Bezielle (BZL101)-induced oxidative stress damage followed by redistribution of metabolic fluxes in breast cancer cells: A combined proteomic and metabolomic study

International Journal of Cancer

Volumn 129, Issue 12, 2011, Pages 2945-2957

  Klawitter, Jelena ^a,b,c   Klawitter, Jost ^a   Gurshtein, Jennifer ^b,c   Corby, Kyler ^a   Fong, Sylvia ^b,c   Tagliaferri, Mary ^b,c   Quattrochi, Linda ^b,c   Cohen, Isaac ^b,c   Shtivelman, Emma ^b,c   Christians, Uwe ^a,b,c  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b Bionovo Inc   (United States)

^c BioNovo Inc   (United States)

Author keywords

Bezielle; BZL101; metabolomics; NMR; proteomics; ROS; Scutellaria barbata

Indexed keywords

2 OXOGLUTARIC ACID; ADENOSINE TRIPHOSPHATE; ALPHA ENOLASE; ANTINEOPLASTIC AGENT; BEZIELLE; BZL 101; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; FATTY ACID SYNTHASE; GLUTATHIONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PENTOSE PHOSPHATE; PEROXIREDOXIN; PHOSPHORYLCHOLINE; PLANT EXTRACT; PYRUVATE CARBOXYLASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SCUTELLARIA BARBATA EXTRACT; SUCCINATE DEHYDROGENASE; THIOREDOXIN; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CARBOHYDRATE METABOLISM; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL DEATH; CELL METABOLISM; CELL PROLIFERATION; CITRIC ACID CYCLE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG TOLERABILITY; ENERGY YIELD; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; HUMAN; HUMAN CELL; LIPID METABOLISM; MASS SPECTROMETRY; METABOLOMICS; OXIDATION REDUCTION POTENTIAL; OXIDATIVE STRESS; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOMICS; PROTON NUCLEAR MAGNETIC RESONANCE; WESTERN BLOTTING; BREAST TUMOR; CELL CYCLE; DRUG EFFECT; FEMALE; METABOLISM; METHODOLOGY; SCUTELLARIA BAICALENSIS; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

BREAST NEOPLASMS; CELL CYCLE; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GLYCOLYSIS; HUMANS; LIPID METABOLISM; METABOLOMICS; OXIDATIVE STRESS; PLANT EXTRACTS; PROTEOMICS; SCUTELLARIA BAICALENSIS; SIGNAL TRANSDUCTION;

EID: 84855163806     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25965     Document Type: Article

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