Jacobson, H.R.; Breyer, R.M. Functional and molecular aspects of renal prostaglandin receptors. J. Am. Soc. Nephrol., 1996, 7, 8-17.
    • (1996) J. Am. Soc. Nephrol. , vol.7 , pp. 8-17
    • Breyer, M.D.1    Jacobson, H.R.2    Breyer, R.M.3
  • 155
    • 0030931666 scopus 로고    scopus 로고
    • P2Y receptor linked to phospholipase C: Stimulation of neuro 2A cells by UTP and ATP and possible regulation by protein kinase C subtype epsilon
    • Chen, C.C.; Chen, W.C. P2Y receptor linked to phospholipase C: stimulation of neuro 2A cells by UTP and ATP and possible regulation by protein kinase C subtype epsilon. J. Neurochem., 1997, 69, 1409-1416.
    • (1997) J. Neurochem. , vol.69 , pp. 1409-1416
    • Chen, C.C.1    Chen, W.C.2
  • 156
    • 0027532297 scopus 로고
    • Bradykinin and inflammatory pain
    • Dray, A.; Perkins, M. Bradykinin and inflammatory pain. Trends Neurosci., 1993, 16, 99-104.
    • (1993) Trends Neurosci , vol.16 , pp. 99-104
    • Dray, A.1    Perkins, M.2
  • 157
    • 34247368093 scopus 로고    scopus 로고
    • MrgD activation inhibits KCNQ/M-currents and contributes to enhanced neuronal excitability
    • Crozier, R.A.; Ajit, S.K.; Kaftan, E.J.; Pausch, M.H. MrgD activation inhibits KCNQ/M-currents and contributes to enhanced neuronal excitability. J. Neurosci., 2007, 27, 4492-4496.
    • (2007) J. Neurosci. , vol.27 , pp. 4492-4496
    • Crozier, R.A.1    Ajit, S.K.2    Kaftan, E.J.3    Pausch, M.H.4
  • 158
    • 84875985219 scopus 로고    scopus 로고
    • + channels mediates reciprocal channel modulation by nitric oxide and reactive oxygen species
    • + channels mediates reciprocal channel modulation by nitric oxide and reactive oxygen species. J Neurosci, 2013, 33, 6041-6046.
    • (2013) J Neurosci , vol.33 , pp. 6041-6046
    • Ooi, L.1    Gigout, S.2    Pettinger, L.3    Gamper, N.4
  • 160
    • 33745979173 scopus 로고    scopus 로고
    • + channels in capsaicin sensitive and insensitive cells of rat dorsal root ganglia
    • + channels in capsaicin sensitive and insensitive cells of rat dorsal root ganglia. Neuroscience, 2006, 141, 955-963.
    • (2006) Neuroscience , vol.141 , pp. 955-963
    • Rau, K.K.1    Cooper, B.Y.2    Johnson, R.D.3
  • 161
    • 33748797928 scopus 로고    scopus 로고
    • Acid-sensing ion channels: Advances, questions and therapeutic opportunities
    • Wemmie, J.A.; Price, M.P.; Welsh, M.J. Acid-sensing ion channels: advances, questions and therapeutic opportunities. Trends Neurosci., 2006, 29, 578-586.
    • (2006) Trends Neurosci , vol.29 , pp. 578-586
    • Wemmie, J.A.1    Price, M.P.2    Welsh, M.J.3
  • 167
    • 0033529324 scopus 로고    scopus 로고
    • Transcriptional and posttranslational plasticity and the generation of inflammatory pain
    • Woolf, C.J.; Costigan, M. Transcriptional and posttranslational plasticity and the generation of inflammatory pain. Proc. Natl. Acad. Sci. U. S. A., 1999, 96, 7723-7730.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 7723-7730
    • Woolf, C.J.1    Costigan, M.2
  • 168
    • 84865996297 scopus 로고    scopus 로고
    • Transforming growth factor beta induces sensory neuronal hyperexcitability, and contributes to pancreatic pain and hyperalgesia in rats with chronic pancreatitis
    • Zhu, Y.; Colak, T.; Shenoy, M.; Liu, L.; Mehta, K.; Pai, R.; Zou, B.; Xie, X.S.; Pasricha, P.J. Transforming growth factor beta induces sensory neuronal hyperexcitability, and contributes to pancreatic pain and hyperalgesia in rats with chronic pancreatitis. Mol. Pain, 2012, 8, 65.
