메뉴 건너뛰기




Volumn 34, Issue 12, 2013, Pages 2814-2822

Pomegranate polyphenolics suppressed azoxymethane-induced colorectal aberrant crypt foci and inflammation: Possible role of miR-126/VCAM-1 and miR-126/PI3K/ AKT/mTOR

Author keywords

[No Author keywords available]

Indexed keywords

ANTAGOMIR; ANTHOCYANIN; AZOXYMETHANE; CYCLOOXYGENASE 2; ELLAGITANNIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MICRORNA 126; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; POLYPHENOL DERIVATIVE; POMEGRANATE EXTRACT; PROTEIN KINASE B; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN;

EID: 84888988840     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt295     Document Type: Article
Times cited : (102)

References (47)
  • 1
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • Siegel,R. et al. (2011) Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. Cancer J. Clin., 61, 212-236.
    • (2011) Cancer J. Clin. , vol.61 , pp. 212-236
    • Siegel, R.1
  • 2
    • 76249088651 scopus 로고    scopus 로고
    • The signal pathways in azoxymethane-induced colon cancer and preventive implications
    • Chen,J. et al. (2009) The signal pathways in azoxymethane-induced colon cancer and preventive implications. Cancer Biol. Ther., 8, 1313-1317.
    • (2009) Cancer Biol. Ther. , vol.8 , pp. 1313-1317
    • Chen, J.1
  • 3
    • 0026726789 scopus 로고
    • Primary prevention of colorectal cancer through dietary modification
    • Vargas,P.A. et al. (1992) Primary prevention of colorectal cancer through dietary modification. Cancer, 70 (suppl. 5), 1229-1235.
    • (1992) Cancer , vol.70 , Issue.SUPPL. 5 , pp. 1229-1235
    • Vargas, P.A.1
  • 4
    • 79952756381 scopus 로고    scopus 로고
    • Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway
    • Chiou,Y.S. et al. (2011) Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway. J. Agric. Food Chem., 59, 2725-2733.
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 2725-2733
    • Chiou, Y.S.1
  • 5
    • 77954355506 scopus 로고    scopus 로고
    • Dietary intake of pterostilbene, a constituent of blueberries, inhibits the beta-catenin/p65 downstream signaling pathway and colon carcinogenesis in rats
    • Paul,S. et al. (2010) Dietary intake of pterostilbene, a constituent of blueberries, inhibits the beta-catenin/p65 downstream signaling pathway and colon carcinogenesis in rats. Carcinogenesis, 31, 1272-1278.
    • (2010) Carcinogenesis , vol.31 , pp. 1272-1278
    • Paul, S.1
  • 6
    • 38849109982 scopus 로고    scopus 로고
    • Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats
    • Xiao,H. et al. (2008) Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats. Carcinogenesis, 29, 113-119.
    • (2008) Carcinogenesis , vol.29 , pp. 113-119
    • Xiao, H.1
  • 7
    • 11144335895 scopus 로고    scopus 로고
    • Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice
    • Afaq,F. et al. (2005) Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice. Int. J. Cancer, 113, 423-433.
    • (2005) Int. J. Cancer , vol.113 , pp. 423-433
    • Afaq, F.1
  • 8
    • 20144381777 scopus 로고    scopus 로고
    • In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice
    • Seeram,N.P. et al. (2005) In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J. Nutr. Biochem., 16, 360-367.
    • (2005) J. Nutr. Biochem. , vol.16 , pp. 360-367
    • Seeram, N.P.1
  • 9
    • 26844566479 scopus 로고    scopus 로고
    • Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer
    • Malik,A. et al. (2005) Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proc. Natl Acad. Sci. USA, 102, 14813-14818.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 14813-14818
    • Malik, A.1
  • 10
    • 84867885344 scopus 로고    scopus 로고
    • Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation
    • Banerjee,N. et al. (2012) Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation. Breast Cancer Res. Treat., 136, 21-34.
    • (2012) Breast Cancer Res. Treat. , vol.136 , pp. 21-34
    • Banerjee, N.1
  • 11
    • 0344845219 scopus 로고    scopus 로고
    • Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice
    • Hora,J.J. et al. (2003) Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice. J. Med. Food, 6, 157-161.
