Suppressed Ca2+/CaM/CaMKII-dependent KATP channel activity in primary afferent neurons mediates hyperalgesia after axotomy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 21, 2009, Pages 8725-8730

  Kawano, Takashi ^a   Zoga, Vasiliki ^a   Gemes, Geza ^a,b   McCallum, J Bruce ^a   Wu, Hsiang En ^a   Pravdic, Danijel ^a   Liang, Mei Ying ^a   Kwok, Wai Meng ^a   Hogan, Quinn ^a   Sarantopoulos, Constantine ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Calcium; Calmodulin; Dorsal root ganglia; Neuropathic pain; Potassium channels

Indexed keywords

ADENOSINE TRIPHOSPHATE; AUTOCAMTIDE 2 RELATED INHIBITORY PEPTIDE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; CALMODULIN; DIAZOXIDE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.1; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; IONOMYCIN; IONOPHORE; PEPTIDES AND PROTEINS; POTASSIUM CHANNEL; SULFONYLUREA RECEPTOR 1; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CALCIUM;

AMPEROMETRY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HYPERALGESIA; HYPERPOLARIZATION; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE STEADY POTENTIAL; MYRISTYLATION; NERVE EXCITABILITY; NERVE FIBER TRANSECTION; NERVE INJURY; NERVE LIGATION; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSORY NERVE; SPINAL GANGLION; SULFONYLUREA RECEPTOR 2; ANIMAL; CELL FREE SYSTEM; ELECTROPHYSIOLOGY; METABOLISM; PATCH CLAMP; SENSORY NERVE CELL; SPRAGUE DAWLEY RAT;

ANIMALIA; RATTUS;

ANIMALS; AXOTOMY; CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CALMODULIN; CELL-FREE SYSTEM; ELECTROPHYSIOLOGICAL PHENOMENA; GANGLIA, SPINAL; HYPERALGESIA; IONOMYCIN; KATP CHANNELS; MALE; NEURONS, AFFERENT; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 66649097000     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0901815106     Document Type: Article

References (31)

1. Gold MS (2000) Spinal nerve ligation: What to blame for the pain and why. Pain 84:117-120. (Pubitemid 30074212)
2. Bridges D, Thompson SW, Rice AS (2001) Mechanisms of neuropathic pain. Br J Anaesth 87:12-26. (Pubitemid 32631672)
3. Fuchs A, Lirk P, Stucky C, Abram SE, Hogan QH (2005) Painful nerve injury decreases resting cytosolic calcium concentrations in sensory neurons of rats. Anesthesiology 102:1217-1225. (Pubitemid 40753579)
4. 2+ signal in axotomized sensory neurons of rats. Anesthesiology 107:106-116.
5. Sarantopoulos C, McCallum B, Sapunar D, Kwok WM, Hogan Q (2003) ATP-sensitive potassium channels in rat primary afferent neurons: The effect of neuropathic injury and gabapentin. Neurosci Lett 343:185-189. (Pubitemid 38365981)
6. Sarantopoulos C, McCallum B, Liang M, Kwok WM, Hogan Q (2008) Electrophysiological parameters specifically mediating neuropathic pain behavior after spinal nerve ligation in the rat. Eur J Anaesthesiol 25:6.
7. + channel of rat ventricular myocytes. Biochim Biophys Acta 943:297-304.
8. + channel in mouse pancreatic beta-cells. Exp Physiol 86:331-339.
9. Ghosh A, Greenberg ME (1995) Calcium signaling in neurons: Molecular mechanisms and cellular consequences. Science 268:239-247.
10. 2+/calmodulin-dependent protein kinase II bound to the C-terminal domain. Proc Natl Acad Sci USA 105:341-346.
11. 2+/calmodulin-dependent protein kinase in rat brain. J Neurosci 5:3270-3277.
12. 2+/calmodulin-dependent protein kinase II. Biochem J 364:593-611.
13. Hunter T, Schulman H (2005) CaMKII structure-an elegant design. Cell 123:765-767.
14. Hanson PI, Meyer T, Stryer L, Schulman H (1994) Dual role of calmodulin in autophosphorylation of multifunctional CaM kinase may underlie decoding of calcium signals. Neuron 12:943-956. (Pubitemid 24178190)
15. 2+-calmodulin-dependent protein kinase II in dorsal root ganglion neurons. J Neurosci 21:6694-6705.
16. Liss B, Roeper J (2001) Molecular physiology of neuronal K-ATP channels. Mol Membr Biol 18:117-127. (Pubitemid 32666791)
17. Hogan Q, Sapunar D, Modric-Jednacak K, McCallum JB (2004) Detection of neuropathic pain in a rat model of peripheral nerve injury. Anesthesiology 101:476-487. (Pubitemid 38988505)
18. Babenko AP, Aguilar-Bryan L, Bryan J (1998) A view of sur/KIR6.X, KATP channels. Annu Rev Physiol 60:667-687. (Pubitemid 28157891)
19. 2+ influx by stimulating store-regulated cation entry and not by a direct action at the plasma membrane. Biochem J 300:665-672.
20. Carlton SM, Hargett GL (2002) Stereological analysis of Ca(2+)/calmodulin-dependent protein kinase II alpha-containing dorsal root ganglion neurons in the rat: Colocalization with isolectin Griffonia simplicifolia, calcitonin gene-related peptide, or vanilloid receptor 1. J Comp Neurol 448:102-110. (Pubitemid 34507500)
21. Sarantopoulos C, McCallum JB, Kwok WM, Hogan Q (2004) Beta-escin diminishes voltage-gated calcium current rundown in perforated patch-clamp recordings from rat primary afferent neurons. J Neurosci Methods 139:61-68. (Pubitemid 39194849)
22. Griffith LC (2004) Regulation of calcium/calmodulin-dependent protein kinase II activation by intramolecular and intermolecular interactions. J Neurosci 24:8394-8398. (Pubitemid 39313759)
23. 2+/CaM-responsive pool of CaMKII by scaffold-dependent autophosphorylation. Neuron 40:1185-1197.
24. Griffith LC (2008) CaMKII: New tricks for an old dog. Cell 133:397-399.
25. Nelson AB, Gittis AH, du Lac S (2005) Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons. Neuron 46:623-631.
26. 2+ ions inactivate and modify ATP-sensitive potassium channels in adult mouse skeletal muscle. Biochim Biophys Acta 1190:257-263.
27. Yamamoto S, Tanaka E, Higashi H (1997) Mediation by intracellular calcium-dependent signals of hypoxic hyperpolarization in rat hippocampal CA1 neurons in vitro. J Neurophysiol 77:386-392. (Pubitemid 27053792)
28. Tandrup T, Woolf CJ, Coggeshall RE (2000) Delayed loss of small dorsal root ganglion cells after transection of the rat sciatic nerve. J Comp Neurol 422:172-180. (Pubitemid 30390162)
29. Sachs D, Cunha FQ, Ferreira SH (2004) Peripheral analgesic blockade of hypernociception: Activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway. Proc Natl Acad Sci USA 101:3680-3685. (Pubitemid 38338254)
30. Sawynok J, Esser MJ, Reid AR (1999) Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. Pain 82:149-158. (Pubitemid 29317527)
31. Tiraboschi E, et al. (2004) Antidepressants activate CaMKII in neuron cell body by Thr286 phosphorylation. Neuroreport 15:2393-2396. (Pubitemid 39488926)