Voltage-gated potassium channels in IB4-positive colonic sensory neurons mediate visceral hypersensitivity in the rat

American Journal of Gastroenterology

Volumn 104, Issue 8, 2009, Pages 2014-2027

  Qian, Ai Hua ^a   Liu, Xin Qiu ^b   Yao, Wei Yan ^a   Wang, Hong Yu ^a   Sun, Jing ^a   Zhou, Lin ^a   Yuan, Yao Zong ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1,1' DIOLEOYL 3,3,3',3 TETRAMETHYLINDOCARBOCYANINE METHANESULFONATE; ACETIC ACID; FLUORESCENT DYE; POTASSIUM CHANNEL KV1.4; POTASSIUM CHANNEL KV3.4; POTASSIUM CHANNEL KV4.3; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FLUORESCENCE ANALYSIS; HYPERALGESIA; IRRITABLE COLON; MALE; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSORY NERVE CELL; SPINAL GANGLION; WESTERN BLOTTING;

ANIMALS; COLON; DISEASE MODELS, ANIMAL; GLYCOPROTEINS; IRRITABLE BOWEL SYNDROME; LECTINS; POTASSIUM CHANNELS, VOLTAGE-GATED; RATS; SENSORY RECEPTOR CELLS; VISCERA;

EID: 68349148357     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2009.227     Document Type: Article

References (33)

1. Lembo AJ, Drossman DA. Contemporary diagnosis and management of irritable bowel syndrome. In Handbooks in Healthcare. Newtown, PA; Handbooks in Healthcare Co., 2002, 43-54.
2. Ritchie R. Pain from distention of the pelvic colon by inflating a balloon in the irritable colon syndrome. Gut 1973;14:125-32.
3. Quigley EM. Disturbances of motility and visceral hypersensitivity in irritable bowel syndrome: biological markers or epiphenomenon. Gastroenterol Clin North Am 2005;34:221-33.
4. Al-Chaer ED, Kawasaki M, Pasricha PJ. A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development. Gastroenterology 2000;119:1276-85.
5. Coutinho SV, Plotsky PM, Sablad M et al. Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat. Am J Physiol 2002;282:307-16.
6. Mayer EA, Collins SM. Evolving pathophysiological models of functional gastrointestinal disorders. Gastroenterology 2002;122:2032-48.
7. Molliver DC, Radeke MJ, Feinstein SC et al. Presence or absence of TrkA protein distinguishes subsets of small sensory neurons with unique cytochemical characteristics and dorsal horn projections. J Comp Neurol 1995;361:404-16.
8. Gerke MB, Plenderleith MB. Ultrastructural analysis of the central terminals of primary sensory neurons labeled by transganglionic transport of bandeiraea simplicifolia I-isolectin B4. Neuroscience 2004;127:165-75.
9. Cheryl L, Stucky, Gary R et al. Isolectin B4-positive and -negative nociceptors are functionally distinct. J Neurosci 1999;19:6497-505.
10. Vydyanathan A, Wu ZZ, Chen SR et al. A-type voltage-gated K + currents influence firing properties of isolectin B4-positive but not isolectin B4. negative primary sensory neurons. J Neurophysiol 2005;93:3401-9.
11. Wu ZZ, Pan HL. High voltage-activated Ca2+ channel currents in isolectin B4-positive and -negative small dorsal root ganglion neurons of rats. Neurosci Lett 2004;368:96-101.
12. Snider WD, McMahon SB. Tackling pain at the source: new ideas about nociceptors. Neuron 1998;20:629-32.
13. Koltzenburg M. The changing sensitivity in the life of the nociceptor. Pain 1999;6:93-102.
14. Bennett DLH, Averill S, Clary DO et al. Postnatal changes in the expression of the trkA high affinity NGF receptor in primary sensory neurons. Eur J Neurosci 1996;8:2204-8.
15. Akins PT, McCleskey EW. Characterization of potassium currents in adult rat sensory neurons and modulation by opioids and cyclic AMP. Neuroscience 1993;56:759-69.
16. Gold MS, Shuster MJ, Levine JD. Characterization of six voltage-gated K + currents in adult rat sensory neurons. J Neurophysiol 1996;75:2629-46.
17. Stewart T, Beyak MJ, Vanner S. Ileitis modulates potassium and sodium currents in guinea pig dorsal root ganglia sensory neurons. J Physiol 2003;552:797-807.
18. Dang K, Bielefeldt K, Gebhart GF. Gastric ulcers reduce A-type potassium currents in rat gastric sensory ganglion neurons. Am J Physiol Gastrointest Liver Physiol 2004; 286. G573-9.
19. Xu GY, Winston JH, Shenoy M et al. Enhanced excitability and suppression of A-type K + current of pancreas-specific afferent neurons in a rat model of chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol 2006; 291. G424-31.
20. Yoshimura N, de Groat WC. Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation. J Neurosci 1999;19:4644-53.
21. Appleyard CB, Wallace JL. Reactivation of hapten-induced colitis and its prevention by anti-inflammatory drugs. Am J Physiol 1995; 269. G119-25.
22. Miranda A, Nordstrom E, Mannem A et al. The role of TRPV1 in mechanical and chemical visceral hyperalgesia following experimental colitis. Neuroscience 2007;148:1021-32.
23. Xu GY, Winston J, Shenoy M et al. Transient receptor potential vanilloid 1 mediates hyperalgesia and is upregulated in rats with chronic pancreatitis. Gastroenterology 2007;133:1282-92.
24. Everill B, Rizzo MA, Kocsis JD. Morphologically identified cutaneous afferent DRG neurons express three different potassium currents in varying proportions. J Neurophysiol 1998;79:1814-24.
25. Winston J, Shenoy M, Medley D et al. The vanilloid receptor initiates and maintains colonic hypersensitivity induced by neonatal colon irritation in rats. Gastroenterology 2007;132:615-27.
26. Mayer EA, Berman S, Chang L, Naliboff BD. Sex-based differences in gastrointestinal pain. Euro J Pain 2004;8:451-63.
27. Robinson DR, McNaughton PA, Evans ML et al. Characterization of the primary spinal afferent innervation of the mouse colon using retrograde labeling. Neurogastroenterol Motil. 2004;16:113-24.
28. Berman S, Munakata J, Naliboff BD et al. Interactions between multiple phosphorylation sites in the inactivation particle of a K+ channel. J Gen Physiol 1998;112:71-84.
29. Sergeant GP, Ohya S, Reihill JA et al. Regulation of Kv4.3 currents by Ca2+/calmodulin-dependent protein kinase II. Am J Physiol Cell Physiol 2005; 288. C304-13.
30. Chien LY, Cheng JK, Chu D et al. Reduced Expression of A-Type Potassium Channels in Primary Sensory Neurons Induces Mechanical Hypersensitivity. J Neurosci 2007;27:9855-65.
31. Xu GY, Shenoy M, Winston JH et al. P2X receptor-mediated visceral hyperalgesia in a rat model of chronic visceral hypersensitivity. Gut 2008;57:1230-7.
32. Chen CC, Akopian AN, Sivilotti L et al. A P2X purinoceptor expressed by a subset of sensory neurons. Nature 1995;377:428-31.
33. Nishiguchi J, Sasaki K, Seki S et al. Effects of isolectin B4-conjugated saporin, a targeting cytotoxin, on bladder overactivity induced by bladder irritation. Eur J Neurosci 2004;20:474-82.