    • (2003) J. Med. Food , vol.6 , pp. 157-161
    • Hora, J.J.1
  • 12
    • 79958214540 scopus 로고    scopus 로고
    • Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms
    • Bishayee,A. et al. (2011) Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms. Carcinogenesis, 32, 888-896.
    • (2011) Carcinogenesis , vol.32 , pp. 888-896
    • Bishayee, A.1
  • 13
    • 33244454723 scopus 로고    scopus 로고
    • Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells
    • Adams,L.S. et al. (2006) Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. J. Agric. Food Chem., 54, 980-985.
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 980-985
    • Adams, L.S.1
  • 14
    • 77952537236 scopus 로고    scopus 로고
    • Cancer chemoprevention by pomegranate: laboratory and clinical evidence
    • Adhami,V.M. et al. (2009) Cancer chemoprevention by pomegranate: laboratory and clinical evidence. Nutr. Cancer, 61, 811-815.
    • (2009) Nutr. Cancer , vol.61 , pp. 811-815
    • Adhami, V.M.1
  • 15
    • 3042551491 scopus 로고    scopus 로고
    • Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats
    • Kohno,H. et al. (2004) Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. Cancer Sci., 95, 481-486.
    • (2004) Cancer Sci. , vol.95 , pp. 481-486
    • Kohno, H.1
  • 16
    • 47549111139 scopus 로고    scopus 로고
    • Therapeutic applications of pomegranate (Punica granatum L.): a review
    • Jurenka,J.S. (2008) Therapeutic applications of pomegranate (Punica granatum L.): a review. Altern. Med. Rev., 13, 128-144.
    • (2008) Altern. Med. Rev. , vol.13 , pp. 128-144
    • Jurenka, J.S.1
  • 17
    • 1842423822 scopus 로고    scopus 로고
    • Differentiation-promoting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells
    • Kawaii,S. et al. (2004) Differentiation-promoting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells. J. Med. Food, 7, 13-18.
    • (2004) J. Med. Food , vol.7 , pp. 13-18
    • Kawaii, S.1
  • 18
    • 0035200234 scopus 로고    scopus 로고
    • Serum levels of E-selectin, ICAM-1 and VCAM-1 in colorectal cancer patients: correlations with clinicopathological features, patient survival and tumour surgery
    • Alexiou,D. et al. (2001) Serum levels of E-selectin, ICAM-1 and VCAM-1 in colorectal cancer patients: correlations with clinicopathological features, patient survival and tumour surgery. Eur. J. Cancer, 37, 2392-2397.
    • (2001) Eur. J. Cancer , vol.37 , pp. 2392-2397
    • Alexiou, D.1
  • 19
    • 4344658425 scopus 로고    scopus 로고
    • Endoglin (CD105) and vascular endothelial growth factor as prognostic markers in colorectal cancer
    • Saad,R.S. et al. (2004) Endoglin (CD105) and vascular endothelial growth factor as prognostic markers in colorectal cancer. Mod. Pathol., 17, 197-203.
    • (2004) Mod. Pathol. , vol.17 , pp. 197-203
    • Saad, R.S.1
  • 20
    • 84863686277 scopus 로고    scopus 로고
    • Red wine polyphenolics reduce the expression of inflammation markers in human colon-derived CCD-18Co myofibroblast cells: potential role of microRNA-126
    • Angel-Morales,G. et al. (2012) Red wine polyphenolics reduce the expression of inflammation markers in human colon-derived CCD-18Co myofibroblast cells: potential role of microRNA-126. Food Funct., 3, 745-752.
    • (2012) Food Funct. , vol.3 , pp. 745-752
    • Angel-Morales, G.1
  • 21
    • 34248215034 scopus 로고    scopus 로고
    • Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice
    • Khan,N. et al. (2007) Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Cancer Res., 67, 3475-3482.
    • (2007) Cancer Res. , vol.67 , pp. 3475-3482
    • Khan, N.1
  • 22
    • 33845612815 scopus 로고    scopus 로고
    • Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice
    • Khan,N. et al. (2007) Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice. Carcinogenesis, 28, 163-173.
    • (2007) Carcinogenesis , vol.28 , pp. 163-173
    • Khan, N.1
  • 23
    • 0035451363 scopus 로고    scopus 로고
    • Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation
    • Surh,Y.J. et al. (2001) Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat. Res., 480-481, 243-268.
