Isoform-specific prolongation of Kv7 (KCNQ) potassium channel opening mediated by new molecular determinants for drug-channel interactions

Journal of Biological Chemistry

Volumn 285, Issue 36, 2010, Pages 28322-28332

  Gao, Zhaobing ^a,c   Zhang, Tangzhi ^b   Wu, Meng ^a   Xiong, Qiaojie ^a,d   Sun, Haiyan ^a,e   Zhang, Yinan ^b   Zu, Liansuo ^b   Wang, Wei ^a,b   Li, Min ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^d Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^e Corning Inc ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION SPECTROSCOPY; ATOMIC ABSORPTION SPECTROMETRY; DRUG INTERACTIONS; POTASSIUM; PROTEINS; RUBIDIUM;

CHANNEL INTERACTIONS; CHANNEL PROTEINS; CLINICAL USE; ISOFORMS; KEY DETERMINANTS; MODE OF ACTION; MOLECULAR DETERMINANTS; NEW STRUCTURES; POTASSIUM CHANNELS;

RUBIDIUM COMPOUNDS;

POTASSIUM CHANNEL KCNQ2; RETIGABINE; RUBIDIUM; BENZAMIDE DERIVATIVE; DRUG; ISOPROTEIN; POTASSIUM CHANNEL KCNQ;

ANIMAL CELL; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; CHANNEL GATING; CONTROLLED STUDY; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SENSITIVITY; DRUG SPECIFICITY; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMISTRY; CHO CELL LINE; CRICETULUS; DRUG EFFECTS; ENZYME SPECIFICITY; HAMSTER; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE;

ANIMALS; BENZAMIDES; CHO CELLS; CRICETINAE; CRICETULUS; DRUG EVALUATION, PRECLINICAL; ION CHANNEL GATING; KCNQ POTASSIUM CHANNELS; PHARMACEUTICAL PREPARATIONS; PROTEIN ISOFORMS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 77956260084     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.116392     Document Type: Article

References (43)