    • (2012) Mol. Pain , vol.8 , pp. 65
    • Zhu, Y.1    Colak, T.2    Shenoy, M.3    Liu, L.4    Mehta, K.5    Pai, R.6    Zou, B.7    Xie, X.S.8    Pasricha, P.J.9
  • 171
    • 43349097329 scopus 로고    scopus 로고
    • The therapeutic potential of neuronal Kv7 (KCNQ) channel modulators: An update
    • Gribkoff, V.K. The therapeutic potential of neuronal Kv7 (KCNQ) channel modulators: an update. Expert Opin. Ther. Targets, 2008, 12, 565-581.
    • (2008) Expert Opin. Ther. Targets , vol.12 , pp. 565-581
    • Gribkoff, V.K.1
  • 174
    • 0031974209 scopus 로고    scopus 로고
    • A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family
    • Charlier, C.; Singh, N.A.; Ryan, S.G.; Lewis, T.B.; Reus, B.E.; Leach, R.J.; Leppert, M. A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nat. Genet., 1998, 18, 53-55.
    • (1998) Nat. Genet. , vol.18 , pp. 53-55
    • Charlier, C.1    Singh, N.A.2    Ryan, S.G.3    Lewis, T.B.4    Reus, B.E.5    Leach, R.J.6    Leppert, M.7
  • 176
    • 0032584595 scopus 로고    scopus 로고
    • Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy
    • Yang, W.P.; Levesque, P.C.; Little, W.A.; Conder, M.L.; Ramakrishnan, P.; Neubauer, M.G.; Blanar, M.A. Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy. J. Biol. Chem., 1998, 273, 19419-19423.
    • (1998) J. Biol. Chem. , vol.273 , pp. 19419-19423
    • Yang, W.P.1    Levesque, P.C.2    Little, W.A.3    Conder, M.L.4    Ramakrishnan, P.5    Neubauer, M.G.6    Blanar, M.A.7
  • 179
    • 79953064996 scopus 로고    scopus 로고
    • Does cure for pain REST on Kv7 channels?
    • Passmore, G.; Delmas, P. Does cure for pain REST on Kv7 channels? Pain, 2011, 152, 709-710.
    • (2011) Pain , vol.152 , pp. 709-710
    • Passmore, G.1    Delmas, P.2
  • 181
    • 77956685284 scopus 로고    scopus 로고
    • Flupirtine in pain management: Pharmacological properties and clinical use
    • Devulder, J. Flupirtine in pain management: pharmacological properties and clinical use. CNS Drugs, 2010, 24, 867-881.
    • (2010) CNS Drugs , vol.24 , pp. 867-881
    • Devulder, J.1
  • 182
    • 15744362456 scopus 로고    scopus 로고
    • Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties
    • Peretz, A.; Degani, N.; Nachman, R.; Uziyel, Y.; Gibor, G.; Shabat, D.; Attali, B. Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties. Mol. Pharmacol., 2005, 67, 1053-1066.
    • (2005) Mol. Pharmacol. , vol.67 , pp. 1053-1066
    • Peretz, A.1    Degani, N.2    Nachman, R.3    Uziyel, Y.4    Gibor, G.5    Shabat, D.6    Attali, B.7
  • 183
    • 70350452558 scopus 로고    scopus 로고
    • Differential effects of selective cyclooxygenase-2 inhibitors on vascular smooth muscle ion channels may account for differences in cardiovascular risk profiles
    • Brueggemann, L.I.; Mackie, A.R.; Mani, B.K.; Cribbs, L.L.; Byron, K.L. Differential effects of selective cyclooxygenase-2 inhibitors on vascular smooth muscle ion channels may account for differences in cardiovascular risk profiles. Mol. Pharmacol., 2009, 76, 1053-1061.
    • (2009) Mol. Pharmacol. , vol.76 , pp. 1053-1061
    • Brueggemann, L.I.1    Mackie, A.R.2    Mani, B.K.3    Cribbs, L.L.4    Byron, K.L.5
  • 186
    • 0035425653 scopus 로고    scopus 로고
    • Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine
    • Tatulian, L.; Delmas, P.; Abogadie, F.C.; Brown, D.A. Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine. J. Neurosci., 2001, 21, 5535-5545.