    • (2001) Mutat. Res. , vol.480-481 , pp. 243-268
    • Surh, Y.J.1
  • 24
    • 52249096359 scopus 로고    scopus 로고
    • The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers
    • Guo,C. et al. (2008) The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes. Chromosomes Cancer, 47, 939-946.
    • (2008) Genes. Chromosomes Cancer , vol.47 , pp. 939-946
    • Guo, C.1
  • 25
    • 84655175072 scopus 로고    scopus 로고
    • Down-regulation of miR-126 expression in colorectal cancer and its clinical significance
    • Li,X.M. et al. (2011) Down-regulation of miR-126 expression in colorectal cancer and its clinical significance. Med. Oncol., 28, 1054-1057.
    • (2011) Med. Oncol. , vol.28 , pp. 1054-1057
    • Li, X.M.1
  • 26
    • 40349103409 scopus 로고    scopus 로고
    • MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1
    • Harris,T.A. et al. (2008) MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc. Natl Acad. Sci. USA, 105, 1516-1521.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 1516-1521
    • Harris, T.A.1
  • 27
    • 84880328502 scopus 로고    scopus 로고
    • Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10
    • Mertens-Talcott,S.U. et al. (2013) Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10. Mol. Carcinog., 52, 591-602.
    • (2013) Mol. Carcinog. , vol.52 , pp. 591-602
    • Mertens-Talcott, S.U.1
  • 28
    • 77953192767 scopus 로고    scopus 로고
    • Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats
    • Leonardi,T. et al. (2010) Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats. Exp. Biol. Med. (Maywood)., 235, 710-717.
    • (2010) Exp. Biol. Med. (Maywood). , vol.235 , pp. 710-717
    • Leonardi, T.1
  • 29
    • 58649101636 scopus 로고    scopus 로고
    • Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis
    • Warren,C.A. et al. (2009) Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis. J. Nutr., 139, 101-105.
    • (2009) J. Nutr. , vol.139 , pp. 101-105
    • Warren, C.A.1
  • 30
    • 40449086665 scopus 로고    scopus 로고
    • Dose translation from animal to human studies revisited
    • Reagan-Shaw,S. et al. (2008) Dose translation from animal to human studies revisited. FASEB J., 22, 659-661.
    • (2008) FASEB J. , vol.22 , pp. 659-661
    • Reagan-Shaw, S.1
  • 31
    • 84888985838 scopus 로고    scopus 로고
    • Food and water intake, growth, and adiposity of Sprague-Dawley rats with diet board for 24 months
    • Laaksonen,K.S. et al. (2013) Food and water intake, growth, and adiposity of Sprague-Dawley rats with diet board for 24 months. Lab Anim., 48, 153-161.
    • (2013) Lab Anim. , vol.48 , pp. 153-161
    • Laaksonen, K.S.1
  • 32
    • 0029003648 scopus 로고
    • Role of aberrant crypt foci in understanding the pathogenesis of colon cancer
    • Bird,R.P. (1995) Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett., 93, 55-71.
    • (1995) Cancer Lett. , vol.93 , pp. 55-71
    • Bird, R.P.1
  • 33
    • 77249148358 scopus 로고    scopus 로고
    • Colon cancer chemopreventive activities of pomegranate ellagitannins and urolithins
    • Kasimsetty,S.G. et al. (2010) Colon cancer chemopreventive activities of pomegranate ellagitannins and urolithins. J. Agric. Food Chem., 58, 2180-2187.
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 2180-2187
    • Kasimsetty, S.G.1
  • 34
    • 54049157928 scopus 로고    scopus 로고
    • Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanism
    • Rettig,M.B. et al. (2008) Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanism. Mol. Cancer Ther., 7, 2662-2671.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 2662-2671
    • Rettig, M.B.1
  • 35
    • 0142227019 scopus 로고    scopus 로고
    • Targeting the PI3K-Akt pathway in human cancer: rationale and promise
    • Luo,J. et al. (2003) Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell, 4, 257-262.
    • (2003) Cancer Cell , vol.4 , pp. 257-262
    • Luo, J.1
  • 36
    • 84862563523 scopus 로고    scopus 로고
    • Mice expressing activated PI3K rapidly develop advanced colon cancer
    • Leystra,A.A. et al. (2012) Mice expressing activated PI3K rapidly develop advanced colon cancer. Cancer Res., 72, 2931-2936.