1. Ashcroft, F. M. (2006) Nature 440, 440-447
2. Doyle, D. A. (2004) Trends Neurosci. 27, 298-302
3. Sigworth, F. J. (1994) Q. Rev. Biophys. 27, 1-40
4. Bezanilla, F., and Stefani, E. (1994) Annu. Rev. Biophys. Biomol. Struct. 23, 819-846
5. Horrigan, F. T., and Aldrich, R. W. (2002) J. Gen. Physiol. 120, 267-305
6. Rae, J. L., Dewey, J., Rae, J. S., and Cooper, K. (1990) Curr. Eye Res. 9, 847-861
7. Lawson, K., and McKay, N. G. (2006) Curr. Pharm. Des. 12, 459-470
8. Surti, T. S., and Jan, L. Y. (2005) Curr. Opin. Investig. Drugs 6, 704-711
9. Singh, N. A., Westenskow, P., Charlier, C., Pappas, C., Leslie, J., Dillon, J., Anderson, V. E., Sanguinetti, M. C., and Leppert, M. F. (2003) Brain 126, 2726-2737
10. Xiong, Q., Gao, Z., Wang, W., and Li, M. (2008) Trends Pharmacol. Sci. 29, 99-107
11. Redrobe, J. P., and Nielsen, A. N. (2009) Behav. Brain Res. 198, 481-485
12. Roeloffs, R., Wickenden, A. D., Crean, C., Werness, S., McNaughton- Smith, G., Stables, J., McNamara, J. O., Ghodadra, N., and Rigdon, G. C. (2008) J. Pharmacol. Exp. Ther. 326, 818-828
13. Rogawski, M. A. (2000) Trends Neurosci. 23, 393-398
14. Wickenden, A. D., Krajewski, J. L., London, B., Wagoner, P. K., Wilson, W. A., Clark, S., Roeloffs, R., McNaughton-Smith, G., and Rigdon, G. C. (2008) Mol. Pharmacol. 73, 977-986
15. Brown, D. A. (2008) J. Physiol. 586, 1781-1783
16. Lange, W., Geissendörfer, J., Schenzer, A., Grötzinger, J., Seebohm, G., Friedrich, T., and Schwake, M. (2009) Mol. Pharmacol. 75, 272-280
17. Kubisch, C., Schroeder, B. C., Friedrich, T., Lütjohann, B., El-Amraoui, A., Marlin, S., Petit, C., and Jentsch, T. J. (1999) Cell 96, 437-446
18. Schroeder, B. C., Hechenberger, M., Weinreich, F., Kubisch, C., and Jentsch, T. J. (2000) J. Biol. Chem. 275, 24089-24095
19. Shapiro, M. S., Roche, J. P., Kaftan, E. J., Cruzblanca, H., Mackie, K., and Hille, B. (2000) J. Neurosci. 20, 1710-1721
20. Wang, H. S., Brown, B. S., McKinnon, D., and Cohen, I. S. (2000) Mol. Pharmacol. 57, 1218-1223
21. Barhanin, J., Lesage, F., Guillemare, E., Fink, M., Lazdunski, M., and Romey, G. (1996) Nature 384, 78-80
22. Sanguinetti, M. C., Curran, M. E., Zou, A., Shen, J., Spector, P. S., Atkinson, D. L., and Keating, M. T. (1996) Nature 384, 80-83
23. Wang, H. S., Pan, Z., Shi, W., Brown, B. S., Wymore, R. S., Cohen, I. S., Dixon, J. E., and McKinnon, D. (1998) Science 282, 1890-1893
24. Schwarz, J. R., Glassmeier, G., Cooper, E. C., Kao, T. C., Nodera, H., Tabuena, D., Kaji, R., and Bostock, H. (2006) J. Physiol. 573, 17-34
25. Dunlop, J., Bowlby, M., Peri, R., Vasilyev, D., and Arias, R. (2008) Nat. Rev. Drug Discov. 7, 358-368
26. Xu, J., Wang, X., Ensign, B., Li, M., Wu, L., Guia, A., and Xu, J. (2001) Drug Discov. Today 6, 1278-1287
27. Terstappen, G. C. (1999) Anal. Biochem. 272, 149-155
28. Weaver, C. D., Harden, D., Dworetzky, S. I., Robertson, B., and Knox, R. J. (2004) J. Biomol. Screen 9, 671-677
29. Sun, H., Liu, X., Xiong, Q., Shikano, S., and Li, M. (2006) J. Biol. Chem. 281, 5877-5884
30. Sun, H., Shikano, S., Xiong, Q., and Li, M. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 16964-16969
31. Xiong, Q., Sun, H., and Li, M. (2007) Nat. Chem. Biol. 3, 287-296
32. Wuttke, T. V., Seebohm, G., Bail, S., Maljevic, S., and Lerche, H. (2005) Mol. Pharmacol. 67, 1009-1017
33. Schenzer, A., Friedrich, T., Pusch, M., Saftig, P., Jentsch, T. J., Grötzinger, J., and Schwake, M. (2005) J. Neurosci. 25, 5051-5060
34. Topliss, J. G. (1972) J. Med. Chem. 15, 1006-1011
35. Topliss, J. G. (1977) J. Med. Chem. 20, 463-469
36. Tatulian, L., Delmas, P., Abogadie, F. C., and Brown, D. A. (2001) J. Neurosci. 21, 5535-5545
37. Seebohm, G., Pusch, M., Chen, J., and Sanguinetti, M. C. (2003) Circ. Res. 93, 941-947
38. Seebohm, G., Strutz-Seebohm, N., Ureche, O. N., Baltaev, R., Lampert, A., Kornichuk, G., Kamiya, K., Wuttke, T. V., Lerche, H., Sanguinetti, M. C., and Lang, F. (2006) Biophys. J. 90, 2235-2244
39. Webster, S. M., Del Camino, D., Dekker, J. P., and Yellen, G. (2004) Nature 428, 864-868
40. Jiang, Y., Lee, A., Chen, J., Cadene, M., Chait, B. T., and MacKinnon, R. (2002) Nature 417, 515-522
41. Jiang, Y., Lee, A., Chen, J., Cadene, M., Chait, B. T., and MacKinnon, R. (2002) Nature 417, 523-526
42. Müller, K., Faeh, C., and Diederich, F. (2007) Science 317, 1881-1886
43. Padilla, K., Wickenden, A. D., Gerlach, A. C., and McCormack, K. (2009) Neurosci. Lett. 465, 138-142