Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 9, 2012, Pages 3031-3037

  Chen, Di ^a   Pamu, Sreedhar ^b   Cui, Qiuzhi ^a   Chan, Tak Hang ^b   Dou, Q Ping ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

AMP activated protein kinase; Breast cancer; Cancer stem cells; Cell proliferation; EGCG analogs

Indexed keywords

2,3 NAPHTHALENE 1,2,3,4 TETRAHYDRO 2,3 BIS (4 ACETAMIDOBENZOIC ACID); 2,3 NAPHTHALENE 1,2,3,4 TETRAHYDRO 2,3 BIS (4 AMINOBENZOIC ACID); 2,3 NAPHTHALENE 1,2,3,4 TETRAHYDRO 2,3 BIS (4 BROMO 3,5 DIHYDROXYBENZOIC ACID); 2,3 NAPHTHALENE 1,2,3,4 TETRAHYDRO 2,3 BIS (4 BROMO 3,5 DIMETHOXYMETHOXYBENZOIC ACID); 2,3 NAPHTHALENE 1,2,3,4 TETRAHYDRO 2,3 BIS(2 T BUTOXYCARBONYL 4 AMINOBENZOIC ACID); 4 BROMO 3,5 DIMETHOXYMETHOXYBENZOIC ACID; CYCLIN DEPENDENT KINASE INHIBITOR 1A; EPIGALLOCATECHIN GALLATE; EPIGALLOCATECHIN GALLATE DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ACTIVATOR; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER INHIBITION; CANCER STEM CELL; CANCER THERAPY; CARCINOGENESIS; CELL POPULATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TARGET CELL; UPREGULATION;

AMP-ACTIVATED PROTEIN KINASES; ANTINEOPLASTIC AGENTS; BENZOATES; CATECHIN; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOWN-REGULATION; HUMANS; NAPHTHALENES; NEOPLASTIC STEM CELLS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; UP-REGULATION;

EID: 84862783302     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.03.002     Document Type: Article

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