    • (2012) Cancer Res. , vol.72 , pp. 2931-2936
    • Leystra, A.A.1
  • 37
    • 32144449094 scopus 로고    scopus 로고
    • Aberrant crypt foci
    • Alrawi,S.J. et al. (2006) Aberrant crypt foci. Anticancer Res., 26(1A), 107-119.
    • (2006) Anticancer Res. , vol.26 , Issue.1 A , pp. 107-119
    • Alrawi, S.J.1
  • 38
    • 84857949057 scopus 로고    scopus 로고
    • Oral infusion of pomegranate fruit extract inhibits prostate carcinogenesis in the TRAMP model
    • Adhami,V.M. et al. (2012) Oral infusion of pomegranate fruit extract inhibits prostate carcinogenesis in the TRAMP model. Carcinogenesis, 33, 644-651.
    • (2012) Carcinogenesis , vol.33 , pp. 644-651
    • Adhami, V.M.1
  • 39
    • 14744277141 scopus 로고    scopus 로고
    • Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappa B in normal human epidermal keratinocytes paragraph sign
    • Afaq,F. et al. (2005) Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappa B in normal human epidermal keratinocytes paragraph sign. Photochem. Photobiol., 81, 38-45.
    • (2005) Photochem. Photobiol. , vol.81 , pp. 38-45
    • Afaq, F.1
  • 40
    • 0032548870 scopus 로고    scopus 로고
    • Over-expression of ICAM-1, VCAM-1 and ELAM-1 might influence tumor progression in colorectal cancer
    • Maurer,C.A. et al. (1998) Over-expression of ICAM-1, VCAM-1 and ELAM-1 might influence tumor progression in colorectal cancer. Int. J. Cancer, 79, 76-81.
    • (1998) Int. J. Cancer , vol.79 , pp. 76-81
    • Maurer, C.A.1
  • 41
    • 34548614576 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis
    • Roy,H.K. et al. (2007) Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis. FEBS Lett., 581, 3857-3862.
    • (2007) FEBS Lett. , vol.581 , pp. 3857-3862
    • Roy, H.K.1
  • 42
    • 33745700890 scopus 로고    scopus 로고
    • Suppression of colon carcinogenesis by bioactive compounds in grapefruit
    • Vanamala,J. et al. (2006) Suppression of colon carcinogenesis by bioactive compounds in grapefruit. Carcinogenesis, 27, 1257-1265.
    • (2006) Carcinogenesis , vol.27 , pp. 1257-1265
    • Vanamala, J.1
  • 43
    • 0003504049 scopus 로고    scopus 로고
    • Cyclooxygenase regulates angiogenesis induced by colon cancer cells
    • Tsujii,M. et al. (1998) Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell, 93, 705-716.
    • (1998) Cell , vol.93 , pp. 705-716
    • Tsujii, M.1
  • 44
    • 22244439197 scopus 로고    scopus 로고
    • COX-2 inhibits anoikis by activation of the PI-3K/Akt pathway in human bladder cancer cells
    • Choi,E.M. et al. (2005) COX-2 inhibits anoikis by activation of the PI-3K/Akt pathway in human bladder cancer cells. Exp. Mol. Med., 37, 199-203.
    • (2005) Exp. Mol. Med. , vol.37 , pp. 199-203
    • Choi, E.M.1
  • 45
    • 78149477179 scopus 로고    scopus 로고
    • Comparison of purple carrot juice and ß-carotene in a high-carbohydrate, high-fat diet-fed rat model of the metabolic syndrome
    • Poudyal,H. et al. (2010) Comparison of purple carrot juice and ß-carotene in a high-carbohydrate, high-fat diet-fed rat model of the metabolic syndrome. Br. J. Nutr., 104, 1322-1332.
    • (2010) Br. J. Nutr. , vol.104 , pp. 1322-1332
    • Poudyal, H.1
  • 46
    • 77950664735 scopus 로고    scopus 로고
    • Purified blueberry anthocyanins and blueberry juice alter development of obesity in mice fed an obesogenic high-fat diet
    • Prior,R.L. et al. (2010) Purified blueberry anthocyanins and blueberry juice alter development of obesity in mice fed an obesogenic high-fat diet. J. Agric. Food Chem., 58, 3970-3976.
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 3970-3976
    • Prior, R.L.1
  • 47
    • 6344258661 scopus 로고    scopus 로고
    • Weight loss leads to reductions in inflammatory biomarkers after a very-low-carbohydrate diet and a low-fat diet in overweight men
    • Sharman,M.J. et al. (2004) Weight loss leads to reductions in inflammatory biomarkers after a very-low-carbohydrate diet and a low-fat diet in overweight men. Clin. Sci. (Lond)., 107, 365-369.
    • (2004) Clin. Sci. (Lond). , vol.107 , pp. 365-369
    • Sharman, M.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.