    • (2001) J. Neurosci. , vol.21 , pp. 5535-5545
    • Tatulian, L.1    Delmas, P.2    Abogadie, F.C.3    Brown, D.A.4
  • 187
    • 0033862433 scopus 로고    scopus 로고
    • Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels
    • Wickenden, A.D.; Yu, W.; Zou, A.; Jegla, T.; Wagoner, P.K. Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels. Mol. Pharmacol., 2000, 58, 591-600.
    • (2000) Mol. Pharmacol. , vol.58 , pp. 591-600
    • Wickenden, A.D.1    Yu, W.2    Zou, A.3    Jegla, T.4    Wagoner, P.K.5
  • 193
    • 34247202495 scopus 로고    scopus 로고
    • Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants
    • Xiong, Q.; Sun, H.; Li, M. Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants. Nat. Chem. Biol., 2007, 3, 287-296.
    • (2007) Nat. Chem. Biol. , vol.3 , pp. 287-296
    • Xiong, Q.1    Sun, H.2    Li, M.3
  • 195
    • 77956260084 scopus 로고    scopus 로고
    • Isoform-specific prolongation of Kv7 (KCNQ) potassium channel opening mediated by new molecular determinants for drug-channel interactions
    • Gao, Z.; Zhang, T.; Wu, M.; Xiong, Q.; Sun, H.; Zhang, Y.; Zu, L.; Wang, W.; Li, M. Isoform-specific prolongation of Kv7 (KCNQ) potassium channel opening mediated by new molecular determinants for drug-channel interactions. J. Biol. Chem., 2010, 285, 28322-28332.
    • (2010) J. Biol. Chem. , vol.285 , pp. 28322-28332
    • Gao, Z.1    Zhang, T.2    Wu, M.3    Xiong, Q.4    Sun, H.5    Zhang, Y.6    Zu, L.7    Wang, W.8    Li, M.9
  • 196
    • 15744400656 scopus 로고    scopus 로고
    • The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate
    • Wuttke, T.V.; Seebohm, G.; Bail, S.; Maljevic, S.; Lerche, H. The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate. Mol. Pharmacol., 2005, 67, 1009-1017.
    • (2005) Mol. Pharmacol. , vol.67 , pp. 1009-1017
    • Wuttke, T.V.1    Seebohm, G.2    Bail, S.3    Maljevic, S.4    Lerche, H.5
  • 198
    • 0038187795 scopus 로고    scopus 로고
    • Effect of the KCNQ potassium channel opener retigabine on single KCNQ2/3 channels expressed in CHO cells
    • Tatulian, L.; Brown, D.A. Effect of the KCNQ potassium channel opener retigabine on single KCNQ2/3 channels expressed in CHO cells. J. Physiol., 2003, 549, 57-63.
    • (2003) J. Physiol. , vol.549 , pp. 57-63
    • Tatulian, L.1    Brown, D.A.2
  • 199
    • 77955961747 scopus 로고    scopus 로고
    • Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats
    • Xu, W.; Wu, Y.; Bi, Y.; Tan, L.; Gan, Y.; Wang, K. Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats. Mol. Pain, 2010, 6, 49.
    • (2010) Mol. Pain , vol.6 , pp. 49
    • Xu, W.1    Wu, Y.2    Bi, Y.3    Tan, L.4    Gan, Y.5    Wang, K.6
  • 204
    • 0036210933 scopus 로고    scopus 로고
    • Effects of the anticonvulsant retigabine on cultured cortical neurons: Changes in electroresponsive properties and synaptic transmission
    • Otto, J.F.; Kimball, M.M.; Wilcox, K.S. Effects of the anticonvulsant retigabine on cultured cortical neurons: changes in electroresponsive properties and synaptic transmission. Mol. Pharmacol., 2002, 61, 921-927.
    • (2002) Mol. Pharmacol. , vol.61 , pp. 921-927
    • Otto, J.F.1    Kimball, M.M.2    Wilcox, K.S.3
  • 205
    • 70349329230 scopus 로고    scopus 로고
    • The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site
    • Padilla, K.; Wickenden, A.D.; Gerlach, A.C.; McCormack, K. The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site. Neurosci. Lett., 2009, 465, 138-142.
