Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine

Journal of Neuroscience

Volumn 21, Issue 15, 2001, Pages 5535-5545

  Tatulian, L ^a   Delmas, P ^a   Abogadie, F C ^a   Brown, D A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Anti convulsant; KCNQ channels; M channels; Potassium channels; Retigabine; Sympathetic neurons

Indexed keywords

RETIGABINE;

ANIMAL CELL; ANTICONVULSANT THERAPY; ARTICLE; CONVULSION; DRUG EFFECT; DRUG POTENCY; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL;

EID: 0035425653     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-15-05535.2001     Document Type: Article

References (39)

1. M-currents and other potassium currents in bullfrog sympathetic neurons
2. Ks Cardiac potassium current
3. 2+ current and M current in rat sympathetic neurons
4. A potassium channel mutation in neonatal human epilepsy
5. M-currents
6. A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family
7. G-proteins and G-protein subunits mediating cholinergic inhibition of N-type calcium currents in sympathetic neurons
8. 2+ current inhibition by neurotransmitters in rat sympathetic neurons
9. Calcium channel gating and modulation by transmitters depend on cellular compartmentalization
10. Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels
11. Neuronal KCNQ potassium channels: Physiology and role in disease
12. + channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway
13. KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness
14. h) contributes to resting potential in rat superior cervical sympathetic neurons
15. Effects of a cognition-enhancer, Linopirdine (DuP 996), on M-type potassium currents (IK(M)) and some other voltage- and ligand-gated membrane currents in rat sympathetic neurons
16. Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity
17. Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine
18. A
19. Control of M-current
20. 1-subtype
21. Agonist activation of transfected human M1 muscarinic acetylcholine receptors in CHO cells results in downregulation of both the receptor and the α subunit of the G-protein Gq
22. Low access resistance perforated patch recordings using amphotericin B
23. + channels and the molecular pathogenesis of epilepsy: Implications for therapy
24. D-23129, a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures
25. + channels in neuronal cells
26. The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells transfected with human KCNQ2/3 subunits
27. Coassembly of KvLQT1 and mink (IsK) proteins to form cardiac I(Ks) potassium channel
28. KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents
29. M-channel gating and simulation
30. Closure of potassium M-channels by muscarinic acetylcholine-receptor stimulants requires a diffusible messenger
31. + channel subunit, erg1 and KCNQ2/3, contribute to the M-like current in a mammalian neuronal cell
32. Single-channel analysis of KCNQ2/3 potassium currents expressed in mammalian (CHO) cells
33. 1 muscarinic acetylcholine receptors
34. + channels that underlie the neuronal M current
35. A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns
36. D-23129: A potent anticonvulsant in the amygdala kindling model of complex partial seizures
37. KCNQ2 and KCNQ3 potassium channel subunits: Molecular correlates of the M-channel
38. Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/3 potassium channels
39. Characterization of KCNQ3/5 potassium channels expressed in mammalian cells