The use of plant-derived bioactive compounds to target cancer stem cells and modulate tumor microenvironment

Food and Chemical Toxicology

Volumn 75, Issue , 2015, Pages 58-70

  Pistollato, Francesca ^a,b   Giampieri, Francesca ^a,c   Battino, Maurizio ^a,c  

^a Universidad Europea del Atlántico   (Spain)

^b Area de Nutrición y Salud Universidad Internacional Iberoamericana UNINI   (Mexico)

^c UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Acidic pH; Cancer stem cells; Hypoxia; Inflammation; Plant compounds; Tumor microenvironment

Indexed keywords

ALPHA TOCOPHEROL; ANNONA MURICATA EXTRACT; BETA CAROTENE; EPIGALLOCATECHIN; GENISTEIN; GLUCOSINOLATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYPOXIA INDUCIBLE FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOTHIOCYANIC ACID DERIVATIVE; JASMONIC ACID METHYL ESTER; LACTIC ACID; LUPEOL; MACLURA POMIFERA EXTRACT; MULBERRY EXTRACT; MYRICETIN; OLIVE OIL; PENTOSE PHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLANT EXTRACT; POMEGRANATE EXTRACT; QUERCETIN; REACTIVE OXYGEN METABOLITE; SILIBININ; SOYBEAN PROTEIN; STAT3 PROTEIN; STILBENE; SULPHORAPHANE; UNCLASSIFIED DRUG; UVOMORULIN; ANTINEOPLASTIC AGENT; PLANT MEDICINAL PRODUCT;

ANNONA MURICATA; APOPTOSIS; CANCER RISK; CANCER STEM CELL; CELL DIFFERENTIATION; CELL GROWTH; CELL METABOLISM; CELL PROLIFERATION; CELL RENEWAL; CELL VIABILITY; CITRIC ACID CYCLE; DIETARY INTAKE; EPITHELIAL MESENCHYMAL TRANSITION; FRUIT; GENE EXPRESSION; GLUCOSE TRANSPORT; GLYCOLYSIS; HIF 1 GENE; HUMAN; MACLURA POMIFERA; MULBERRY; NONHUMAN; PH; PLANT LEAF; POMEGRANATE; PROTEIN EXPRESSION; PROTEIN STABILITY; REVIEW; RISK REDUCTION; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT; UPREGULATION; ANIMAL; CELL HYPOXIA; DRUG DELIVERY SYSTEM; DRUG EFFECTS; DRUG SCREENING; NEOPLASM RECURRENCE, LOCAL; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL DIFFERENTIATION; CELL HYPOXIA; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DELIVERY SYSTEMS; HUMANS; NEOPLASM RECURRENCE, LOCAL; NEOPLASTIC STEM CELLS; PHYTOCHEMICALS; TUMOR MICROENVIRONMENT; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84911414510     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2014.11.004     Document Type: Review

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