    • (2009) Neurosci. Lett. , vol.465 , pp. 138-142
    • Padilla, K.1    Wickenden, A.D.2    Gerlach, A.C.3    McCormack, K.4
  • 209
    • 79955881045 scopus 로고    scopus 로고
    • Activation of KCNQ2/3 potassium channels by novel pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives
    • Jia, C.; Qi, J.; Zhang, F.; Mi, Y.; Zhang, X.; Chen, X.; Liu, L.; Du, X.; Zhang, H. Activation of KCNQ2/3 potassium channels by novel pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives. Pharmacology, 2011, 87, 297-310.
    • (2011) Pharmacology , vol.87 , pp. 297-310
    • Jia, C.1    Qi, J.2    Zhang, F.3    Mi, Y.4    Zhang, X.5    Chen, X.6    Liu, L.7    Du, X.8    Zhang, H.9
  • 210
    • 79951610176 scopus 로고    scopus 로고
    • Synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/ KCNQ potassium channel activators
    • Qi, J.; Zhang, F.; Mi, Y.; Fu, Y.; Xu, W.; Zhang, D.; Wu, Y.; Du, X.; Jia, Q.; Wang, K.; Zhang, H. Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/ KCNQ potassium channel activators. Eur. J. Med. Chem., 2011, 46, 934-943.
    • (2011) Eur. J. Med. Chem. , vol.46 , pp. 934-943
    • Qi, J.1    Zhang, F.2    Mi, Y.3    Fu, Y.4    Xu, W.5    Zhang, D.6    Wu, Y.7    Du, X.8    Jia, Q.9    Wang, K.10    Zhang, H.D.11
  • 211
    • 84872963548 scopus 로고    scopus 로고
    • Modulation of Kv7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58
    • Zhang, F.; Mi, Y.; Qi, J.L.; Li, J.W.; Si, M.; Guan, B.C.; Du, X.N.; An, H.L.; Zhang, H.L. Modulation of Kv7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58. Br. J. Pharmacol., 2012, 168 (4),1030-42.
    • (2012) Br. J. Pharmacol. , vol.168 , Issue.4 , pp. 1030-1042
    • Zhang, F.1    Mi, Y.2    Qi, J.L.3    Li, J.W.4    Si, M.5    Guan, B.C.6    Du, X.N.7    An, H.L.8    Zhang, H.L.9
  • 214
    • 2642529579 scopus 로고    scopus 로고
    • + channels reveals the mechanism of augmentation by a cysteine-modifying reagent
    • + channels reveals the mechanism of augmentation by a cysteine-modifying reagent. J. Neurosci., 2004, 24, 5079-5090.
    • (2004) J. Neurosci. , vol.24 , pp. 5079-5090
    • Li, Y.1    Gamper, N.2    Shapiro, M.S.3
  • 216
    • 33749244927 scopus 로고    scopus 로고
    • Potassium Channels as Targets for the Management of Pain
    • Lawson, K. Potassium Channels as Targets for the Management of Pain. Central Nervous System Agents Med. Chem., 2006, 6, 119-128.
    • (2006) Central Nervous System Agents Med. Chem. , vol.6 , pp. 119-128
    • Lawson, K.1
  • 218
    • 79955127400 scopus 로고    scopus 로고
    • TRESK channel contribution to nociceptive sensory neurons excitability: Modulation by nerve injury
    • Tulleuda, A.; Cokic, B.; Callejo, G.; Saiani, B.; Serra, J.; Gasull, X. TRESK channel contribution to nociceptive sensory neurons excitability: modulation by nerve injury. Mol. Pain, 2011, 7, 30.
    • (2011) Mol. Pain , vol.7 , pp. 30
    • Tulleuda, A.1    Cokic, B.2    Callejo, G.3    Saiani, B.4    Serra, J.5    Gasull, X.6
  • 219
    • 33846212798 scopus 로고    scopus 로고
    • Opposing effects of spinal nerve ligation on calcium-activated potassium currents in axotomized and adjacent mammalian primary afferent neurons
    • Sarantopoulos, C.D.; McCallum, J.B.; Rigaud, M.; Fuchs, A.; Kwok, W.M.; Hogan, Q.H. Opposing effects of spinal nerve ligation on calcium-activated potassium currents in axotomized and adjacent mammalian primary afferent neurons. Brain Res., 2007, 1132, 84-99.
    • (2007) Brain Res , vol.1132 , pp. 84-99
    • Sarantopoulos, C.D.1    McCallum, J.B.2    Rigaud, M.3    Fuchs, A.4    Kwok, W.M.5    Hogan, Q.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.