(S,E)-N-[1-(3-Heteroarylphenyl)ethyl]-3-(2-fluorophenyl)acrylamides: Synthesis and KCNQ2 potassium channel opener activity

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 2, 2005, Pages 363-366

  L'Heureux, Alexandre ^a   Martel, Alain ^a   He, Huan ^a   Chen, Jie ^a   Sun, Li Qiang ^a   Starrett, John E ^a   Natale, Joanne ^a   Dworetzky, Steven I ^a   Knox, Ronald J ^a   Harden, David G ^a   Weaver, David ^a   Thompson, Mark W ^a   Wu, Yong Jin ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Acrylamides; KCNQ2

Indexed keywords

ACRYLAMIDE DERIVATIVE; N 1 [3 (1H PYRAZOL 1 YL)PHENYL]ETHYL 3 (2 FLUOROPHENYL)ACRYLAMIDE; N 1 [3 (6 FLUOROPYRIDIN 3 YL)PHENYL]ETHYL 3 (2 FLUOROPHENYL)ACRYLAMIDE; N [(1 BENZO[D][1,3]DIOXOL 5 YL)ETHYL] 3 (2 CHLOROPHENYL)ACRYLAMIDE; N [1 (3 MORPHOLINOPHENYL)ETHYL] 3 PHENYLACRYLAMIDE; N [1 (4 CYCLOPROPYLMETHYL 3,4 DIHYDRO 2H BENZ[1,4]OXAZIN 6 YL)ETHYL] 3 (2 FLUOROPHENYL)ACRYLAMIDE; POTASSIUM CHANNEL; POTASSIUM CHANNEL KCNQ2; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; EMBRYO; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; SUBSTITUTION REACTION;

ACRYLAMIDES; ACTION POTENTIALS; ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KCNQ2 POTASSIUM CHANNEL; MOLECULAR STRUCTURE; POTASSIUM CHANNELS, VOLTAGE-GATED;

EID: 10644255478     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.10.065     Document Type: Article

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